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Items: 1 to 50 of 67

1.

The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans.

Müthel S, Uyar B, He M, Krause A, Vitrinel B, Bulut S, Vasiljevic D, Marchal I, Kempa S, Akalin A, Tursun B.

Aging Cell. 2019 Aug 9:e13012. doi: 10.1111/acel.13012. [Epub ahead of print]

2.

C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice.

Ackermann T, Hartleben G, Müller C, Mastrobuoni G, Groth M, Sterken BA, Zaini MA, Youssef SA, Zuidhof HR, Krauss SR, Kortman G, de Haan G, de Bruin A, Wang ZQ, Platzer M, Kempa S, Calkhoven CF.

Commun Biol. 2019 Jun 14;2:208. doi: 10.1038/s42003-019-0461-z. eCollection 2019.

3.

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis.

Rohwer N, Jumpertz S, Erdem M, Egners A, Warzecha KT, Fragoulis A, Kühl AA, Kramann R, Neuss S, Rudolph I, Endermann T, Zasada C, Apostolova I, Gerling M, Kempa S, Hughes R, Lewis CE, Brenner W, Malinowski MB, Stockmann M, Schomburg L, Faller W, Sansom OJ, Tacke F, Morkel M, Cramer T.

Oncogene. 2019 Jul;38(28):5670-5685. doi: 10.1038/s41388-019-0816-4. Epub 2019 May 1.

PMID:
31043706
4.

Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity Toxicol Appl Pharmacol, 354 (2018) 64-80.

Delp J, Gutbier S, Cerff M, Zasada C, Niedenführ S, Zhao L, Smirnova L, Hartung T, Borlinghaus H, Schreiber F, Bergemann J, Gätgens J, Beyss M, Azzouzi S, Waldmann T, Kempa S, Nöh K, Leist M.

Toxicol Appl Pharmacol. 2019 Jun 1;372:70. doi: 10.1016/j.taap.2019.04.010. Epub 2019 Apr 16. No abstract available.

PMID:
31002859
5.

Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.

Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kräker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, Müller DN, Stegbauer J, Wilck N.

Circulation. 2019 Mar 12;139(11):1407-1421. doi: 10.1161/CIRCULATIONAHA.118.036652.

6.

Muscle Atrophy Due to Nerve Damage Is Accompanied by Elevated Myofibrillar Protein Synthesis Rates.

Langer HT, Senden JMG, Gijsen AP, Kempa S, van Loon LJC, Spuler S.

Front Physiol. 2018 Aug 31;9:1220. doi: 10.3389/fphys.2018.01220. eCollection 2018.

7.

Corrigendum: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.

Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewis GR, Birchmeier C.

Genes Dev. 2018 Aug 1;32(15-16):1101. doi: 10.1101/gad.318477.118. No abstract available.

8.

Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations.

Fritsche-Guenther R, Zasada C, Mastrobuoni G, Royla N, Rainer R, Roßner F, Pietzke M, Klipp E, Sers C, Kempa S.

Sci Rep. 2018 Jun 15;8(1):9204. doi: 10.1038/s41598-018-27394-1.

9.

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.

Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C.

Genes Dev. 2018 May 1;32(9-10):645-657. doi: 10.1101/gad.310490.117. Epub 2018 May 10. Erratum in: Genes Dev. 2018 Aug 1;32(15-16):1101.

10.

Combined Human Genome-wide RNAi and Metabolite Analyses Identify IMPDH as a Host-Directed Target against Chlamydia Infection.

Rother M, Gonzalez E, Teixeira da Costa AR, Wask L, Gravenstein I, Pardo M, Pietzke M, Gurumurthy RK, Angermann J, Laudeley R, Glage S, Meyer M, Chumduri C, Kempa S, Dinkel K, Unger A, Klebl B, Klos A, Meyer TF.

Cell Host Microbe. 2018 May 9;23(5):661-671.e8. doi: 10.1016/j.chom.2018.04.002. Epub 2018 Apr 26.

11.

Proteomic analysis of chemosensory organs in the honey bee parasite Varroa destructor: A comprehensive examination of the potential carriers for semiochemicals.

Iovinella I, McAfee A, Mastrobuoni G, Kempa S, Foster LJ, Pelosi P, Dani FR.

J Proteomics. 2018 Jun 15;181:131-141. doi: 10.1016/j.jprot.2018.04.009. Epub 2018 Apr 10.

