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Items: 44

1.

Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy.

Zhang SJ, Li XX, Yu Y, Chiu AP, Lo LH, To JC, Rowlands DK, Keng VW.

Biochem Biophys Res Commun. 2019 Jul 12;515(1):50-56. doi: 10.1016/j.bbrc.2019.05.014. Epub 2019 May 21.

PMID:
31122699
2.

HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism.

Chiu AP, Tschida BR, Sham TT, Lo LH, Moriarity BS, Li XX, Lo RC, Hinton DE, Rowlands DK, Chan CO, Mok DKW, Largaespada DA, Warner N, Keng VW.

Mol Cancer Res. 2019 Jul;17(7):1582-1593. doi: 10.1158/1541-7786.MCR-18-1127. Epub 2019 Apr 11.

PMID:
30975706
3.

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation.

Li XX, Lu XY, Zhang SJ, Chiu AP, Lo LH, Largaespada DA, Chen QB, Keng VW.

Biomed Pharmacother. 2019 Mar;111:68-75. doi: 10.1016/j.biopha.2018.12.019. Epub 2018 Dec 18.

4.

Liver-Specific Delivery of Sleeping Beauty Transposon System by Hydrodynamic Injection for Cancer Gene Validation.

Chiu AP, Keng VW.

Methods Mol Biol. 2019;1907:185-196. doi: 10.1007/978-1-4939-8967-6_15.

PMID:
30543001
5.

Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation.

Li XX, Zhang SJ, Chiu AP, Lo LH, To JC, Cui HN, Rowlands DK, Keng VW.

G3 (Bethesda). 2019 Jan 9;9(1):297-303. doi: 10.1534/g3.118.200795.

6.

Targeting of AKT/ERK/CTNNB1 by DAW22 as a potential therapeutic compound for malignant peripheral nerve sheath tumor.

Li XX, Zhang SJ, Chiu AP, Lo LH, Huang J, Rowlands DK, Wang J, Keng VW.

Cancer Med. 2018 Sep;7(9):4791-4800. doi: 10.1002/cam4.1732. Epub 2018 Aug 15.

7.

Sleeping Beauty Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors.

Tschida BR, Temiz NA, Kuka TP, Lee LA, Riordan JD, Tierrablanca CA, Hullsiek R, Wagner S, Hudson WA, Linden MA, Amin K, Beckmann PJ, Heuer RA, Sarver AL, Yang JD, Roberts LR, Nadeau JH, Dupuy AJ, Keng VW, Largaespada DA.

Cancer Res. 2017 Dec 1;77(23):6576-6588. doi: 10.1158/0008-5472.CAN-17-2281. Epub 2017 Oct 9.

8.

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.

Riordan JD, Feddersen CR, Tschida BR, Beckmann PJ, Keng VW, Linden MA, Amin K, Stipp CS, Largaespada DA, Dupuy AJ.

Hepatology. 2018 Mar;67(3):924-939. doi: 10.1002/hep.29565. Epub 2018 Jan 26.

9.

The CCCTC-binding factor (CTCF)-forkhead box protein M1 axis regulates tumour growth and metastasis in hepatocellular carcinoma.

Zhang B, Zhang Y, Zou X, Chan AW, Zhang R, Lee TK, Liu H, Lau EY, Ho NP, Lai PB, Cheung YS, To KF, Wong HK, Choy KW, Keng VW, Chow LM, Chan KK, Cheng AS, Ko BC.

J Pathol. 2017 Dec;243(4):418-430. doi: 10.1002/path.4976. Epub 2017 Oct 27.

10.

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

Wu J, Keng VW, Patmore DM, Kendall JJ, Patel AV, Jousma E, Jessen WJ, Choi K, Tschida BR, Silverstein KA, Fan D, Schwartz EB, Fuchs JR, Zou Y, Kim MO, Dombi E, Levy DE, Huang G, Cancelas JA, Stemmer-Rachamimov AO, Spinner RJ, Largaespada DA, Ratner N.

Cell Rep. 2016 Mar 1;14(8):1979-90. doi: 10.1016/j.celrep.2016.01.074. Epub 2016 Feb 18.

11.

Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma.

Chiu AP, Tschida BR, Lo LH, Moriarity BS, Rowlands DK, Largaespada DA, Keng VW.

World J Gastroenterol. 2015 Nov 14;21(42):12157-70. doi: 10.3748/wjg.v21.i42.12157. Review.

12.

Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity.

Watson AL, Anderson LK, Greeley AD, Keng VW, Rahrmann EP, Halfond AL, Powell NM, Collins MH, Rizvi T, Moertel CL, Ratner N, Largaespada DA.

