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Items: 1 to 50 of 120

1.

SCALOP: sequence-based antibody canonical loop structure annotation.

Ki Wong W, Georges G, Ros F, Kelm S, Lewis AP, Taddese B, Leem J, Deane CM.

Bioinformatics. 2018 Oct 15. doi: 10.1093/bioinformatics/bty877. [Epub ahead of print]

PMID:
30321295
2.

High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1.

Myllykoski M, Eichel MA, Jung RB, Kelm S, Werner HB, Kursula P.

J Neurochem. 2018 Sep 27. doi: 10.1111/jnc.14598. [Epub ahead of print]

PMID:
30261098
3.

Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires.

Kovaltsuk A, Leem J, Kelm S, Snowden J, Deane CM, Krawczyk K.

J Immunol. 2018 Oct 15;201(8):2502-2509. doi: 10.4049/jimmunol.1800708. Epub 2018 Sep 14.

PMID:
30217829
4.

Structurally Mapping Antibody Repertoires.

Krawczyk K, Kelm S, Kovaltsuk A, Galson JD, Kelly D, Trück J, Regep C, Leem J, Wong WK, Nowak J, Snowden J, Wright M, Starkie L, Scott-Tucker A, Shi J, Deane CM.

Front Immunol. 2018 Jul 23;9:1698. doi: 10.3389/fimmu.2018.01698. eCollection 2018.

5.

Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.

Stöppler D, Macpherson A, Smith-Penzel S, Basse N, Lecomte F, Deboves H, Taylor RD, Norman T, Porter J, Waters LC, Westwood M, Cossins B, Cain K, White J, Griffin R, Prosser C, Kelm S, Sullivan AH, Fox D 3rd, Carr MD, Henry A, Taylor R, Meier BH, Oschkinat H, Lawson AD.

PLoS Biol. 2018 May 21;16(5):e2006192. doi: 10.1371/journal.pbio.2006192. eCollection 2018 May.

6.

Postoperative rehabilitation after deep brain stimulation surgery for movement disorders.

Allert N, Cheeran B, Deuschl G, Barbe MT, Csoti I, Ebke M, Glaser M, Kang JS, Kelm S, Krack P, Kroth J, Jobst U, Leisse M, Oliviero A, Nolte PN, Quick-Weller J, Strothjohann M, Tamás G, Werner M, Muthuraman M, Volkmann J, Fasano A, Groppa S.

Clin Neurophysiol. 2018 Mar;129(3):592-601. doi: 10.1016/j.clinph.2017.12.035. Epub 2018 Jan 10. Review.

PMID:
29414403
7.

Molecular screening of tsetse flies and cattle reveal different Trypanosoma species including T. grayi and T. theileri in northern Cameroon.

Ngomtcho SCH, Weber JS, Ngo Bum E, Gbem TT, Kelm S, Achukwi MD.

Parasit Vectors. 2017 Dec 29;10(1):631. doi: 10.1186/s13071-017-2540-7.

8.

Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.

Marks C, Nowak J, Klostermann S, Georges G, Dunbar J, Shi J, Kelm S, Deane CM.

Bioinformatics. 2017 May 1;33(9):1346-1353. doi: 10.1093/bioinformatics/btw823.

9.

A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.

Pearce NM, Krojer T, Bradley AR, Collins P, Nowak RP, Talon R, Marsden BD, Kelm S, Shi J, Deane CM, von Delft F.

Nat Commun. 2017 Apr 24;8:15123. doi: 10.1038/ncomms15123.

10.

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.

Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K.

Sci Rep. 2017 Apr 5;7:45319. doi: 10.1038/srep45319.

11.

Intra- or extra-exosomal secretion of HDGF isoforms: the extraordinary function of the HDGF-A N-terminal peptide.

Nüße J, Blumrich EM, Mirastschijski U, Kappelmann L, Kelm S, Dietz F.

Biol Chem. 2017 Jun 27;398(7):793-811. doi: 10.1515/hsz-2016-0315.

PMID:
27926477
12.

Design, Response Rates, and Population Characteristics of a Cross-Sectional Study in Zanzibar, Tanzania.

Nyangasa MA, Kelm S, Sheikh MA, Hebestreit A.

JMIR Res Protoc. 2016 Dec 1;5(4):e235.

13.

Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy.

Madge PD, Maggioni A, Pascolutti M, Amin M, Waespy M, Bellette B, Thomson RJ, Kelm S, von Itzstein M, Haselhorst T.

