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A Cross-Sectional Study of Compositional and Functional Profiles of Gut Microbiota in Sardinian Centenarians.

Wu L, Zeng T, Zinellu A, Rubino S, Kelvin DJ, Carru C.

mSystems. 2019 Jul 9;4(4). pii: e00325-19. doi: 10.1128/mSystems.00325-19.


A Survey of Molecular Heterogeneity in Hepatocellular Carcinoma.

Jovel J, Lin Z, O'keefe S, Willows S, Wang W, Zhang G, Patterson J, Moctezuma-Velázquez C, Kelvin DJ, Ka-Shu Wong G, Mason AL.

Hepatol Commun. 2018 Jul 12;2(8):941-955. doi: 10.1002/hep4.1197. eCollection 2018 Aug.


Host gene expression profiles in ferrets infected with genetically distinct henipavirus strains.

Leon AJ, Borisevich V, Boroumand N, Seymour R, Nusbaum R, Escaffre O, Xu L, Kelvin DJ, Rockx B.

PLoS Negl Trop Dis. 2018 Mar 14;12(3):e0006343. doi: 10.1371/journal.pntd.0006343. eCollection 2018 Mar.


Inhibition of influenza A virus infection by ginsenosides.

Dong W, Farooqui A, Leon AJ, Kelvin DJ.

PLoS One. 2017 Feb 10;12(2):e0171936. doi: 10.1371/journal.pone.0171936. eCollection 2017.


More on Probable Hospital Cluster of H7N9 Influenza Infection.

Kelvin DJ, Leon AJ, Farooqui A, Liu W.

N Engl J Med. 2016 Sep 8;375(10):e23. doi: 10.1056/NEJMc1608034. No abstract available.


Probable Hospital Cluster of H7N9 Influenza Infection.

Farooqui A, Liu W, Zeng T, Liu Y, Zhang L, Khan A, Wu X, Wu R, Wu S, Huang L, Cai Y, Kelvin AA, Paquette SG, Hu K, Zheng N, Chen H, Xu S, Lin C, Sun P, Yao Z, Wang J, Ma H, Zhu Z, Lin P, Chen W, Fang X, Bermejo-Martin JF, Leon AJ, Kelvin DJ; H7N9 Shantou Working Group.

N Engl J Med. 2016 Feb 11;374(6):596-8. doi: 10.1056/NEJMc1505359. No abstract available.


Defining immunological dysfunction in sepsis: A requisite tool for precision medicine.

Bermejo-Martin JF, Andaluz-Ojeda D, Almansa R, Gandía F, Gómez-Herreras JI, Gomez-Sanchez E, Heredia-Rodríguez M, Eiros JM, Kelvin DJ, Tamayo E.

J Infect. 2016 May;72(5):525-36. doi: 10.1016/j.jinf.2016.01.010. Epub 2016 Feb 3. Review.


Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils.

Zhang Z, Huang T, Yu F, Liu X, Zhao C, Chen X, Kelvin DJ, Gu J.

Sci Rep. 2015 Dec 7;5:17809. doi: 10.1038/srep17809.


Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses.

Paquette SG, Banner D, Huang SS, Almansa R, Leon A, Xu L, Bartoszko J, Kelvin DJ, Kelvin AA.

PLoS Pathog. 2015 Oct 8;11(10):e1005173. doi: 10.1371/journal.ppat.1005173. eCollection 2015 Oct.


Assessment of Antiviral Properties of Peramivir against H7N9 Avian Influenza Virus in an Experimental Mouse Model.

Farooqui A, Huang L, Wu S, Cai Y, Su M, Lin P, Chen W, Fang X, Zhang L, Liu Y, Zeng T, Paquette SG, Khan A, Kelvin AA, Kelvin DJ.

Antimicrob Agents Chemother. 2015 Dec;59(12):7255-64. doi: 10.1128/AAC.01885-15. Epub 2015 Sep 14.


Lessons to learn from MERS-CoV outbreak in South Korea.

Khan A, Farooqui A, Guan Y, Kelvin DJ.

