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Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Bonsignori M, Scott E, Wiehe K, Easterhoff D, Alam SM, Hwang KK, Cooper M, Xia SM, Zhang R, Montefiori DC, Henderson R, Nie X, Kelsoe G, Moody MA, Chen X, Joyce MG, Kwong PD, Connors M, Mascola JR, McGuire AT, Stamatatos L, Medina-Ramírez M, Sanders RW, Saunders KO, Kepler TB, Haynes BF.

Immunity. 2018 Dec 18;49(6):1162-1174.e8. doi: 10.1016/j.immuni.2018.10.015. Epub 2018 Dec 11.


The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID.

Kuraoka M, Meffre E, Kelsoe G.

Adv Immunol. 2018;139:51-92. doi: 10.1016/ Epub 2018 May 7.


Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design.

Finney J, Kelsoe G.

Retrovirology. 2018 Jul 28;15(1):53. doi: 10.1186/s12977-018-0435-0. Review.


Germinal center responses to complex antigens.

Finney J, Yeh CH, Kelsoe G, Kuraoka M.

Immunol Rev. 2018 Jul;284(1):42-50. doi: 10.1111/imr.12661.


Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density.

Yeh CH, Nojima T, Kuraoka M, Kelsoe G.

Nat Commun. 2018 Mar 2;9(1):928. doi: 10.1038/s41467-018-03382-x.


Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires.

McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Kepler TB, Schmidt AG, Kelsoe G, Harrison SC.

Immunity. 2018 Jan 16;48(1):174-184.e9. doi: 10.1016/j.immuni.2017.12.009.


Targeted Elimination of Immunodominant B Cells Drives the Germinal Center Reaction toward Subdominant Epitopes.

Silva M, Nguyen TH, Philbrook P, Chu M, Sears O, Hatfield S, Abbott RK, Kelsoe G, Sitkovsky MV.

Cell Rep. 2017 Dec 26;21(13):3672-3680. doi: 10.1016/j.celrep.2017.12.014.


Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.

Williams WB, Zhang J, Jiang C, Nicely NI, Fera D, Luo K, Moody MA, Liao HX, Alam SM, Kepler TB, Ramesh A, Wiehe K, Holland JA, Bradley T, Vandergrift N, Saunders KO, Parks R, Foulger A, Xia SM, Bonsignori M, Montefiori DC, Louder M, Eaton A, Santra S, Scearce R, Sutherland L, Newman A, Bouton-Verville H, Bowman C, Bomze H, Gao F, Marshall DJ, Whitesides JF, Nie X, Kelsoe G, Reed SG, Fox CB, Clary K, Koutsoukos M, Franco D, Mascola JR, Harrison SC, Haynes BF, Verkoczy L.

Nat Commun. 2017 Nov 23;8(1):1732. doi: 10.1038/s41467-017-01336-3.


Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodies.

Moody MA, Pedroza-Pacheco I, Vandergrift NA, Chui C, Lloyd KE, Parks R, Soderberg KA, Ogbe AT, Cohen MS, Liao HX, Gao F, McMichael AJ, Montefiori DC, Verkoczy L, Kelsoe G, Huang J, Shea PR, Connors M, Borrow P, Haynes BF.

Sci Immunol. 2016 Jul 29;1(1):aag0851. doi: 10.1126/sciimmunol.aag0851. Epub 2016 Jul 29.


Potent and broad HIV-neutralizing antibodies in memory B cells and plasma.

Williams LD, Ofek G, Schätzle S, McDaniel JR, Lu X, Nicely NI, Wu L, Lougheed CS, Bradley T, Louder MK, McKee K, Bailer RT, O'Dell S, Georgiev IS, Seaman MS, Parks RJ, Marshall DJ, Anasti K, Yang G, Nie X, Tumba NL, Wiehe K, Wagh K, Korber B, Kepler TB, Munir Alam S, Morris L, Kamanga G, Cohen MS, Bonsignori M, Xia SM, Montefiori DC, Kelsoe G, Gao F, Mascola JR, Moody MA, Saunders KO, Liao HX, Tomaras GD, Georgiou G, Haynes BF.

