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Items: 1 to 50 of 93

1.

High-Throughput Single Cell Proteomics Enabled by Multiplex Isobaric Labelling in a Nanodroplet Sample Preparation Platform.

Dou M, Clair G, Tsai CF, Xu K, Chrisler WB, Sontag RL, Zhao R, Moore RJ, Liu T, Paša-Tolić L, Smith RD, Shi T, Adkins JN, Qian WJ, Kelly RT, Ansong C, Zhu Y.

Anal Chem. 2019 Sep 11. doi: 10.1021/acs.analchem.9b03349. [Epub ahead of print]

PMID:
31509397
2.

Automated Nanoflow Two-Dimensional Reversed-Phase Liquid Chromatography System Enables In-Depth Proteome and Phosphoproteome Profiling of Nanoscale Samples.

Dou M, Tsai CF, Piehowski PD, Wang Y, Fillmore TL, Zhao R, Moore RJ, Zhang P, Qian WJ, Smith RD, Liu T, Kelly RT, Shi T, Zhu Y.

Anal Chem. 2019 Aug 6;91(15):9707-9715. doi: 10.1021/acs.analchem.9b01248. Epub 2019 Jul 9.

3.

Ultrasmall sample biochemical analysis.

Kelly RT, Zhu Y.

Anal Bioanal Chem. 2019 Aug;411(21):5349-5350. doi: 10.1007/s00216-019-01957-1. No abstract available.

PMID:
31197421
4.

Microfluidic Sensors with Impregnated Fluorophores for Simultaneous Imaging of Spatial Structure and Chemical Oxygen Gradients.

Grate JW, Liu B, Kelly RT, Anheier NC, Schmidt TM.

ACS Sens. 2019 Feb 22;4(2):317-325. doi: 10.1021/acssensors.8b00924. Epub 2019 Jan 18.

PMID:
30609370
5.

New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells.

Couvillion SP, Zhu Y, Nagy G, Adkins JN, Ansong C, Renslow RS, Piehowski PD, Ibrahim YM, Kelly RT, Metz TO.

Analyst. 2019 Jan 28;144(3):794-807. doi: 10.1039/c8an01574k. Review.

PMID:
30507980
6.

Benchtop-compatible sample processing workflow for proteome profiling of < 100 mammalian cells.

Xu K, Liang Y, Piehowski PD, Dou M, Schwarz KC, Zhao R, Sontag RL, Moore RJ, Zhu Y, Kelly RT.

Anal Bioanal Chem. 2019 Jul;411(19):4587-4596. doi: 10.1007/s00216-018-1493-9. Epub 2018 Nov 20.

PMID:
30460388
7.

Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses.

Dou M, Chouinard CD, Zhu Y, Nagy G, Liyu AV, Ibrahim YM, Smith RD, Kelly RT.

Anal Bioanal Chem. 2019 Aug;411(21):5363-5372. doi: 10.1007/s00216-018-1452-5. Epub 2018 Nov 5.

PMID:
30397757
8.

Nanoproteomics comes of age.

Zhu Y, Piehowski PD, Kelly RT, Qian WJ.

Expert Rev Proteomics. 2018 Nov;15(11):865-871. doi: 10.1080/14789450.2018.1537787. Epub 2018 Oct 30. Review.

PMID:
30375896
9.

Jin-Ming Lin (Ed.): Cell analysis on microfluidics.

Kelly RT.

Anal Bioanal Chem. 2018 Dec;410(30):7825-7826. doi: 10.1007/s00216-018-1366-2. No abstract available.

PMID:
30291390
10.

Proteome Profiling of 1 to 5 Spiked Circulating Tumor Cells Isolated from Whole Blood Using Immunodensity Enrichment, Laser Capture Microdissection, Nanodroplet Sample Processing, and Ultrasensitive nanoLC-MS.

Zhu Y, Podolak J, Zhao R, Shukla AK, Moore RJ, Thomas GV, Kelly RT.

Anal Chem. 2018 Oct 16;90(20):11756-11759. doi: 10.1021/acs.analchem.8b03268. Epub 2018 Oct 5.

PMID:
30269481
11.

Nanowell-mediated two-dimensional liquid chromatography enables deep proteome profiling of <1000 mammalian cells.

Dou M, Zhu Y, Liyu A, Liang Y, Chen J, Piehowski PD, Xu K, Zhao R, Moore RJ, Atkinson MA, Mathews CE, Qian WJ, Kelly RT.

Chem Sci. 2018 Jul 18;9(34):6944-6951. doi: 10.1039/c8sc02680g. eCollection 2018 Sep 14.

12.

Spatially Resolved Proteome Profiling of <200 Cells from Tomato Fruit Pericarp by Integrating Laser-Capture Microdissection with Nanodroplet Sample Preparation.

