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Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency.

Hoffmeyer K, Junghans D, Kanzler B, Kemler R.

Cell Rep. 2017 Mar 21;18(12):2815-2824. doi: 10.1016/j.celrep.2017.02.076.


Editor's Highlight: Identification and Characterization of Teratogenic Chemicals Using Embryonic Stem Cells Isolated From a Wnt/β-Catenin-Reporter Transgenic Mouse Line.

Kugler J, Kemler R, Luch A, Oelgeschläger M.

Toxicol Sci. 2016 Aug;152(2):382-94. doi: 10.1093/toxsci/kfw094. Epub 2016 May 20.


A Bmp Reporter Transgene Mouse Embryonic Stem Cell Model as a Tool to Identify and Characterize Chemical Teratogens.

Kugler J, Tharmann J, Chuva de Sousa Lopes SM, Kemler R, Luch A, Oelgeschläger M.

Toxicol Sci. 2015 Aug;146(2):374-85. doi: 10.1093/toxsci/kfv103. Epub 2015 May 21.


François Jacob's spirit.

Kemler R.

Res Microbiol. 2014 Jun;165(5):386-7. doi: 10.1016/j.resmic.2014.05.007. Epub 2014 May 27. No abstract available.


Beta-catenin is vital for the integrity of mouse embryonic stem cells.

Raggioli A, Junghans D, Rudloff S, Kemler R.

PLoS One. 2014 Jan 21;9(1):e86691. doi: 10.1371/journal.pone.0086691. eCollection 2014.


Wnt3a-dependent and -independent protein interaction networks of chromatin-bound β-catenin in mouse embryonic stem cells.

Yakulov T, Raggioli A, Franz H, Kemler R.

Mol Cell Proteomics. 2013 Jul;12(7):1980-94. doi: 10.1074/mcp.M112.026914. Epub 2013 Apr 15.


E-cadherin is required for the proper activation of the Lifr/Gp130 signaling pathway in mouse embryonic stem cells.

del Valle I, Rudloff S, Carles A, Li Y, Liszewska E, Vogt R, Kemler R.

Development. 2013 Apr;140(8):1684-92. doi: 10.1242/dev.088690. Epub 2013 Mar 13.


Differential requirements for β-catenin during mouse development.

Rudloff S, Kemler R.

Development. 2012 Oct;139(20):3711-21.


Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.

Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, Hein K, Vogt R, Kemler R.

Science. 2012 Jun 22;336(6088):1549-54. doi: 10.1126/science.1218370.


Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation.

Kotb AM, Hierholzer A, Kemler R.

Breast Cancer Res. 2011 Oct 26;13(5):R104. doi: 10.1186/bcr3046.


Lineage specification of parietal epithelial cells requires β-catenin/Wnt signaling.

Grouls S, Iglesias DM, Wentzensen N, Moeller MJ, Bouchard M, Kemler R, Goodyer P, Niggli F, Gröne HJ, Kriz W, Koesters R.

J Am Soc Nephrol. 2012 Jan;23(1):63-72. doi: 10.1681/ASN.2010121257. Epub 2011 Oct 21.


Biological and mathematical modeling of melanocyte development.

Luciani F, Champeval D, Herbette A, Denat L, Aylaj B, Martinozzi S, Ballotti R, Kemler R, Goding CR, De Vuyst F, Larue L, Delmas V.

Development. 2011 Sep;138(18):3943-54. doi: 10.1242/dev.067447.


Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

Wray J, Kalkan T, Gomez-Lopez S, Eckardt D, Cook A, Kemler R, Smith A.

Nat Cell Biol. 2011 Jun 19;13(7):838-45. doi: 10.1038/ncb2267. Erratum in: Nat Cell Biol. 2012 May;14(5):555.


N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation.

Libusova L, Stemmler MP, Hierholzer A, Schwarz H, Kemler R.

Development. 2010 Jul;137(14):2297-305. doi: 10.1242/dev.048488. Epub 2010 Jun 9.


Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.

Messerschmidt DM, Kemler R.

Dev Biol. 2010 Aug 1;344(1):129-37. doi: 10.1016/j.ydbio.2010.04.020. Epub 2010 May 12.


Beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos.

Hierholzer A, Kemler R.

Dev Dyn. 2010 Jan;239(1):191-9. doi: 10.1002/dvdy.22075.


Abrogation of E-cadherin-mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.

Soncin F, Mohamet L, Eckardt D, Ritson S, Eastham AM, Bobola N, Russell A, Davies S, Kemler R, Merry CL, Ward CM.

Stem Cells. 2009 Sep;27(9):2069-80. doi: 10.1002/stem.134.


[E-cadherin as a novel surface marker of spermatogonial stem cells].

Tolkunova EN, Malashicheva AB, Chikhirzhina EV, Kostyleva EI, Zeng W, Luo J, Dobrinskiĭ I, Hierholzer A, Kemler R, Tomilin AN.

Tsitologiia. 2009;51(3):212-8. Russian.


Cdx1::Cre allele for gene analysis in the extraembryonic ectoderm and the three germ layers of mice at mid-gastrulation.

Hierholzer A, Kemler R.

Genesis. 2009 Mar;47(3):204-9. doi: 10.1002/dvg.20484.


Neural progenitors of the postnatal and adult mouse forebrain retain the ability to self-replicate, form neurospheres, and undergo multipotent differentiation in vivo.

Neumeister B, Grabosch A, Basak O, Kemler R, Taylor V.

Stem Cells. 2009 Mar;27(3):714-23. doi: 10.1634/stemcells.2008-0985.


Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system.

Junghans D, Heidenreich M, Hack I, Taylor V, Frotscher M, Kemler R.

Eur J Neurosci. 2008 Feb;27(3):559-71. doi: 10.1111/j.1460-9568.2008.06052.x.


Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.

Koch U, Wilson A, Cobas M, Kemler R, Macdonald HR, Radtke F.

Blood. 2008 Jan 1;111(1):160-4. Epub 2007 Sep 13.


beta-Catenin regulates excitatory postsynaptic strength at hippocampal synapses.

Okuda T, Yu LM, Cingolani LA, Kemler R, Goda Y.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13479-84. Epub 2007 Aug 6.


Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis.

Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Martin J, Kemler R, Rosenfeld MG, Chen J, Evans SM.

Proc Natl Acad Sci U S A. 2007 May 29;104(22):9313-8. Epub 2007 May 22.


E-cadherin inhibits cell surface localization of the pro-migratory 5T4 oncofetal antigen in mouse embryonic stem cells.

Spencer HL, Eastham AM, Merry CL, Southgate TD, Perez-Campo F, Soncin F, Ritson S, Kemler R, Stern PL, Ward CM.

Mol Biol Cell. 2007 Aug;18(8):2838-51. Epub 2007 May 16.


Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note.

Handa K, Takatani-Nakase T, Larue L, Stemmler MP, Kemler R, Hakomori SI.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):247-52. Epub 2007 Apr 24.


Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function.

Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z.

Genesis. 2007 Apr;45(4):157-68.


Conditional inactivation of the E-cadherin gene in thyroid follicular cells affects gland development but does not impair junction formation.

Calì G, Zannini M, Rubini P, Tacchetti C, D'Andrea B, Affuso A, Wintermantel T, Boussadia O, Terracciano D, Silberschmidt D, Amendola E, De Felice M, Schütz G, Kemler R, Di Lauro R, Nitsch L.

Endocrinology. 2007 Jun;148(6):2737-46. Epub 2007 Mar 8.


Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm.

Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R.

Development. 2007 Jan;134(1):31-41. Epub 2006 Nov 30.


N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons.

Jüngling K, Eulenburg V, Moore R, Kemler R, Lessmann V, Gottmann K.

J Neurosci. 2006 Jun 28;26(26):6968-78.


Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.

Olson LE, Tollkuhn J, Scafoglio C, Krones A, Zhang J, Ohgi KA, Wu W, Taketo MM, Kemler R, Grosschedl R, Rose D, Li X, Rosenfeld MG.

Cell. 2006 May 5;125(3):593-605.


Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern.