Oncotarget. 2014 Mar 30;5(6):1502-14.

13.

Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studies.

Tschida BR, Largaespada DA, Keng VW.

Semin Cell Dev Biol. 2014 Mar;27:86-95. doi: 10.1016/j.semcdb.2014.01.006. Epub 2014 Jan 24. Review.

14.

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

Rahrmann EP, Watson AL, Keng VW, Choi K, Moriarity BS, Beckmann DA, Wolf NK, Sarver A, Collins MH, Moertel CL, Wallace MR, Gel B, Serra E, Ratner N, Largaespada DA.

Nat Genet. 2013 Jul;45(7):756-66. doi: 10.1038/ng.2641. Epub 2013 May 19.

15.

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ.

PLoS Genet. 2013 Apr;9(4):e1003441. doi: 10.1371/journal.pgen.1003441. Epub 2013 Apr 4.

16.

Canonical Wnt/β-catenin signaling drives human schwann cell transformation, progression, and tumor maintenance.

Watson AL, Rahrmann EP, Moriarity BS, Choi K, Conboy CB, Greeley AD, Halfond AL, Anderson LK, Wahl BR, Keng VW, Rizzardi AE, Forster CL, Collins MH, Sarver AL, Wallace MR, Schmechel SC, Ratner N, Largaespada DA.

Cancer Discov. 2013 Jun;3(6):674-89. doi: 10.1158/2159-8290.CD-13-0081. Epub 2013 Mar 27.

17.

Modular assembly of transposon integratable multigene vectors using RecWay assembly.

Moriarity BS, Rahrmann EP, Keng VW, Manlove LS, Beckmann DA, Wolf NK, Khurshid T, Bell JB, Largaespada DA.

Nucleic Acids Res. 2013 Apr;41(8):e92. doi: 10.1093/nar/gkt115. Epub 2013 Feb 26.

18.

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.

Keng VW, Watson AL, Rahrmann EP, Li H, Tschida BR, Moriarity BS, Choi K, Rizvi TA, Collins MH, Wallace MR, Ratner N, Largaespada DA.

Sarcoma. 2012;2012:620834. doi: 10.1155/2012/620834. Epub 2012 Dec 18.

19.

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated with EGFR.

Keng VW, Sia D, Sarver AL, Tschida BR, Fan D, Alsinet C, Solé M, Lee WL, Kuka TP, Moriarity BS, Villanueva A, Dupuy AJ, Riordan JD, Bell JB, Silverstein KA, Llovet JM, Largaespada DA.

Hepatology. 2013 Jan;57(1):120-30. doi: 10.1002/hep.26004. Epub 2012 Oct 19.

20.

PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.

Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA.

Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14.

21.

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

O'Donnell KA, Keng VW, York B, Reineke EL, Seo D, Fan D, Silverstein KA, Schrum CT, Xie WR, Mularoni L, Wheelan SJ, Torbenson MS, O'Malley BW, Largaespada DA, Boeke JD.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):E1377-86. doi: 10.1073/pnas.1115433109. Epub 2012 May 3.

22.

Why men are at higher risk for hepatocellular carcinoma?

Keng VW, Largaespada DA, Villanueva A.

J Hepatol. 2012 Aug;57(2):453-4. doi: 10.1016/j.jhep.2012.03.004. Epub 2012 Mar 13. No abstract available.

23.

Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system.

Keng VW, Tschida BR, Bell JB, Largaespada DA.

Hepatology. 2011 Mar;53(3):781-90. doi: 10.1002/hep.24091. Epub 2011 Jan 3.

24.

Efficient transposition of Tol2 in the mouse germline.

Keng VW, Ryan BJ, Wangensteen KJ, Balciunas D, Schmedt C, Ekker SC, Largaespada DA.

Genetics. 2009 Dec;183(4):1565-73. doi: 10.1534/genetics.109.100768. Epub 2009 Oct 5.

25.

Generating mutant rats using the Sleeping Beauty transposon system.

Kitada K, Keng VW, Takeda J, Horie K.

Methods. 2009 Nov;49(3):236-42. doi: 10.1016/j.ymeth.2009.04.010. Epub 2009 May 4.

PMID:
19398007
26.

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, Copeland NG, Llovet JM, Largaespada DA.

Nat Biotechnol. 2009 Mar;27(3):264-74. doi: 10.1038/nbt.1526. Epub 2009 Feb 22.

27.
28.

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver.