Liang Y, Zhu Y, Dou M, Xu K, Chu RK, Chrisler WB, Zhao R, Hixson KK, Kelly RT.

Anal Chem. 2018 Sep 18;90(18):11106-11114. doi: 10.1021/acs.analchem.8b03005. Epub 2018 Aug 30.

PMID:
30118597
13.

Spatially Resolved Proteome Mapping of Laser Capture Microdissected Tissue with Automated Sample Transfer to Nanodroplets.

Zhu Y, Dou M, Piehowski PD, Liang Y, Wang F, Chu RK, Chrisler WB, Smith JN, Schwarz KC, Shen Y, Shukla AK, Moore RJ, Smith RD, Qian WJ, Kelly RT.

Mol Cell Proteomics. 2018 Sep;17(9):1864-1874. doi: 10.1074/mcp.TIR118.000686. Epub 2018 Jun 24.

14.

Proteomic Analysis of Single Mammalian Cells Enabled by Microfluidic Nanodroplet Sample Preparation and Ultrasensitive NanoLC-MS.

Zhu Y, Clair G, Chrisler WB, Shen Y, Zhao R, Shukla AK, Moore RJ, Misra RS, Pryhuber GS, Smith RD, Ansong C, Kelly RT.

Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12370-12374. doi: 10.1002/anie.201802843. Epub 2018 Jun 14.

PMID:
29797682
15.

The role of electron irradiation history in liquid cell transmission electron microscopy.

Moser TH, Mehta H, Park C, Kelly RT, Shokuhfar T, Evans JE.

Sci Adv. 2018 Apr 20;4(4):eaaq1202. doi: 10.1126/sciadv.aaq1202. eCollection 2018 Apr.

16.

Subnanogram proteomics: impact of LC column selection, MS instrumentation and data analysis strategy on proteome coverage for trace samples.

Zhu Y, Zhao R, Piehowski PD, Moore RJ, Lim S, Orphan VJ, Paša-Tolić L, Qian WJ, Smith RD, Kelly RT.

Int J Mass Spectrom. 2018 Apr;427:4-10. doi: 10.1016/j.ijms.2017.08.016. Epub 2017 Sep 1.

17.

Nanodroplet processing platform for deep and quantitative proteome profiling of 10-100 mammalian cells.

Zhu Y, Piehowski PD, Zhao R, Chen J, Shen Y, Moore RJ, Shukla AK, Petyuk VA, Campbell-Thompson M, Mathews CE, Smith RD, Qian WJ, Kelly RT.

Nat Commun. 2018 Feb 28;9(1):882. doi: 10.1038/s41467-018-03367-w.

18.

A Customizable Flow Injection System for Automated, High Throughput, and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements.

Orton DJ, Tfaily MM, Moore RJ, LaMarche BL, Zheng X, Fillmore TL, Chu RK, Weitz KK, Monroe ME, Kelly RT, Smith RD, Baker ES.

Anal Chem. 2018 Jan 2;90(1):737-744. doi: 10.1021/acs.analchem.7b02986. Epub 2017 Dec 13.

19.

Multimodal microfluidic platform for controlled culture and analysis of unicellular organisms.

Geng T, Smallwood CR, Bredeweg EL, Pomraning KR, Plymale AE, Baker SE, Evans JE, Kelly RT.

Biomicrofluidics. 2017 Sep 19;11(5):054104. doi: 10.1063/1.4986533. eCollection 2017 Sep.

20.

Direct Surface and Droplet Microsampling for Electrospray Ionization Mass Spectrometry Analysis with an Integrated Dual-Probe Microfluidic Chip.

Huang CM, Zhu Y, Jin DQ, Kelly RT, Fang Q.

Anal Chem. 2017 Sep 5;89(17):9009-9016. doi: 10.1021/acs.analchem.7b01679. Epub 2017 Aug 15.

PMID:
28780855
21.

Continuous, One-pot Synthesis and Post-Synthetic Modification of NanoMOFs Using Droplet Nanoreactors.

Jambovane SR, Nune SK, Kelly RT, McGrail BP, Wang Z, Nandasiri MI, Katipamula S, Trader C, Schaef HT.

Sci Rep. 2016 Nov 8;6:36657. doi: 10.1038/srep36657.

22.

Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform.

Cong Y, Katipamula S, Trader CD, Orton DJ, Geng T, Baker ES, Kelly RT.

Lab Chip. 2016 Apr 26;16(9):1544-8. doi: 10.1039/c6lc00183a.

23.

Bayesian Integration and Classification of Composition C-4 Plastic Explosives Based on Time-of-Flight-Secondary Ion Mass Spectrometry and Laser Ablation-Inductively Coupled Plasma Mass Spectrometry.

Mahoney CM, Kelly RT, Alexander L, Newburn M, Bader S, Ewing RG, Fahey AJ, Atkinson DA, Beagley N.

