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[A woman with a swelling in the mouth].

van Kempen PMW, Peters HPM, Thomeer HGXM.

Ned Tijdschr Geneeskd. 2019 Nov 21;163. pii: D3837. Dutch.


The Composition of Reconstituted High-Density Lipoproteins (rHDL) Dictates the Degree of rHDL Cargo- and Size-Remodeling via Direct Interactions with Endogenous Lipoproteins.

Pedersbæk D, Kræmer MK, Kempen PJ, Ashley J, Braesch-Andersen S, Andresen TL, Simonsen JB.

Bioconjug Chem. 2019 Oct 16;30(10):2634-2646. doi: 10.1021/acs.bioconjchem.9b00552. Epub 2019 Sep 19.


Chlorhexidine Inefficacy in Ventilated Patients: Comment.

Kempen PM.

Anesthesiology. 2019 Oct;131(4):938-939. doi: 10.1097/ALN.0000000000002925. No abstract available.


Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo.

Johnsen KB, Bak M, Melander F, Thomsen MS, Burkhart A, Kempen PJ, Andresen TL, Moos T.

J Control Release. 2019 Feb 10;295:237-249. doi: 10.1016/j.jconrel.2019.01.005. Epub 2019 Jan 10.


Remote loading of liposomes with a 124I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model.

Engudar G, Schaarup-Jensen H, Fliedner FP, Hansen AE, Kempen P, Jølck RI, Kjæer A, Andresen TL, Clausen MH, Jensen AI, Henriksen JR.

Theranostics. 2018 Nov 12;8(21):5828-5841. doi: 10.7150/thno.26706. eCollection 2018.


Multifarious Biologic Loaded Liposomes that Stimulate the Mammalian Target of Rapamycin Signaling Pathway Show Retina Neuroprotection after Retina Damage.

Eriksen AZ, Eliasen R, Oswald J, Kempen PJ, Melander F, Andresen TL, Young M, Baranov P, Urquhart AJ.

ACS Nano. 2018 Aug 28;12(8):7497-7508. doi: 10.1021/acsnano.8b00596. Epub 2018 Jul 18.


Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.

Johnsen KB, Bak M, Kempen PJ, Melander F, Burkhart A, Thomsen MS, Nielsen MS, Moos T, Andresen TL.

Theranostics. 2018 May 24;8(12):3416-3436. doi: 10.7150/thno.25228. eCollection 2018.


Endothelial Protein C-Targeting Liposomes Show Enhanced Uptake and Improved Therapeutic Efficacy in Human Retinal Endothelial Cells.

Arta A, Eriksen AZ, Melander F, Kempen P, Larsen M, Andresen TL, Urquhart AJ.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2119-2132. doi: 10.1167/iovs.18-23800.


The War on Drugs...or Doctors?

Kempen PM.

W V Med J. 2017 Mar-Apr;113(2):24-5. No abstract available.


Influence of tumor and microenvironment characteristics on diffusion-weighted imaging in oropharyngeal carcinoma: A pilot study.

Swartz JE, Driessen JP, van Kempen PMW, de Bree R, Janssen LM, Pameijer FA, Terhaard CHJ, Philippens MEP, Willems S.

Oral Oncol. 2018 Feb;77:9-15. doi: 10.1016/j.oraloncology.2017.12.001. Epub 2017 Dec 12.


Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.

Johnsen KB, Burkhart A, Melander F, Kempen PJ, Vejlebo JB, Siupka P, Nielsen MS, Andresen TL, Moos T.

Sci Rep. 2017 Sep 4;7(1):10396. doi: 10.1038/s41598-017-11220-1.


Essential Thrombocytosis and Labor Epidural Placement While on Aspirin: Assessing Hemorrhagic Risks: A Case Report.

Kempen PM.

A A Case Rep. 2017 Sep 15;9(6):172-174. doi: 10.1213/XAA.0000000000000558.