J Infect Dev Ctries. 2015 Jul 4;9(6):543-6. doi: 10.3855/jidc.7278.


Genetic diversity of the 2013-14 human isolates of influenza H7N9 in China.

Farooqui A, Leon AJ, Huang L, Wu S, Cai Y, Lin P, Chen W, Fang X, Zeng T, Liu Y, Zhang L, Su T, Chen W, Ghedin E, Zhu H, Guan Y, Kelvin DJ.

BMC Infect Dis. 2015 Feb 28;15:109. doi: 10.1186/s12879-015-0829-8.


The third wave: H7N9 endemic reassortant viruses and patient clusters.

Liu Y, Paquette SG, Zhang L, Leon AJ, Liu W, Xiuming W, Huang L, Wu S, Lin P, Chen W, Fang X, Zeng T, Kelvin N, Farooqui A, Kelvin DJ.

J Infect Dev Ctries. 2015 Feb 19;9(2):122-7. doi: 10.3855/jidc.6759.


CXCL14 deficiency does not impact the outcome of influenza or Escherichia coli infections in mice.

Sidahmed AM, Leon AJ, Banner D, Kelvin AA, Rowe T, Boudakov I, Degousse N, Rubin BB, Kelvin DJ.

J Infect Dev Ctries. 2014 Oct 15;8(10):1301-6. doi: 10.3855/jidc.3890.


Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection.

Paquette SG, Huang SSH, Banner D, Xu L, Leόn A, Kelvin AA, Kelvin DJ.

Virology. 2014 Sep;464-465:177-183. doi: 10.1016/j.virol.2014.07.013. Epub 2014 Aug 1.


A CD4+ T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function.

Jacobs ES, Persad D, Ran L, Danesh A, Heitman JW, Deng X, Cameron MJ, Kelvin DJ, Norris PJ.

Retrovirology. 2014 Jul 5;11:57. doi: 10.1186/1742-4690-11-57.


Pathogenic influenza B virus in the ferret model establishes lower respiratory tract infection.

Huang SS, Banner D, Paquette SG, Leon AJ, Kelvin AA, Kelvin DJ.

J Gen Virol. 2014 Oct;95(Pt 10):2127-39. doi: 10.1099/vir.0.064352-0. Epub 2014 Jul 2.


Next-generation sequencing and bioinformatic approaches to detect and analyze influenza virus in ferrets.

Lin Z, Farooqui A, Li G, Wong GK, Mason AL, Banner D, Kelvin AA, Kelvin DJ, León AJ.

J Infect Dev Ctries. 2014 Apr 15;8(4):498-509. doi: 10.3855/jidc.3749.


Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection.

Kelvin AA, Degousee N, Banner D, Stefanski E, Leόn AJ, Angoulvant D, Paquette SG, Huang SS, Danesh A, Robbins CS, Noyan H, Husain M, Lambeau G, Gelb M, Kelvin DJ, Rubin BB.

Virology. 2014 Apr;454-455:78-92. doi: 10.1016/j.virol.2014.01.030. Epub 2014 Feb 25.


Pandemic H1N1 influenza A directly induces a robust and acute inflammatory gene signature in primary human bronchial epithelial cells downstream of membrane fusion.

Paquette SG, Banner D, Chi le TB, Leόn AJ, Xu L, Ran L, Huang SS, Farooqui A, Kelvin DJ, Kelvin AA.

Virology. 2014 Jan 5;448:91-103. doi: 10.1016/j.virol.2013.09.022. Epub 2013 Oct 22.


Mesenchymal stromal (stem) cell therapy fails to improve outcomes in experimental severe influenza.

Darwish I, Banner D, Mubareka S, Kim H, Besla R, Kelvin DJ, Kain KC, Liles WC.

PLoS One. 2013 Aug 15;8(8):e71761. doi: 10.1371/journal.pone.0071761. eCollection 2013.


The genesis and source of the H7N9 influenza viruses causing human infections in China.

