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Items: 1 to 50 of 130

1.

Brain Injury-Mediated Neuroinflammatory Response and Alzheimer's Disease.

Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Dhaliwal AS, Dubova I, Mentor S, Premkumar K, Saeed D, Zahoor H, Raikwar SP, Zaheer S, Iyer SS, Zaheer A.

Neuroscientist. 2019 May 16:1073858419848293. doi: 10.1177/1073858419848293. [Epub ahead of print]

PMID:
31092147
2.

Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders.

Raikwar SP, Kikkeri NS, Sakuru R, Saeed D, Zahoor H, Premkumar K, Mentor S, Thangavel R, Dubova I, Ahmed ME, Selvakumar GP, Kempuraj D, Zaheer S, Iyer SS, Zaheer A.

J Neuroimmune Pharmacol. 2019 Apr 23. doi: 10.1007/s11481-019-09849-y. [Epub ahead of print] Review.

PMID:
31011884
3.

Synergy in Disruption of Mitochondrial Dynamics by Aβ (1-42) and Glia Maturation Factor (GMF) in SH-SY5Y Cells Is Mediated Through Alterations in Fission and Fusion Proteins.

Ahmed ME, Selvakumar GP, Kempuraj D, Thangavel R, Mentor S, Dubova I, Raikwar SP, Zaheer S, Iyer S, Zaheer A.

Mol Neurobiol. 2019 Oct;56(10):6964-6975. doi: 10.1007/s12035-019-1544-z. Epub 2019 Apr 4.

PMID:
30949973
4.

Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer's Disease.

Kempuraj D, Mentor S, Thangavel R, Ahmed ME, Selvakumar GP, Raikwar SP, Dubova I, Zaheer S, Iyer SS, Zaheer A.

Front Cell Neurosci. 2019 Feb 19;13:54. doi: 10.3389/fncel.2019.00054. eCollection 2019.

5.

CRISPR/Cas9 Editing of Glia Maturation Factor Regulates Mitochondrial Dynamics by Attenuation of the NRF2/HO-1 Dependent Ferritin Activation in Glial Cells.

Selvakumar GP, Ahmed ME, Raikwar SP, Thangavel R, Kempuraj D, Dubova I, Saeed D, Zahoor H, Premkumar K, Zaheer S, Iyer S, Zaheer A.

J Neuroimmune Pharmacol. 2019 Feb 27. doi: 10.1007/s11481-019-09833-6. [Epub ahead of print]

PMID:
30810907
6.

Glia Maturation Factor and Mast Cell-Dependent Expression of Inflammatory Mediators and Proteinase Activated Receptor-2 in Neuroinflammation.

Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Kumar KK, Yelam A, Kaur H, Dubova I, Raikwar SP, Iyer SS, Zaheer A.

J Alzheimers Dis. 2018;66(3):1117-1129. doi: 10.3233/JAD-180786.

7.

Molecular Association of Glia Maturation Factor with the Autophagic Machinery in Rat Dopaminergic Neurons: a Role for Endoplasmic Reticulum Stress and MAPK Activation.

Selvakumar GP, Iyer SS, Kempuraj D, Ahmed ME, Thangavel R, Dubova I, Raikwar SP, Zaheer S, Zaheer A.

Mol Neurobiol. 2019 Jun;56(6):3865-3881. doi: 10.1007/s12035-018-1340-1. Epub 2018 Sep 14.

8.

Neuro-Immuno-Gene- and Genome-Editing-Therapy for Alzheimer's Disease: Are We There Yet?

Raikwar SP, Thangavel R, Dubova I, Ahmed ME, Selvakumar PG, Kempuraj D, Zaheer S, Iyer S, Zaheer A.

J Alzheimers Dis. 2018;65(2):321-344. doi: 10.3233/JAD-180422. Review.

9.

Mast Cell Proteases Activate Astrocytes and Glia-Neurons and Release Interleukin-33 by Activating p38 and ERK1/2 MAPKs and NF-κB.

Kempuraj D, Thangavel R, Selvakumar GP, Ahmed ME, Zaheer S, Raikwar SP, Zahoor H, Saeed D, Dubova I, Giler G, Herr S, Iyer SS, Zaheer A.

Mol Neurobiol. 2019 Mar;56(3):1681-1693. doi: 10.1007/s12035-018-1177-7. Epub 2018 Jun 18.

PMID:
29916143
10.

Are Tanycytes the Missing Link Between Type 2 Diabetes and Alzheimer's Disease?

