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SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043.


mTOR signaling in mouse models of accelerated aging.

Lee JY, Kennedy BK, Liao CY.

J Gerontol A Biol Sci Med Sci. 2019 Mar 1. pii: glz059. doi: 10.1093/gerona/glz059. [Epub ahead of print]


Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.

Sasikumar AN, Killilea DW, Kennedy BK, Brem RB.

Exp Gerontol. 2019 Jun;120:101-106. doi: 10.1016/j.exger.2019.02.001. Epub 2019 Feb 8.


Mixing old and young: enhancing rejuvenation and accelerating aging.

Lau A, Kennedy BK, Kirkland JL, Tullius SG.

J Clin Invest. 2019 Jan 2;129(1):4-11. doi: 10.1172/JCI123946. Epub 2019 Jan 2. Review.


Aging and Health Policies in Chile: New Agendas for Research.

Thumala D, Kennedy BK, Calvo E, Gonzalez-Billault C, Zitko P, Lillo P, Villagra R, Ibáñez A, Assar R, Andrade M, Slachevsky A.

Health Syst Reform. 2017 Oct 2;3(4):253-260. doi: 10.1080/23288604.2017.1353844.


Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness.

Levy Y, Ross JA, Niglas M, Snetkov VA, Lynham S, Liao CY, Puckelwartz MJ, Hsu YM, McNally EM, Alsheimer M, Harridge SD, Young SG, Fong LG, Español Y, Lopez-Otin C, Kennedy BK, Lowe DA, Ochala J.

JCI Insight. 2018 Oct 4;3(19). pii: 120920. doi: 10.1172/jci.insight.120920.


Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins.

Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Garrett BJ, Kwok CS, Academia EC, Hsu YM, Miller DM, Bair AM, Wilson JA, Tannady G, Stewart EM, Adamson SS, Wang J, Withers DJ, Kennedy BK.

Cell Discov. 2017 Oct 31;3:17039. doi: 10.1038/celldisc.2017.39. eCollection 2017.


H2S to Mitigate Vascular Aging: A SIRT1 Connection.

Arumugam TV, Kennedy BK.

Cell. 2018 Mar 22;173(1):8-10. doi: 10.1016/j.cell.2018.03.011.


The yeast replicative aging model.

He C, Zhou C, Kennedy BK.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2690-2696. doi: 10.1016/j.bbadis.2018.02.023. Epub 2018 Mar 8. Review.


A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.

Huang J, Mousley CJ, Dacquay L, Maitra N, Drin G, He C, Ridgway ND, Tripathi A, Kennedy M, Kennedy BK, Liu W, Baetz K, Polymenis M, Bankaitis VA.

Dev Cell. 2018 Feb 5;44(3):378-391.e5. doi: 10.1016/j.devcel.2017.12.026. Epub 2018 Jan 27.


mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance.

Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers JT, Jasper H.

Cell Stem Cell. 2017 Dec 7;21(6):806-818.e5. doi: 10.1016/j.stem.2017.11.008.


Accelerated aging in schizophrenia and related disorders: Future research.

Kirkpatrick B, Kennedy BK.

Schizophr Res. 2018 Jun;196:4-8. doi: 10.1016/j.schres.2017.06.034. Epub 2017 Jul 6.


Microbiome and Longevity: Gut Microbes Send Signals to Host Mitochondria.

Gruber J, Kennedy BK.

Cell. 2017 Jun 15;169(7):1168-1169. doi: 10.1016/j.cell.2017.05.048.


Unbalanced Growth, Senescence and Aging.

Polymenis M, Kennedy BK.

Adv Exp Med Biol. 2017;1002:189-208. doi: 10.1007/978-3-319-57127-0_8. Review.


The replicative lifespan-extending deletion of SGF73 results in altered ribosomal gene expression in yeast.

Mason AG, Garza RM, McCormick MA, Patel B, Kennedy BK, Pillus L, La Spada AR.

Aging Cell. 2017 Aug;16(4):785-796. doi: 10.1111/acel.12611. Epub 2017 May 31.


2nd interventions in aging conference.

Kennedy BK, Partridge L.

Aging (Albany NY). 2017 Apr;9(4):1090-1095. doi: 10.18632/aging.101221. No abstract available.


T(ell)TALE signs of aging.