PMID:
29653265
12.

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity.

Delp J, Gutbier S, Cerff M, Zasada C, Niedenführ S, Zhao L, Smirnova L, Hartung T, Borlinghaus H, Schreiber F, Bergemann J, Gätgens J, Beyss M, Azzouzi S, Waldmann T, Kempa S, Nöh K, Leist M.

Toxicol Appl Pharmacol. 2018 Sep 1;354:64-80. doi: 10.1016/j.taap.2017.12.013. Epub 2017 Dec 24. Erratum in: Toxicol Appl Pharmacol. 2019 Jun 1;372:70.

PMID:
29278688
13.

Salt-responsive gut commensal modulates TH17 axis and disease.

Wilck N, Matus MG, Kearney SM, Olesen SW, Forslund K, Bartolomaeus H, Haase S, Mähler A, Balogh A, Markó L, Vvedenskaya O, Kleiner FH, Tsvetkov D, Klug L, Costea PI, Sunagawa S, Maier L, Rakova N, Schatz V, Neubert P, Frätzer C, Krannich A, Gollasch M, Grohme DA, Côrte-Real BF, Gerlach RG, Basic M, Typas A, Wu C, Titze JM, Jantsch J, Boschmann M, Dechend R, Kleinewietfeld M, Kempa S, Bork P, Linker RA, Alm EJ, Müller DN.

Nature. 2017 Nov 30;551(7682):585-589. doi: 10.1038/nature24628. Epub 2017 Nov 15.

14.

The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance.

Royla N, Kempa S.

Mol Cell Oncol. 2017 Jul 5;4(4):e1338209. doi: 10.1080/23723556.2017.1338209. eCollection 2017.

15.

Retinol saturase coordinates liver metabolism by regulating ChREBP activity.

Heidenreich S, Witte N, Weber P, Goehring I, Tolkachov A, von Loeffelholz C, Döcke S, Bauer M, Stockmann M, Pfeiffer AFH, Birkenfeld AL, Pietzke M, Kempa S, Muenzner M, Schupp M.

Nat Commun. 2017 Aug 30;8(1):384. doi: 10.1038/s41467-017-00430-w.

16.

The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.

Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L, Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S.

Nature. 2017 Jun 8;546(7657):302-306. doi: 10.1038/nature22353. Epub 2017 May 31.

PMID:
28562582
17.

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

PMID:
28428423
18.

The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, Mastrobuoni G, Vanselow JT, Schlosser A, Wolf E, Kempa S, Eilers M.

EMBO J. 2017 Jul 3;36(13):1854-1868. doi: 10.15252/embj.201796662. Epub 2017 Apr 13.

19.

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

Lutter D, Ullrich F, Lueck JC, Kempa S, Jentsch TJ.

J Cell Sci. 2017 Mar 15;130(6):1122-1133. doi: 10.1242/jcs.196253. Epub 2017 Feb 13.

20.

On Mass Ambiguities in High-Resolution Shotgun Lipidomics.

Bielow C, Mastrobuoni G, Orioli M, Kempa S.

Anal Chem. 2017 Mar 7;89(5):2986-2994. doi: 10.1021/acs.analchem.6b04456. Epub 2017 Feb 21.

PMID:
28193003
21.

Quantitative Analysis of Cancer Metabolism: From pSIRM to MFA.

Zasada C, Kempa S.

Recent Results Cancer Res. 2016;207:207-20. doi: 10.1007/978-3-319-42118-6_9. Review.

PMID:
27557540
22.

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.

Schmidt V, Schulz N, Yan X, Schürmann A, Kempa S, Kern M, Blüher M, Poy MN, Olivecrona G, Willnow TE.

J Clin Invest. 2016 Jul 1;126(7):2706-20. doi: 10.1172/JCI84708. Epub 2016 Jun 20.

23.

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

Immunity. 2016 Apr 19;44(4):951-3. doi: 10.1016/j.immuni.2016.04.006. No abstract available.

24.

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B.

PLoS Pathog. 2016 Feb 1;12(2):e1005408. doi: 10.1371/journal.ppat.1005408. eCollection 2016 Feb.

25.

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.

Fritsche-Guenther R, Witzel F, Kempa S, Brummer T, Sers C, Blüthgen N.

Oncotarget. 2016 Feb 16;7(7):7960-9. doi: 10.18632/oncotarget.6959.

