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Items: 24

1.

Two Contrasting Failure Modes of Enteric Coated Beads.

Shi GH, Dong X, Lytle M, Kemp CAJ, Behme RJ, Hinds J, Xiao Z.

AAPS PharmSciTech. 2018 May;19(4):1827-1836. doi: 10.1208/s12249-018-1000-9. Epub 2018 Apr 9.

PMID:
29633154
2.

Determination of the Degradation Chemistry of the Antitumor Agent Pemetrexed Disodium.

Jansen PJ, Smith WK, Baertschi SW, Dorman DE, Kemp CAJ, McCune KA.

J Pharm Sci. 2016 Nov;105(11):3256-3268. doi: 10.1016/j.xphs.2016.06.029. Epub 2016 Aug 15.

PMID:
27539558
3.

On-column nitrosation of amines observed in liquid chromatography impurity separations employing ammonium hydroxide and acetonitrile as mobile phase.

Myers DP, Hetrick EM, Liang Z, Hadden CE, Bandy S, Kemp CA, Harris TM, Baertschi SW.

J Chromatogr A. 2013 Dec 6;1319:57-64. doi: 10.1016/j.chroma.2013.10.021. Epub 2013 Oct 15.

PMID:
24182763
4.

In vitro monitoring of dissolution of an immediate release tablet by focused beam reflectance measurement.

Coutant CA, Skibic MJ, Doddridge GD, Kemp CA, Sperry DC.

Mol Pharm. 2010 Oct 4;7(5):1508-15. doi: 10.1021/mp1001476. Epub 2010 Sep 1.

PMID:
20715796
5.
6.

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.

Maréchal JD, Kemp CA, Roberts GC, Paine MJ, Wolf CR, Sutcliffe MJ.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S82-9. Epub 2007 Nov 19. Review.

7.

Isolation, identification, and synthesis of two oxidative degradation products of olanzapine (LY170053) in solid oral formulations.

Baertschi SW, Brunner H, Bunnell CA, Cooke GG, Diseroad B, Dorman DE, Jansen PJ, Kemp CA, Maple SR, McCune KA, Speakman JL.

J Pharm Sci. 2008 Feb;97(2):883-92.

PMID:
17879984
8.

Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans.

Kemp CA, Song MH, Addepalli MK, Hunter G, O'Connell K.

Genetics. 2007 May;176(1):95-113. Epub 2007 Apr 19.

9.

Use of the chronic pain coping inventory to assess older adults' pain coping strategies.

Ersek M, Turner JA, Kemp CA.

J Pain. 2006 Nov;7(11):833-42.

PMID:
17074625
10.

In silico prediction of drug binding to CYP2D6: identification of a new metabolite of metoclopramide.

Yu J, Paine MJ, Maréchal JD, Kemp CA, Ward CJ, Brown S, Sutcliffe MJ, Roberts GC, Rankin EM, Wolf CR.

Drug Metab Dispos. 2006 Aug;34(8):1386-92. Epub 2006 May 12.

PMID:
16698891
12.

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

McLaughlin LA, Paine MJ, Kemp CA, Maréchal JD, Flanagan JU, Ward CJ, Sutcliffe MJ, Roberts GC, Wolf CR.

J Biol Chem. 2005 Nov 18;280(46):38617-24. Epub 2005 Sep 14.

13.

Progress in cytochrome P450 active site modeling.

Kemp CA, Maréchal JD, Sutcliffe MJ.

Arch Biochem Biophys. 2005 Jan 15;433(2):361-8. Review.

PMID:
15581592
14.

Qigong as a therapeutic intervention with older adults.

Kemp CA.

J Holist Nurs. 2004 Dec;22(4):351-73. Review.

PMID:
15486154
15.

Validation of model of cytochrome P450 2D6: an in silico tool for predicting metabolism and inhibition.

Kemp CA, Flanagan JU, van Eldik AJ, Maréchal JD, Wolf CR, Roberts GC, Paine MJ, Sutcliffe MJ.

J Med Chem. 2004 Oct 21;47(22):5340-6.

PMID:
15481972
16.

Thermodynamic and biophysical characterization of cytochrome P450 BioI from Bacillus subtilis.

Lawson RJ, Leys D, Sutcliffe MJ, Kemp CA, Cheesman MR, Smith SJ, Clarkson J, Smith WE, Haq I, Perkins JB, Munro AW.

Biochemistry. 2004 Oct 5;43(39):12410-26.

PMID:
15449931
17.
18.

Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2.

Kemp CA, Kopish KR, Zipperlen P, Ahringer J, O'Connell KF.

Dev Cell. 2004 Apr;6(4):511-23.

19.

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite.

Flanagan JU, Maréchal JD, Ward R, Kemp CA, McLaughlin LA, Sutcliffe MJ, Roberts GC, Paine MJ, Wolf CR.

Biochem J. 2004 Jun 1;380(Pt 2):353-60.

20.

Cytochromes P450: novel drug targets in the war against multidrug-resistant Mycobacterium tuberculosis.

Munro AW, McLean KJ, Marshall KR, Warman AJ, Lewis G, Roitel O, Sutcliffe MJ, Kemp CA, Modi S, Scrutton NS, Leys D.

Biochem Soc Trans. 2003 Jun;31(Pt 3):625-30. Review.

PMID:
12773169
21.

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Paine MJ, McLaughlin LA, Flanagan JU, Kemp CA, Sutcliffe MJ, Roberts GC, Wolf CR.

J Biol Chem. 2003 Feb 7;278(6):4021-7. Epub 2002 Nov 22.

22.

Impact of incorporating the 2C5 crystal structure into comparative models of cytochrome P450 2D6.

Kirton SB, Kemp CA, Tomkinson NP, St-Gallay S, Sutcliffe MJ.

Proteins. 2002 Nov 1;49(2):216-31.

PMID:
12211002
23.

The degradation of the antitumor agent gemcitabine hydrochloride in an acidic aqueous solution at pH 3.2 and identification of degradation products.

Jansen PJ, Akers MJ, Amos RM, Baertschi SW, Cooke GG, Dorman DE, Kemp CA, Maple SR, McCune KA.

J Pharm Sci. 2000 Jul;89(7):885-91.

PMID:
10861589

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