Raikwar SP, Bhagavan SM, Ramaswamy SB, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer S, Iyer S, Zaheer A.

Mol Neurobiol. 2019 Feb;56(2):833-843. doi: 10.1007/s12035-018-1123-8. Epub 2018 May 24. Review.

11.

Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target.

Raikwar SP, Thangavel R, Dubova I, Selvakumar GP, Ahmed ME, Kempuraj D, Zaheer SA, Iyer SS, Zaheer A.

Mol Neurobiol. 2019 Jan;56(1):378-393. doi: 10.1007/s12035-018-1068-y. Epub 2018 Apr 27.

12.

Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells.

Selvakumar GP, Iyer SS, Kempuraj D, Raju M, Thangavel R, Saeed D, Ahmed ME, Zahoor H, Raikwar SP, Zaheer S, Zaheer A.

Mol Neurobiol. 2018 Sep;55(9):7132-7152. doi: 10.1007/s12035-018-0882-6. Epub 2018 Jan 30.

13.

Mast Cell Activation in Brain Injury, Stress, and Post-traumatic Stress Disorder and Alzheimer's Disease Pathogenesis.

Kempuraj D, Selvakumar GP, Thangavel R, Ahmed ME, Zaheer S, Raikwar SP, Iyer SS, Bhagavan SM, Beladakere-Ramaswamy S, Zaheer A.

Front Neurosci. 2017 Dec 12;11:703. doi: 10.3389/fnins.2017.00703. eCollection 2017. Review.

14.

Measurement of Elevated IL-37 Levels in Acute Ischemic Brain Injury: A Cross-sectional Pilot Study.

Zafar A, Ikram A, Jillella DV, Kempuraj D, Khan MM, Bushnaq S, Adam H, Ortega-Gutierrez S, Quadri SA, Farooqui M, Zaheer A, Leira EC.

Cureus. 2017 Oct 11;9(10):e1767. doi: 10.7759/cureus.1767.

15.

Co-Expression of Glia Maturation Factor and Apolipoprotein E4 in Alzheimer's Disease Brain.

Thangavel R, Bhagavan SM, Ramaswamy SB, Surpur S, Govindarajan R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A.

J Alzheimers Dis. 2018;61(2):553-560. doi: 10.3233/JAD-170777.

16.

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer's Disease Brain.

Ahmed ME, Iyer S, Thangavel R, Kempuraj D, Selvakumar GP, Raikwar SP, Zaheer S, Zaheer A.

J Alzheimers Dis. 2017;60(3):1143-1160. doi: 10.3233/JAD-170634.

17.

Cross-Talk between Glia, Neurons and Mast Cells in Neuroinflammation Associated with Parkinson's Disease.

Kempuraj D, Selvakumar GP, Zaheer S, Thangavel R, Ahmed ME, Raikwar S, Govindarajan R, Iyer S, Zaheer A.

J Neuroimmune Pharmacol. 2018 Mar;13(1):100-112. doi: 10.1007/s11481-017-9766-1. Epub 2017 Sep 26.

18.

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration.

Kempuraj D, Thangavel R, Selvakumar GP, Zaheer S, Ahmed ME, Raikwar SP, Zahoor H, Saeed D, Natteru PA, Iyer S, Zaheer A.

Front Cell Neurosci. 2017 Jul 24;11:216. doi: 10.3389/fncel.2017.00216. eCollection 2017. Review.

19.

Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer's Disease Brain.

Thangavel R, Kempuraj D, Zaheer S, Raikwar S, Ahmed ME, Selvakumar GP, Iyer SS, Zaheer A.

Front Aging Neurosci. 2017 May 18;9:150. doi: 10.3389/fnagi.2017.00150. eCollection 2017.

20.

Are mast cells important in diabetes?

Kempuraj D, Caraffa A, Ronconi G, Lessiani G, Conti P.

Pol J Pathol. 2016;67(3):199-206. doi: 10.5114/pjp.2016.63770. Review.

21.

Neuroinflammation Induces Neurodegeneration.

Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, Zaheer S, Iyer SS, Zaheer A.

J Neurol Neurosurg Spine. 2016;1(1). pii: 1003. Epub 2016 Nov 18.

22.

Important role of mast cells in multiple sclerosis.

Conti P, Kempuraj D.

Mult Scler Relat Disord. 2016 Jan;5:77-80. doi: 10.1016/j.msard.2015.11.005. Epub 2015 Nov 11. Review.