26.

Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T.

Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793.

27.

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer.

von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, McDuffus LA, Sauer M, Rosenwald A, Evan GI, Kempa S, Eilers M.

Cancer Cell. 2015 Dec 14;28(6):743-757. doi: 10.1016/j.ccell.2015.10.013.

28.

Proteomics Quality Control: Quality Control Software for MaxQuant Results.

Bielow C, Mastrobuoni G, Kempa S.

J Proteome Res. 2016 Mar 4;15(3):777-87. doi: 10.1021/acs.jproteome.5b00780. Epub 2015 Dec 28.

PMID:
26653327
29.

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Haghikia A, Jörg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thöne J, Demir S, Müller DN, Gold R, Linker RA.

Immunity. 2015 Oct 20;43(4):817-29. doi: 10.1016/j.immuni.2015.09.007. Erratum in: Immunity. 2016 Apr 19;44(4):951-3.

30.

Extensive identification and analysis of conserved small ORFs in animals.

Mackowiak SD, Zauber H, Bielow C, Thiel D, Kutz K, Calviello L, Mastrobuoni G, Rajewsky N, Kempa S, Selbach M, Obermayer B.

Genome Biol. 2015 Sep 14;16:179. doi: 10.1186/s13059-015-0742-x.

31.

Crosstalk between Two bZIP Signaling Pathways Orchestrates Salt-Induced Metabolic Reprogramming in Arabidopsis Roots.

Hartmann L, Pedrotti L, Weiste C, Fekete A, Schierstaedt J, Göttler J, Kempa S, Krischke M, Dietrich K, Mueller MJ, Vicente-Carbajosa J, Hanson J, Dröge-Laser W.

Plant Cell. 2015 Aug;27(8):2244-60. doi: 10.1105/tpc.15.00163. Epub 2015 Aug 14.

32.

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.

Murakawa Y, Hinz M, Mothes J, Schuetz A, Uhl M, Wyler E, Yasuda T, Mastrobuoni G, Friedel CC, Dölken L, Kempa S, Schmidt-Supprian M, Blüthgen N, Backofen R, Heinemann U, Wolf J, Scheidereit C, Landthaler M.

Nat Commun. 2015 Jul 14;6:7367. doi: 10.1038/ncomms8367.

33.

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells.

Moussaieff A, Rouleau M, Kitsberg D, Cohen M, Levy G, Barasch D, Nemirovski A, Shen-Orr S, Laevsky I, Amit M, Bomze D, Elena-Herrmann B, Scherf T, Nissim-Rafinia M, Kempa S, Itskovitz-Eldor J, Meshorer E, Aberdam D, Nahmias Y.

Cell Metab. 2015 Mar 3;21(3):392-402. doi: 10.1016/j.cmet.2015.02.002.

34.

Maui-VIA: A User-Friendly Software for Visual Identification, Alignment, Correction, and Quantification of Gas Chromatography-Mass Spectrometry Data.

Kuich PH, Hoffmann N, Kempa S.

Front Bioeng Biotechnol. 2015 Jan 21;2:84. doi: 10.3389/fbioe.2014.00084. eCollection 2014.

35.

Decoding the dynamics of cellular metabolism and the action of 3-bromopyruvate and 2-deoxyglucose using pulsed stable isotope-resolved metabolomics.

Pietzke M, Zasada C, Mudrich S, Kempa S.

Cancer Metab. 2014 Jun 30;2:9. doi: 10.1186/2049-3002-2-9. eCollection 2014.

36.

Pulsed stable isotope-resolved metabolomic studies of cancer cells.

Pietzke M, Kempa S.

Methods Enzymol. 2014;543:179-98. doi: 10.1016/B978-0-12-801329-8.00009-X.

PMID:
24924133
37.

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

Gregersen LH, Schueler M, Munschauer M, Mastrobuoni G, Chen W, Kempa S, Dieterich C, Landthaler M.

Mol Cell. 2014 May 22;54(4):573-85. doi: 10.1016/j.molcel.2014.03.017. Epub 2014 Apr 10.

38.

A proteomic investigation of soluble olfactory proteins in Anopheles gambiae.

Mastrobuoni G, Qiao H, Iovinella I, Sagona S, Niccolini A, Boscaro F, Caputo B, Orejuela MR, Della Torre A, Kempa S, Felicioli A, Pelosi P, Moneti G, Dani FR.

