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The influence of constraints on the efficient allocation of resources for HIV prevention.

Stuart RM, Kelly SL, Kerr CC, Martin-Hughes R, Wilson DP.

AIDS. 2019 Oct 1;33(12):1949-1950. doi: 10.1097/QAD.0000000000002267. No abstract available.


Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens.

Warrilow AGS, Parker JE, Price CL, Rolley NJ, Nes WD, Kelly DE, Kelly SL.

Int J Antimicrob Agents. 2019 Oct;54(4):449-455. doi: 10.1016/j.ijantimicag.2019.07.011. Epub 2019 Jul 13.


Prevalence of Mental Illness in Adolescents and Adults With Congenital Heart Disease from the Colorado Congenital Heart Defect Surveillance System.

Khanna AD, Duca LM, Kay JD, Shore J, Kelly SL, Crume T.

Am J Cardiol. 2019 Aug 15;124(4):618-626. doi: 10.1016/j.amjcard.2019.05.023. Epub 2019 Jun 11.


NanoRefinery of carbonaceous nanomaterials: Complementing dairy manure gasification and their applications in cellular imaging and heavy metal sensing.

Plácido J, Bustamante-López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Nov 1;689:10-20. doi: 10.1016/j.scitotenv.2019.06.390. Epub 2019 Jun 25.


Multivariate analysis of biochar-derived carbonaceous nanomaterials for detection of heavy metal ions in aqueous systems.

Plácido J, Bustamante López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Oct 20;688:751-761. doi: 10.1016/j.scitotenv.2019.06.342. Epub 2019 Jun 24.


On the occurrence of cytochrome P450 in viruses.

Lamb DC, Follmer AH, Goldstone JV, Nelson DR, Warrilow AG, Price CL, True MY, Kelly SL, Poulos TL, Stegeman JJ.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12343-12352. doi: 10.1073/pnas.1901080116. Epub 2019 Jun 5.


What is the impact of a 20% funding cut in international HIV aid from the United States?

Ten Brink D, Martin-Hughes R, Kelly SL, Wilson DP.

AIDS. 2019 Jul 1;33(8):1406-1408. doi: 10.1097/QAD.0000000000002214. No abstract available.


Initiating a Fontan multidisciplinary clinic: Decreasing care variability, improving surveillance, and subsequent treatment of Fontan survivors.

Di Maria MV, Barrett C, Rafferty C, Wolfe K, Kelly SL, Liptzin DR, Brigham D, Younoszai A.

Congenit Heart Dis. 2019 Jul;14(4):590-599. doi: 10.1111/chd.12769. Epub 2019 Apr 8.


Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus.

Rybak JM, Ge W, Wiederhold NP, Parker JE, Kelly SL, Rogers PD, Fortwendel JR.

MBio. 2019 Apr 2;10(2). pii: e00437-19. doi: 10.1128/mBio.00437-19.


In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.

Nishimoto AT, Wiederhold NP, Flowers SA, Zhang Q, Kelly SL, Morschhäuser J, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00341-19. doi: 10.1128/AAC.00341-19. Print 2019 Jun.


The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions.

Warrilow AG, Nishimoto AT, Parker JE, Price CL, Flowers SA, Kelly DE, Rogers PD, Kelly SL.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02586-18. doi: 10.1128/AAC.02586-18. Print 2019 May.


Implementing a Home-Based Telehealth Group Adherence Intervention with Adolescent Transplant Recipients.

Kelly SL, Steinberg EA, Suplee A, Upshaw NC, Campbell KR, Thomas JF, Buchanan CL.

Telemed J E Health. 2019 Jan 25. doi: 10.1089/tmj.2018.0164. [Epub ahead of print]


Applying the 'no-one worse off' criterion to design Pareto efficient HIV responses in Sudan and Togo.

Stuart RM, Haghparast-Bidgoli H, Panovska-Griffiths J, Grobicki L, Skordis J, Kerr CC, Kedziora DJ, Martin-Hughes R, Kelly SL, Wilson DP.