Multicompartment Artificial Organelles Conducting Enzymatic Cascade Reactions inside Cells.

Godoy-Gallardo M, Labay C, Trikalitis VD, Kempen PJ, Larsen JB, Andresen TL, Hosta-Rigau L.

ACS Appl Mater Interfaces. 2017 May 17;9(19):15907-15921. doi: 10.1021/acsami.6b16275. Epub 2017 Feb 13.


Rationally addressing the opiate drug problem.

Kempen PM.

W V Med J. 2016 Nov-Dec;112(6):8. No abstract available.


Mouse Positron Emission Tomography Study of the Biodistribution of Gold Nanoparticles with Different Surface Coatings Using Embedded Copper-64.

Frellsen AF, Hansen AE, Jølck RI, Kempen PJ, Severin GW, Rasmussen PH, Kjær A, Jensen AT, Andresen TL.

ACS Nano. 2016 Nov 22;10(11):9887-9898. Epub 2016 Oct 25.


FGFR Family Members Protein Expression as Prognostic Markers in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma.

Koole K, Clausen MJ, van Es RJ, van Kempen PM, Melchers LJ, Koole R, Langendijk JA, van Diest PJ, Roodenburg JL, Schuuring E, Willems SM.

Mol Diagn Ther. 2016 Aug;20(4):363-74. doi: 10.1007/s40291-016-0204-5.


Poor prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α.

Swartz JE, Pothen AJ, van Kempen PM, Stegeman I, Formsma FK, Cann EM, Willems SM, Grolman W.

Head Neck. 2016 Sep;38(9):1338-46. doi: 10.1002/hed.24445. Epub 2016 Mar 30.


THE METAMORPHOSIS OF MEDICINE. Opportunities for Physician Leadership NOW!

Kempen PM.

W V Med J. 2016 Mar-Apr;112(2):8-9. No abstract available.


Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.

van Kempen PM, Noorlag R, Swartz JE, Bovenschen N, Braunius WW, Vermeulen JF, Van Cann EM, Grolman W, Willems SM.

Cancer Immunol Immunother. 2016 May;65(5):575-85. doi: 10.1007/s00262-016-1819-4. Epub 2016 Mar 18.


FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma.

Koole K, Brunen D, van Kempen PM, Noorlag R, de Bree R, Lieftink C, van Es RJ, Bernards R, Willems SM.

Clin Cancer Res. 2016 Aug 1;22(15):3884-93. doi: 10.1158/1078-0432.CCR-15-1874. Epub 2016 Mar 2.


Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma.

Koole K, van Kempen PM, Swartz JE, Peeters T, van Diest PJ, Koole R, van Es RJ, Willems SM.

Cancer Med. 2016 Feb;5(2):275-84. doi: 10.1002/cam4.595. Epub 2015 Dec 28.


FGFR4 Is a Potential Predictive Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma.

Koole K, van Kempen PM, van Bockel LW, Smets T, van der Klooster Z, Dutman AC, Peeters T, Koole R, van Diest P, van Es RJ, Willems SM.

Pathobiology. 2015;82(6):280-9. doi: 10.1159/000439536. Epub 2015 Nov 10.


Molecular Magnetic Resonance Imaging of Tumor Response to Therapy.

Shuhendler AJ, Ye D, Brewer KD, Bazalova-Carter M, Lee KH, Kempen P, Dane Wittrup K, Graves EE, Rutt B, Rao J.

Sci Rep. 2015 Oct 6;5:14759. doi: 10.1038/srep14759.


A Tale of Silent Aspiration: Are Guidelines Good for Every Patient?

Kempen PM.

Anesth Analg. 2015 Sep;121(3):829-31. doi: 10.1213/ANE.0000000000000852. No abstract available.


Clinical relevance of copy number profiling in oral and oropharyngeal squamous cell carcinoma.

van Kempen PM, Noorlag R, Braunius WW, Moelans CB, Rifi W, Savola S, Koole R, Grolman W, van Es RJ, Willems SM.

