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Ap4A Regulates Directional Mobility and Antigen Presentation in Dendritic Cells.

Shu S, Paruchuru LB, Tay NQ, Chua YL, Foo ASY, Yang CM, Liong KH, Koh EGL, Lee A, Nechushtan H, Razin E, Kemeny DM.

iScience. 2019 Jun 28;16:524-534. doi: 10.1016/j.isci.2019.05.045. Epub 2019 Jun 4.


Prior exposure to inhaled allergen enhances anti-viral immunity and T cell priming by dendritic cells.

Lee DCP, Tay NQ, Thian M, Prabhu N, Furuhashi K, Kemeny DM.

PLoS One. 2018 Jan 2;13(1):e0190063. doi: 10.1371/journal.pone.0190063. eCollection 2018.


CD40L Expression Allows CD8+ T Cells to Promote Their Own Expansion and Differentiation through Dendritic Cells.

Tay NQ, Lee DCP, Chua YL, Prabhu N, Gascoigne NRJ, Kemeny DM.

Front Immunol. 2017 Nov 6;8:1484. doi: 10.3389/fimmu.2017.01484. eCollection 2017.


Blomia tropicalis allergen 5 (Blo t 5) T-cell epitopes and their ability to suppress the allergic immune response.

Wong KH, Zhou Q, Prabhu N, Furuhashi K, Chua YL, Grotenbreg GM, Kemeny DM.

Immunology. 2017 Oct;152(2):344-355. doi: 10.1111/imm.12772. Epub 2017 Jul 17. Erratum in: Immunology. 2018 Mar;153(3):397.


Priming with high and low respiratory allergen dose induces differential CD4+ T helper type 2 cells and IgE/IgG1 antibody responses in mice.

Furuhashi K, Chua YL, Wong KHS, Zhou Q, Lee DCP, Liong KH, Teo GH, Hutchinson PE, Kemeny DM.

Immunology. 2017 Jun;151(2):227-238. doi: 10.1111/imm.12726. Epub 2017 Apr 3.


Molecular engineering of a therapeutic antibody for Blo t 5-induced allergic asthma.

Chan JHS, Chua YL, Peh HY, Jovanovic V, Gascoigne NRJ, Wong WSF, Chew FT, Hanson BJ, Kemeny DM, MacAry PA.

J Allergy Clin Immunol. 2017 May;139(5):1705-1708.e6. doi: 10.1016/j.jaci.2016.10.028. Epub 2016 Dec 5. No abstract available.


Blomia tropicalis-Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13-Dependent Mechanism.

Chua YL, Liong KH, Huang CH, Wong HS, Zhou Q, Ler SS, Tang Y, Low CP, Koh HY, Kuo IC, Zhang Y, Wong WS, Peh HY, Lim HY, Ge MQ, Haczku A, Angeli V, MacAry PA, Chua KY, Kemeny DM.

J Immunol. 2016 Nov 15;197(10):3771-3781. Epub 2016 Oct 12.


Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.

Flint SM, Jovanovic V, Teo BW, Mak A, Thumboo J, McKinney EF, Lee JC, MacAry P, Kemeny DM, Jayne DR, Fong KY, Lyons PA, Smith KG.

RMD Open. 2016 May 16;2(1):e000183. doi: 10.1136/rmdopen-2015-000183. eCollection 2016.


Correction: Cutting Edge: Role of NK Cells and Surfactant Protein D in Dendritic Cell Lymph Node Homing: Effects of Ozone Exposure.

Ge MQ, Kokalari B, Flayer CH, Killingbeck SS, Redai IG, MacFarlane AW 4th, Hwang JW, Kolupoti A, Kemeny DM, Campbell KS, Haczku A.

J Immunol. 2016 Apr 1;196(7):3212. doi: 10.4049/jimmunol.1600095. No abstract available.


Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice.

Yang Q, Ge MQ, Kokalari B, Redai IG, Wang X, Kemeny DM, Bhandoola A, Haczku A.

J Allergy Clin Immunol. 2016 Feb;137(2):571-8. doi: 10.1016/j.jaci.2015.06.037. Epub 2015 Aug 15.


Virus-specific T lymphocytes home to the skin during natural dengue infection.

Rivino L, Kumaran EA, Thein TL, Too CT, Gan VC, Hanson BJ, Wilder-Smith A, Bertoletti A, Gascoigne NR, Lye DC, Leo YS, Akbar AN, Kemeny DM, MacAry PA.