Taneja R, Kennedy BK.

Cell Res. 2017 Apr;27(4):453-454. doi: 10.1038/cr.2017.33. Epub 2017 Mar 10.


CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes.

Beaupere C, Wasko BM, Lorusso J, Kennedy BK, Kaeberlein M, Labunskyy VM.

Cell Rep. 2017 Feb 21;18(8):1884-1892. doi: 10.1016/j.celrep.2017.01.077.


Ribosomal Proteins Rpl22 and Rpl22l1 Control Morphogenesis by Regulating Pre-mRNA Splicing.

Zhang Y, O'Leary MN, Peri S, Wang M, Zha J, Melov S, Kappes DJ, Feng Q, Rhodes J, Amieux PS, Morris DR, Kennedy BK, Wiest DL.

Cell Rep. 2017 Jan 10;18(2):545-556. doi: 10.1016/j.celrep.2016.12.034.


Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells.

Blank HM, Perez R, He C, Maitra N, Metz R, Hill J, Lin Y, Johnson CD, Bankaitis VA, Kennedy BK, Aramayo R, Polymenis M.

EMBO J. 2017 Feb 15;36(4):487-502. doi: 10.15252/embj.201695050. Epub 2017 Jan 5.


Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.

Kennedy BK, Pennypacker JK.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S398-S401. doi: 10.1513/AnnalsATS.201609-680AW. Review.


Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J.

Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15.


Rapamycin Reverses Metabolic Deficits in Lamin A/C-Deficient Mice.

Liao CY, Anderson SS, Chicoine NH, Mayfield JR, Academia EC, Wilson JA, Pongkietisak C, Thompson MA, Lagmay EP, Miller DM, Hsu YM, McCormick MA, O'Leary MN, Kennedy BK.

Cell Rep. 2016 Dec 6;17(10):2542-2552. doi: 10.1016/j.celrep.2016.10.040.


Stem Cell Models: A Guide to Understand and Mitigate Aging?

Brunauer R, Alavez S, Kennedy BK.

Gerontology. 2017;63(1):84-90. Epub 2016 Oct 20. Review.


Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.

Tsai SY, Rodriguez AA, Dastidar SG, Del Greco E, Carr KL, Sitzmann JM, Academia EC, Viray CM, Martinez LL, Kaplowitz BS, Ashe TD, La Spada AR, Kennedy BK.

Cell Rep. 2016 Aug 16;16(7):1903-14. doi: 10.1016/j.celrep.2016.07.029. Epub 2016 Aug 4.


The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.

Kennedy BK, Lamming DW.

Cell Metab. 2016 Jun 14;23(6):990-1003. doi: 10.1016/j.cmet.2016.05.009. Review.


Does Longer Lifespan Mean Longer Healthspan?

Hansen M, Kennedy BK.

Trends Cell Biol. 2016 Aug;26(8):565-568. doi: 10.1016/j.tcb.2016.05.002. Epub 2016 May 27.


Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.

Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krut'ko V, Zhavoronkov A, Kennedy BK.

Aging Cell. 2016 Jun;15(3):407-15. doi: 10.1111/acel.12463. Epub 2016 Mar 11. Review.


C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension.

McQuary PR, Liao CY, Chang JT, Kumsta C, She X, Davis A, Chu CC, Gelino S, Gomez-Amaro RL, Petrascheck M, Brill LM, Ladiges WC, Kennedy BK, Hansen M.

Cell Rep. 2016 Mar 8;14(9):2059-2067. doi: 10.1016/j.celrep.2016.02.012. Epub 2016 Feb 25.


SIRT6, oxidative stress, and aging.

Liao CY, Kennedy BK.

Cell Res. 2016 Feb;26(2):143-4. doi: 10.1038/cr.2016.8. Epub 2016 Jan 19.


A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.

McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK.

Cell Metab. 2015 Nov 3;22(5):895-906. doi: 10.1016/j.cmet.2015.09.008. Epub 2015 Oct 8.


Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society.

Nikolich-Žugich J, Goldman DP, Cohen PR, Cortese D, Fontana L, Kennedy BK, Mohler MJ, Olshansky SJ, Perls T, Perry D, Richardson A, Ritchie C, Wertheimer AM, Faragher RG, Fain MJ.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):435-44. doi: 10.1093/gerona/glv164. Epub 2015 Sep 29.


