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Editorial: The DNA Replication Machinery as Therapeutic Targets.

Gardner AF, Kelman Z.

Front Mol Biosci. 2019 May 21;6:35. doi: 10.3389/fmolb.2019.00035. eCollection 2019. No abstract available.


Engineering ClpS for selective and enhanced N-terminal amino acid binding.

Tullman J, Callahan N, Ellington B, Kelman Z, Marino JP.

Appl Microbiol Biotechnol. 2019 Mar;103(6):2621-2633. doi: 10.1007/s00253-019-09624-2. Epub 2019 Jan 24.


Neutron scattering in the biological sciences: progress and prospects.

Ashkar R, Bilheux HZ, Bordallo H, Briber R, Callaway DJE, Cheng X, Chu XQ, Curtis JE, Dadmun M, Fenimore P, Fushman D, Gabel F, Gupta K, Herberle F, Heinrich F, Hong L, Katsaras J, Kelman Z, Kharlampieva E, Kneller GR, Kovalevsky A, Krueger S, Langan P, Lieberman R, Liu Y, Losche M, Lyman E, Mao Y, Marino J, Mattos C, Meilleur F, Moody P, Nickels JD, O'Dell WB, O'Neill H, Perez-Salas U, Peters J, Petridis L, Sokolov AP, Stanley C, Wagner N, Weinrich M, Weiss K, Wymore T, Zhang Y, Smith JC.

Acta Crystallogr D Struct Biol. 2018 Dec 1;74(Pt 12):1129-1168. doi: 10.1107/S2059798318017503. Epub 2018 Dec 20.


DNA Sliding Clamps as Therapeutic Targets.

Altieri AS, Kelman Z.

Front Mol Biosci. 2018 Oct 22;5:87. doi: 10.3389/fmolb.2018.00087. eCollection 2018. Review.


Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli.

Reddy PT, Brinson RG, Hoopes JT, McClung C, Ke N, Kashi L, Berkmen M, Kelman Z.

MAbs. 2018 Oct;10(7):992-1002. doi: 10.1080/19420862.2018.1496879. Epub 2018 Jul 30.


Heterologous recombinant expression of non-originator NISTmAb.

Kashi L, Yandrofski K, Preston RJ, Arbogast LW, Giddens JP, Marino JP, Schiel JE, Kelman Z.

MAbs. 2018 Aug/Sep;10(6):922-933. doi: 10.1080/19420862.2018.1486355. Epub 2018 Jul 30.


Archaeal DNA replication and repair: new genetic, biophysical and molecular tools for discovering and characterizing enzymes, pathways and mechanisms.

Zatopek KM, Gardner AF, Kelman Z.

FEMS Microbiol Rev. 2018 Jul 1;42(4):477-488. doi: 10.1093/femsre/fuy017. Review.


Do Archaea Need an Origin of Replication?

Kelman LM, Kelman Z.

Trends Microbiol. 2018 Mar;26(3):172-174. doi: 10.1016/j.tim.2017.12.001. Review.


Genome Replication in Thermococcus kodakarensis Independent of Cdc6 and an Origin of Replication.

Gehring AM, Astling DP, Matsumi R, Burkhart BW, Kelman Z, Reeve JN, Jones KL, Santangelo TJ.

Front Microbiol. 2017 Oct 27;8:2084. doi: 10.3389/fmicb.2017.02084. eCollection 2017.


The GAN Exonuclease or the Flap Endonuclease Fen1 and RNase HII Are Necessary for Viability of Thermococcus kodakarensis.

Burkhart BW, Cubonova L, Heider MR, Kelman Z, Reeve JN, Santangelo TJ.

J Bacteriol. 2017 Jun 13;199(13). pii: e00141-17. doi: 10.1128/JB.00141-17. Print 2017 Jul 1.


A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp.

Altieri AS, Ladner JE, Li Z, Robinson H, Sallman ZF, Marino JP, Kelman Z.

Nucleic Acids Res. 2016 Nov 16;44(20):10015. Epub 2016 Sep 12. No abstract available.


High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases.

Schermerhorn KM, Tanner N, Kelman Z, Gardner AF.

Nucleic Acids Res. 2016 Oct 14;44(18):8764-8771. Epub 2016 Jul 5.


A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp.

Altieri AS, Ladner JE, Li Z, Robinson H, Sallman ZF, Marino JP, Kelman Z.

Nucleic Acids Res. 2016 Jul 27;44(13):6232-41. doi: 10.1093/nar/gkw351. Epub 2016 May 3. Erratum in: Nucleic Acids Res. 2016 Nov 16;44(20):10015.


Evaluation of microbial qPCR workflows using engineered Saccharomyces cerevisiae.

Da Silva SM, Vang LK, Olson ND, Lund SP, Downey AS, Kelman Z, Salit ML, Lin NJ, Morrow JB.

Biomol Detect Quantif. 2016 Feb 19;7:27-33. doi: 10.1016/j.bdq.2016.01.001. eCollection 2016 Mar.



Kelman Z.

