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Items: 1 to 50 of 86

1.

First-in-class fatty acid synthase inhibitor TVB-2640 reduces hepatic de novo lipogenesis in males with metabolic abnormalities.

Syed-Abdul MM, Parks EJ, Gaballah AH, Bingham K, Hammoud GM, Kemble G, Buckley D, McCulloch W, Manrique CM.

Hepatology. 2019 Oct 20. doi: 10.1002/hep.31000. [Epub ahead of print]

PMID:
31630414
2.

Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.

Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers M.

Oncotarget. 2018 May 15;9(37):24787-24800. doi: 10.18632/oncotarget.25361. eCollection 2018 May 15.

3.

Genomic analysis of chimeric human cytomegalovirus vaccine candidates derived from strains Towne and Toledo.

Suárez NM, Lau B, Kemble GM, Lee R, Mocarski ES, Wilkinson GWG, Adler SP, McVoy MA, Davison AJ.

Virus Genes. 2017 Aug;53(4):650-655. doi: 10.1007/s11262-017-1452-0. Epub 2017 Apr 8.

4.

Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target.

Buckley D, Duke G, Heuer TS, O'Farrell M, Wagman AS, McCulloch W, Kemble G.

Pharmacol Ther. 2017 Sep;177:23-31. doi: 10.1016/j.pharmthera.2017.02.021. Epub 2017 Feb 12. Review.

6.

A Phase 1 Study of 4 Live, Recombinant Human Cytomegalovirus Towne/Toledo Chimera Vaccines in Cytomegalovirus-Seronegative Men.

Adler SP, Manganello AM, Lee R, McVoy MA, Nixon DE, Plotkin S, Mocarski E, Cox JH, Fast PE, Nesterenko PA, Murray SE, Hill AB, Kemble G.

J Infect Dis. 2016 Nov 1;214(9):1341-1348. Epub 2016 Aug 11.

7.

Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses.

Ohol YM, Wang Z, Kemble G, Duke G.

PLoS One. 2015 Dec 11;10(12):e0144648. doi: 10.1371/journal.pone.0144648. eCollection 2015.

8.

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.

Ventura R, Mordec K, Waszczuk J, Wang Z, Lai J, Fridlib M, Buckley D, Kemble G, Heuer TS.

EBioMedicine. 2015 Jul 2;2(8):808-24. doi: 10.1016/j.ebiom.2015.06.020. eCollection 2015 Aug.

9.

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells.

Benjamin DI, Li DS, Lowe W, Heuer T, Kemble G, Nomura DK.

ACS Chem Biol. 2015 Jul 17;10(7):1616-23. doi: 10.1021/acschembio.5b00240. Epub 2015 Apr 17.

10.

African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates.

Matsuoka Y, Suguitan A Jr, Orandle M, Paskel M, Boonnak K, Gardner DJ, Feldmann F, Feldmann H, Marino M, Jin H, Kemble G, Subbarao K.

J Virol. 2014 Jul;88(14):8139-52. doi: 10.1128/JVI.00425-14. Epub 2014 May 7.

11.

Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.

Chen GL, Lamirande EW, Cheng X, Torres-Velez F, Orandle M, Jin H, Kemble G, Subbarao K.

J Virol. 2014 Mar;88(5):2867-76. doi: 10.1128/JVI.01829-13. Epub 2013 Dec 26.

12.

Genetic engineering of live attenuated influenza viruses.

Jin H, Chen Z, Liu J, Kemble G.

Methods Mol Biol. 2012;865:163-74. doi: 10.1007/978-1-61779-621-0_10.

PMID:
22528159
13.

An open-label phase I trial of a live attenuated H2N2 influenza virus vaccine in healthy adults.

Talaat KR, Karron RA, Liang PH, McMahon BA, Luke CJ, Thumar B, Chen GL, Min JY, Lamirande EW, Jin H, Coelingh KL, Kemble GW, Subbarao K.

Influenza Other Respir Viruses. 2013 Jan;7(1):66-73. doi: 10.1111/j.1750-2659.2012.00350.x. Epub 2012 Mar 14.

14.

An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults.

Talaat KR, Karron RA, Luke CJ, Thumar B, McMahon BA, Chen GL, Lamirande EW, Jin H, Coelingh KL, Kemble G, Subbarao K.