Anal Chem. 2016 Apr 5;88(7):3598-607. doi: 10.1021/acs.analchem.5b04151. Epub 2016 Mar 25.

PMID:
26913559
24.

Compartmentalized microchannel array for high-throughput analysis of single cell polarized growth and dynamics.

Geng T, Bredeweg EL, Szymanski CJ, Liu B, Baker SE, Orr G, Evans JE, Kelly RT.

Sci Rep. 2015 Nov 4;5:16111. doi: 10.1038/srep16111.

25.

Spontaneous Subcapsular Hematoma of the Fetal Liver: A Case Report and Review of Literature.

Maher JE, Van Beek B, Kelly RT, Hsu P.

AJP Rep. 2015 Oct;5(2):e203-6. doi: 10.1055/s-0035-1558403. Epub 2015 Jul 24.

26.

Reagent-free and portable detection of Bacillus anthracis spores using a microfluidic incubator and smartphone microscope.

Hutchison JR, Erikson RL, Sheen AM, Ozanich RM, Kelly RT.

Analyst. 2015 Sep 21;140(18):6269-76. doi: 10.1039/c5an01304f.

PMID:
26266749
27.

Electrokinetic sample preconcentration and hydrodynamic sample injection for microchip electrophoresis using a pneumatic microvalve.

Cong Y, Katipamula S, Geng T, Prost SA, Tang K, Kelly RT.

Electrophoresis. 2016 Feb;37(3):455-62. doi: 10.1002/elps.201500286. Epub 2015 Nov 6.

PMID:
26255610
28.

Enhancing bottom-up and top-down proteomic measurements with ion mobility separations.

Baker ES, Burnum-Johnson KE, Ibrahim YM, Orton DJ, Monroe ME, Kelly RT, Moore RJ, Zhang X, Théberge R, Costello CE, Smith RD.

Proteomics. 2015 Aug;15(16):2766-76. doi: 10.1002/pmic.201500048. Epub 2015 Jul 3.

29.

Alexa fluor-labeled fluorescent cellulose nanocrystals for bioimaging solid cellulose in spatially structured microenvironments.

Grate JW, Mo KF, Shin Y, Vasdekis A, Warner MG, Kelly RT, Orr G, Hu D, Dehoff KJ, Brockman FJ, Wilkins MJ.

Bioconjug Chem. 2015 Mar 18;26(3):593-601. doi: 10.1021/acs.bioconjchem.5b00048. Epub 2015 Mar 2.

PMID:
25730280
30.

A hexameric peptide barrel as building block of amyloid-β protofibrils.

Lendel C, Bjerring M, Dubnovitsky A, Kelly RT, Filippov A, Antzutkin ON, Nielsen NC, Härd T.

Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12756-60. doi: 10.1002/anie.201406357. Epub 2014 Sep 26.

PMID:
25256598
31.

Pneumatic microvalve-based hydrodynamic sample injection for high-throughput, quantitative zone electrophoresis in capillaries.

Kelly RT, Wang C, Rausch SJ, Lee CS, Tang K.

Anal Chem. 2014 Jul 1;86(13):6723-9. doi: 10.1021/ac501910p. Epub 2014 Jun 9.

32.

Solvent immersion imprint lithography.

Vasdekis AE, Wilkins MJ, Grate JW, Kelly RT, Konopka AE, Xantheas SS, Chang TM.

Lab Chip. 2014 Jun 21;14(12):2072-80. doi: 10.1039/c4lc00226a. Epub 2014 May 2.

PMID:
24789571
33.

Improving the sensitivity of mass spectrometry by using a new sheath flow electrospray emitter array at subambient pressures.

Cox JT, Marginean I, Kelly RT, Smith RD, Tang K.

J Am Soc Mass Spectrom. 2014 Dec;25(12):2028-37. doi: 10.1007/s13361-014-0856-5. Epub 2014 Mar 28.

34.

Picoelectrospray ionization mass spectrometry using narrow-bore chemically etched emitters.

Marginean I, Tang K, Smith RD, Kelly RT.

J Am Soc Mass Spectrom. 2014 Jan;25(1):30-6.

35.

Controlled dispensing and mixing of pico- to nanoliter volumes using on-demand droplet-based microfluidics.

Sun X, Tang K, Smith RD, Kelly RT.

Microfluid Nanofluidics. 2013 Jul 1;15(1):117-126.

36.

Silicon-on-glass pore network micromodels with oxygen-sensing fluorophore films for chemical imaging and defined spatial structure.

Grate JW, Kelly RT, Suter J, Anheier NC.

Lab Chip. 2012 Nov 21;12(22):4796-801. doi: 10.1039/c2lc40776k.

PMID:
22995983
37.