Methods Enzymol. 2016;566:xv-xvi. doi: 10.1016/S0076-6879(15)00692-8. No abstract available.



Kelman Z.

Methods Enzymol. 2015;565:xix-xx. doi: 10.1016/S0076-6879(15)00622-9. No abstract available.


Isotopic labeling of proteins in Halobacterium salinarum.

Cleveland TE 4th, Kelman Z.

Methods Enzymol. 2015;565:147-65. doi: 10.1016/bs.mie.2015.06.002. Epub 2015 Aug 4.


Protein labeling in Escherichia coli with (2)H, (13)C, and (15)N.

Hoopes JT, Elberson MA, Preston RJ, Reddy PT, Kelman Z.

Methods Enzymol. 2015;565:27-44. doi: 10.1016/bs.mie.2015.08.023. Epub 2015 Oct 17.


The roles of family B and D DNA polymerases in Thermococcus species 9°N Okazaki fragment maturation.

Greenough L, Kelman Z, Gardner AF.

J Biol Chem. 2015 May 15;290(20):12514-22. doi: 10.1074/jbc.M115.638130. Epub 2015 Mar 26.


DNA polymerases in biotechnology.

Gardner AF, Kelman Z.

Front Microbiol. 2014 Dec 1;5:659. doi: 10.3389/fmicb.2014.00659. eCollection 2014. No abstract available.


Archaeal DNA replication.

Kelman LM, Kelman Z.

Annu Rev Genet. 2014;48:71-97. doi: 10.1146/annurev-genet-120213-092148. Review.


Detection of contaminating enzymatic activity in plant-derived recombinant biotechnology products.

Brinson RG, Giulian GG, Kelman Z, Marino JP.

Anal Chem. 2014 Dec 2;86(23):11508-12. doi: 10.1021/ac503864m. Epub 2014 Nov 18.


Rolf Bernander (1956-2014): pioneer of the archaeal cell cycle.

Ettema TJ, Lindås AC, Hjort K, Poplawski AB, Kaessmann H, Grogan DW, Kelman Z, Andersson AF, Pelve EA, Lundgren M, Svärd SG.

Mol Microbiol. 2014 Jun;92(5):903-9. doi: 10.1111/mmi.12608. Erratum in: Mol Microbiol. 2014 Aug;93(3):582.


The solution structure of full-length dodecameric MCM by SANS and molecular modeling.

Krueger S, Shin JH, Curtis JE, Rubinson KA, Kelman Z.

Proteins. 2014 Oct;82(10):2364-74. doi: 10.1002/prot.24598. Epub 2014 May 29.


Characterization of family D DNA polymerase from Thermococcus sp. 9°N.

Greenough L, Menin JF, Desai NS, Kelman Z, Gardner AF.

Extremophiles. 2014 Jul;18(4):653-64. doi: 10.1007/s00792-014-0646-9. Epub 2014 May 3.


A novel mechanism for regulating the activity of proliferating cell nuclear antigen by a small protein.

Li Z, Huang RY, Yopp DC, Hileman TH, Santangelo TJ, Hurwitz J, Hudgens JW, Kelman Z.

Nucleic Acids Res. 2014 May;42(9):5776-89. doi: 10.1093/nar/gku239. Epub 2014 Apr 11.


Thermococcus kodakarensis has two functional PCNA homologs but only one is required for viability.

Pan M, Santangelo TJ, Čuboňová L, Li Z, Metangmo H, Ladner J, Hurwitz J, Reeve JN, Kelman Z.

Extremophiles. 2013 May;17(3):453-61. doi: 10.1007/s00792-013-0526-8. Epub 2013 Mar 24.


Archaeal DNA polymerase D but not DNA polymerase B is required for genome replication in Thermococcus kodakarensis.

Cubonová L, Richardson T, Burkhart BW, Kelman Z, Connolly BA, Reeve JN, Santangelo TJ.

J Bacteriol. 2013 May;195(10):2322-8. doi: 10.1128/JB.02037-12. Epub 2013 Mar 15.


Thermococcus kodakarensis DNA replication.

Li Z, Kelman LM, Kelman Z.

Biochem Soc Trans. 2013 Feb 1;41(1):332-8. doi: 10.1042/BST20120303. Review.


The archaeal DNA replication machinery: past, present and future.

Ishino S, Kelman LM, Kelman Z, Ishino Y.

Genes Genet Syst. 2013;88(6):315-9. Review.


The modern "3G" age of archaeal molecular biology.

Robb FT, Lowe TM, Kelman Z.

Front Microbiol. 2012 Dec 20;3:430. doi: 10.3389/fmicb.2012.00430. eCollection 2012. No abstract available.


DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion.

Suhasini AN, Sommers JA, Yu S, Wu Y, Xu T, Kelman Z, Kaplan DL, Brosh RM Jr.

J Biol Chem. 2012 Jun 1;287(23):19188-98. doi: 10.1074/jbc.M112.352757. Epub 2012 Apr 12.


Formation of dAMP-glycerol and dAMP-Tris derivatives by Thermococcus kodakaraensis DNA primase.

