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Matrix Metalloproteinase-3 is Key Effector of TNF-α-Induced Collagen Degradation in Skin.

Mirastschijski U, Lupše B, Maedler K, Sarma B, Radtke A, Belge G, Dorsch M, Wedekind D, McCawley LJ, Boehm G, Zier U, Yamamoto K, Kelm S, Ågren MS.

Int J Mol Sci. 2019 Oct 22;20(20). pii: E5234. doi: 10.3390/ijms20205234.


Computational approaches to therapeutic antibody design: established methods and emerging trends.

Norman RA, Ambrosetti F, Bonvin AMJJ, Colwell LJ, Kelm S, Kumar S, Krawczyk K.

Brief Bioinform. 2019 Oct 18. pii: bbz095. doi: 10.1093/bib/bbz095. [Epub ahead of print]


Widespread co-endemicity of Trypanosoma species infecting cattle in the Sudano-Sahelian and Guinea Savannah zones of Cameroon.

Paguem A, Abanda B, Ndjonka D, Weber JS, Ngomtcho SCH, Manchang KT, Adoulmoumini M, Eisenbarth A, Renz A, Kelm S, Achukwi MD.

BMC Vet Res. 2019 Oct 16;15(1):344. doi: 10.1186/s12917-019-2111-6.


Genetic diversity of trypanosome species in tsetse flies (Glossina spp.) in Nigeria.

Weber JS, Ngomtcho SCH, Shaida SS, Chechet GD, Gbem TT, Nok JA, Mamman M, Achukwi DM, Kelm S.

Parasit Vectors. 2019 Oct 14;12(1):481. doi: 10.1186/s13071-019-3718-y.


Reconstruction of apo A2A receptor activation pathways reveal ligand-competent intermediates and state-dependent cholesterol hotspots.

Lovera S, Cuzzolin A, Kelm S, De Fabritiis G, Sands ZA.

Sci Rep. 2019 Oct 2;9(1):14199. doi: 10.1038/s41598-019-50752-6.


B-cell epitopes: Discontinuity and conformational analysis.

Ferdous S, Kelm S, Baker TS, Shi J, Martin ACR.

Mol Immunol. 2019 Oct;114:643-650. doi: 10.1016/j.molimm.2019.09.014. Epub 2019 Sep 20.


Association between cardiometabolic risk factors and body mass index, waist circumferences and body fat in a Zanzibari cross-sectional study.

Nyangasa MA, Buck C, Kelm S, Sheikh MA, Brackmann KL, Hebestreit A.

BMJ Open. 2019 Jul 4;9(7):e025397. doi: 10.1136/bmjopen-2018-025397.


The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor.

Landin EJB, Lovera S, de Fabritiis G, Kelm S, Mercier J, McMillan D, Sessions RB, Taylor RJ, Sands ZA, Joedicke L, Crump MP.

Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9399-9403. doi: 10.1002/anie.201902852. Epub 2019 Jun 5.


Exploring Food Access and Sociodemographic Correlates of Food Consumption and Food Insecurity in Zanzibari Households.

Nyangasa MA, Buck C, Kelm S, Sheikh M, Hebestreit A.

Int J Environ Res Public Health. 2019 May 4;16(9). pii: E1557. doi: 10.3390/ijerph16091557.


Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses.

Mirastschijski U, Dinesh N, Baskaran S, Wedekind D, Gavrilovic J, Murray MY, Bevan D, Kelm S.

Wound Repair Regen. 2019 Jul;27(4):309-323. doi: 10.1111/wrr.12704. Epub 2019 Mar 7.


Diversity and phylogenetic relationships of Glossina populations in Nigeria and the Cameroonian border region.

Shaida SS, Weber JS, Gbem TT, Ngomtcho SCH, Musa UB, Achukwi MD, Mamman M, Ndams IS, Nok JA, Kelm S.

BMC Microbiol. 2018 Nov 23;18(Suppl 1):180. doi: 10.1186/s12866-018-1293-6.


Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives.