Hydrogen bonding in Alzheimer's amyloid-β fibrils probed by 15N{17O} REAPDOR solid-state NMR spectroscopy.

Antzutkin ON, Iuga D, Filippov AV, Kelly RT, Becker-Baldus J, Brown SP, Dupree R.

Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10289-92. doi: 10.1002/anie.201203595. Epub 2012 Sep 13. No abstract available.

PMID:
22976560
38.

Mass spectrometry-based proteomics: existing capabilities and future directions.

Angel TE, Aryal UK, Hengel SM, Baker ES, Kelly RT, Robinson EW, Smith RD.

Chem Soc Rev. 2012 May 21;41(10):3912-28. doi: 10.1039/c2cs15331a. Epub 2012 Apr 13. Review.

39.

Improving liquid chromatography-mass spectrometry sensitivity using a subambient pressure ionization with nanoelectrospray (SPIN) interface.

Tang K, Page JS, Marginean I, Kelly RT, Smith RD.

J Am Soc Mass Spectrom. 2011 Aug;22(8):1318-25. doi: 10.1007/s13361-011-0135-7. Epub 2011 Apr 22.

40.

Membrane-based emitter for coupling microfluidics with ultrasensitive nanoelectrospray ionization-mass spectrometry.

Sun X, Kelly RT, Tang K, Smith RD.

Anal Chem. 2011 Jul 15;83(14):5797-803. doi: 10.1021/ac200960h. Epub 2011 Jun 22.

41.

Hydrodynamic injection with pneumatic valving for microchip electrophoresis with total analyte utilization.

Sun X, Kelly RT, Danielson WF, Agrawal N, Tang K, Smith RD.

Electrophoresis. 2011 Jun;32(13):1610-8. doi: 10.1002/elps.201000522. Epub 2011 Apr 26.

42.

Ultrasensitive nanoelectrospray ionization-mass spectrometry using poly(dimethylsiloxane) microchips with monolithically integrated emitters.

Sun X, Kelly RT, Tang K, Smith RD.

Analyst. 2010 Sep;135(9):2296-302. doi: 10.1039/c0an00253d. Epub 2010 Jul 9.

43.

Enhanced sensitivity for selected reaction monitoring mass spectrometry-based targeted proteomics using a dual stage electrodynamic ion funnel interface.

Hossain M, Kaleta DT, Robinson EW, Liu T, Zhao R, Page JS, Kelly RT, Moore RJ, Tang K, Camp DG 2nd, Qian WJ, Smith RD.

Mol Cell Proteomics. 2011 Feb;10(2):M000062-MCP201. doi: 10.1074/mcp.M000062-MCP201. Epub 2010 Apr 21.

44.

Effect of pressure on electrospray characteristics.

Marginean I, Page JS, Kelly RT, Tang K, Smith RD.

Appl Phys Lett. 2009 Nov 2;95(18):184103. Epub 2009 Nov 6.

45.

Biases in ion transmission through an electrospray ionization-mass spectrometry capillary inlet.

Page JS, Marginean I, Baker ES, Kelly RT, Tang K, Smith RD.

J Am Soc Mass Spectrom. 2009 Dec;20(12):2265-72. doi: 10.1016/j.jasms.2009.08.018. Epub 2009 Sep 2.

46.

Dilution-free analysis from picoliter droplets by nano-electrospray ionization mass spectrometry.

Kelly RT, Page JS, Marginean I, Tang K, Smith RD.

Angew Chem Int Ed Engl. 2009;48(37):6832-5. doi: 10.1002/anie.200902501. No abstract available.

47.

Improving FAIMS sensitivity using a planar geometry with slit interfaces.

Mabrouki R, Kelly RT, Prior DC, Shvartsburg AA, Tang K, Smith RD.

J Am Soc Mass Spectrom. 2009 Sep;20(9):1768-74. doi: 10.1016/j.jasms.2009.05.019. Epub 2009 Jun 21.

48.

The ion funnel: theory, implementations, and applications.

Kelly RT, Tolmachev AV, Page JS, Tang K, Smith RD.

Mass Spectrom Rev. 2010 Mar-Apr;29(2):294-312. doi: 10.1002/mas.20232.

49.

Selection of the optimum electrospray voltage for gradient elution LC-MS measurements.

Marginean I, Kelly RT, Moore RJ, Prior DC, LaMarche BL, Tang K, Smith RD.

J Am Soc Mass Spectrom. 2009 Apr;20(4):682-8. doi: 10.1016/j.jasms.2008.12.004. Epub 2008 Dec 13.

50.

Analytical characterization of the electrospray ion source in the nanoflow regime.

Marginean I, Kelly RT, Prior DC, LaMarche BL, Tang K, Smith RD.

Anal Chem. 2008 Sep 1;80(17):6573-9. doi: 10.1021/ac800683s. Epub 2008 Jul 29.

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