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Items: 1 to 50 of 66

1.

Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas.

Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ.

Leukemia. 2019 Jan;33(1):132-147. doi: 10.1038/s41375-018-0178-x. Epub 2018 Jun 26.

2.

EBF1 binds to EBNA2 and promotes the assembly of EBNA2 chromatin complexes in B cells.

Glaser LV, Rieger S, Thumann S, Beer S, Kuklik-Roos C, Martin DE, Maier KC, Harth-Hertle ML, Grüning B, Backofen R, Krebs S, Blum H, Zimmer R, Erhard F, Kempkes B.

PLoS Pathog. 2017 Oct 2;13(10):e1006664. doi: 10.1371/journal.ppat.1006664. eCollection 2017 Oct.

3.

Human RAD52 - a novel player in DNA repair in cancer and immunodeficiency.

Ghosh S, Hönscheid A, Dückers G, Ginzel S, Gohlke H, Gombert M, Kempkes B, Klapper W, Kuhlen M, Laws HJ, Linka RM, Meisel R, Mielke C, Niehues T, Schindler D, Schneider D, Schuster FR, Speckmann C, Borkhardt A.

Haematologica. 2017 Feb;102(2):e69-e72. doi: 10.3324/haematol.2016.155838. Epub 2016 Dec 15. No abstract available.

4.

Systemic Radical Scavenger Treatment of a Mouse Model of Rett Syndrome: Merits and Limitations of the Vitamin E Derivative Trolox.

Janc OA, Hüser MA, Dietrich K, Kempkes B, Menzfeld C, Hülsmann S, Müller M.

Front Cell Neurosci. 2016 Nov 15;10:266. eCollection 2016.

5.

Fatal Lymphoproliferative Disease in Two Siblings Lacking Functional FAAP24.

Daschkey S, Bienemann K, Schuster V, Kreth HW, Linka RM, Hönscheid A, Fritz G, Johannes C, Fleckenstein B, Kempkes B, Gombert M, Ginzel S, Borkhardt A.

J Clin Immunol. 2016 Oct;36(7):684-92. doi: 10.1007/s10875-016-0317-y. Epub 2016 Jul 29.

PMID:
27473539
6.

Redox Indicator Mice Stably Expressing Genetically Encoded Neuronal roGFP: Versatile Tools to Decipher Subcellular Redox Dynamics in Neuropathophysiology.

Wagener KC, Kolbrink B, Dietrich K, Kizina KM, Terwitte LS, Kempkes B, Bao G, Müller M.

Antioxid Redox Signal. 2016 Jul 1;25(1):41-58. doi: 10.1089/ars.2015.6587. Epub 2016 May 24.

7.

RUNX super-enhancer control through the Notch pathway by Epstein-Barr virus transcription factors regulates B cell growth.

Gunnell A, Webb HM, Wood CD, McClellan MJ, Wichaidit B, Kempkes B, Jenner RG, Osborne C, Farrell PJ, West MJ.

Nucleic Acids Res. 2016 Jun 2;44(10):4636-50. doi: 10.1093/nar/gkw085. Epub 2016 Feb 15.

8.

EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells.

Kalchschmidt JS, Gillman AC, Paschos K, Bazot Q, Kempkes B, Allday MJ.

PLoS Pathog. 2016 Jan 11;12(1):e1005383. doi: 10.1371/journal.ppat.1005383. eCollection 2016 Jan.

9.

Epstein-Barr virus latency: current and future perspectives.

Kempkes B, Robertson ES.

Curr Opin Virol. 2015 Oct;14:138-44. doi: 10.1016/j.coviro.2015.09.007. Review.

10.

EBNA2 and Its Coactivator EBNA-LP.

Kempkes B, Ling PD.

Curr Top Microbiol Immunol. 2015;391:35-59. doi: 10.1007/978-3-319-22834-1_2. Review.

PMID:
26428371
11.

The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation.

Friberg A, Thumann S, Hennig J, Zou P, Nössner E, Ling PD, Sattler M, Kempkes B.

PLoS Pathog. 2015 May 29;11(5):e1004910. doi: 10.1371/journal.ppat.1004910. eCollection 2015 May.

12.

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma.

Bruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A.

Sci Transl Med. 2015 Apr 8;7(282):282ra47. doi: 10.1126/scitranslmed.aaa3230.

PMID:
25855493
13.

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors.

God JM, Cameron C, Figueroa J, Amria S, Hossain A, Kempkes B, Bornkamm GW, Stuart RK, Blum JS, Haque A.

J Immunol. 2015 Feb 15;194(4):1434-45. doi: 10.4049/jimmunol.1402382. Epub 2015 Jan 16.

14.

Loss of the Notch effector RBPJ promotes tumorigenesis.

Kulic I, Robertson G, Chang L, Baker JH, Lockwood WW, Mok W, Fuller M, Fournier M, Wong N, Chou V, Robinson MD, Chun HJ, Gilks B, Kempkes B, Thomson TA, Hirst M, Minchinton AI, Lam WL, Jones S, Marra M, Karsan A.