Kariithi HM, Meki IK, Schneider DI, De Vooght L, Khamis FM, Geiger A, Demirbaş-Uzel G, Vlak JM, iNCE IA, Kelm S, Njiokou F, Wamwiri FN, Malele II, Weiss BL, Abd-Alla AMM.

BMC Microbiol. 2018 Nov 23;18(Suppl 1):179. doi: 10.1186/s12866-018-1280-y.


Filtering Next-Generation Sequencing of the Ig Gene Repertoire Data Using Antibody Structural Information.

Kovaltsuk A, Krawczyk K, Kelm S, Snowden J, Deane CM.

J Immunol. 2018 Dec 15;201(12):3694-3704. doi: 10.4049/jimmunol.1800669. Epub 2018 Nov 5.


SCALOP: sequence-based antibody canonical loop structure annotation.

Wong WK, Georges G, Ros F, Kelm S, Lewis AP, Taddese B, Leem J, Deane CM.

Bioinformatics. 2019 May 15;35(10):1774-1776. doi: 10.1093/bioinformatics/bty877.


High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1.

Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P.

J Neurochem. 2018 Dec;147(6):764-783. doi: 10.1111/jnc.14598. Epub 2018 Nov 26.


Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires.

Kovaltsuk A, Leem J, Kelm S, Snowden J, Deane CM, Krawczyk K.

J Immunol. 2018 Oct 15;201(8):2502-2509. doi: 10.4049/jimmunol.1800708. Epub 2018 Sep 14.


Structurally Mapping Antibody Repertoires.

Krawczyk K, Kelm S, Kovaltsuk A, Galson JD, Kelly D, Trück J, Regep C, Leem J, Wong WK, Nowak J, Snowden J, Wright M, Starkie L, Scott-Tucker A, Shi J, Deane CM.

Front Immunol. 2018 Jul 23;9:1698. doi: 10.3389/fimmu.2018.01698. eCollection 2018.


Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.

Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD.

PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. eCollection 2018 May.


Postoperative rehabilitation after deep brain stimulation surgery for movement disorders.

Allert N, Cheeran B, Deuschl G, Barbe MT, Csoti I, Ebke M, Glaser M, Kang JS, Kelm S, Krack P, Kroth J, Jobst U, Leisse M, Oliviero A, Nolte PN, Quick-Weller J, Strothjohann M, Tamás G, Werner M, Muthuraman M, Volkmann J, Fasano A, Groppa S.

Clin Neurophysiol. 2018 Mar;129(3):592-601. doi: 10.1016/j.clinph.2017.12.035. Epub 2018 Jan 10. Review.


Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon.

Ngomtcho SCH, Weber JS, Ngo Bum E, Gbem TT, Kelm S, Achukwi MD.

Parasit Vectors. 2017 Dec 29;10(1):631. doi: 10.1186/s13071-017-2540-7.


Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.

Marks C, Nowak J, Klostermann S, Georges G, Dunbar J, Shi J, Kelm S, Deane CM.

Bioinformatics. 2017 May 1;33(9):1346-1353. doi: 10.1093/bioinformatics/btw823.


A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

Pearce NM, Krojer T, Bradley AR, Collins P, Nowak RP, Talon R, Marsden BD, Kelm S, Shi J, Deane CM, von Delft F.

Nat Commun. 2017 Apr 24;8:15123. doi: 10.1038/ncomms15123.


Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K.

Sci Rep. 2017 Apr 5;7:45319. doi: 10.1038/srep45319.


Intra- or extra-exosomal secretion of HDGF isoforms: the extraordinary function of the HDGF-A N-terminal peptide.

Nüße J, Blumrich EM, Mirastschijski U, Kappelmann L, Kelm S, Dietz F.

Biol Chem. 2017 Jun 27;398(7):793-811. doi: 10.1515/hsz-2016-0315.


Design, Response Rates, and Population Characteristics of a Cross-Sectional Study in Zanzibar, Tanzania.

Nyangasa MA, Kelm S, Sheikh MA, Hebestreit A.