Lam TT, Wang J, Shen Y, Zhou B, Duan L, Cheung CL, Ma C, Lycett SJ, Leung CY, Chen X, Li L, Hong W, Chai Y, Zhou L, Liang H, Ou Z, Liu Y, Farooqui A, Kelvin DJ, Poon LL, Smith DK, Pybus OG, Leung GM, Shu Y, Webster RG, Webby RJ, Peiris JS, Rambaut A, Zhu H, Guan Y.

Nature. 2013 Oct 10;502(7470):241-4. doi: 10.1038/nature12515. Epub 2013 Aug 21.


Infectivity, transmission, and pathology of human-isolated H7N9 influenza virus in ferrets and pigs.

Zhu H, Wang D, Kelvin DJ, Li L, Zheng Z, Yoon SW, Wong SS, Farooqui A, Wang J, Banner D, Chen R, Zheng R, Zhou J, Zhang Y, Hong W, Dong W, Cai Q, Roehrl MH, Huang SS, Kelvin AA, Yao T, Zhou B, Chen X, Leung GM, Poon LL, Webster RG, Webby RJ, Peiris JS, Guan Y, Shu Y.

Science. 2013 Jul 12;341(6142):183-6. doi: 10.1126/science.1239844. Epub 2013 May 23. Erratum in: Science. 2013 Aug 30;341(6149):959.


Immunity toward H1N1 influenza hemagglutinin of historical and contemporary strains suggests protection and vaccine failure.

Huang SS, Lin Z, Banner D, León AJ, Paquette SG, Rubin B, Rubino S, Guan Y, Kelvin DJ, Kelvin AA.

Sci Rep. 2013;3:1698. doi: 10.1038/srep01698.


H7N9 Incident, immune status, the elderly and a warning of an influenza pandemic.

Guan Y, Farooqui A, Zhu H, Dong W, Wang J, Kelvin DJ.

J Infect Dev Ctries. 2013 Apr 17;7(4):302-7. doi: 10.3855/jidc.3675.


Extremely low vaccine effectiveness against influenza H3N2 in the elderly during the 2012/2013 flu season.

Kelvin DJ, Farooqui A.

J Infect Dev Ctries. 2013 Mar 14;7(3):299-301. doi: 10.3855/jidc.3544. No abstract available.


Influenza monitoring in Sardinia, Italy identifies H3 subtype in Mediterranean wild migratory birds.

Kelvin AA, Meloni D, Sansonetti P, Borghetto I, Rowe T, Santangelo R, Pisu D, Cameron CM, Paglietti B, Banner D, Farooqui A, Marongiu P, Santona A, Fadda G, Kelvin DJ, Rubino S.

J Infect Dev Ctries. 2012 Nov 26;6(11):786-97. doi: 10.3855/jidc.2793.


Sequencing, annotation, and characterization of the influenza ferret infectome.

León AJ, Banner D, Xu L, Ran L, Peng Z, Yi K, Chen C, Xu F, Huang J, Zhao Z, Lin Z, Huang SH, Fang Y, Kelvin AA, Ross TM, Farooqui A, Kelvin DJ.

J Virol. 2013 Feb;87(4):1957-66. doi: 10.1128/JVI.02476-12. Epub 2012 Dec 12.


Differential pathological and immune responses in newly weaned ferrets are associated with a mild clinical outcome of pandemic 2009 H1N1 infection.

Huang SS, Banner D, Degousee N, Leon AJ, Xu L, Paquette SG, Kanagasabai T, Fang Y, Rubino S, Rubin B, Kelvin DJ, Kelvin AA.

J Virol. 2012 Dec;86(24):13187-201. doi: 10.1128/JVI.01456-12. Epub 2012 Oct 10.


Lack of innate interferon responses during SARS coronavirus infection in a vaccination and reinfection ferret model.

Cameron MJ, Kelvin AA, Leon AJ, Cameron CM, Ran L, Xu L, Chu YK, Danesh A, Fang Y, Li Q, Anderson A, Couch RC, Paquette SG, Fomukong NG, Kistner O, Lauchart M, Rowe T, Harrod KS, Jonsson CB, Kelvin DJ.