PMID:
26856948
23.

Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)).

Kempuraj D, Thangavel R, Fattal R, Pattani S, Yang E, Zaheer S, Santillan DA, Santillan MK, Zaheer A.

Neurochem Res. 2016 May;41(5):1042-9. doi: 10.1007/s11064-015-1790-z. Epub 2015 Dec 8.

24.

Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins α-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.

Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan DA, Santillan MK, Zaheer A.

PLoS One. 2015 Aug 14;10(8):e0135776. doi: 10.1371/journal.pone.0135776. eCollection 2015.

25.

Absence of glia maturation factor protects dopaminergic neurons and improves motor behavior in mouse model of parkinsonism.

Khan MM, Zaheer S, Thangavel R, Patel M, Kempuraj D, Zaheer A.

Neurochem Res. 2015 May;40(5):980-90. doi: 10.1007/s11064-015-1553-x. Epub 2015 Mar 10.

26.

Glia maturation factor deficiency suppresses 1-methyl-4-phenylpyridinium-induced oxidative stress in astrocytes.

Khan MM, Kempuraj D, Zaheer S, Zaheer A.

J Mol Neurosci. 2014 Aug;53(4):590-9. doi: 10.1007/s12031-013-0225-z. Epub 2014 Jan 16.

27.

Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain.

Xiong Z, Thangavel R, Kempuraj D, Yang E, Zaheer S, Zaheer A.

J Alzheimers Dis. 2014;40(2):297-308. doi: 10.3233/JAD-132081.

28.

Glia maturation factor expression in entorhinal cortex of Alzheimer's disease brain.

Thangavel R, Kempuraj D, Stolmeier D, Anantharam P, Khan M, Zaheer A.

Neurochem Res. 2013 Sep;38(9):1777-84. doi: 10.1007/s11064-013-1080-6. Epub 2013 May 29.

29.

Glia maturation factor expression in hippocampus of human Alzheimer's disease.

Stolmeier D, Thangavel R, Anantharam P, Khan MM, Kempuraj D, Zaheer A.

Neurochem Res. 2013 Aug;38(8):1580-9. doi: 10.1007/s11064-013-1059-3. Epub 2013 May 3.

30.

The novel cytokine interleukin-33 activates acinar cell proinflammatory pathways and induces acute pancreatic inflammation in mice.

Kempuraj D, Twait EC, Williard DE, Yuan Z, Meyerholz DK, Samuel I.

PLoS One. 2013;8(2):e56866. doi: 10.1371/journal.pone.0056866. Epub 2013 Feb 13.

31.

Glia maturation factor induces interleukin-33 release from astrocytes: implications for neurodegenerative diseases.

Kempuraj D, Khan MM, Thangavel R, Xiong Z, Yang E, Zaheer A.

J Neuroimmune Pharmacol. 2013 Jun;8(3):643-50. doi: 10.1007/s11481-013-9439-7. Epub 2013 Feb 10.

32.

Protection of MPTP-induced neuroinflammation and neurodegeneration by Pycnogenol.

Khan MM, Kempuraj D, Thangavel R, Zaheer A.

Neurochem Int. 2013 Mar;62(4):379-88. doi: 10.1016/j.neuint.2013.01.029. Epub 2013 Feb 4.

33.

Enhanced expression of glia maturation factor correlates with glial activation in the brain of triple transgenic Alzheimer's disease mice.

Zaheer S, Thangavel R, Wu Y, Khan MM, Kempuraj D, Zaheer A.

Neurochem Res. 2013 Jan;38(1):218-25. doi: 10.1007/s11064-012-0913-z. Epub 2012 Oct 20.

34.

Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis.

Yuan Z, Meyerholz DK, Twait EC, Kempuraj D, Williard DE, Samuel I.

J Gastrointest Surg. 2011 Oct;15(10):1670-8. doi: 10.1007/s11605-011-1643-2. Epub 2011 Jul 29.

PMID:
21800226
35.

Amitriptyline and prochlorperazine inhibit proinflammatory mediator release from human mast cells: possible relevance to chronic fatigue syndrome.

Clemons A, Vasiadi M, Kempuraj D, Kourelis T, Vandoros G, Theoharides TC.

J Clin Psychopharmacol. 2011 Jun;31(3):385-7. doi: 10.1097/JCP.0b013e3182196e50. No abstract available.

36.

Luteolin and thiosalicylate inhibit HgCl(2) and thimerosal-induced VEGF release from human mast cells.