PLoS One. 2013 Nov 25;8(11):e75162. doi: 10.1371/journal.pone.0075162. eCollection 2013.

39.

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S, Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA.

Nature. 2013 Sep 19;501(7467):421-5. doi: 10.1038/nature12437. Epub 2013 Aug 14.

PMID:
23945590
40.

Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.

Graf R, Munschauer M, Mastrobuoni G, Mayr F, Heinemann U, Kempa S, Rajewsky N, Landthaler M.

RNA Biol. 2013 Jul;10(7):1146-59. doi: 10.4161/rna.25194. Epub 2013 May 29.

41.

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.

Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, Kempa S, Petersen CM, Willnow TE.

J Neurosci. 2013 Jan 2;33(1):358-70. doi: 10.1523/JNEUROSCI.2425-12.2013.

42.

The growing complexity of HIF-1α's role in tumorigenesis: DNA repair and beyond.

Rohwer N, Zasada C, Kempa S, Cramer T.

Oncogene. 2013 Aug 1;32(31):3569-76. doi: 10.1038/onc.2012.510. Epub 2012 Nov 19. Review.

PMID:
23160373
43.

Stress-induced GSK3 regulates the redox stress response by phosphorylating glucose-6-phosphate dehydrogenase in Arabidopsis.

Dal Santo S, Stampfl H, Krasensky J, Kempa S, Gibon Y, Petutschnig E, Rozhon W, Heuck A, Clausen T, Jonak C.

Plant Cell. 2012 Aug;24(8):3380-92. Epub 2012 Aug 10.

44.

Proteome dynamics and early salt stress response of the photosynthetic organism Chlamydomonas reinhardtii.

Mastrobuoni G, Irgang S, Pietzke M, Assmus HE, Wenzel M, Schulze WX, Kempa S.

BMC Genomics. 2012 May 31;13:215.

45.

Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells.

Onal P, Grün D, Adamidi C, Rybak A, Solana J, Mastrobuoni G, Wang Y, Rahn HP, Chen W, Kempa S, Ziebold U, Rajewsky N.

EMBO J. 2012 Jun 13;31(12):2755-69. doi: 10.1038/emboj.2012.110. Epub 2012 Apr 27.

46.

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

Liu L, Ulbrich J, Müller J, Wüstefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ.

Nature. 2012 Mar 28;483(7391):608-12. doi: 10.1038/nature10927.

PMID:
22460906
47.

In vivo and transcriptome-wide identification of RNA binding protein target sites.

Jungkamp AC, Stoeckius M, Mecenas D, Grün D, Mastrobuoni G, Kempa S, Rajewsky N.

Mol Cell. 2011 Dec 9;44(5):828-40. doi: 10.1016/j.molcel.2011.11.009.

48.

Expression of root glutamate dehydrogenase genes in tobacco plants subjected to boron deprivation.

Beato VM, Teresa Navarro-Gochicoa M, Rexach J, Begoña Herrera-Rodríguez M, Camacho-Cristóbal JJ, Kempa S, Weckwerth W, González-Fontes A.

Plant Physiol Biochem. 2011 Nov;49(11):1350-4. doi: 10.1016/j.plaphy.2011.06.001. Epub 2011 Jun 12.

PMID:
21705226
49.

De novo assembly and validation of planaria transcriptome by massive parallel sequencing and shotgun proteomics.

Adamidi C, Wang Y, Gruen D, Mastrobuoni G, You X, Tolle D, Dodt M, Mackowiak SD, Gogol-Doering A, Oenal P, Rybak A, Ross E, Sánchez Alvarado A, Kempa S, Dieterich C, Rajewsky N, Chen W.

Genome Res. 2011 Jul;21(7):1193-200. doi: 10.1101/gr.113779.110. Epub 2011 May 2.

50.

Targeted proteomics for Chlamydomonas reinhardtii combined with rapid subcellular protein fractionation, metabolomics and metabolic flux analyses.

Wienkoop S, Weiss J, May P, Kempa S, Irgang S, Recuenco-Munoz L, Pietzke M, Schwemmer T, Rupprecht J, Egelhofer V, Weckwerth W.

Mol Biosyst. 2010 Jun;6(6):1018-31. doi: 10.1039/b920913a. Epub 2010 Mar 31.

PMID:
20358043

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