PLoS One. 2012;7(9):e45842. doi: 10.1371/journal.pone.0045842. Epub 2012 Sep 24.


The impact of JIDC.

Kelvin DJ, Wain J, Rubino S.

J Infect Dev Ctries. 2012 Jul 23;6(7):542. No abstract available.


Induction of Fas mediated caspase-8 independent apoptosis in immune cells by Armigeres subalbatus saliva.

Liu S, Kelvin DJ, Leon AJ, Jin L, Farooqui A.

PLoS One. 2012;7(7):e41145. doi: 10.1371/journal.pone.0041145. Epub 2012 Jul 17.


Interleukin-6 is a potential biomarker for severe pandemic H1N1 influenza A infection.

Paquette SG, Banner D, Zhao Z, Fang Y, Huang SS, Leόn AJ, Ng DC, Almansa R, Martin-Loeches I, Ramirez P, Socias L, Loza A, Blanco J, Sansonetti P, Rello J, Andaluz D, Shum B, Rubino S, de Lejarazu RO, Tran D, Delogu G, Fadda G, Krajden S, Rubin BB, Bermejo-Martin JF, Kelvin AA, Kelvin DJ.

PLoS One. 2012;7(6):e38214. doi: 10.1371/journal.pone.0038214. Epub 2012 Jun 5.


Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice.

Farooqui A, Leon AJ, Lei Y, Wang P, Huang J, Tenorio R, Dong W, Rubino S, Lin J, Li G, Zhao Z, Kelvin DJ.

Virol J. 2012 Jun 6;9:104.


CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro.

Sidahmed AM, León AJ, Bosinger SE, Banner D, Danesh A, Cameron MJ, Kelvin DJ.

Cytokine. 2012 Aug;59(2):433-41. doi: 10.1016/j.cyto.2012.05.002. Epub 2012 May 30.


Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.

Mir KD, Bosinger SE, Gasper M, Ho O, Else JG, Brenchley JM, Kelvin DJ, Silvestri G, Hu SL, Sodora DL.

J Virol. 2012 Jul;86(14):7605-15. doi: 10.1128/JVI.06813-11. Epub 2012 May 2.


Sensitive detection assays for influenza RNA do not reveal viremia in US blood donors.

Stramer SL, Collins C, Nugent T, Wang X, Fuschino M, Heitman JW, Law J, Krysztof DE, Kiely N, Todd D, Vermeulen NM, Harrington K, Kamel H, Kelvin DJ, Busch MP, St George K, Hewlett IK, Linnen JM, Norris PJ; NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II).

J Infect Dis. 2012 Mar 15;205(6):886-94. doi: 10.1093/infdis/jir863. Epub 2012 Jan 31.


Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism.

Fang Y, Banner D, Kelvin AA, Huang SS, Paige CJ, Corfe SA, Kane KP, Bleackley RC, Rowe T, Leon AJ, Kelvin DJ.

J Virol. 2012 Feb;86(4):2229-38. doi: 10.1128/JVI.05540-11. Epub 2011 Nov 30.


Comparative analyses of pandemic H1N1 and seasonal H1N1, H3N2, and influenza B infections depict distinct clinical pictures in ferrets.

Huang SS, Banner D, Fang Y, Ng DC, Kanagasabai T, Kelvin DJ, Kelvin AA.

PLoS One. 2011;6(11):e27512. doi: 10.1371/journal.pone.0027512. Epub 2011 Nov 16.


Imbalanced pro- and anti-Th17 responses (IL-17/granulocyte colony-stimulating factor) predict fatal outcome in 2009 pandemic influenza.

Almansa R, Socias L, Ramirez P, Martin-Loeches I, Vallés J, Loza A, Rello J, Kelvin DJ, León C, Blanco J, Andaluz D, Micheloud D, Maraví E, Ortiz de Lejarazu R, Bermejo-Martin JF.

Crit Care. 2011;15(5):448. doi: 10.1186/cc10426. Epub 2011 Oct 20. No abstract available.


Genetic and clinical assessment of 2009 pandemic influenza in southern China.