Sci Rep. 2016 Nov 3;6:36012. doi: 10.1038/srep36012.

14.

Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.

Meyer A, Paroni F, Günther K, Dharmadhikari G, Ahrens W, Kelm S, Maedler K.

PLoS One. 2016 Aug 30;11(8):e0161778. doi: 10.1371/journal.pone.0161778. eCollection 2016.

15.

Examining the Conservation of Kinks in Alpha Helices.

Law EC, Wilman HR, Kelm S, Shi J, Deane CM.

PLoS One. 2016 Jun 17;11(6):e0157553. doi: 10.1371/journal.pone.0157553. eCollection 2016.

16.

SAbPred: a structure-based antibody prediction server.

Dunbar J, Krawczyk K, Leem J, Marks C, Nowak J, Regep C, Georges G, Kelm S, Popovic B, Deane CM.

Nucleic Acids Res. 2016 Jul 8;44(W1):W474-8. doi: 10.1093/nar/gkw361. Epub 2016 Apr 29.

17.

Length-independent structural similarities enrich the antibody CDR canonical class model.

Nowak J, Baker T, Georges G, Kelm S, Klostermann S, Shi J, Sridharan S, Deane CM.

MAbs. 2016 May-Jun;8(4):751-60. doi: 10.1080/19420862.2016.1158370.

18.

Two new isoforms of the human hepatoma-derived growth factor interact with components of the cytoskeleton.

Nüße J, Mirastschijski U, Waespy M, Oetjen J, Brandes N, Rebello O, Paroni F, Kelm S, Dietz F.

Biol Chem. 2016 May;397(5):417-36. doi: 10.1515/hsz-2015-0273.

PMID:
26845719
19.

Correction: Carbohydrate Recognition Specificity of Trans-sialidase Lectin Domain from Trypanosoma congolense.

Waespy M, Gbem TT, Elenschneider L, Jeck AP, Day CJ, Hartley-Tassell L, Bovin N, Tiralongo J, Haselhorst T, Kelm S.

PLoS Negl Trop Dis. 2015 Dec 29;9(12):e0004344. doi: 10.1371/journal.pntd.0004344. eCollection 2015 Dec. No abstract available.

20.

Carbohydrate Recognition Specificity of Trans-sialidase Lectin Domain from Trypanosoma congolense.

Waespy M, Gbem TT, Elenschneider L, Jeck AP, Day CJ, Hartley-Tassell L, Bovin N, Tiralongo J, Haselhorst T, Kelm S.

PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004120. doi: 10.1371/journal.pntd.0004120. eCollection 2015. Erratum in: PLoS Negl Trop Dis. 2015 Dec;9(12):e0004344.

21.

Splice variants of perlucin from Haliotis laevigata modulate the crystallisation of CaCO3.

Dodenhof T, Dietz F, Franken S, Grunwald I, Kelm S.

PLoS One. 2014 May 13;9(5):e97126. doi: 10.1371/journal.pone.0097126. eCollection 2014.

22.

Biochemical diversity in the Trypanosoma congolense trans-sialidase family.

Gbem TT, Waespy M, Hesse B, Dietz F, Smith J, Chechet GD, Nok JA, Kelm S.

PLoS Negl Trop Dis. 2013 Dec 5;7(12):e2549. doi: 10.1371/journal.pntd.0002549. eCollection 2013.

23.

SIGLEC-4 (MAG) Antagonists: From the Natural Carbohydrate Epitope to Glycomimetics.

Schwardt O, Kelm S, Ernst B.

Top Curr Chem. 2015;367:151-200. doi: 10.1007/128_2013_498. Review.

PMID:
24276958
24.

Memoir: template-based structure prediction for membrane proteins.

Ebejer JP, Hill JR, Kelm S, Shi J, Deane CM.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W379-83. doi: 10.1093/nar/gkt331. Epub 2013 May 2.

25.

Fragment-based modeling of membrane protein loops: successes, failures, and prospects for the future.

Kelm S, Vangone A, Choi Y, Ebejer JP, Shi J, Deane CM.

Proteins. 2014 Feb;82(2):175-86. doi: 10.1002/prot.24299. Epub 2013 Oct 17.

PMID:
23589399
26.

C-4 modified sialosides enhance binding to Siglec-2 (CD22): towards potent Siglec inhibitors for immunoglycotherapy.