Cancer Med. 2015 Oct;4(10):1525-35. doi: 10.1002/cam4.499. Epub 2015 Jul 21.


Fibroblast Growth Factor Receptor Family Members as Prognostic Biomarkers in Head and Neck Squamous Cell Carcinoma: A Systematic Review.

Ipenburg NA, Koole K, Liem KS, van Kempen PM, Koole R, van Diest PJ, van Es RJ, Willems SM.

Target Oncol. 2016 Feb;11(1):17-27. doi: 10.1007/s11523-015-0374-9. Review.


Insuring clear declaration of corporate conflicts of interest in all medical journals: the highest priority.

Kempen PM.

J Clin Anesth. 2015 Aug;27(5):434-5. doi: 10.1016/j.jclinane.2015.03.028. Epub 2015 Apr 23. No abstract available.


Theranostic mesoporous silica nanoparticles biodegrade after pro-survival drug delivery and ultrasound/magnetic resonance imaging of stem cells.

Kempen PJ, Greasley S, Parker KA, Campbell JL, Chang HY, Jones JR, Sinclair R, Gambhir SS, Jokerst JV.

Theranostics. 2015 Mar 1;5(6):631-42. doi: 10.7150/thno.11389. eCollection 2015.


Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas.

Driessen JP, van Bemmel AJ, van Kempen PM, Janssen LM, Terhaard CH, Pameijer FA, Willems SM, Stegeman I, Grolman W, Philippens ME.

Head Neck. 2016 Apr;38 Suppl 1:E613-8. doi: 10.1002/hed.24051. Epub 2015 Jul 14.


TP53 Y220C Is a Hotspot Mutation in Oropharyngeal Squamous Cell Carcinoma.

van Kempen PM, Verdam FJ, de Poel E, Braunius WW, de Weger RA, van Es RJ, Grolman W, Willems SM.

Pathobiology. 2015;82(1):21-27. Epub 2015 Feb 28.


The diagnostic value of 11q13 amplification and protein expression in the detection of nodal metastasis from oral squamous cell carcinoma: a systematic review and meta-analysis.

Noorlag R, van Kempen PM, Stegeman I, Koole R, van Es RJ, Willems SM.

Virchows Arch. 2015 Apr;466(4):363-73. doi: 10.1007/s00428-015-1719-6. Epub 2015 Feb 7. Review.


Old guidelines or methods cannot insure quality or progress.

Kempen PM.

Anesthesiology. 2015 Jan;122(1):218-9. doi: 10.1097/ALN.0000000000000492. No abstract available.


A correlative optical microscopy and scanning electron microscopy approach to locating nanoparticles in brain tumors.

Kempen PJ, Kircher MF, de la Zerda A, Zavaleta CL, Jokerst JV, Mellinghoff IK, Gambhir SS, Sinclair R.

Micron. 2015 Jan;68:70-76. doi: 10.1016/j.micron.2014.09.004. Epub 2014 Sep 26.


DDX3 has divergent roles in head and neck squamous cell carcinomas in smoking versus non-smoking patients.

Heerma van Voss MR, van Kempen PM, Noorlag R, van Diest PJ, Willems SM, Raman V.

Oral Dis. 2015 Mar;21(2):270-1. doi: 10.1111/odi.12299. Epub 2015 Jan 19. No abstract available.


Promoter hypermethylation using 24-gene array in early head and neck cancer: better outcome in oral than in oropharyngeal cancer.

Noorlag R, van Kempen PM, Moelans CB, de Jong R, Blok LE, Koole R, Grolman W, van Diest PJ, van Es RJ, Willems SM.

Epigenetics. 2014 Sep;9(9):1220-7. doi: 10.4161/epi.29785. Epub 2014 Jul 8.


HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation.

van Kempen PM, van Bockel L, Braunius WW, Moelans CB, van Olst M, de Jong R, Stegeman I, van Diest PJ, Grolman W, Willems SM.

