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Comparative Biochemical and Structural Analysis of Novel Cellulose Binding Proteins (Tāpirins) from Extremely Thermophilic Caldicellulosiruptor Species.

Lee LL, Hart WS, Lunin VV, Alahuhta M, Bomble YJ, Himmel ME, Blumer-Schuette SE, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2018 Nov 26. pii: AEM.01983-18. doi: 10.1128/AEM.01983-18. [Epub ahead of print]


Bat rabies in Washington State: Temporal-spatial trends and risk factors for zoonotic transmission (2000-2017).

Bonwitt J, Oltean H, Lang M, Kelly RM, Goldoft M.

PLoS One. 2018 Oct 9;13(10):e0205069. doi: 10.1371/journal.pone.0205069. eCollection 2018.


A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum.

Zeldes BM, Straub CT, Otten JK, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2018 Dec;115(12):2951-2961. doi: 10.1002/bit.26829. Epub 2018 Oct 23.


Simultaneous biosynthesis of (R)-acetoin and ethylene glycol from D-xylose through in vitro metabolic engineering.

Jia X, Kelly RM, Han Y.

Metab Eng Commun. 2018 Jun 27;7:e00074. doi: 10.1016/j.mec.2018.e00074. eCollection 2018 Dec.


Engineering redox-balanced ethanol production in the cellulolytic and extremely thermophilic bacterium, Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Rubinstein GM, Scott IM, Lipscomb GL, Poole Ii FL, Kelly RM, Adams MWW.

Metab Eng Commun. 2018 May 28;7:e00073. doi: 10.1016/j.mec.2018.e00073. eCollection 2018 Dec.


Parsing in vivo and in vitro contributions to microcrystalline cellulose hydrolysis by multidomain glycoside hydrolases in the Caldicellulosiruptor bescii secretome.

Conway JM, Crosby JR, McKinley BS, Seals NL, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2018 Oct;115(10):2426-2440. doi: 10.1002/bit.26773. Epub 2018 Aug 1.


Biotechnology of extremely thermophilic archaea.

Straub CT, Counts JA, Nguyen DMN, Wu CH, Zeldes BM, Crosby JR, Conway JM, Otten JK, Lipscomb GL, Schut GJ, Adams MWW, Kelly RM.

FEMS Microbiol Rev. 2018 Sep 1;42(5):543-578. doi: 10.1093/femsre/fuy012.


Clonal variation in productivity and proteolytic clipping of an Fc-fusion protein in CHO cells: Proteomic analysis suggests a role for defective protein folding and the UPR.

Henry M, Gallagher C, Kelly RM, Frye CC, Osborne MD, Brady CP, Barron N, Clynes M, Meleady P.

J Biotechnol. 2018 Sep 10;281:21-30. doi: 10.1016/j.jbiotec.2018.05.018. Epub 2018 May 31.


Generation of High Expressing Chinese Hamster Ovary Cell Pools Using the Leap-In Transposon System.

Balasubramanian S, Peery RB, Minshull J, Lee M, White R, Kelly RM, Barnard GC.

Biotechnol J. 2018 Oct;13(10):e1700748. doi: 10.1002/biot.201700748. Epub 2018 Jun 11.


Native xylose-inducible promoter expands the genetic tools for the biomass-degrading, extremely thermophilic bacterium Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Awuku NK, Lipscomb GL, Poole FL, Rubinstein GM, Conway JM, Kelly RM, Adams MWW.

Extremophiles. 2018 Jul;22(4):629-638. doi: 10.1007/s00792-018-1023-x. Epub 2018 May 24.


Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.

Owen DL, Mahmud SA, Vang KB, Kelly RM, Blazar BR, Smith KA, Farrar MA.

J Immunol. 2018 Jun 15;200(12):3926-3933. doi: 10.4049/jimmunol.1800097. Epub 2018 May 4.


The diversity and specificity of the extracellular proteome in the cellulolytic bacterium Caldicellulosiruptor bescii is driven by the nature of the cellulosic growth substrate.

Poudel S, Giannone RJ, Basen M, Nookaew I, Poole FL 2nd, Kelly RM, Adams MWW, Hettich RL.

Biotechnol Biofuels. 2018 Mar 23;11:80. doi: 10.1186/s13068-018-1076-1. eCollection 2018.


Genus-Wide Assessment of Lignocellulose Utilization in the Extremely Thermophilic Genus Caldicellulosiruptor by Genomic, Pangenomic, and Metagenomic Analyses.

Lee LL, Blumer-Schuette SE, Izquierdo JA, Zurawski JV, Loder AJ, Conway JM, Elkins JG, Podar M, Clum A, Jones PC, Piatek MJ, Weighill DA, Jacobson DA, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2018 Apr 16;84(9). pii: e02694-17. doi: 10.1128/AEM.02694-17. Print 2018 May 1.