Asadi S, Zhang B, Weng Z, Angelidou A, Kempuraj D, Alysandratos KD, Theoharides TC.

Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1015-20.

PMID:
21244751
37.

Interrelationship between vitamins and cytokines in immunity.

Castellani ML, Shaik-Dasthagirisaheb YB, Tripodi D, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Fulcheri M, Tetè S, Galzio R, Salini V, Caraffa A, Antinolfi P, Frydas I, Sabatino G, Kempuraj D.

J Biol Regul Homeost Agents. 2010 Oct-Dec;24(4):385-90. Review.

PMID:
21122276
38.

IL-32 is increased along with tryptase in lesional psoriatic skin and is up-regulated by substance P in human mast cells.

Kempuraj D, Conti P, Vasiadi M, Alysandratos KD, Tagen M, Kalogeromitros D, Kourelis T, Gregoriou S, Makris M, Stavrianeas NG, Theoharides TC.

Eur J Dermatol. 2010 Nov-Dec;20(6):865-7. doi: 10.1684/ejd.2010.1110. Epub 2010 Nov 4. No abstract available.

39.

A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality.

Samuel I, Yuan Z, Meyerholz DK, Twait E, Williard DE, Kempuraj D.

Pancreatology. 2010;10(5):536-44. doi: 10.1159/000320776. Epub 2010 Oct 26.

40.

Brain metastases of mouse mammary adenocarcinoma is increased by acute stress.

Rozniecki JJ, Sahagian GG, Kempuraj D, Tao K, Jocobson S, Zhang B, Theoharides TC.

Brain Res. 2010 Dec 17;1366:204-10. doi: 10.1016/j.brainres.2010.09.085. Epub 2010 Sep 29.

PMID:
20887716
41.

IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells.

Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D.

J Biol Regul Homeost Agents. 2010 Apr-Jun;24(2):131-5.

PMID:
20487626
42.

Impact of RANTES, MCP-1 and IL-8 in mast cells.

Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, Shaik B.

J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):1-6. Review.

PMID:
20385066
43.

Mercury induces inflammatory mediator release from human mast cells.

Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC.

J Neuroinflammation. 2010 Mar 11;7:20. doi: 10.1186/1742-2094-7-20.

44.

Corticotropin-releasing hormone-receptor 2 is required for acute stress-induced bladder vascular permeability and release of vascular endothelial growth factor.

Boucher W, Kempuraj D, Michaelian M, Theoharides TC.

BJU Int. 2010 Nov;106(9):1394-9. doi: 10.1111/j.1464-410X.2010.09237.x.

45.

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin.

Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P.

Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4448-53. doi: 10.1073/pnas.1000803107. Epub 2010 Feb 16.

46.

Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content.

Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley CL, Shirihai OS, Theoharides TC.

J Immunol. 2009 Nov 15;183(10):6313-9. doi: 10.4049/jimmunol.0803422. Epub 2009 Oct 21.

47.

IL-32: a newly-discovered proinflammatory cytokine.

Felaco P, Castellani ML, De Lutiis MA, Felaco M, Pandolfi F, Salini V, De Amicis D, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Cuccurullo C, Perrella A, Theoharides TC, Conti P, Toniato E, Kempuraj D, Shaik YB.

J Biol Regul Homeost Agents. 2009 Jul-Sep;23(3):141-7. Review.

PMID:
19828090
48.

Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli.

Vasiadi M, Kalogeromitros D, Kempuraj D, Clemons A, Zhang B, Chliva C, Makris M, Wolfberg A, House M, Theoharides TC.

Int Arch Allergy Immunol. 2010;151(1):38-45. doi: 10.1159/000232569. Epub 2009 Aug 6.

PMID:
19672095
49.

Autism: an emerging 'neuroimmune disorder' in search of therapy.

Theoharides TC, Kempuraj D, Redwood L.

Expert Opin Pharmacother. 2009 Sep;10(13):2127-43. doi: 10.1517/14656560903107789. Review.

PMID:
19640207
50.

The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator.

Castellani ML, Kempuraj D, Salini V, Vecchiet J, Tete S, Ciampoli C, Conti F, Cerulli G, Caraffa A, Antinolfi P, Theoharides TC, De Amicis D, Perrella A, Cuccurullo C, Boscolo P, Shaik Y.

J Biol Regul Homeost Agents. 2009 Jan-Mar;23(1):11-4.

PMID:
19321041

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