JMIR Res Protoc. 2016 Dec 1;5(4):e235.


Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy.

Madge PD, Maggioni A, Pascolutti M, Amin M, Waespy M, Bellette B, Thomson RJ, Kelm S, von Itzstein M, Haselhorst T.

Sci Rep. 2016 Nov 3;6:36012. doi: 10.1038/srep36012.


Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

Meyer A, Paroni F, Günther K, Dharmadhikari G, Ahrens W, Kelm S, Maedler K.

PLoS One. 2016 Aug 30;11(8):e0161778. doi: 10.1371/journal.pone.0161778. eCollection 2016.


Examining the Conservation of Kinks in Alpha Helices.

Law EC, Wilman HR, Kelm S, Shi J, Deane CM.

PLoS One. 2016 Jun 17;11(6):e0157553. doi: 10.1371/journal.pone.0157553. eCollection 2016.


SAbPred: a structure-based antibody prediction server.

Dunbar J, Krawczyk K, Leem J, Marks C, Nowak J, Regep C, Georges G, Kelm S, Popovic B, Deane CM.

Nucleic Acids Res. 2016 Jul 8;44(W1):W474-8. doi: 10.1093/nar/gkw361. Epub 2016 Apr 29.


Length-independent structural similarities enrich the antibody CDR canonical class model.

Nowak J, Baker T, Georges G, Kelm S, Klostermann S, Shi J, Sridharan S, Deane CM.

MAbs. 2016 May-Jun;8(4):751-60. doi: 10.1080/19420862.2016.1158370.


Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

Nüße J, Mirastschijski U, Waespy M, Oetjen J, Brandes N, Rebello O, Paroni F, Kelm S, Dietz F.

Biol Chem. 2016 May;397(5):417-36. doi: 10.1515/hsz-2015-0273.


Correction: Carbohydrate Recognition Specificity of Trans-sialidase Lectin Domain from Trypanosoma congolense.

Waespy M, Gbem TT, Elenschneider L, Jeck AP, Day CJ, Hartley-Tassell L, Bovin N, Tiralongo J, Haselhorst T, Kelm S.

PLoS Negl Trop Dis. 2015 Dec 29;9(12):e0004344. doi: 10.1371/journal.pntd.0004344. eCollection 2015 Dec. No abstract available.


Carbohydrate Recognition Specificity of Trans-sialidase Lectin Domain from Trypanosoma congolense.

Waespy M, Gbem TT, Elenschneider L, Jeck AP, Day CJ, Hartley-Tassell L, Bovin N, Tiralongo J, Haselhorst T, Kelm S.

PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004120. doi: 10.1371/journal.pntd.0004120. eCollection 2015. Erratum in: PLoS Negl Trop Dis. 2015 Dec;9(12):e0004344.


Splice variants of perlucin from Haliotis laevigata modulate the crystallisation of CaCO3.

Dodenhof T, Dietz F, Franken S, Grunwald I, Kelm S.

PLoS One. 2014 May 13;9(5):e97126. doi: 10.1371/journal.pone.0097126. eCollection 2014.


Biochemical diversity in the Trypanosoma congolense trans-sialidase family.

Gbem TT, Waespy M, Hesse B, Dietz F, Smith J, Chechet GD, Nok JA, Kelm S.

PLoS Negl Trop Dis. 2013 Dec 5;7(12):e2549. doi: 10.1371/journal.pntd.0002549. eCollection 2013.


SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics.

Schwardt O, Kelm S, Ernst B.

Top Curr Chem. 2015;367:151-200. doi: 10.1007/128_2013_498. Review.


Memoir: template-based structure prediction for membrane proteins.

Ebejer JP, Hill JR, Kelm S, Shi J, Deane CM.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W379-83. doi: 10.1093/nar/gkt331. Epub 2013 May 2.


Fragment-based modeling of membrane protein loops: successes, failures, and prospects for the future.

Kelm S, Vangone A, Choi Y, Ebejer JP, Shi J, Deane CM.