Understanding biopharmaceutical production at single nucleotide resolution using ribosome footprint profiling.

Tzani I, Monger C, Kelly P, Barron N, Kelly RM, Clarke C.

Curr Opin Biotechnol. 2018 Oct;53:182-190. doi: 10.1016/j.copbio.2018.01.030. Epub 2018 Feb 19. Review.


Distribution and removal of organochlorine pesticides in waste clay bricks from an abandoned manufacturing plant using low-temperature thermal desorption technology.

Cong X, Li F, Kelly RM, Xue N.

Environ Sci Pollut Res Int. 2018 Apr;25(12):12119-12126. doi: 10.1007/s11356-018-1422-7. Epub 2018 Feb 17.


Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors.

Saera-Vila A, Louie KW, Sha C, Kelly RM, Kish PE, Kahana A.

PLoS One. 2018 Feb 7;13(2):e0192214. doi: 10.1371/journal.pone.0192214. eCollection 2018.


Appropriate use criteria for transthoracic echocardiography: Are they relevant to European centers?

Kerley RN, Thornton KP, Kelly RM, O'Flynn S.

Echocardiography. 2018 Jan;35(1):17-23. doi: 10.1111/echo.13730. Epub 2017 Nov 21.


Modulation of IgG1 immunoeffector function by glycoengineering of the GDP-fucose biosynthesis pathway.

Kelly RM, Kowle RL, Lian Z, Strifler BA, Witcher DR, Parekh BS, Wang T, Frye CC.

Biotechnol Bioeng. 2018 Mar;115(3):705-718. doi: 10.1002/bit.26496. Epub 2017 Dec 1.


Functional analysis of the Glucan Degradation Locus (GDL) in Caldicellulosiruptor bescii reveals essential roles of component glycoside hydrolases in plant biomass deconstruction.

Conway JM, McKinley BS, Seals NL, Hernandez D, Khatibi PA, Poudel S, Giannone RJ, Hettich RL, Williams-Rhaesa AM, Lipscomb GL, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2017 Oct 6. pii: AEM.01828-17. doi: 10.1128/AEM.01828-17. [Epub ahead of print]


Impact of growth mode, phase, and rate on the metabolic state of the extremely thermophilic archaeon Pyrococcus furiosus.

Khatibi PA, Chou CJ, Loder AJ, Zurawski JV, Adams MWW, Kelly RM.

Biotechnol Bioeng. 2017 Dec;114(12):2947-2954. doi: 10.1002/bit.26408. Epub 2017 Oct 6.


Bioavailability of Carbohydrate Content in Natural and Transgenic Switchgrasses for the Extreme Thermophile Caldicellulosiruptor bescii.

Zurawski JV, Khatibi PA, Akinosho HO, Straub CT, Compton SH, Conway JM, Lee LL, Ragauskas AJ, Davison BH, Adams MWW, Kelly RM.

Appl Environ Microbiol. 2017 Aug 17;83(17). pii: e00969-17. doi: 10.1128/AEM.00969-17. Print 2017 Sep 1.


VapC toxins drive cellular dormancy under uranium stress for the extreme thermoacidophile Metallosphaera prunae.

Mukherjee A, Wheaton GH, Counts JA, Ijeomah B, Desai J, Kelly RM.

Environ Microbiol. 2017 Jul;19(7):2831-2842. doi: 10.1111/1462-2920.13808. Epub 2017 Jul 7.


Genome Stability in Engineered Strains of the Extremely Thermophilic Lignocellulose-Degrading Bacterium Caldicellulosiruptor bescii.

Williams-Rhaesa AM, Poole FL 2nd, Dinsmore JT, Lipscomb GL, Rubinstein GM, Scott IM, Conway JM, Lee LL, Khatibi PA, Kelly RM, Adams MWW.

Appl Environ Microbiol. 2017 Jun 30;83(14). pii: e00444-17. doi: 10.1128/AEM.00444-17. Print 2017 Jul 15.


Haemophagocytic lymphohistiocytosis presenting as HELLP syndrome: a diagnostic and therapeutic challenge.

Kerley RN, Kelly RM, Cahill MR, Kenny LC.

BMJ Case Rep. 2017 Apr 22;2017. pii: bcr-2017-219516. doi: 10.1136/bcr-2017-219516.


Two Distinct α-l-Arabinofuranosidases in Caldicellulosiruptor Species Drive Degradation of Arabinose-Based Polysaccharides.

Saleh MA, Han WJ, Lu M, Wang B, Li H, Kelly RM, Li FL.

Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00574-17. doi: 10.1128/AEM.00574-17. Print 2017 Jul 1.


Selective Loss of Smaller Spines in Schizophrenia.

MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA.