Farooqui A, Lei Y, Wang P, Huang J, Lin J, Li G, Leon AJ, Zhao Z, Kelvin DJ.

J Infect Dev Ctries. 2011 Oct 13;5(10):700-10.


Direct association between pharyngeal viral secretion and host cytokine response in severe pandemic influenza.

Almansa R, Anton A, Ramirez P, Martin-Loeches I, Banner D, Pumarola T, Xu L, Blanco J, Ran L, Lopez-Campos G, Martin-Sanchez F, Socias L, Loza A, Andaluz D, Maravi E, Gordón M, Gallegos MC, Fernandez V, León C, Merino P, Marcos MA, Gandía F, Bobillo F, Resino S, Eiros JM, Castro C, Mateo P, Gonzalez-Rivera M, Rello J, de Lejarazu RO, Kelvin DJ, Bermejo-Martin JF.

BMC Infect Dis. 2011 Aug 31;11:232. doi: 10.1186/1471-2334-11-232.


Inflammatory cytokine expression is associated with chikungunya virus resolution and symptom severity.

Kelvin AA, Banner D, Silvi G, Moro ML, Spataro N, Gaibani P, Cavrini F, Pierro A, Rossini G, Cameron MJ, Bermejo-Martin JF, Paquette SG, Xu L, Danesh A, Farooqui A, Borghetto I, Kelvin DJ, Sambri V, Rubino S.

PLoS Negl Trop Dis. 2011 Aug;5(8):e1279. doi: 10.1371/journal.pntd.0001279. Epub 2011 Aug 16.


Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.

Degousee N, Kelvin DJ, Geisslinger G, Hwang DM, Stefanski E, Wang XH, Danesh A, Angioni C, Schmidt H, Lindsay TF, Gelb MH, Bollinger J, Payré C, Lambeau G, Arm JP, Keating A, Rubin BB.

J Biol Chem. 2011 Oct 14;286(41):35650-62. doi: 10.1074/jbc.M111.262733. Epub 2011 Aug 17.


Escherichia coli (STEC) serotype O104 outbreak causing haemolytic syndrome (HUS) in Germany and France.

Rubino S, Cappuccinelli P, Kelvin DJ.

J Infect Dev Ctries. 2011 Jul 4;5(6):437-40.


Influenza-associated encephalopathy with elevated antibody titers to pandemic (H1N1) 2009 influenza.

Thampi N, Bitnun A, Banner D, Rowe T, Kelvin DJ, Richardson SE, Parkin P, Tran D.

J Child Neurol. 2011 Apr;26(4):501-6. doi: 10.1177/0883073810381128. Epub 2011 Jan 26.


Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation.

Danesh A, Cameron CM, León AJ, Ran L, Xu L, Fang Y, Kelvin AA, Rowe T, Chen H, Guan Y, Jonsson CB, Cameron MJ, Kelvin DJ.

Virology. 2011 Jan 5;409(1):102-12. doi: 10.1016/j.virol.2010.10.002. Epub 2010 Oct 28.


HIV‐exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV‐dependent host factors.

McLaren PJ, Ball TB, Wachihi C, Jaoko W, Kelvin DJ, Danesh A, Kimani J, Plummer FA, Fowke KR.

J Infect Dis. 2010 Nov 1;202 Suppl 3:S339-44. doi: 10.1086/655968.


Adjuvant immunotherapy increases beta cell regenerative factor Reg2 in the pancreas of diabetic mice.

Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B.

J Immunol. 2010 Nov 1;185(9):5120-9. doi: 10.4049/jimmunol.1001596. Epub 2010 Sep 27.


In vivo ribavirin activity against severe pandemic H1N1 Influenza A/Mexico/4108/2009.

Rowe T, Banner D, Farooqui A, Ng DC, Kelvin AA, Rubino S, Huang SS, Fang Y, Kelvin DJ.

J Gen Virol. 2010 Dec;91(Pt 12):2898-906. doi: 10.1099/vir.0.024323-0. Epub 2010 Aug 25.


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