Kelm S, Madge P, Islam T, Bennett R, Koliwer-Brandl H, Waespy M, von Itzstein M, Haselhorst T.

Angew Chem Int Ed Engl. 2013 Mar 25;52(13):3616-20. doi: 10.1002/anie.201207267. Epub 2013 Feb 25. No abstract available.

PMID:
23440868
27.

Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice.

Dauth S, Schmidt MM, Rehders M, Dietz F, Kelm S, Dringen R, Brix K.

Biol Chem. 2012 Sep;393(9):959-70. doi: 10.1515/hsz-2012-0145.

PMID:
22944695
28.

Purification and biochemical characterization of a lysosomal α-fucosidase from the deuterostomia Asterias rubens.

Visa M, Hammer E, Völker U, Koliwer-Brandl H, Kelm S, Nadimpalli SK.

Biochimie. 2012 May;94(5):1199-205. doi: 10.1016/j.biochi.2012.02.007. Epub 2012 Feb 17.

PMID:
22366030
29.

Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer.

Thakar K, Votteler I, Kelkar D, Shidore T, Gupta S, Kelm S, Dietz F.

FEBS J. 2012 Mar;279(5):737-51. doi: 10.1111/j.1742-4658.2011.08464.x. Epub 2012 Jan 12.

30.

From a library of MAG antagonists to nanomolar CD22 ligands.

Mesch S, Lemme K, Wittwer M, Koliwer-Brandl H, Schwardt O, Kelm S, Ernst B.

ChemMedChem. 2012 Jan 2;7(1):134-43. doi: 10.1002/cmdc.201100407. Epub 2011 Oct 11.

PMID:
21990163
31.

A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

Jones C, Denecke J, Sträter R, Stölting T, Schunicht Y, Zeuschner D, Klumperman J, Lefeber DJ, Spelten O, Zarbock A, Kelm S, Strenge K, Haslam SM, Lühn K, Stahl D, Gentile L, Schreiter T, Hilgard P, Beck-Sickinger AG, Marquardt T, Wild MK.

Am J Pathol. 2011 Oct;179(4):1969-77. doi: 10.1016/j.ajpath.2011.06.012. Epub 2011 Aug 22.

32.

Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense.

Koliwer-Brandl H, Gbem TT, Waespy M, Reichert O, Mandel P, Drebitz E, Dietz F, Kelm S.

BMC Biochem. 2011 Jul 30;12:39. doi: 10.1186/1471-2091-12-39.

33.

Environment specific substitution tables improve membrane protein alignment.

Hill JR, Kelm S, Shi J, Deane CM.

Bioinformatics. 2011 Jul 1;27(13):i15-23. doi: 10.1093/bioinformatics/btr230.

34.

Impact of strong and weak lipid-protein interactions on the structure of a lipid bilayer on a gold electrode surface.

Nullmeier M, Koliwer-Brandl H, Kelm S, Zägel P, Koch KW, Brand I.

Chemphyschem. 2011 Apr 18;12(6):1066-79. doi: 10.1002/cphc.201100036. Epub 2011 Mar 25.

PMID:
21442718
35.

Secretion of hepatoma-derived growth factor is regulated by N-terminal processing.

Thakar K, Kröcher T, Savant S, Gollnast D, Kelm S, Dietz F.

Biol Chem. 2010 Dec;391(12):1401-10. doi: 10.1515/BC.2010.147.

PMID:
21087088
36.

MEDELLER: homology-based coordinate generation for membrane proteins.

Kelm S, Shi J, Deane CM.

Bioinformatics. 2010 Nov 15;26(22):2833-40. doi: 10.1093/bioinformatics/btq554. Epub 2010 Oct 5.

37.

Design, synthesis, biological evaluation, and modeling of a non-carbohydrate antagonist of the myelin-associated glycoprotein.

Schwardt O, Koliwer-Brandl H, Zimmerli R, Mesch S, Rossato G, Spreafico M, Vedani A, Kelm S, Ernst B.

Bioorg Med Chem. 2010 Oct 15;18(20):7239-51. doi: 10.1016/j.bmc.2010.08.027. Epub 2010 Aug 17.

PMID:
20843694
38.

A fragment-based in situ combinatorial approach to identify high-affinity ligands for unknown binding sites.

Shelke SV, Cutting B, Jiang X, Koliwer-Brandl H, Strasser DS, Schwardt O, Kelm S, Ernst B.