Sci Immunol. 2017 Jan 27;2(7). pii: eaal2200. doi: 10.1126/sciimmunol.aal2200.


What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Breaking through Immunity's Glass Ceiling.

Kelsoe G, Haynes BF.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a029397. doi: 10.1101/cshperspect.a029397. Review.


Role of germinal centers for the induction of broadly-reactive memory B cells.

Takahashi Y, Kelsoe G.

Curr Opin Immunol. 2017 Apr;45:119-125. doi: 10.1016/j.coi.2017.03.002. Epub 2017 Mar 27. Review.


Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.

Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, Xia SM, Cooper M, Louder MK, McKee K, Bailer RT, Pier BW, Jette CA, Kelsoe G, Williams WB, Morris L, Kappes J, Wagh K, Kamanga G, Cohen MS, Hraber PT, Montefiori DC, Trama A, Liao HX, Kepler TB, Moody MA, Gao F, Danishefsky SJ, Mascola JR, Shaw GM, Hahn BH, Harrison SC, Korber BT, Haynes BF.

Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7514. doi: 10.1126/scitranslmed.aai7514.


BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance.

Kuraoka M, Snowden PB, Nojima T, Verkoczy L, Haynes BF, Kitamura D, Kelsoe G.

Cell Rep. 2017 Feb 14;18(7):1627-1635. doi: 10.1016/j.celrep.2017.01.050.


Host controls of HIV broadly neutralizing antibody development.

Kelsoe G, Haynes BF.

Immunol Rev. 2017 Jan;275(1):79-88. doi: 10.1111/imr.12508. Review.


Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.

Wiehe K, Nicely NI, Lockwood B, Kuraoka M, Anasti K, Arora S, Bowman CM, Stolarchuk C, Parks R, Lloyd KE, Xia SM, Duffy R, Shen X, Kyratsous CA, Macdonald LE, Murphy AJ, Scearce RM, Moody MA, Alam SM, Verkoczy L, Tomaras GD, Kelsoe G, Haynes BF.

J Immunol. 2017 Feb 1;198(3):1047-1055. doi: 10.4049/jimmunol.1601640. Epub 2016 Dec 23.


Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

Huang J, Kang BH, Ishida E, Zhou T, Griesman T, Sheng Z, Wu F, Doria-Rose NA, Zhang B, McKee K, O'Dell S, Chuang GY, Druz A, Georgiev IS, Schramm CA, Zheng A, Joyce MG, Asokan M, Ransier A, Darko S, Migueles SA, Bailer RT, Louder MK, Alam SM, Parks R, Kelsoe G, Von Holle T, Haynes BF, Douek DC, Hirsch V, Seaman MS, Shapiro L, Mascola JR, Kwong PD, Connors M.

Immunity. 2016 Nov 15;45(5):1108-1121. doi: 10.1016/j.immuni.2016.10.027.


HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.

Bradley T, Yang G, Ilkayeva O, Holl TM, Zhang R, Zhang J, Santra S, Fox CB, Reed SG, Parks R, Bowman CM, Bouton-Verville H, Sutherland LL, Scearce RM, Vandergrift N, Kepler TB, Moody MA, Liao HX, Alam SM, McLendon R, Everitt JI, Newgard CB, Verkoczy L, Kelsoe G, Haynes BF.

J Immunol. 2016 Dec 15;197(12):4663-4673. Epub 2016 Nov 14.


An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.

van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW.

Nat Microbiol. 2016 Nov 14;2:16199. doi: 10.1038/nmicrobiol.2016.199.


Efficient Culture of Human Naive and Memory B Cells for Use as APCs.

Su KY, Watanabe A, Yeh CH, Kelsoe G, Kuraoka M.

J Immunol. 2016 Nov 15;197(10):4163-4176. Epub 2016 Oct 10.


Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination.

Abbott RK, Thayer M, Labuda J, Silva M, Philbrook P, Cain DW, Kojima H, Hatfield S, Sethumadhavan S, Ohta A, Reinherz EL, Kelsoe G, Sitkovsky M.