Vaccine. 2011 Apr 12;29(17):3144-8. doi: 10.1016/j.vaccine.2011.02.043. Epub 2011 Mar 4.

15.

Herpes simplex vaccines.

Kemble G, Spaete R.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 69.

16.

Comparison of a live attenuated 2009 H1N1 vaccine with seasonal influenza vaccines against 2009 pandemic H1N1 virus infection in mice and ferrets.

Chen GL, Min JY, Lamirande EW, Santos C, Jin H, Kemble G, Subbarao K.

J Infect Dis. 2011 Apr 1;203(7):930-6. doi: 10.1093/infdis/jiq144. Epub 2011 Jan 21.

17.

Plasmablast-derived polyclonal antibody response after influenza vaccination.

He XS, Sasaki S, Narvaez CF, Zhang C, Liu H, Woo JC, Kemble GW, Dekker CL, Davis MM, Greenberg HB.

J Immunol Methods. 2011 Feb 28;365(1-2):67-75. doi: 10.1016/j.jim.2010.12.008. Epub 2010 Dec 21.

18.

Safety and immunogenicity following administration of a live, attenuated monovalent 2009 H1N1 influenza vaccine to children and adults in two randomized controlled trials.

Mallory RM, Malkin E, Ambrose CS, Bellamy T, Shi L, Yi T, Jones T, Kemble G, Dubovsky F.

PLoS One. 2010 Oct 29;5(10):e13755. doi: 10.1371/journal.pone.0013755.

19.

Nasal turbinate enlargement due to cartilage and bone proliferation: a normal developmental finding in young ferrets.

Funk KA, Frantz C, Dyke AS, Ryan PC, Jin H, Kemble G, Dixit R, Leininger JR.

Toxicol Pathol. 2010 Dec;38(7):1064-9. doi: 10.1177/0192623310378867. Epub 2010 Sep 13.

PMID:
20837975
20.

A live attenuated H7N7 candidate vaccine virus induces neutralizing antibody that confers protection from challenge in mice, ferrets, and monkeys.

Min JY, Vogel L, Matsuoka Y, Lu B, Swayne D, Jin H, Kemble G, Subbarao K.

J Virol. 2010 Nov;84(22):11950-60. doi: 10.1128/JVI.01305-10. Epub 2010 Sep 1.

21.

The hemagglutinin protein of influenza A/Vietnam/1203/2004 (H5N1) contributes to hyperinduction of proinflammatory cytokines in human epithelial cells.

Cheng X, Xu Q, Song E, Yang CF, Kemble G, Jin H.

Virology. 2010 Oct 10;406(1):28-36. doi: 10.1016/j.virol.2010.06.048. Epub 2010 Jul 27.

22.

Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected children.

Weinberg A, Song LY, Walker R, Allende M, Fenton T, Patterson-Bartlett J, Nachman S, Kemble G, Yi TT, Defechereux P, Wara D, Read JS, Levin M; IMPAACT P1057 Team.

J Acquir Immune Defic Syndr. 2010 Oct;55(2):189-96. doi: 10.1097/QAI.0b013e3181e46308.

23.

Evaluation of replication and cross-reactive antibody responses of H2 subtype influenza viruses in mice and ferrets.

Chen GL, Lamirande EW, Yang CF, Jin H, Kemble G, Subbarao K.

J Virol. 2010 Aug;84(15):7695-702. doi: 10.1128/JVI.00511-10. Epub 2010 May 26.

24.

Genetic sequence analysis of influenza viruses and illness severity in ill children previously vaccinated with live attenuated or inactivated influenza vaccine.

Yang CF, Belshe RB, Kemble G, Song E, Ye D, Liang B, Yi T, Ambrose CS, Coelingh K, Walker RE.

Vaccine. 2010 Jul 12;28(31):5128-34. doi: 10.1016/j.vaccine.2010.02.109. Epub 2010 May 14.

PMID:
20472026
25.

Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets.

Wang W, Lu B, Zhou H, Suguitan AL Jr, Cheng X, Subbarao K, Kemble G, Jin H.

J Virol. 2010 Jul;84(13):6570-7. doi: 10.1128/JVI.00221-10. Epub 2010 Apr 28.

26.