The Essence of Aging.

Vijg J, Kennedy BK.

Gerontology. 2016;62(4):381-5. doi: 10.1159/000439348. Epub 2015 Sep 22. Review.


Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry.

Yang J, McCormick MA, Zheng J, Xie Z, Tsuchiya M, Tsuchiyama S, El-Samad H, Ouyang Q, Kaeberlein M, Kennedy BK, Li H.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11977-82. doi: 10.1073/pnas.1506054112. Epub 2015 Sep 8.


Doxycycline: new tricks for an old drug.

Barbie DA, Kennedy BK.

Oncotarget. 2015 Aug 14;6(23):19336-7. No abstract available.


Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity.

Douglas PM, Baird NA, Simic MS, Uhlein S, McCormick MA, Wolff SC, Kennedy BK, Dillin A.

Cell Rep. 2015 Aug 18;12(7):1196-1204. doi: 10.1016/j.celrep.2015.07.026. Epub 2015 Aug 6.


H3K36 methylation promotes longevity by enhancing transcriptional fidelity.

Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL.

Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115.


Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity.

Tsai S, Sitzmann JM, Dastidar SG, Rodriguez AA, Vu SL, McDonald CE, Academia EC, O'Leary MN, Ashe TD, La Spada AR, Kennedy BK.

J Clin Invest. 2015 Aug 3;125(8):2952-64. doi: 10.1172/JCI77361. Epub 2015 Jun 29.


A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.

Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.


Medicine. Progeria accelerates adult stem cell aging.

Brunauer R, Kennedy BK.

Science. 2015 Jun 5;348(6239):1093-4. doi: 10.1126/science.aac4214. No abstract available.


MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts.

Xiong XD, Jung HJ, Gombar S, Park JY, Zhang CL, Zheng H, Ruan J, Li JB, Kaeberlein M, Kennedy BK, Zhou Z, Liu X, Suh Y.

Mutat Res. 2015 Jul;777:69-78. doi: 10.1016/j.mrfmmm.2015.04.010. Epub 2015 Apr 24.


PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae.

Cui HJ, Liu XG, McCormick M, Wasko BM, Zhao W, He X, Yuan Y, Fang BX, Sun XR, Kennedy BK, Suh Y, Zhou ZJ, Kaeberlein M, Feng WL.

Age (Dordr). 2015 Jun;37(3):9788. doi: 10.1007/s11357-015-9788-7. Epub 2015 May 4.


Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.


Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.

Schreiber KH, Ortiz D, Academia EC, Anies AC, Liao CY, Kennedy BK.

Aging Cell. 2015 Apr;14(2):265-73. doi: 10.1111/acel.12313. Epub 2015 Feb 4.


Proteasomes, Sir2, and Hxk2 form an interconnected aging network that impinges on the AMPK/Snf1-regulated transcriptional repressor Mig1.

Yao Y, Tsuchiyama S, Yang C, Bulteau AL, He C, Robison B, Tsuchiya M, Miller D, Briones V, Tar K, Potrero A, Friguet B, Kennedy BK, Schmidt M.

PLoS Genet. 2015 Jan 28;11(1):e1004968. doi: 10.1371/journal.pgen.1004968. eCollection 2015 Jan.


Aging interventions get human.

Kennedy BK, Pennypacker JK.

Oncotarget. 2015 Jan 20;6(2):590-1. No abstract available.


Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import.

He C, Tsuchiyama SK, Nguyen QT, Plyusnina EN, Terrill SR, Sahibzada S, Patel B, Faulkner AR, Shaposhnikov MV, Tian R, Tsuchiya M, Kaeberlein M, Moskalev AA, Kennedy BK, Polymenis M.

PLoS Genet. 2014 Dec 18;10(12):e1004860. doi: 10.1371/journal.pgen.1004860. eCollection 2014 Dec.


Life history: mother-specific proteins that promote aging.

Zhou C, Li R, Kennedy BK.

Curr Biol. 2014 Dec 15;24(24):R1162-4. doi: 10.1016/j.cub.2014.11.007.


Geroscience: linking aging to chronic disease.

Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F.

Cell. 2014 Nov 6;159(4):709-13. doi: 10.1016/j.cell.2014.10.039.

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