Angew Chem Int Ed Engl. 2010 Aug 2;49(33):5721-5. doi: 10.1002/anie.200907254. No abstract available.

PMID:
20818756
39.

2-deoxyribose deprives cultured astrocytes of their glutathione.

Schmidt MM, Greb H, Koliwer-Brandl H, Kelm S, Dringen R.

Neurochem Res. 2010 Nov;35(11):1848-56. doi: 10.1007/s11064-010-0251-y. Epub 2010 Aug 24.

PMID:
20734229
40.

[Rehabilitation of Parkinson's patients with deep brain stimulation. Experiences of the Neurological Rehabilitation Center Godeshöhe].

Allert N, Dohle C, Horn JW, Kelm S, Kirsch H, Nolte PN, Weirich W, Karbe H.

Nervenarzt. 2011 Apr;82(4):462-7. doi: 10.1007/s00115-010-3092-7. German.

PMID:
20676600
41.

Kinetic and thermodynamic properties of MAG antagonists.

Mesch S, Lemme K, Koliwer-Brandl H, Strasser DS, Schwardt O, Kelm S, Ernst B.

Carbohydr Res. 2010 Jul 2;345(10):1348-59. doi: 10.1016/j.carres.2010.03.010. Epub 2010 Mar 16.

PMID:
20359700
42.

Low molecular weight antagonists of the myelin-associated glycoprotein: synthesis, docking, and biological evaluation.

Mesch S, Moser D, Strasser DS, Kelm A, Cutting B, Rossato G, Vedani A, Koliwer-Brandl H, Wittwer M, Rabbani S, Schwardt O, Kelm S, Ernst B.

J Med Chem. 2010 Feb 25;53(4):1597-615. doi: 10.1021/jm901517k.

PMID:
20095613
43.

iMembrane: homology-based membrane-insertion of proteins.

Kelm S, Shi J, Deane CM.

Bioinformatics. 2009 Apr 15;25(8):1086-8. doi: 10.1093/bioinformatics/btp102. Epub 2009 Feb 23.

44.

Examination of the biological role of the alpha(2-->6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).

Schwardt O, Gäthje H, Vedani A, Mesch S, Gao GP, Spreafico M, von Orelli J, Kelm S, Ernst B.

J Med Chem. 2009 Feb 26;52(4):989-1004. doi: 10.1021/jm801058n.

PMID:
19175312
45.

Binding epitopes of gangliosides to their neuronal receptor, myelin-associated glycoprotein, from saturation transfer difference NMR.

Shin SY, Gäthje H, Schwardt O, Gao GP, Ernst B, Kelm S, Meyer B.

Chembiochem. 2008 Dec 15;9(18):2946-9. doi: 10.1002/cbic.200800485. No abstract available.

PMID:
19040245
46.

Consistent bioactive conformation of the Neu5Acalpha(2-->3)Gal epitope upon lectin binding.

Bhunia A, Schwardt O, Gäthje H, Gao GP, Kelm S, Benie AJ, Hricovini M, Peters T, Ernst B.

Chembiochem. 2008 Dec 15;9(18):2941-5. doi: 10.1002/cbic.200800458. No abstract available.

PMID:
18850605
47.

Design, synthesis, and structure-affinity relationships of novel series of sialosides as CD22-specific inhibitors.

Abdu-Allah HH, Tamanaka T, Yu J, Zhuoyuan L, Sadagopan M, Adachi T, Tsubata T, Kelm S, Ishida H, Kiso M.

J Med Chem. 2008 Nov 13;51(21):6665-81. doi: 10.1021/jm8000696. Epub 2008 Oct 8.

PMID:
18841881
48.

SUMOylation of the hepatoma-derived growth factor negatively influences its binding to chromatin.

Thakar K, Niedenthal R, Okaz E, Franken S, Jakobs A, Gupta S, Kelm S, Dietz F.

FEBS J. 2008 Apr;275(7):1411-26. doi: 10.1111/j.1742-4658.2008.06303.x. Epub 2008 Mar 5.

49.
50.

Mimetics of the tri- and tetrasaccharide epitope of GQ1balpha as myelin-associated glycoprotein (MAG) ligands.

Gao G, Smiesko M, Schwardt O, Gäthje H, Kelm S, Vedani A, Ernst B.

Bioorg Med Chem. 2007 Dec 1;15(23):7459-69. Epub 2007 Aug 21.

PMID:
17870542

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