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Items: 19


Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma.

Kennedy BE, Sadek M, Elnenaei MO, Reiman A, Gujar SA.

Trends Cancer. 2020 Jan;6(1):9-12. doi: 10.1016/j.trecan.2019.11.005. Epub 2019 Dec 31.


Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells.

Giacomantonio MA, Sterea AM, Kim Y, Paulo JA, Clements DR, Kennedy BE, Bydoun MJ, Shi G, Waisman DM, Gygi SP, Giacomantonio CA, Murphy JP, Gujar S.

J Proteome Res. 2020 Jan 17. doi: 10.1021/acs.jproteome.9b00583. [Epub ahead of print]


Inhibition of Pyruvate Dehydrogenase Kinase Enhances the Antitumor Efficacy of Oncolytic Reovirus.

Kennedy BE, Murphy JP, Clements DR, Konda P, Holay N, Kim Y, Pathak GP, Giacomantonio MA, Hiani YE, Gujar S.

Cancer Res. 2019 Aug 1;79(15):3824-3836. doi: 10.1158/0008-5472.CAN-18-2414. Epub 2019 May 14.


TAp73 Modifies Metabolism and Positively Regulates Growth of Cancer Stem-Like Cells in a Redox-Sensitive Manner.

Sharif T, Dai C, Martell E, Ghassemi-Rad MS, Hanes MR, Murphy PJ, Kennedy BE, Venugopal C, Subapanditha M, Giacomantonio CA, Marcato P, Singh SK, Gujar S.

Clin Cancer Res. 2019 Mar 15;25(6):2001-2017. doi: 10.1158/1078-0432.CCR-17-3177. Epub 2018 Dec 28.


The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.

Murphy JP, Giacomantonio MA, Paulo JA, Everley RA, Kennedy BE, Pathak GP, Clements DR, Kim Y, Dai C, Sharif T, Gygi SP, Gujar S.

Cell Rep. 2018 Aug 28;24(9):2381-2391.e5. doi: 10.1016/j.celrep.2018.07.086.


RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers.

Pathak GP, Shah R, Kennedy BE, Murphy JP, Clements D, Konda P, Giacomantonio M, Xu Z, Schlaepfer IR, Gujar S.

Mol Ther. 2018 Aug 1;26(8):2019-2033. doi: 10.1016/j.ymthe.2018.05.026. Epub 2018 Jun 30.


TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway.

Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y.

J Biol Chem. 2018 Mar 9;293(10):3637-3650. doi: 10.1074/jbc.M117.817635. Epub 2018 Jan 17.


Regulation of Cancer and Cancer-Related Genes via NAD.

Sharif T, Martell E, Dai C, Ghassemi-Rad MS, Kennedy BE, Lee PWK, Gujar S.

Antioxid Redox Signal. 2019 Feb 20;30(6):906-923. doi: 10.1089/ars.2017.7478. Epub 2018 Feb 22.


Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis.

Warford JR, Lamport AC, Clements DR, Malone A, Kennedy BE, Kim Y, Gujar SA, Hoskin DW, Easton AS.

Acta Neuropathol Commun. 2018 Jan 4;6(1):4. doi: 10.1186/s40478-017-0506-9.


Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages.

Clements DR, Murphy JP, Sterea A, Kennedy BE, Kim Y, Helson E, Almasi S, Holay N, Konda P, Paulo JA, Sharif T, Lee PW, Weekes MP, Gygi SP, Gujar S.

J Proteome Res. 2017 Sep 1;16(9):3391-3406. doi: 10.1021/acs.jproteome.7b00425. Epub 2017 Aug 23.


Measurement of Mitochondrial Cholesterol Import Using a Mitochondria-Targeted CYP11A1 Fusion Construct.

Kennedy BE, Charman M, Karten B.

Methods Mol Biol. 2017;1583:163-184. doi: 10.1007/978-1-4939-6875-6_12.


Autophagic homeostasis is required for the pluripotency of cancer stem cells.

Sharif T, Martell E, Dai C, Kennedy BE, Murphy P, Clements DR, Kim Y, Lee PW, Gujar SA.

Autophagy. 2017 Feb;13(2):264-284. doi: 10.1080/15548627.2016.1260808. Epub 2016 Dec 8.


NAD+ salvage pathway in cancer metabolism and therapy.

Kennedy BE, Sharif T, Martell E, Dai C, Kim Y, Lee PW, Gujar SA.

Pharmacol Res. 2016 Dec;114:274-283. doi: 10.1016/j.phrs.2016.10.027. Epub 2016 Nov 2. Review.


Presymptomatic Alterations in Amino Acid Metabolism and DNA Methylation in the Cerebellum of a Murine Model of Niemann-Pick Type C Disease.

Kennedy BE, Hundert AS, Goguen D, Weaver IC, Karten B.

Am J Pathol. 2016 Jun;186(6):1582-97. doi: 10.1016/j.ajpath.2016.02.012. Epub 2016 Apr 12.


Mitochondrial cholesterol: mechanisms of import and effects on mitochondrial function.

Martin LA, Kennedy BE, Karten B.

J Bioenerg Biomembr. 2016 Apr;48(2):137-51. doi: 10.1007/s10863-014-9592-6. Epub 2014 Nov 26. Review.


Adaptations of energy metabolism associated with increased levels of mitochondrial cholesterol in Niemann-Pick type C1-deficient cells.

Kennedy BE, Madreiter CT, Vishnu N, Malli R, Graier WF, Karten B.

J Biol Chem. 2014 Jun 6;289(23):16278-89. doi: 10.1074/jbc.M114.559914. Epub 2014 Apr 30.


Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain.

Kennedy BE, LeBlanc VG, Mailman TM, Fice D, Burton I, Karakach TK, Karten B.

PLoS One. 2013 Dec 18;8(12):e82685. doi: 10.1371/journal.pone.0082685. eCollection 2013.


Niemann-Pick Type C2 protein contributes to the transport of endosomal cholesterol to mitochondria without interacting with NPC1.

Kennedy BE, Charman M, Karten B.

J Lipid Res. 2012 Dec;53(12):2632-42. doi: 10.1194/jlr.M029942. Epub 2012 Sep 7.


MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein.

Charman M, Kennedy BE, Osborne N, Karten B.

J Lipid Res. 2010 May;51(5):1023-34. doi: 10.1194/jlr.M002345. Epub 2009 Oct 29.

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