Chemnitz Galal W, Pan M, Giulian G, Yuan W, Li S, Edwards JL, Marino JP, Kelman Z, Hurwitz J.

J Biol Chem. 2012 May 11;287(20):16220-9. doi: 10.1074/jbc.M111.338160. Epub 2012 Mar 16.


Characterization of DNA primase complex isolated from the archaeon, Thermococcus kodakaraensis.

Chemnitz Galal W, Pan M, Kelman Z, Hurwitz J.

J Biol Chem. 2012 May 11;287(20):16209-19. doi: 10.1074/jbc.M111.338145. Epub 2012 Feb 17.


The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes.

Makarova KS, Koonin EV, Kelman Z.

Biol Direct. 2012 Feb 13;7:7. doi: 10.1186/1745-6150-7-7.


Atomistic ensemble modeling and small-angle neutron scattering of intrinsically disordered protein complexes: applied to minichromosome maintenance protein.

Krueger S, Shin JH, Raghunandan S, Curtis JE, Kelman Z.

Biophys J. 2011 Dec 21;101(12):2999-3007. doi: 10.1016/j.bpj.2011.11.006. Epub 2011 Dec 20.


A nuclear magnetic resonance based approach to accurate functional annotation of putative enzymes in the methanogen Methanosarcina acetivorans.

Chen Y, Apolinario E, Brachova L, Kelman Z, Li Z, Nikolau BJ, Showman L, Sowers K, Orban J.

BMC Genomics. 2011 Jun 15;12 Suppl 1:S7. doi: 10.1186/1471-2164-12-S1-S7.


Thermococcus kodakarensis encodes three MCM homologs but only one is essential.

Pan M, Santangelo TJ, Li Z, Reeve JN, Kelman Z.

Nucleic Acids Res. 2011 Dec;39(22):9671-80. doi: 10.1093/nar/gkr624. Epub 2011 Aug 5.


Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements.

Chen C, Gorlatova N, Kelman Z, Herzberg O.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6456-61. doi: 10.1073/pnas.1013657108. Epub 2011 Apr 4.


A novel DNA nuclease is stimulated by association with the GINS complex.

Li Z, Pan M, Santangelo TJ, Chemnitz W, Yuan W, Edwards JL, Hurwitz J, Reeve JN, Kelman Z.

Nucleic Acids Res. 2011 Aug;39(14):6114-23. doi: 10.1093/nar/gkr181. Epub 2011 Mar 31.


Mutational analysis of conserved aspartic acid residues in the Methanothermobacter thermautotrophicus MCM helicase.

Sakakibara N, Kasiviswanathan R, Kelman Z.

Extremophiles. 2011 Mar;15(2):245-52. doi: 10.1007/s00792-010-0352-1. Epub 2011 Jan 28.


Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis.

Ladner JE, Pan M, Hurwitz J, Kelman Z.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2711-6. doi: 10.1073/pnas.1019179108. Epub 2011 Jan 26.


The archaeal PCNA proteins.

Pan M, Kelman LM, Kelman Z.

Biochem Soc Trans. 2011 Jan;39(1):20-4. doi: 10.1042/BST0390020. Review.


Different residues on the surface of the Methanothermobacter thermautotrophicus MCM helicase interact with single- and double-stranded DNA.

Sakakibara N, Kasiviswanathan R, Kelman Z.

Archaea. 2010 Dec 1;2010:505693. doi: 10.1155/2010/505693.


Affinity purification of an archaeal DNA replication protein network.

Li Z, Santangelo TJ, Cuboňová L, Reeve JN, Kelman Z.

MBio. 2010 Oct 26;1(5). pii: e00221-10. doi: 10.1128/mBio.00221-10.


Helicase ATPase activity of the Tobacco mosaic virus 126-kDa protein modulates replicase complex assembly.

Wang X, Kelman Z, Culver JN.

Virology. 2010 Jul 5;402(2):292-302. doi: 10.1016/j.virol.2010.03.019. Epub 2010 Apr 21.


Cell cycle regulated genes in the three domains of life.

Kelman LM, Kelman Z.

Cell Cycle. 2010 Mar 1;9(5):863-4. Epub 2010 Mar 1. No abstract available.


Low cobalamin levels associated with sickle cell disease: Contrasting origins and clinical meanings in two instructive patients.

Carmel R, Bellevue R, Kelman Z.

Am J Hematol. 2010 Jun;85(6):436-9. doi: 10.1002/ajh.21678. No abstract available.


Alternative mechanisms for coordinating polymerase alpha and MCM helicase.

Lee C, Liachko I, Bouten R, Kelman Z, Tye BK.

Mol Cell Biol. 2010 Jan;30(2):423-35. doi: 10.1128/MCB.01240-09. Epub 2009 Nov 16.


Genomic mutations associated with mild and severe deficiencies of transcobalamin I (haptocorrin) that cause mildly and severely low serum cobalamin levels.

Carmel R, Parker J, Kelman Z.

Br J Haematol. 2009 Nov;147(3):386-91. doi: 10.1111/j.1365-2141.2009.07855.x. Epub 2009 Aug 17.


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