J Exp Med. 2015 Jan 12;212(1):37-52. doi: 10.1084/jem.20121192. Epub 2014 Dec 15.

15.

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.

Bazot Q, Deschamps T, Tafforeau L, Siouda M, Leblanc P, Harth-Hertle ML, Rabourdin-Combe C, Lotteau V, Kempkes B, Tommasino M, Gruffat H, Manet E.

Nucleic Acids Res. 2014 Sep;42(15):9700-16. doi: 10.1093/nar/gku697. Epub 2014 Aug 4.

16.

Macrophage polarisation: an immunohistochemical approach for identifying M1 and M2 macrophages.

Barros MH, Hauck F, Dreyer JH, Kempkes B, Niedobitek G.

PLoS One. 2013 Nov 15;8(11):e80908. doi: 10.1371/journal.pone.0080908. eCollection 2013.

17.

Inactivation of intergenic enhancers by EBNA3A initiates and maintains polycomb signatures across a chromatin domain encoding CXCL10 and CXCL9.

Harth-Hertle ML, Scholz BA, Erhard F, Glaser LV, Dölken L, Zimmer R, Kempkes B.

PLoS Pathog. 2013 Sep;9(9):e1003638. doi: 10.1371/journal.ppat.1003638. Epub 2013 Sep 19.

18.

Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming.

McClellan MJ, Wood CD, Ojeniyi O, Cooper TJ, Kanhere A, Arvey A, Webb HM, Palermo RD, Harth-Hertle ML, Kempkes B, Jenner RG, West MJ.

PLoS Pathog. 2013 Sep;9(9):e1003636. doi: 10.1371/journal.ppat.1003636. Epub 2013 Sep 12.

19.

Contrast curves of five different intraoral X-ray sensors: a technical note.

Brüllmann DD, Kempkes B, d'Hoedt B, Schulze R.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jun;115(6):e55-61. doi: 10.1016/j.oooo.2013.03.007.

PMID:
23706925
20.

Abortive lytic reactivation of KSHV in CBF1/CSL deficient human B cell lines.

Scholz BA, Harth-Hertle ML, Malterer G, Haas J, Ellwart J, Schulz TF, Kempkes B.

PLoS Pathog. 2013;9(5):e1003336. doi: 10.1371/journal.ppat.1003336. Epub 2013 May 16.

21.

Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome.

Grosser E, Hirt U, Janc OA, Menzfeld C, Fischer M, Kempkes B, Vogelgesang S, Manzke TU, Opitz L, Salinas-Riester G, Müller M.

Neurobiol Dis. 2012 Oct;48(1):102-14. doi: 10.1016/j.nbd.2012.06.007. Epub 2012 Jun 30.

PMID:
22750529
22.

Restraint Stress Intensifies Interstitial K(+) Accumulation during Severe Hypoxia.

Schnell C, Janc OA, Kempkes B, Callis CA, Flügge G, Hülsmann S, Müller M.

Front Pharmacol. 2012 Mar 28;3:53. doi: 10.3389/fphar.2012.00053. eCollection 2012.

23.

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.

Ehm O, Göritz C, Covic M, Schäffner I, Schwarz TJ, Karaca E, Kempkes B, Kremmer E, Pfrieger FW, Espinosa L, Bigas A, Giachino C, Taylor V, Frisén J, Lie DC.

J Neurosci. 2010 Oct 13;30(41):13794-807. doi: 10.1523/JNEUROSCI.1567-10.2010.

24.

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling.

Heinzelmann K, Scholz BA, Nowak A, Fossum E, Kremmer E, Haas J, Frank R, Kempkes B.

J Virol. 2010 Dec;84(23):12255-64. doi: 10.1128/JVI.01484-10. Epub 2010 Sep 22.

25.

Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes.

Yenamandra SP, Hellman U, Kempkes B, Darekar SD, Petermann S, Sculley T, Klein G, Kashuba E.

Cell Mol Life Sci. 2010 Dec;67(24):4249-56. doi: 10.1007/s00018-010-0441-4. Epub 2010 Jul 1.

PMID:
20593215
26.

Differential gene expression patterns of EBV infected EBNA-3A positive and negative human B lymphocytes.

Hertle ML, Popp C, Petermann S, Maier S, Kremmer E, Lang R, Mages J, Kempkes B.

PLoS Pathog. 2009 Jul;5(7):e1000506. doi: 10.1371/journal.ppat.1000506. Epub 2009 Jul 3.

27.

Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene.

Unterberger C, Staples KJ, Smallie T, Williams L, Foxwell B, Schaefer A, Kempkes B, Hofer TP, Koeppel M, Lohrum M, Stunnenberg H, Frankenberger M, Ziegler-Heitbrock L.

Mol Immunol. 2008 Jun;45(11):3230-7. doi: 10.1016/j.molimm.2008.02.020. Epub 2008 Apr 9.

PMID:
18403020
28.

EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells.

Boccellato F, Anastasiadou E, Rosato P, Kempkes B, Frati L, Faggioni A, Trivedi P.