A whole genome transcriptional analysis of the early immune response induced by live attenuated and inactivated influenza vaccines in young children.

Zhu W, Higgs BW, Morehouse C, Streicher K, Ambrose CS, Woo J, Kemble GW, Jallal B, Yao Y.

Vaccine. 2010 Apr 1;28(16):2865-76. doi: 10.1016/j.vaccine.2010.01.060. Epub 2010 Feb 12.

PMID:
20153794
27.

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

Chen GL, Lamirande EW, Jin H, Kemble G, Subbarao K.

Virology. 2010 Mar 1;398(1):109-14. doi: 10.1016/j.virol.2009.12.003. Epub 2009 Dec 24.

28.

Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs.

Chen Z, Wang W, Zhou H, Suguitan AL Jr, Shambaugh C, Kim L, Zhao J, Kemble G, Jin H.

J Virol. 2010 Jan;84(1):44-51. doi: 10.1128/JVI.02106-09.

29.

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus.

Suguitan AL Jr, Marino MP, Desai PD, Chen LM, Matsuoka Y, Donis RO, Jin H, Swayne DE, Kemble G, Subbarao K.

Virology. 2009 Dec 20;395(2):280-8. doi: 10.1016/j.virol.2009.09.017. Epub 2009 Oct 14.

30.

Use of MDCK cells for production of live attenuated influenza vaccine.

Liu J, Shi X, Schwartz R, Kemble G.

Vaccine. 2009 Oct 30;27(46):6460-3. doi: 10.1016/j.vaccine.2009.06.024. Epub 2009 Jun 24.

PMID:
19559113
31.

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults.

Karron RA, Talaat K, Luke C, Callahan K, Thumar B, Dilorenzo S, McAuliffe J, Schappell E, Suguitan A, Mills K, Chen G, Lamirande E, Coelingh K, Jin H, Murphy BR, Kemble G, Subbarao K.

Vaccine. 2009 Aug 6;27(36):4953-60. doi: 10.1016/j.vaccine.2009.05.099. Epub 2009 Jun 21.

32.

A live attenuated H7N3 influenza virus vaccine is well tolerated and immunogenic in a Phase I trial in healthy adults.

Talaat KR, Karron RA, Callahan KA, Luke CJ, DiLorenzo SC, Chen GL, Lamirande EW, Jin H, Coelingh KL, Murphy BR, Kemble G, Subbarao K.

Vaccine. 2009 Jun 8;27(28):3744-53. doi: 10.1016/j.vaccine.2009.03.082. Epub 2009 Apr 17.

33.

A live attenuated H9N2 influenza vaccine is well tolerated and immunogenic in healthy adults.

Karron RA, Callahan K, Luke C, Thumar B, McAuliffe J, Schappell E, Joseph T, Coelingh K, Jin H, Kemble G, Murphy BR, Subbarao K.

J Infect Dis. 2009 Mar 1;199(5):711-6. doi: 10.1086/596558.

34.

H5N1 vaccine-specific B cell responses in ferrets primed with live attenuated seasonal influenza vaccines.

Cheng X, Eisenbraun M, Xu Q, Zhou H, Kulkarni D, Subbarao K, Kemble G, Jin H.

PLoS One. 2009;4(2):e4436. doi: 10.1371/journal.pone.0004436. Epub 2009 Feb 11.

35.

Evaluation of live attenuated influenza a virus h6 vaccines in mice and ferrets.

Chen Z, Santos C, Aspelund A, Gillim-Ross L, Jin H, Kemble G, Subbarao K.

J Virol. 2009 Jan;83(1):65-72. doi: 10.1128/JVI.01775-08. Epub 2008 Oct 22.

36.

Molecular studies of temperature-sensitive replication of the cold-adapted B/Ann Arbor/1/66, the master donor virus for live attenuated influenza FluMist vaccines.

Chen Z, Aspelund A, Kemble G, Jin H.

Virology. 2008 Oct 25;380(2):354-62. doi: 10.1016/j.virol.2008.08.010. Epub 2008 Sep 20.

37.
38.

Avian influenza h6 viruses productively infect and cause illness in mice and ferrets.

Gillim-Ross L, Santos C, Chen Z, Aspelund A, Yang CF, Ye D, Jin H, Kemble G, Subbarao K.