J Immunol. 2016 Nov 15;197(10):4014-4020. Epub 2016 Oct 19.


The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).

Khandelwal S, Lee GM, Hester CG, Poncz M, McKenzie SE, Sachais BS, Rauova L, Kelsoe G, Cines DB, Frank M, Arepally GM.

Blood. 2016 Oct 6;128(14):1789-1799. doi: 10.1182/blood-2016-04-709634. Epub 2016 Jul 13.


Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages.

Zhang R, Verkoczy L, Wiehe K, Munir Alam S, Nicely NI, Santra S, Bradley T, Pemble CW 4th, Zhang J, Gao F, Montefiori DC, Bouton-Verville H, Kelsoe G, Larimore K, Greenberg PD, Parks R, Foulger A, Peel JN, Luo K, Lu X, Trama AM, Vandergrift N, Tomaras GD, Kepler TB, Moody MA, Liao HX, Haynes BF.

Sci Transl Med. 2016 Apr 27;8(336):336ra62. doi: 10.1126/scitranslmed.aaf0618.


Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.

Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C; NISC Comparative Sequencing Program, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF.

Cell. 2016 Apr 7;165(2):449-63. doi: 10.1016/j.cell.2016.02.022. Epub 2016 Mar 3.


Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.

Kuraoka M, Schmidt AG, Nojima T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB, Kelsoe G.

Immunity. 2016 Mar 15;44(3):542-552. doi: 10.1016/j.immuni.2016.02.010. Epub 2016 Mar 3.


HIV-Host Interactions: Implications for Vaccine Design.

Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, Borrow P, McMichael AJ.

Cell Host Microbe. 2016 Mar 9;19(3):292-303. doi: 10.1016/j.chom.2016.02.002. Epub 2016 Feb 25. Review.


Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.

Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SSA, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BF.

Cell Rep. 2016 Jan 5;14(1):43-54. doi: 10.1016/j.celrep.2015.12.017. Epub 2015 Dec 24.


TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.

Ci X, Kuraoka M, Wang H, Carico Z, Hopper K, Shin J, Deng X, Qiu Y, Unniraman S, Kelsoe G, Zhong XP.

PLoS One. 2015 May 22;10(5):e0127527. doi: 10.1371/journal.pone.0127527. eCollection 2015.


Heavy-chain receptor editing unbound.

Kelsoe G.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2297-8. doi: 10.1073/pnas.1501480112. Epub 2015 Feb 17. No abstract available.


Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.

Wiehe K, Easterhoff D, Luo K, Nicely NI, Bradley T, Jaeger FH, Dennison SM, Zhang R, Lloyd KE, Stolarchuk C, Parks R, Sutherland LL, Scearce RM, Morris L, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Sinangil F, Phogat S, Michael NL, Kim JH, Kelsoe G, Montefiori DC, Tomaras GD, Bonsignori M, Santra S, Kepler TB, Alam SM, Moody MA, Liao HX, Haynes BF.

Immunity. 2014 Dec 18;41(6):909-18. doi: 10.1016/j.immuni.2014.11.014. Epub 2014 Nov 29.


Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.

Reynolds AE, Kuraoka M, Kelsoe G.

J Immunol. 2015 Jan 1;194(1):231-42. doi: 10.4049/jimmunol.1401203. Epub 2014 Nov 26.


Polyreactivity and autoreactivity among HIV-1 antibodies.

Liu M, Yang G, Wiehe K, Nicely NI, Vandergrift NA, Rountree W, Bonsignori M, Alam SM, Gao J, Haynes BF, Kelsoe G.

J Virol. 2015 Jan;89(1):784-98. doi: 10.1128/JVI.02378-14. Epub 2014 Oct 29.


Curiouser and curiouser: the role(s) of AID expression in self-tolerance.

Kelsoe G.

Eur J Immunol. 2014 Oct;44(10):2876-9. doi: 10.1002/eji.201445102.


Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies.

Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF.