AIDS. 2019 Jun 1;33(7):1247-1252. doi: 10.1097/QAD.0000000000002155.


Microalgae biochar-derived carbon dots and their application in heavy metal sensing in aqueous systems.

Plácido J, Bustamante-López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Mar 15;656:531-539. doi: 10.1016/j.scitotenv.2018.11.393. Epub 2018 Nov 27.


Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.

Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22.


ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait.

Ahmad S, Joseph L, Parker JE, Asadzadeh M, Kelly SL, Meis JF, Khan Z.

Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01900-18. doi: 10.1128/AAC.01900-18. Print 2019 Feb.


Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.

Alsanafi M, Kelly SL, Jubair K, McNaughton M, Tate RJ, Merrill AH Jr, Pyne S, Pyne NJ.

Mol Cell Biol. 2018 Nov 13;38(23). pii: e00222-18. doi: 10.1128/MCB.00222-18. Print 2018 Dec 1.


Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.

Zhou W, Warrilow AGS, Thomas CD, Ramos E, Parker JE, Price CL, Vanderloop BH, Fisher PM, Loftis MD, Kelly DE, Kelly SL, Nes WD.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1164-1178. doi: 10.1016/j.bbalip.2018.07.004. Epub 2018 Jul 22.


Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity.

Luna-Tapia A, Willems HME, Parker JE, Tournu H, Barker KS, Nishimoto AT, Rogers PD, Kelly SL, Peters BM, Palmer GE.

MBio. 2018 May 22;9(3). pii: e00225-18. doi: 10.1128/mBio.00225-18.


Pulmonary Screening in Subjects after the Fontan Procedure.

Liptzin DR, Di Maria MV, Younoszai A, Narkewicz MR, Kelly SL, Wolfe KR, Veress LA.

J Pediatr. 2018 Aug;199:140-143. doi: 10.1016/j.jpeds.2018.03.050. Epub 2018 May 7.


How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries.

Stuart RM, Grobicki L, Haghparast-Bidgoli H, Panovska-Griffiths J, Skordis J, Keiser O, Estill J, Baranczuk Z, Kelly SL, Reporter I, Kedziora DJ, Shattock AJ, Petravic J, Hussain SA, Grantham KL, Gray RT, Yap XF, Martin-Hughes R, Benedikt CJ, Fraser-Hurt N, Masaki E, Wilson DJ, Gorgens M, Mziray E, Cheikh N, Shubber Z, Kerr CC, Wilson DP.

J Int AIDS Soc. 2018 Apr;21(4):e25097. doi: 10.1002/jia2.25097. Review.


FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.

Ison G, Howie LJ, Amiri-Kordestani L, Zhang L, Tang S, Sridhara R, Pierre V, Charlab R, Ramamoorthy A, Song P, Li F, Yu J, Manheng W, Palmby TR, Ghosh S, Horne HN, Lee EY, Philip R, Dave K, Chen XH, Kelly SL, Janoria KG, Banerjee A, Eradiri O, Dinin J, Goldberg KB, Pierce WF, Ibrahim A, Kluetz PG, Blumenthal GM, Beaver JA, Pazdur R.

Clin Cancer Res. 2018 Sep 1;24(17):4066-4071. doi: 10.1158/1078-0432.CCR-18-0042. Epub 2018 Apr 12.


The global Optima HIV allocative efficiency model: targeting resources in efforts to end AIDS.

Kelly SL, Martin-Hughes R, Stuart RM, Yap XF, Kedziora DJ, Grantham KL, Hussain SA, Reporter I, Shattock AJ, Grobicki L, Haghparast-Bidgoli H, Skordis-Worrall J, Baranczuk Z, Keiser O, Estill J, Petravic J, Gray RT, Benedikt CJ, Fraser N, Gorgens M, Wilson D, Kerr CC, Wilson DP.

Lancet HIV. 2018 Apr;5(4):e190-e198. doi: 10.1016/S2352-3018(18)30024-9. Epub 2018 Mar 11.


A tale of two countries: progress towards UNAIDS 90-90-90 targets in Botswana and Australia.