Sci Transl Med. 2015 Mar 11;7(278):278ra35. doi: 10.1126/scitranslmed.aaa0526.


STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation.

Sheng W, Yang F, Zhou Y, Yang H, Low PY, Kemeny DM, Tan P, Moh A, Kaplan MH, Zhang Y, Fu XY.

Cell Res. 2014 Dec;24(12):1387-402. doi: 10.1038/cr.2014.154. Epub 2014 Nov 21.


Multifunctional cytomegalovirus (CMV)-specific CD8(+) T cells are not restricted by telomere-related senescence in young or old adults.

Riddell NE, Griffiths SJ, Rivino L, King DC, Teo GH, Henson SM, Cantisan S, Solana R, Kemeny DM, MacAry PA, Larbi A, Akbar AN.

Immunology. 2015 Apr;144(4):549-60. doi: 10.1111/imm.12409.


GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.

Zhou Q, Ho AW, Schlitzer A, Tang Y, Wong KH, Wong FH, Chua YL, Angeli V, Mortellaro A, Ginhoux F, Kemeny DM.

J Immunol. 2014 Jul 15;193(2):496-509. doi: 10.4049/jimmunol.1303138. Epub 2014 Jun 18.


Neutrophils contribute to inflammatory lymphangiogenesis by increasing VEGF-A bioavailability and secreting VEGF-D.

Tan KW, Chong SZ, Wong FH, Evrard M, Tan SM, Keeble J, Kemeny DM, Ng LG, Abastado JP, Angeli V.

Blood. 2013 Nov 21;122(22):3666-77. doi: 10.1182/blood-2012-11-466532. Epub 2013 Oct 10.


CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells.

Chong SZ, Tan KW, Wong FHS, Chua YL, Tang Y, Ng LG, Angeli V, Kemeny DM.

J Invest Dermatol. 2014 Mar;134(3):666-676. doi: 10.1038/jid.2013.403. Epub 2013 Sep 23.


Gamma interferon regulates contraction of the influenza virus-specific CD8 T cell response and limits the size of the memory population.

Prabhu N, Ho AW, Wong KH, Hutchinson PE, Chua YL, Kandasamy M, Lee DC, Sivasankar B, Kemeny DM.

J Virol. 2013 Dec;87(23):12510-22. doi: 10.1128/JVI.01776-13. Epub 2013 Sep 11.


Age-associated increase of low-avidity cytomegalovirus-specific CD8+ T cells that re-express CD45RA.

Griffiths SJ, Riddell NE, Masters J, Libri V, Henson SM, Wertheimer A, Wallace D, Sims S, Rivino L, Larbi A, Kemeny DM, Nikolich-Zugich J, Kern F, Klenerman P, Emery VC, Akbar AN.

J Immunol. 2013 Jun 1;190(11):5363-72. doi: 10.4049/jimmunol.1203267. Epub 2013 May 1.


CD137 ligand signaling enhances myelopoiesis during infections.

Tang Q, Jiang D, Alonso S, Pant A, Martínez Gómez JM, Kemeny DM, Chen L, Schwarz H.

Eur J Immunol. 2013 Jun;43(6):1555-67. doi: 10.1002/eji.201243071. Epub 2013 Apr 24.


Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.

Kandasamy M, Ying PC, Ho AW, Sumatoh HR, Schlitzer A, Hughes TR, Kemeny DM, Morgan BP, Ginhoux F, Sivasankar B.

PLoS Pathog. 2013 Jan;9(1):e1003115. doi: 10.1371/journal.ppat.1003115. Epub 2013 Jan 10.


Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

Rivino L, Kumaran EA, Jovanovic V, Nadua K, Teo EW, Pang SW, Teo GH, Gan VC, Lye DC, Leo YS, Hanson BJ, Smith KG, Bertoletti A, Kemeny DM, MacAry PA.

J Virol. 2013 Mar;87(5):2693-706. doi: 10.1128/JVI.02675-12. Epub 2012 Dec 19.


Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models.

Li R, Cheng C, Chong SZ, Lim AR, Goh YF, Locht C, Kemeny DM, Angeli V, Wong WS, Alonso S.

Allergy. 2012 Oct;67(10):1250-8. doi: 10.1111/j.1398-9995.2012.02884.x. Epub 2012 Aug 22.


