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Items: 14

1.

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.

Monk BC, Keniya MV, Sabherwal M, Wilson RK, Graham DO, Hassan HF, Chen D, Tyndall JDA.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e02114-18. doi: 10.1128/AAC.02114-18. Print 2019 Jan.

PMID:
30397057
2.

Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.

Keniya MV, Sabherwal M, Wilson RK, Woods MA, Sagatova AA, Tyndall JDA, Monk BC.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01134-18. doi: 10.1128/AAC.01134-18. Print 2018 Nov.

PMID:
30126961
3.

Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.

Keniya MV, Ruma YN, Tyndall JDA, Monk BC.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01131-18. doi: 10.1128/AAC.01131-18. Print 2018 Nov.

PMID:
30126959
4.

Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova AA, Keniya MV, Tyndall JDA, Monk BC.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02242-17. doi: 10.1128/AAC.02242-17. Print 2018 Mar.

5.

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.

Tyndall JD, Sabherwal M, Sagatova AA, Keniya MV, Negroni J, Wilson RK, Woods MA, Tietjen K, Monk BC.

PLoS One. 2016 Dec 1;11(12):e0167485. doi: 10.1371/journal.pone.0167485. eCollection 2016.

6.

Targeting efflux pumps to overcome antifungal drug resistance.

Holmes AR, Cardno TS, Strouse JJ, Ivnitski-Steele I, Keniya MV, Lackovic K, Monk BC, Sklar LA, Cannon RD.

Future Med Chem. 2016 Aug;8(12):1485-501. doi: 10.4155/fmc-2016-0050. Epub 2016 Jul 27. Review.

7.

Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase.

Sagatova AA, Keniya MV, Wilson RK, Sabherwal M, Tyndall JD, Monk BC.

Sci Rep. 2016 May 18;6:26213. doi: 10.1038/srep26213.

8.

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.

Sagatova AA, Keniya MV, Wilson RK, Monk BC, Tyndall JD.

Antimicrob Agents Chemother. 2015 Aug;59(8):4982-9. doi: 10.1128/AAC.00925-15. Epub 2015 Jun 8.

9.

Inhibitors of the Candida albicans Major Facilitator Superfamily Transporter Mdr1p Responsible for Fluconazole Resistance.

Keniya MV, Fleischer E, Klinger A, Cannon RD, Monk BC.

PLoS One. 2015 May 7;10(5):e0126350. doi: 10.1371/journal.pone.0126350. eCollection 2015.

10.

Drug resistance is conferred on the model yeast Saccharomyces cerevisiae by expression of full-length melanoma-associated human ATP-binding cassette transporter ABCB5.

Keniya MV, Holmes AR, Niimi M, Lamping E, Gillet JP, Gottesman MM, Cannon RD.

Mol Pharm. 2014 Oct 6;11(10):3452-62. doi: 10.1021/mp500230b. Epub 2014 Aug 22.

11.

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.

Monk BC, Tomasiak TM, Keniya MV, Huschmann FU, Tyndall JD, O'Connell JD 3rd, Cannon RD, McDonald JG, Rodriguez A, Finer-Moore JS, Stroud RM.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3865-70. doi: 10.1073/pnas.1324245111. Epub 2014 Feb 3.

12.

Heterologous expression of Candida albicans Pma1p in Saccharomyces cerevisiae.

Keniya MV, Cannon RD, Nguyễn Â, Tyndall JD, Monk BC.

FEMS Yeast Res. 2013 May;13(3):302-11. doi: 10.1111/1567-1364.12035. Epub 2013 Mar 15.

13.

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.

Holmes AR, Keniya MV, Ivnitski-Steele I, Monk BC, Lamping E, Sklar LA, Cannon RD.

Antimicrob Agents Chemother. 2012 Mar;56(3):1508-15. doi: 10.1128/AAC.05706-11. Epub 2011 Dec 27.

14.

Efflux-mediated antifungal drug resistance.

Cannon RD, Lamping E, Holmes AR, Niimi K, Baret PV, Keniya MV, Tanabe K, Niimi M, Goffeau A, Monk BC.

Clin Microbiol Rev. 2009 Apr;22(2):291-321, Table of Contents. doi: 10.1128/CMR.00051-08. Review.

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