Proteins. 2014 Feb;82(2):175-86. doi: 10.1002/prot.24299. Epub 2013 Oct 17.


C-4 modified sialosides enhance binding to Siglec-2 (CD22): towards potent Siglec inhibitors for immunoglycotherapy.

Kelm S, Madge P, Islam T, Bennett R, Koliwer-Brandl H, Waespy M, von Itzstein M, Haselhorst T.

Angew Chem Int Ed Engl. 2013 Mar 25;52(13):3616-20. doi: 10.1002/anie.201207267. Epub 2013 Feb 25. No abstract available.


Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

Dauth S, Schmidt MM, Rehders M, Dietz F, Kelm S, Dringen R, Brix K.

Biol Chem. 2012 Sep;393(9):959-70. doi: 10.1515/hsz-2012-0145.


Purification and biochemical characterization of a lysosomal α-fucosidase from the deuterostomia Asterias rubens.

Visa M, Hammer E, Völker U, Koliwer-Brandl H, Kelm S, Nadimpalli SK.

Biochimie. 2012 May;94(5):1199-205. doi: 10.1016/j.biochi.2012.02.007. Epub 2012 Feb 17.


Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer.

Thakar K, Votteler I, Kelkar D, Shidore T, Gupta S, Kelm S, Dietz F.

FEBS J. 2012 Mar;279(5):737-51. doi: 10.1111/j.1742-4658.2011.08464.x. Epub 2012 Jan 12.


From a library of MAG antagonists to nanomolar CD22 ligands.

Mesch S, Lemme K, Wittwer M, Koliwer-Brandl H, Schwardt O, Kelm S, Ernst B.

ChemMedChem. 2012 Jan 2;7(1):134-43. doi: 10.1002/cmdc.201100407. Epub 2011 Oct 11.


A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

Jones C, Denecke J, Sträter R, Stölting T, Schunicht Y, Zeuschner D, Klumperman J, Lefeber DJ, Spelten O, Zarbock A, Kelm S, Strenge K, Haslam SM, Lühn K, Stahl D, Gentile L, Schreiter T, Hilgard P, Beck-Sickinger AG, Marquardt T, Wild MK.

Am J Pathol. 2011 Oct;179(4):1969-77. doi: 10.1016/j.ajpath.2011.06.012. Epub 2011 Aug 22.


Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense.

Koliwer-Brandl H, Gbem TT, Waespy M, Reichert O, Mandel P, Drebitz E, Dietz F, Kelm S.

BMC Biochem. 2011 Jul 30;12:39. doi: 10.1186/1471-2091-12-39.


Environment specific substitution tables improve membrane protein alignment.

Hill JR, Kelm S, Shi J, Deane CM.

Bioinformatics. 2011 Jul 1;27(13):i15-23. doi: 10.1093/bioinformatics/btr230.


Impact of strong and weak lipid-protein interactions on the structure of a lipid bilayer on a gold electrode surface.

Nullmeier M, Koliwer-Brandl H, Kelm S, Zägel P, Koch KW, Brand I.

Chemphyschem. 2011 Apr 18;12(6):1066-79. doi: 10.1002/cphc.201100036. Epub 2011 Mar 25.


Secretion of hepatoma-derived growth factor is regulated by N-terminal processing.

Thakar K, Kröcher T, Savant S, Gollnast D, Kelm S, Dietz F.

Biol Chem. 2010 Dec;391(12):1401-10. doi: 10.1515/BC.2010.147.


MEDELLER: homology-based coordinate generation for membrane proteins.

Kelm S, Shi J, Deane CM.

Bioinformatics. 2010 Nov 15;26(22):2833-40. doi: 10.1093/bioinformatics/btq554. Epub 2010 Oct 5.


Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein.

Schwardt O, Koliwer-Brandl H, Zimmerli R, Mesch S, Rossato G, Spreafico M, Vedani A, Kelm S, Ernst B.

Bioorg Med Chem. 2010 Oct 15;18(20):7239-51. doi: 10.1016/j.bmc.2010.08.027. Epub 2010 Aug 17.


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