Am J Psychiatry. 2017 Jun 1;174(6):586-594. doi: 10.1176/appi.ajp.2017.16070814. Epub 2017 Mar 31.


Caldicellulosiruptor saccharolyticus transcriptomes reveal consequences of chemical pretreatment and genetic modification of lignocellulose.

Blumer-Schuette SE, Zurawski JV, Conway JM, Khatibi P, Lewis DL, Li Q, Chiang VL, Kelly RM.

Microb Biotechnol. 2017 Nov;10(6):1546-1557. doi: 10.1111/1751-7915.12494. Epub 2017 Mar 20.


Extremely thermophilic energy metabolisms: biotechnological prospects.

Straub CT, Zeldes BM, Schut GJ, Adams MW, Kelly RM.

Curr Opin Biotechnol. 2017 Jun;45:104-112. doi: 10.1016/j.copbio.2017.02.016. Epub 2017 Mar 16. Review.


Physiological, metabolic and biotechnological features of extremely thermophilic microorganisms.

Counts JA, Zeldes BM, Lee LL, Straub CT, Adams MWW, Kelly RM.

Wiley Interdiscip Rev Syst Biol Med. 2017 May;9(3). doi: 10.1002/wsbm.1377. Epub 2017 Feb 16. Review.


Ethanol production by the hyperthermophilic archaeon Pyrococcus furiosus by expression of bacterial bifunctional alcohol dehydrogenases.

Keller MW, Lipscomb GL, Nguyen DM, Crowley AT, Schut GJ, Scott I, Kelly RM, Adams MWW.

Microb Biotechnol. 2017 Nov;10(6):1535-1545. doi: 10.1111/1751-7915.12486. Epub 2017 Feb 14.


The renaissance of life near the boiling point - at last, genetics and metabolic engineering.

Adams MW, Kelly RM.

Microb Biotechnol. 2017 Jan;10(1):37-39. doi: 10.1111/1751-7915.12463. Epub 2016 Dec 8.


Detection, Prevalence and Phylogenetic Relationships of Demodex spp and further Skin Prostigmata Mites (Acari, Arachnida) in Wild and Domestic Mammals.

Sastre N, Francino O, Curti JN, Armenta TC, Fraser DL, Kelly RM, Hunt E, Silbermayr K, Zewe C, Sánchez A, Ferrer L.

PLoS One. 2016 Nov 1;11(11):e0165765. doi: 10.1371/journal.pone.0165765. eCollection 2016.


Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO2 incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus.

Lian H, Zeldes BM, Lipscomb GL, Hawkins AB, Han Y, Loder AJ, Nishiyama D, Adams MW, Kelly RM.

Biotechnol Bioeng. 2016 Dec;113(12):2652-2660. doi: 10.1002/bit.26033. Epub 2016 Jun 30.


Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO2 fixation cycle in extremely thermoacidophilic archaea.

Loder AJ, Han Y, Hawkins AB, Lian H, Lipscomb GL, Schut GJ, Keller MW, Adams MWW, Kelly RM.

Metab Eng. 2016 Nov;38:446-463. doi: 10.1016/j.ymben.2016.10.009. Epub 2016 Oct 19.


Transcriptomes of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Exposed to Metal "Shock" Reveal Generic and Specific Metal Responses.

Wheaton GH, Mukherjee A, Kelly RM.

Appl Environ Microbiol. 2016 Jul 15;82(15):4613-4627. doi: 10.1128/AEM.01176-16. Print 2016 Aug 1.


A Highly Thermostable Kanamycin Resistance Marker Expands the Tool Kit for Genetic Manipulation of Caldicellulosiruptor bescii.

Lipscomb GL, Conway JM, Blumer-Schuette SE, Kelly RM, Adams MWW.

Appl Environ Microbiol. 2016 Jun 30;82(14):4421-4428. doi: 10.1128/AEM.00570-16. Print 2016 Jul 15.


Heterologous Production of an Energy-Conserving Carbon Monoxide Dehydrogenase Complex in the Hyperthermophile Pyrococcus furiosus.

Schut GJ, Lipscomb GL, Nguyen DM, Kelly RM, Adams MW.

Front Microbiol. 2016 Jan 29;7:29. doi: 10.3389/fmicb.2016.00029. eCollection 2016.


Multidomain, Surface Layer-associated Glycoside Hydrolases Contribute to Plant Polysaccharide Degradation by Caldicellulosiruptor Species.

Conway JM, Pierce WS, Le JH, Harper GW, Wright JH, Tucker AL, Zurawski JV, Lee LL, Blumer-Schuette SE, Kelly RM.

J Biol Chem. 2016 Mar 25;291(13):6732-47. doi: 10.1074/jbc.M115.707810. Epub 2016 Jan 26.


Temperature-dependent acetoin production by Pyrococcus furiosus is catalyzed by a biosynthetic acetolactate synthase and its deletion improves ethanol production.