The role of the T follicular helper cells in allergic disease.

Kemeny DM.

Cell Mol Immunol. 2012 Sep;9(5):386-9. doi: 10.1038/cmi.2012.31. Epub 2012 Aug 20. Review.


NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.

Ge MQ, Ho AW, Tang Y, Wong KH, Chua BY, Gasser S, Kemeny DM.

J Immunol. 2012 Sep 1;189(5):2099-109. doi: 10.4049/jimmunol.1103474. Epub 2012 Aug 6.


The structural basis for serotype-specific neutralization of dengue virus by a human antibody.

Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, MacAry PA.

Sci Transl Med. 2012 Jun 20;4(139):139ra83. doi: 10.1126/scitranslmed.3003888.


Antigen-specific effector CD8 T cells regulate allergic responses via IFN-γ and dendritic cell function.

Tang Y, Guan SP, Chua BY, Zhou Q, Ho AW, Wong KH, Wong KL, Wong WS, Kemeny DM.

J Allergy Clin Immunol. 2012 Jun;129(6):1611-20.e4. doi: 10.1016/j.jaci.2011.12.976. Epub 2012 Mar 3.


Antibody-mediated pure red cell aplasia in chronic kidney disease patients receiving erythropoiesis-stimulating agents: new insights.

Macdougall IC, Roger SD, de Francisco A, Goldsmith DJ, Schellekens H, Ebbers H, Jelkmann W, London G, Casadevall N, Hörl WH, Kemeny DM, Pollock C.

Kidney Int. 2012 Apr;81(8):727-32. doi: 10.1038/ki.2011.500. Epub 2012 Feb 15. Review.


Soluble molecules are key in maintaining the immunomodulatory activity of murine mesenchymal stromal cells.

Liu H, Lu K, MacAry PA, Wong KL, Heng A, Cao T, Kemeny DM.

J Cell Sci. 2012 Jan 1;125(Pt 1):200-8. doi: 10.1242/jcs.093070. Epub 2012 Jan 16.


Influenza A virus infection results in a robust, antigen-responsive, and widely disseminated Foxp3+ regulatory T cell response.

Betts RJ, Prabhu N, Ho AW, Lew FC, Hutchinson PE, Rotzschke O, Macary PA, Kemeny DM.

J Virol. 2012 Mar;86(5):2817-25. doi: 10.1128/JVI.05685-11. Epub 2011 Dec 28.


Partial depletion of natural CD4⁺CD25⁺ regulatory T cells with anti-CD25 antibody does not alter the course of acute influenza A virus infection.

Betts RJ, Ho AW, Kemeny DM.

PLoS One. 2011;6(11):e27849. doi: 10.1371/journal.pone.0027849. Epub 2011 Nov 18.


Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.

Ho AW, Prabhu N, Betts RJ, Ge MQ, Dai X, Hutchinson PE, Lew FC, Wong KL, Hanson BJ, Macary PA, Kemeny DM.

J Immunol. 2011 Dec 1;187(11):6011-21. doi: 10.4049/jimmunol.1100987. Epub 2011 Oct 31.


Human CD8⁺ T cells drive Th1 responses through the differentiation of TNF/iNOS-producing dendritic cells.

Chong SZ, Wong KL, Lin G, Yang CM, Wong SC, Angeli V, Macary PA, Kemeny DM.

Eur J Immunol. 2011 Jun;41(6):1639-51. doi: 10.1002/eji.201041022. Epub 2011 May 9.


Importin beta plays an essential role in the regulation of the LysRS-Ap(4)A pathway in immunologically activated mast cells.

Carmi-Levy I, Motzik A, Ofir-Birin Y, Yagil Z, Yang CM, Kemeny DM, Han JM, Kim S, Kay G, Nechushtan H, Suzuki R, Rivera J, Razin E.

Mol Cell Biol. 2011 May;31(10):2111-21. doi: 10.1128/MCB.01159-10. Epub 2011 Mar 14.


A novel anti-apoptotic role for apolipoprotein L2 in IFN-γ-induced cytotoxicity in human bronchial epithelial cells.

Liao W, Goh FY, Betts RJ, Kemeny DM, Tam J, Bay BH, Wong WS.

J Cell Physiol. 2011 Feb;226(2):397-406. doi: 10.1002/jcp.22345.


A novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity.

Lethbridge MW, Kemeny DM, Ratoff JC, O'Connor BJ, Hawrylowicz CM, Corrigan CJ.