Bagheri-Fam S, Barrionuevo F, Dohrmann U, Günther T, Schüle R, Kemler R, Mallo M, Kanzler B, Scherer G.

Dev Biol. 2006 Mar 15;291(2):382-97. Epub 2006 Feb 3.


N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis.

Tillet E, Vittet D, Féraud O, Moore R, Kemler R, Huber P.

Exp Cell Res. 2005 Nov 1;310(2):392-400. Epub 2005 Oct 3.


Mammalian cadherins and protocadherins: about cell death, synapses and processing.

Junghans D, Haas IG, Kemler R.

Curr Opin Cell Biol. 2005 Oct;17(5):446-52. Review.


Differential expression of individual gamma-protocadherins during mouse brain development.

Frank M, Ebert M, Shan W, Phillips GR, Arndt K, Colman DR, Kemler R.

Mol Cell Neurosci. 2005 Aug;29(4):603-16.


Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.

Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J.

Development. 2005 Jun;132(11):2599-609. Epub 2005 Apr 27.


Beta-catenin-mediated cell-adhesion is vital for embryonic forebrain development.

Junghans D, Hack I, Frotscher M, Taylor V, Kemler R.

Dev Dyn. 2005 Jun;233(2):528-39.


E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions.

Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Günzel D, Fromm M, Kemler R, Krieg T, Niessen CM.

EMBO J. 2005 Mar 23;24(6):1146-56. Epub 2005 Mar 3.


E-cadherin intron 2 contains cis-regulatory elements essential for gene expression.

Stemmler MP, Hecht A, Kemler R.

Development. 2005 Mar;132(5):965-76. Epub 2005 Jan 26.


Presenilin-dependent processing and nuclear function of gamma-protocadherins.

Haas IG, Frank M, Véron N, Kemler R.

J Biol Chem. 2005 Mar 11;280(10):9313-9. Epub 2004 Dec 20.


Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast.

Kemler R, Hierholzer A, Kanzler B, Kuppig S, Hansen K, Taketo MM, de Vries WN, Knowles BB, Solter D.

Development. 2004 Dec;131(23):5817-24. Epub 2004 Nov 3.


Maternal beta-catenin and E-cadherin in mouse development.

De Vries WN, Evsikov AV, Haac BE, Fancher KS, Holbrook AE, Kemler R, Solter D, Knowles BB.

Development. 2004 Sep;131(18):4435-45. Epub 2004 Aug 11.


Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.

Cobas M, Wilson A, Ernst B, Mancini SJ, MacDonald HR, Kemler R, Radtke F.

J Exp Med. 2004 Jan 19;199(2):221-9. Epub 2004 Jan 12.


Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells.

Lee HY, Kléber M, Hari L, Brault V, Suter U, Taketo MM, Kemler R, Sommer L.

Science. 2004 Feb 13;303(5660):1020-3. Epub 2004 Jan 8.


Role of beta-catenin in the developing cortical and hippocampal neuroepithelium.

Machon O, van den Bout CJ, Backman M, Kemler R, Krauss S.

Neuroscience. 2003;122(1):129-43.


E-cadherin controls adherens junctions in the epidermis and the renewal of hair follicles.

Young P, Boussadia O, Halfter H, Grose R, Berger P, Leone DP, Robenek H, Charnay P, Kemler R, Suter U.

EMBO J. 2003 Nov 3;22(21):5723-33.


The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility.

Cattelino A, Liebner S, Gallini R, Zanetti A, Balconi G, Corsi A, Bianco P, Wolburg H, Moore R, Oreda B, Kemler R, Dejana E.

J Cell Biol. 2003 Sep 15;162(6):1111-22.


Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148.

Grazia Lampugnani M, Zanetti A, Corada M, Takahashi T, Balconi G, Breviario F, Orsenigo F, Cattelino A, Kemler R, Daniel TO, Dejana E.

J Cell Biol. 2003 May 26;161(4):793-804.


Analysis of regulatory elements of E-cadherin with reporter gene constructs in transgenic mouse embryos.

Stemmler MP, Hecht A, Kinzel B, Kemler R.

Dev Dyn. 2003 Jun;227(2):238-45.

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