Marukutira T, Stoové M, Lockman S, Mills LA, Gaolathe T, Lebelonyane R, Jarvis JN, Kelly SL, Wilson DP, Luchters S, Crowe SM, Hellard M.

J Int AIDS Soc. 2018 Mar;21(3). doi: 10.1002/jia2.25090.


In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.


Critical Role for Very-Long Chain Sphingolipids in Invariant Natural Killer T Cell Development and Homeostasis.

Saroha A, Pewzner-Jung Y, Ferreira NS, Sharma P, Jouan Y, Kelly SL, Feldmesser E, Merrill AH Jr, Trottein F, Paget C, Lang KS, Futerman AH.

Front Immunol. 2017 Nov 1;8:1386. doi: 10.3389/fimmu.2017.01386. eCollection 2017.


Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase.

Sewell TR, Hawkins NJ, Stotz HU, Huang Y, Kelly SL, Kelly DE, Fraaije B, Fitt BDL.

Sci Rep. 2017 Nov 20;7(1):15849. doi: 10.1038/s41598-017-15545-9.


Achieving 90-90-90 Human Immunodeficiency Virus (HIV) Targets Will Not Be Enough to Achieve the HIV Incidence Reduction Target in Australia.

Scott N, Stoové M, Kelly SL, Wilson DP, Hellard ME.

Clin Infect Dis. 2018 Mar 19;66(7):1019-1023. doi: 10.1093/cid/cix939.


Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases.

Hull CM, Warrilow AGS, Rolley NJ, Price CL, Donnison IS, Kelly DE, Kelly SL.

Biotechnol Biofuels. 2017 Sep 29;10:226. doi: 10.1186/s13068-017-0904-z. eCollection 2017.


Target Abundance-Based Fitness Screening (TAFiS) Facilitates Rapid Identification of Target-Specific and Physiologically Active Chemical Probes.

Butts A, DeJarnette C, Peters TL, Parker JE, Kerns ME, Eberle KE, Kelly SL, Palmer GE.

mSphere. 2017 Oct 4;2(5). pii: e00379-17. doi: 10.1128/mSphere.00379-17. eCollection 2017 Sep-Oct.


Getting it right when budgets are tight: Using optimal expansion pathways to prioritize responses to concentrated and mixed HIV epidemics.

Stuart RM, Kerr CC, Haghparast-Bidgoli H, Estill J, Grobicki L, Baranczuk Z, Prieto L, Montañez V, Reporter I, Gray RT, Skordis-Worrall J, Keiser O, Cheikh N, Boonto K, Osornprasop S, Lavadenz F, Benedikt CJ, Martin-Hughes R, Hussain SA, Kelly SL, Kedziora DJ, Wilson DP.

PLoS One. 2017 Oct 3;12(10):e0185077. doi: 10.1371/journal.pone.0185077. eCollection 2017.


Medication adherence among adolescent solid-organ transplant recipients: A survey of healthcare providers.

Mehta P, Steinberg EA, Kelly SL, Buchanan C, Rawlinson AR.

Pediatr Transplant. 2017 Nov;21(7). doi: 10.1111/petr.13018. Epub 2017 Jul 2.


Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis.

Rybak JM, Dickens CM, Parker JE, Caudle KE, Manigaba K, Whaley SG, Nishimoto AT, Luna-Tapia A, Roy S, Zhang Q, Barker KS, Palmer GE, Sutter TR, Homayouni R, Wiederhold NP, Kelly SL, Rogers PD.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00651-17. doi: 10.1128/AAC.00651-17. Print 2017 Sep.


The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.

Warrilow AGS, Parker JE, Price CL, Garvey EP, Hoekstra WJ, Schotzinger RJ, Wiederhold NP, Nes WD, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00333-17. doi: 10.1128/AAC.00333-17. Print 2017 Jul.


Regulation of very-long acyl chain ceramide synthesis by acyl-CoA-binding protein.

Ferreira NS, Engelsby H, Neess D, Kelly SL, Volpert G, Merrill AH, Futerman AH, Færgeman NJ.