Clin Exp Immunol. 2010 Sep;161(3):560-9. doi: 10.1111/j.1365-2249.2010.04198.x.


A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.

McKinney EF, Lyons PA, Carr EJ, Hollis JL, Jayne DR, Willcocks LC, Koukoulaki M, Brazma A, Jovanovic V, Kemeny DM, Pollard AJ, Macary PA, Chaudhry AN, Smith KG.

Nat Med. 2010 May;16(5):586-91, 1p following 591. doi: 10.1038/nm.2130. Epub 2010 Apr 18.


Fc gamma receptor biology and systemic lupus erythematosus.

Jovanovic V, Dai X, Lim YT, Kemeny DM, MacAry PA.

Int J Rheum Dis. 2009 Dec;12(4):293-8. doi: 10.1111/j.1756-185X.2009.01426.x. Review.


The enigma of the role of protein inhibitor of activated STAT3 (PIAS3) in the immune response.

Yagil Z, Nechushtan H, Kay G, Yang CM, Kemeny DM, Razin E.

Trends Immunol. 2010 May;31(5):199-204. doi: 10.1016/ Epub 2010 Feb 22. Review.


CD44high memory CD8 T cells synergize with CpG DNA to activate dendritic cell IL-12p70 production.

Wong KL, Tang LF, Lew FC, Wong HS, Chua YL, MacAry PA, Kemeny DM.

J Immunol. 2009 Jul 1;183(1):41-50. doi: 10.4049/jimmunol.0803473. Epub 2009 Jun 17.


LysRS serves as a key signaling molecule in the immune response by regulating gene expression.

Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H, Razin E.

Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.


A subpopulation of mesenchymal stromal cells with high osteogenic potential.

Liu H, Toh WS, Lu K, MacAry PA, Kemeny DM, Cao T.

J Cell Mol Med. 2009 Aug;13(8B):2436-47. doi: 10.1111/j.1582-4934.2009.00793.x. Epub 2009 Jun 5.


Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa.

Dai X, Jayapal M, Tay HK, Reghunathan R, Lin G, Too CT, Lim YT, Chan SH, Kemeny DM, Floto RA, Smith KG, Melendez AJ, MacAry PA.

Blood. 2009 Jul 9;114(2):318-27. doi: 10.1182/blood-2008-10-184457. Epub 2009 May 6. Erratum in: Blood. 2013 Apr 4;121(14):2814.


A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway.

Bao Z, Guan S, Cheng C, Wu S, Wong SH, Kemeny DM, Leung BP, Wong WS.

Am J Respir Crit Care Med. 2009 Apr 15;179(8):657-65. doi: 10.1164/rccm.200809-1516OC. Epub 2009 Feb 6.


CD8+ T cells in asthma: friend or foe?

Betts RJ, Kemeny DM.

Pharmacol Ther. 2009 Feb;121(2):123-31. doi: 10.1016/j.pharmthera.2008.09.001. Epub 2008 Oct 1. Review.


CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production.

Wong KL, Lew FC, MacAry PA, Kemeny DM.

Eur J Immunol. 2008 Aug;38(8):2251-62. doi: 10.1002/eji.200838199.


Nitric-oxide synthase 2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development.

Huang D, Cai DT, Chua RY, Kemeny DM, Wong SH.

J Biol Chem. 2008 Jan 18;283(3):1713-22. Epub 2007 Nov 14.


Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation.

Lo AS, Taylor JR, Farzaneh F, Kemeny DM, Dibb NJ, Maher J.

Mol Immunol. 2008 Mar;45(5):1276-87. Epub 2007 Oct 24.


Modulation of dendritic cell differentiation by colony-stimulating factor-1: role of phosphatidylinositol 3'-kinase and delayed caspase activation.

Lo AS, Gorak-Stolinska P, Bachy V, Ibrahim MA, Kemeny DM, Maher J.

J Leukoc Biol. 2007 Dec;82(6):1446-54. Epub 2007 Sep 12.


An essential role for IL-18 in CD8 T cell-mediated suppression of IgE responses.

Salagianni M, Wong KL, Thomas MJ, Noble A, Kemeny DM.

J Immunol. 2007 Apr 15;178(8):4771-8. Erratum in: J Immunol. 2007 Jun 1;178(11):7488. Loon, Wong Kok [corrected to Wong, Kok Loon].

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