Wangensteen KJ, Wilber A, Keng VW, He Z, Matise I, Wangensteen L, Carson CM, Chen Y, Steer CJ, McIvor RS, Largaespada DA, Wang X, Ekker SC.

Hepatology. 2008 May;47(5):1714-24. doi: 10.1002/hep.22195.

29.

Germline mutagenesis mediated by Sleeping Beauty transposon system in mice.

Takeda J, Keng VW, Horie K.

Genome Biol. 2007;8 Suppl 1:S14. Review.

30.

Retrotransposons influence the mouse transcriptome: implication for the divergence of genetic traits.

Horie K, Saito ES, Keng VW, Ikeda R, Ishihara H, Takeda J.

Genetics. 2007 Jun;176(2):815-27. Epub 2007 Apr 15.

31.

Transposon-tagged mutagenesis in the rat.

Kitada K, Ishishita S, Tosaka K, Takahashi R, Ueda M, Keng VW, Horie K, Takeda J.

Nat Methods. 2007 Feb;4(2):131-3. Epub 2007 Jan 14.

PMID:
17220894
32.

Sleeping beauty transposase has an affinity for heterochromatin conformation.

Ikeda R, Kokubu C, Yusa K, Keng VW, Horie K, Takeda J.

Mol Cell Biol. 2007 Mar;27(5):1665-76. Epub 2006 Dec 18.

33.

Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth.

Yae K, Keng VW, Koike M, Yusa K, Kouno M, Uno Y, Kondoh G, Gotow T, Uchiyama Y, Horie K, Takeda J.

Mol Cell Biol. 2006 Aug;26(16):6185-96.

34.

Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system.

Keng VW, Yae K, Hayakawa T, Mizuno S, Uno Y, Yusa K, Kokubu C, Kinoshita T, Akagi K, Jenkins NA, Copeland NG, Horie K, Takeda J.

Nat Methods. 2005 Oct;2(10):763-9.

PMID:
16179923
35.

Identification and characterization of the hematopoietic cell-specific enhancer-like element of the mouse hex gene.

Sato A, Keng VW, Yamamoto T, Kasamatsu S, Ban T, Tanaka H, Satoh S, Yamada K, Noguchi T.

J Biochem. 2004 Feb;135(2):259-68.

36.

Identification of the transactivating region of the homeodomain protein, hex.

Kasamatsu S, Sato A, Yamamoto T, Keng VW, Yoshida H, Yamazaki Y, Shimoda M, Miyazaki J, Noguchi T.

J Biochem. 2004 Feb;135(2):217-23.

37.

Characterization of Sleeping Beauty transposition and its application to genetic screening in mice.

Horie K, Yusa K, Yae K, Odajima J, Fischer SE, Keng VW, Hayakawa T, Mizuno S, Kondoh G, Ijiri T, Matsuda Y, Plasterk RH, Takeda J.

Mol Cell Biol. 2003 Dec;23(24):9189-207.

38.

Insulin stimulates expression of the pyruvate kinase M gene in 3T3-L1 adipocytes.

Asai Y, Yamada K, Watanabe T, Keng VW, Noguchi T.

Biosci Biotechnol Biochem. 2003 Jun;67(6):1272-7.

39.

Sp family members stimulate transcription of the hex gene via interactions with GC boxes.

Kikkawa E, Hinata M, Keng VW, Myint Z, Sato A, Yamada K, Tanaka T, Noguchi T.

J Biochem. 2001 Dec;130(6):885-91.

40.

Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.

Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M, Noguchi T.

Biochem Biophys Res Commun. 2000 Oct 5;276(3):1155-61. Erratum in: Biochem Biophys Res Commun 2000 Dec 20;279(2):739.

PMID:
11027604
41.

Genomic organization and promoter analysis of a mouse homeobox gene, Hex.

Myint Z, Inazu T, Tanaka T, Yamada K, Keng VW, Inoue Y, Kuriyama M, Noguchi T.

J Biochem. 1999 Apr;125(4):795-802.

42.

cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein.

Tanaka T, Inazu T, Yamada K, Myint Z, Keng VW, Inoue Y, Taniguchi N, Noguchi T.

Biochem J. 1999 Apr 1;339 ( Pt 1):111-7.

43.

Expression of Hex mRNA in early murine postimplantation embryo development.

Keng VW, Fujimori KE, Myint Z, Tamamaki N, Nojyo Y, Noguchi T.

FEBS Lett. 1998 Apr 17;426(2):183-6.

44.

Blood cells and red cell morphology in the urine of healthy children.

Loh EH, Keng VW, Ward PB.

Clin Nephrol. 1990 Oct;34(4):185-7.

PMID:
2257705

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