Nguyen DMN, Lipscomb GL, Schut GJ, Vaccaro BJ, Basen M, Kelly RM, Adams MWW.

Metab Eng. 2016 Mar;34:71-79. doi: 10.1016/j.ymben.2015.12.006. Epub 2015 Dec 22.


Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.

Mimura Y, Kelly RM, Unwin L, Albrecht S, Jefferis R, Goodall M, Mizukami Y, Mimura-Kimura Y, Matsumoto T, Ueoka H, Rudd PM.

J Immunol Methods. 2016 Jan;428:30-6. doi: 10.1016/j.jim.2015.11.009. Epub 2015 Nov 26.


Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals.

Zeldes BM, Keller MW, Loder AJ, Straub CT, Adams MW, Kelly RM.

Front Microbiol. 2015 Nov 5;6:1209. doi: 10.3389/fmicb.2015.01209. eCollection 2015. Review.


Cytotoxic oplopane sesquiterpenoids from Arnoglossum atriplicifolium.

Clement JA, Bleich RM, Campbell HE, Naylor K, Flood MJ, Kelly RM, Wu SB, Kennelly EJ, Schmitt JD.

Nat Prod Res. 2016 Sep;30(18):2028-33. doi: 10.1080/14786419.2015.1107063. Epub 2015 Nov 5.


A New Class of Tungsten-Containing Oxidoreductase in Caldicellulosiruptor, a Genus of Plant Biomass-Degrading Thermophilic Bacteria.

Scott IM, Rubinstein GM, Lipscomb GL, Basen M, Schut GJ, Rhaesa AM, Lancaster WA, Poole FL 2nd, Kelly RM, Adams MW.

Appl Environ Microbiol. 2015 Oct;81(20):7339-47. doi: 10.1128/AEM.01634-15. Epub 2015 Aug 14.


Alcohol Selectivity in a Synthetic Thermophilic n-Butanol Pathway Is Driven by Biocatalytic and Thermostability Characteristics of Constituent Enzymes.

Loder AJ, Zeldes BM, Garrison GD 2nd, Lipscomb GL, Adams MW, Kelly RM.

Appl Environ Microbiol. 2015 Oct;81(20):7187-200. doi: 10.1128/AEM.02028-15. Epub 2015 Aug 7.


Comparative Analysis of Extremely Thermophilic Caldicellulosiruptor Species Reveals Common and Unique Cellular Strategies for Plant Biomass Utilization.

Zurawski JV, Conway JM, Lee LL, Simpson HJ, Izquierdo JA, Blumer-Schuette S, Nookaew I, Adams MW, Kelly RM.

Appl Environ Microbiol. 2015 Oct;81(20):7159-70. doi: 10.1128/AEM.01622-15. Epub 2015 Aug 7.


Complete Genome Sequences of Caldicellulosiruptor sp. Strain Rt8.B8, Caldicellulosiruptor sp. Strain Wai35.B1, and "Thermoanaerobacter cellulolyticus".

Lee LL, Izquierdo JA, Blumer-Schuette SE, Zurawski JV, Conway JM, Cottingham RW, Huntemann M, Copeland A, Chen IM, Kyrpides N, Markowitz V, Palaniappan K, Ivanova N, Mikhailova N, Ovchinnikova G, Andersen E, Pati A, Stamatis D, Reddy TB, Shapiro N, Nordberg HP, Cantor MN, Hua SX, Woyke T, Kelly RM.

Genome Announc. 2015 May 14;3(3). pii: e00440-15. doi: 10.1128/genomeA.00440-15.


Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

Schilling J, Nepomuceno AI, Planchart A, Yoder JA, Kelly RM, Muddiman DC, Daniels HV, Hiramatsu N, Reading BJ.

Proteomics. 2015 Aug;15(15):2678-90. doi: 10.1002/pmic.201400606. Epub 2015 Jun 11.


Bioprocessing analysis of Pyrococcus furiosus strains engineered for CO₂-based 3-hydroxypropionate production.

Hawkins AB, Lian H, Zeldes BM, Loder AJ, Lipscomb GL, Schut GJ, Keller MW, Adams MW, Kelly RM.

Biotechnol Bioeng. 2015 Aug;112(8):1533-43. doi: 10.1002/bit.25584. Epub 2015 Jun 11.


Discrete and structurally unique proteins (tāpirins) mediate attachment of extremely thermophilic Caldicellulosiruptor species to cellulose.

Blumer-Schuette SE, Alahuhta M, Conway JM, Lee LL, Zurawski JV, Giannone RJ, Hettich RL, Lunin VV, Himmel ME, Kelly RM.

J Biol Chem. 2015 Apr 24;290(17):10645-56. doi: 10.1074/jbc.M115.641480. Epub 2015 Feb 26.

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