Cancer Med. 2014 Oct;3(5):1185-96. doi: 10.1002/cam4.313. Epub 2014 Jul 26.


Corporate interests necessitate conflict of interest declarations by all authors.

Kempen PM.

Anesthesiology. 2014 Aug;121(2):431-2. doi: 10.1097/ALN.0000000000000326. No abstract available.


Redox-triggered self-assembly of gadolinium-based MRI probes for sensing reducing environment.

Ye D, Pandit P, Kempen P, Lin J, Xiong L, Sinclair R, Rutt B, Rao J.

Bioconjug Chem. 2014 Aug 20;25(8):1526-36. doi: 10.1021/bc500254g. Epub 2014 Jul 21.


Maintenance of certification and licensure: regulatory capture of medicine.

Kempen PM.

Anesth Analg. 2014 Jun;118(6):1378-86. doi: 10.1213/ANE.0000000000000061. No abstract available.


Not all adverse outcomes are medical errors.

Kempen P.

Anaesthesia. 2014 Apr;69(4):396. doi: 10.1111/anae.12655. No abstract available.


A tunable silk-alginate hydrogel scaffold for stem cell culture and transplantation.

Ziv K, Nuhn H, Ben-Haim Y, Sasportas LS, Kempen PJ, Niedringhaus TP, Hrynyk M, Sinclair R, Barron AE, Gambhir SS.

Biomaterials. 2014 Apr;35(12):3736-43. doi: 10.1016/j.biomaterials.2014.01.029. Epub 2014 Jan 28.


Diffusion-weighted imaging in head and neck squamous cell carcinomas: a systematic review.

Driessen JP, van Kempen PM, van der Heijden GJ, Philippens ME, Pameijer FA, Stegeman I, Terhaard CH, Janssen LM, Grolman W.

Head Neck. 2015 Mar;37(3):440-8. doi: 10.1002/hed.23575. Epub 2014 Feb 12. Review.


Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: a systematic review.

van Kempen PM, Noorlag R, Braunius WW, Stegeman I, Willems SM, Grolman W.

Epigenetics. 2014 Feb;9(2):194-203. doi: 10.4161/epi.26881. Epub 2013 Oct 29. Review.


Maintenance of Certification - important and to whom?

Kempen PM.

J Community Hosp Intern Med Perspect. 2013 Apr 17;3(1). doi: 10.3402/jchimp.v3i1.20326. Print 2013. No abstract available.


Iron administration before stem cell harvest enables MR imaging tracking after transplantation.

Khurana A, Chapelin F, Beck G, Lenkov OD, Donig J, Nejadnik H, Messing S, Derugin N, Chan RC, Gaur A, Sennino B, McDonald DM, Kempen PJ, Tikhomirov GA, Rao J, Daldrup-Link HE.

Radiology. 2013 Oct;269(1):186-97. doi: 10.1148/radiol.13130858. Epub 2013 Jul 12.


A scanning transmission electron microscopy approach to analyzing large volumes of tissue to detect nanoparticles.

Kempen PJ, Thakor AS, Zavaleta C, Gambhir SS, Sinclair R.

Microsc Microanal. 2013 Oct;19(5):1290-7. doi: 10.1017/S143192761300192X. Epub 2013 Jun 27.


Advanced Characterization Techniques for Nanoparticles for Cancer Research: Applications of SEM and NanoSIMS for Locating Au Nanoparticles in Cells.

Kempen PJ, Hitzman C, Sasportas LS, Gambhir SS, Sinclair R.

Mater Res Soc Symp Proc. 2013 May 13;1569:157-163.


Revisiting gastric decompression tube insertion after endonasal neurosurgery: blamed if you do, blamed if you do not.

Nelson P, Kempen PM, Kofke WA.

J Neurosurg Anesthesiol. 2013 Apr;25(2):215. doi: 10.1097/ANA.0b013e3182808ca5. No abstract available.


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