J Biol Chem. 2017 May 5;292(18):7588-7597. doi: 10.1074/jbc.M117.785345. Epub 2017 Mar 19.


In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.


Kazakhstan can achieve ambitious HIV targets despite expected donor withdrawal by combining improved ART procurement mechanisms with allocative and implementation efficiencies.

Shattock AJ, Benedikt C, Bokazhanova A, Đurić P, Petrenko I, Ganina L, Kelly SL, Stuart RM, Kerr CC, Vinichenko T, Zhang S, Hamelmann C, Manova M, Masaki E, Wilson DP, Gray RT.

PLoS One. 2017 Feb 16;12(2):e0169530. doi: 10.1371/journal.pone.0169530. eCollection 2017.


GBD 2015 and HIV estimates from the Optima model.

Kelly SL, Wilson DP.

Lancet HIV. 2016 Dec;3(12):e558. doi: 10.1016/S2352-3018(16)30192-8. No abstract available.


Allocative and implementation efficiency in HIV prevention and treatment for people who inject drugs.

Benedikt C, Kelly SL, Wilson D, Wilson DP; Optima Consortium.

Int J Drug Policy. 2016 Dec;38:73-80. doi: 10.1016/j.drugpo.2016.10.011. Epub 2016 Nov 22.


Proper Sterol Distribution Is Required for Candida albicans Hyphal Formation and Virulence.

McCourt P, Liu HY, Parker JE, Gallo-Ebert C, Donigan M, Bata A, Giordano C, Kelly SL, Nickels JT Jr.

G3 (Bethesda). 2016 Nov 8;6(11):3455-3465. doi: 10.1534/g3.116.033969.


Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.

Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL.

Sci Rep. 2016 Jun 13;6:27690. doi: 10.1038/srep27690.


Optimizing HIV/AIDS resources in Armenia: increasing ART investment and examining HIV programmes for seasonal migrant labourers.

Kelly SL, Shattock AJ, Kerr CC, Stuart RM, Papoyan A, Grigoryan T, Hovhannisyan R, Grigoryan S, Benedikt C, Wilson DP.

J Int AIDS Soc. 2016 Jun 7;19(1):20772. doi: 10.7448/IAS.19.1.20772. eCollection 2016.


The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow AG, Parker JE, Price CL, Nes WD, Garvey EP, Hoekstra WJ, Schotzinger RJ, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8. doi: 10.1128/AAC.00349-16. Print 2016 Aug.


Does percutaneous tibial nerve stimulation improve global pelvic function in women with faecal incontinence?

Kelly SL, Radley SC, Brown SR.

Colorectal Dis. 2016 May;18(5):O158-63. doi: 10.1111/codi.13329.


Prognostic value of cardiac biomarkers in the risk stratification of syncope: a systematic review.

Thiruganasambandamoorthy V, Ramaekers R, Rahman MO, Stiell IG, Sikora L, Kelly SL, Christ M, Claret PG, Reed MJ.

Intern Emerg Med. 2015 Dec;10(8):1003-14. doi: 10.1007/s11739-015-1318-1. Epub 2015 Oct 23. Review.


In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus.

Warrilow AG, Parker JE, Price CL, Nes WD, Kelly SL, Kelly DE.

Antimicrob Agents Chemother. 2015 Dec;59(12):7771-8. doi: 10.1128/AAC.01806-15. Epub 2015 Oct 12.


Multidrug Transporters and Alterations in Sterol Biosynthesis Contribute to Azole Antifungal Resistance in Candida parapsilosis.

Berkow EL, Manigaba K, Parker JE, Barker KS, Kelly SL, Rogers PD.

Antimicrob Agents Chemother. 2015 Oct;59(10):5942-50. doi: 10.1128/AAC.01358-15. Epub 2015 Jul 13.


Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51).

Lamb DC, Warrilow AG, Rolley NJ, Parker JE, Nes WD, Smith SN, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2015 Aug;59(8):4707-13. doi: 10.1128/AAC.00476-15. Epub 2015 May 26.

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