J Virol. 2007 Mar;81(5):2274-82. Epub 2006 Dec 6.

29.

The CR4 region of EBNA2 confers viability of Epstein-Barr virus-transformed B cells by CBF1-independent signalling.

Grabusic K, Maier S, Hartmann A, Mantik A, Hammerschmidt W, Kempkes B.

J Gen Virol. 2006 Nov;87(Pt 11):3169-76.

PMID:
17030849
30.

Cellular target genes of Epstein-Barr virus nuclear antigen 2.

Maier S, Staffler G, Hartmann A, Höck J, Henning K, Grabusic K, Mailhammer R, Hoffmann R, Wilmanns M, Lang R, Mages J, Kempkes B.

J Virol. 2006 Oct;80(19):9761-71.

31.

Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth.

Tobollik S, Meyer L, Buettner M, Klemmer S, Kempkes B, Kremmer E, Niedobitek G, Jungnickel B.

Blood. 2006 Dec 1;108(12):3859-64. Epub 2006 Aug 1.

32.

Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway.

Pegman PM, Smith SM, D'Souza BN, Loughran ST, Maier S, Kempkes B, Cahill PA, Simmons MJ, Gélinas C, Walls D.

J Virol. 2006 Aug;80(16):8133-44.

33.

Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1.

Mohan J, Dement-Brown J, Maier S, Ise T, Kempkes B, Tolnay M.

Blood. 2006 Jun 1;107(11):4433-9. Epub 2006 Jan 26.

35.

EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli.

Lee JM, Lee KH, Farrell CJ, Ling PD, Kempkes B, Park JH, Hayward SD.

J Virol. 2004 Nov;78(22):12694-7.

36.
37.

Epstein-Barr virus antagonizes the antiproliferative activity of transforming growth factor-beta but does not abolish its signaling.

Horndasch M, Raschke EE, Bommer G, Schuhmacher M, Dumont E, Kuklik-Roos C, Eick D, Kempkes B.

Int J Cancer. 2002 Oct 10;101(5):442-7.

38.

Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.

Nahta R, Iglehart JD, Kempkes B, Schmidt EV.

Cancer Res. 2002 Apr 15;62(8):2267-71.

39.

Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1.

Adler B, Schaadt E, Kempkes B, Zimber-Strobl U, Baier B, Bornkamm GW.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):437-42. Epub 2001 Dec 18.

40.

Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction.

Fuchs KP, Bommer G, Dumont E, Christoph B, Vidal M, Kremmer E, Kempkes B.

Eur J Biochem. 2001 Sep;268(17):4639-46.

41.

Notch1IC partially replaces EBNA2 function in B cells immortalized by Epstein-Barr virus.

Gordadze AV, Peng R, Tan J, Liu G, Sutton R, Kempkes B, Bornkamm GW, Ling PD.

J Virol. 2001 Jul;75(13):5899-912.

42.

Direct and indirect regulation of cytokine and cell cycle proteins by EBNA-2 during Epstein-Barr virus infection.

Spender LC, Cornish GH, Rowland B, Kempkes B, Farrell PJ.

J Virol. 2001 Apr;75(8):3537-46.

43.

Cell cycle activation by c-myc in a burkitt lymphoma model cell line.

Pajic A, Spitkovsky D, Christoph B, Kempkes B, Schuhmacher M, Staege MS, Brielmeier M, Ellwart J, Kohlhuber F, Bornkamm GW, Polack A, Eick D.

Int J Cancer. 2000 Sep 15;87(6):787-93.

44.

Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.

Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.

J Cell Biol. 2000 Jun 26;149(7):1419-32.

45.

Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signalling.

Dumont E, Fuchs KP, Bommer G, Christoph B, Kremmer E, Kempkes B.

Oncogene. 2000 Jan 27;19(4):556-61.

46.

Induction of autophagy and inhibition of tumorigenesis by beclin 1.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B.

Nature. 1999 Dec 9;402(6762):672-6.

PMID:
10604474
47.

EBNA2 and c-myc in B cell immortalization by Epstein-Barr virus and in the pathogenesis of Burkitt's lymphoma.

Zimber-Strobl U, Strobl L, Höfelmayr H, Kempkes B, Staege MS, Laux G, Christoph B, Polack A, Bornkamm GW.

Curr Top Microbiol Immunol. 1999;246:315-20; discussion 321. Review. No abstract available.

PMID:
10396071
48.

The proto-oncogene c-myc is a direct target gene of Epstein-Barr virus nuclear antigen 2.

Kaiser C, Laux G, Eick D, Jochner N, Bornkamm GW, Kempkes B.

J Virol. 1999 May;73(5):4481-4.

50.

Epstein-Barr virus latent membrane protein (LMP1) is not sufficient to maintain proliferation of B cells but both it and activated CD40 can prolong their survival.

Zimber-Strobl U, Kempkes B, Marschall G, Zeidler R, Van Kooten C, Banchereau J, Bornkamm GW, Hammerschmidt W.

EMBO J. 1996 Dec 16;15(24):7070-8.

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