Cell Host Microbe. 2014 Sep 10;16(3):304-13. doi: 10.1016/j.chom.2014.08.006.


Progress in HIV-1 vaccine development.

Haynes BF, Moody MA, Alam M, Bonsignori M, Verkoczy L, Ferrari G, Gao F, Tomaras GD, Liao HX, Kelsoe G.

J Allergy Clin Immunol. 2014 Jul;134(1):3-10; quiz 11. doi: 10.1016/j.jaci.2014.04.025. Epub 2014 Jun 26. Review.


Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF.

Cell. 2014 Jul 31;158(3):481-91. doi: 10.1016/j.cell.2014.06.022. Epub 2014 Jul 24.


Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies.

Kelsoe G, Verkoczy L, Haynes BF.

Vaccines (Basel). 2014 Mar;2(1):1-14. doi: 10.3390/vaccines2010001.


Redemption of autoreactive B cells.

Haynes BF, Verkoczy L, Kelsoe G.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9022-3. doi: 10.1073/pnas.1407877111. Epub 2014 Jun 11. No abstract available.


HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development.

Verkoczy L, Kelsoe G, Haynes BF.

PLoS Pathog. 2014 May 22;10(5):e1004073. doi: 10.1371/journal.ppat.1004073. eCollection 2014 May. No abstract available.


Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation.

Kepler TB, Munshaw S, Wiehe K, Zhang R, Yu JS, Woods CW, Denny TN, Tomaras GD, Alam SM, Moody MA, Kelsoe G, Liao HX, Haynes BF.

Front Immunol. 2014 Apr 22;5:170. doi: 10.3389/fimmu.2014.00170. eCollection 2014.


Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.

Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC.

J Immunol. 2014 Apr 15;192(8):3626-36. doi: 10.4049/jimmunol.1302062. Epub 2014 Mar 10.


IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria.

Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, Catera R, Yan XJ, Chu CC, Kelsoe G, Liao HX, Chiorazzi N, Haynes BF.

PLoS One. 2014 Mar 10;9(3):e90725. doi: 10.1371/journal.pone.0090725. eCollection 2014.


An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.

J Clin Invest. 2014 Apr;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10.


Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes.

Holl TM, Yang G, Kuraoka M, Verkoczy L, Alam SM, Moody MA, Haynes BF, Kelsoe G.

J Immunol. 2014 Apr 1;192(7):3269-79. doi: 10.4049/jimmunol.1302829. Epub 2014 Mar 3.


A tribute to Michael S. Neuberger.

Gearhart PJ, Kelsoe G.

J Clin Invest. 2014 Jan;124(1):3-5. doi: 10.1172/JCI74366. Epub 2014 Jan 2. No abstract available.


Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages.

Cain DW, O'Koren EG, Kan MJ, Womble M, Sempowski GD, Hopper K, Gunn MD, Kelsoe G.

J Immunol. 2013 Nov 1;191(9):4665-75. doi: 10.4049/jimmunol.1300581. Epub 2013 Sep 27.


Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry.

Kim M, Song L, Moon J, Sun ZY, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, Reinherz EL.

J Biol Chem. 2013 Nov 1;288(44):31888-901. doi: 10.1074/jbc.M113.494609. Epub 2013 Sep 18.


The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.

McWilliams L, Su KY, Liang X, Liao D, Floyd S, Amos J, Moody MA, Kelsoe G, Kuraoka M.

J Leukoc Biol. 2013 Nov;94(5):991-1001. doi: 10.1189/jlb.0113048. Epub 2013 Jul 30.


Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.

Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR, Haynes BF.

Nature. 2013 Apr 25;496(7446):469-76. doi: 10.1038/nature12053. Epub 2013 Apr 3.


Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies.

Yang G, Holl TM, Liu Y, Li Y, Lu X, Nicely NI, Kepler TB, Alam SM, Liao HX, Cain DW, Spicer L, VandeBerg JL, Haynes BF, Kelsoe G.

J Exp Med. 2013 Feb 11;210(2):241-56. doi: 10.1084/jem.20121977. Epub 2013 Jan 28.

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