J Virol. 2008 Nov;82(21):10854-63. doi: 10.1128/JVI.01206-08. Epub 2008 Aug 20.

39.

Influence of prior influenza vaccination on antibody and B-cell responses.

Sasaki S, He XS, Holmes TH, Dekker CL, Kemble GW, Arvin AM, Greenberg HB.

PLoS One. 2008 Aug 20;3(8):e2975. doi: 10.1371/journal.pone.0002975.

40.

Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children.

Levin MJ, Song LY, Fenton T, Nachman S, Patterson J, Walker R, Kemble G, Allende M, Hultquist M, Yi T, Nowak B, Weinberg A.

Vaccine. 2008 Aug 5;26(33):4210-7. doi: 10.1016/j.vaccine.2008.05.054. Epub 2008 Jun 10.

41.

Baseline levels of influenza-specific CD4 memory T-cells affect T-cell responses to influenza vaccines.

He XS, Holmes TH, Sasaki S, Jaimes MC, Kemble GW, Dekker CL, Arvin AM, Greenberg HB.

PLoS One. 2008 Jul 2;3(7):e2574. doi: 10.1371/journal.pone.0002574.

42.

A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.

Joseph T, McAuliffe J, Lu B, Vogel L, Swayne D, Jin H, Kemble G, Subbarao K.

Virology. 2008 Aug 15;378(1):123-32. doi: 10.1016/j.virol.2008.05.021. Epub 2008 Jun 27.

43.

Phenotypic changes in influenza-specific CD8+ T cells after immunization of children and adults with influenza vaccines.

He XS, Holmes TH, Mahmood K, Kemble GW, Dekker CL, Arvin AM, Greenberg HB.

J Infect Dis. 2008 Mar 15;197(6):803-11. doi: 10.1086/528804.

PMID:
18279048
44.

Toxicological evaluation of live attenuated, cold-adapted H5N1 vaccines in ferrets.

Jin H, Manetz S, Leininger J, Luke C, Subbarao K, Murphy B, Kemble G, Coelingh KL.

Vaccine. 2007 Dec 17;25(52):8664-72. Epub 2007 Nov 5.

PMID:
18031873
45.

Evaluation of replication and pathogenicity of avian influenza a H7 subtype viruses in a mouse model.

Joseph T, McAuliffe J, Lu B, Jin H, Kemble G, Subbarao K.

J Virol. 2007 Oct;81(19):10558-66. Epub 2007 Jul 18.

46.

Live attenuated versus inactivated influenza vaccine in infants and young children.

Belshe RB, Edwards KM, Vesikari T, Black SV, Walker RE, Hultquist M, Kemble G, Connor EM; CAIV-T Comparative Efficacy Study Group.

N Engl J Med. 2007 Feb 15;356(7):685-96. Erratum in: N Engl J Med. 2007 Mar 22;356(12):1283.

47.

Humoral and cellular immune responses in children given annual immunization with trivalent inactivated influenza vaccine.

Zeman AM, Holmes TH, Stamatis S, Tu W, He XS, Bouvier N, Kemble G, Greenberg HB, Lewis DB, Arvin AM, Dekker CL.

Pediatr Infect Dis J. 2007 Feb;26(2):107-15.

PMID:
17259871
48.

Comparison of the influenza virus-specific effector and memory B-cell responses to immunization of children and adults with live attenuated or inactivated influenza virus vaccines.

Sasaki S, Jaimes MC, Holmes TH, Dekker CL, Mahmood K, Kemble GW, Arvin AM, Greenberg HB.

J Virol. 2007 Jan;81(1):215-28. Epub 2006 Oct 18.

49.

Cellular immune responses in children and adults receiving inactivated or live attenuated influenza vaccines.

He XS, Holmes TH, Zhang C, Mahmood K, Kemble GW, Lewis DB, Dekker CL, Greenberg HB, Arvin AM.

J Virol. 2006 Dec;80(23):11756-66. Epub 2006 Sep 13.

50.

Live, attenuated influenza A H5N1 candidate vaccines provide broad cross-protection in mice and ferrets.

Suguitan AL Jr, McAuliffe J, Mills KL, Jin H, Duke G, Lu B, Luke CJ, Murphy B, Swayne DE, Kemble G, Subbarao K.

PLoS Med. 2006 Sep;3(9):e360.

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