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Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.

Taylor MC, Ward A, Olmo F, Jayawardhana S, Francisco AF, Lewis MD, Kelly JM.

PLoS Negl Trop Dis. 2020 Mar 20;14(3):e0008007. doi: 10.1371/journal.pntd.0008007. [Epub ahead of print]


Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitamin K1) supplementation.

Westerman K, Kelly JM, Ordovás JM, Booth SL, DeMeo DL.

Epigenetics. 2020 Mar 5:1-12. doi: 10.1080/15592294.2020.1734714. [Epub ahead of print]


Lipophilic Guanylhydrazone Analogues As Promising Trypanocidal Agents: An Extended SAR Study.

Pardali V, Giannakopoulou E, Balourdas DI, Myrianthopoulos V, Taylor MC, Šekutor M, Mlinarić-Majerski K, Kelly JM, Zoidis G.

Curr Pharm Des. 2020 Feb 10. doi: 10.2174/1381612826666200210150127. [Epub ahead of print]


Correction to: High in vitro survival rate of sheep in vitro produced blastocysts vitrified with a new method and device.

Ledda S, Kelly JM, Nieddu S, Bebbere D, Ariu F, Bogliolo L, Natan D, Arav A.

J Anim Sci Biotechnol. 2019 Dec 17;10:98. doi: 10.1186/s40104-019-0415-9. eCollection 2019.


The Light and the Dark of Early and Intermediate AMD: Cone- and Rod-Mediated Changes Are Linked to Fundus Photograph and FAF Abnormalities.

Rodrigo-Diaz E, Tahir HJ, Kelly JM, Parry NRA, Aslam T, Murray IJ.

Invest Ophthalmol Vis Sci. 2019 Dec 2;60(15):5070-5079. doi: 10.1167/iovs.19-27971.


High in vitro survival rate of sheep in vitro produced blastocysts vitrified with a new method and device.

Ledda S, Kelly JM, Nieddu S, Bebbere D, Ariu F, Bogliolo L, Natan D, Arav A.

J Anim Sci Biotechnol. 2019 Nov 1;10:90. doi: 10.1186/s40104-019-0390-1. eCollection 2019. Erratum in: J Anim Sci Biotechnol. 2019 Dec 17;10:98.


Plasma anti-Müllerian hormone concentration as a predictive endocrine marker for selection of donor lambs to improve success in juvenile in vitro embryo transfer programs.

McGrice H, Kelly JM, Kleemann DO, Kind KL, Hampton AJ, Hannemann P, Walker SK, van Wettere WHEJ.

Reprod Fertil Dev. 2020 Feb;32(4):383-391. doi: 10.1071/RD18498.


VarSight: prioritizing clinically reported variants with binary classification algorithms.

Holt JM, Wilk B, Birch CL, Brown DM, Gajapathy M, Moss AC, Sosonkina N, Wilk MA, Anderson JA, Harris JM, Kelly JM, Shaterferdosian F, Uno-Antonison AE, Weborg A; Undiagnosed Diseases Network, Worthey EA.

BMC Bioinformatics. 2019 Oct 15;20(1):496. doi: 10.1186/s12859-019-3026-8.


Targeting epigenetic nuclear reprogramming in aggregated cloned equine embryos.

Damasceno Teixeira TV, Fry RC, McKinnon A, Fry KL, Kelly JM, Verma PJ, Burden C, Salamone DF, Gambini A.

Reprod Fertil Dev. 2019 Jan;31(12):1885-1893. doi: 10.1071/RD19239.


3D-printed automation for optimized PET radiochemistry.

Amor-Coarasa A, Kelly JM, Babich JW.

Sci Adv. 2019 Sep 13;5(9):eaax4762. doi: 10.1126/sciadv.aax4762. eCollection 2019 Sep.


The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation.

Kelly JM, Ordovas JM, Matuszek G, Smith CE, Huggins GS, Dashti HS, Ichikawa R, Booth SL.

Mol Nutr Food Res. 2019 Dec;63(24):e1900399. doi: 10.1002/mnfr.201900399. Epub 2019 Oct 3.


Metabolomics, lipidomics and proteomics profiling of myoblasts infected with Trypanosoma cruzi after treatment with different drugs against Chagas disease.

Hennig K, Abi-Ghanem J, Bunescu A, Meniche X, Biliaut E, Ouattara AD, Lewis MD, Kelly JM, Braillard S, Courtemanche G, Chatelain E, Béquet F.

Metabolomics. 2019 Aug 22;15(9):117. doi: 10.1007/s11306-019-1583-5.


Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species.

Giannakopoulou E, Pardali V, Frakolaki E, Siozos V, Myrianthopoulos V, Mikros E, Taylor MC, Kelly JM, Vassilaki N, Zoidis G.

Medchemcomm. 2019 May 16;10(6):991-1006. doi: 10.1039/c9md00200f. eCollection 2019 Jun 1.


Novel 2,6-diketopiperazine-derived acetohydroxamic acids as promising anti-Trypanosoma brucei agents.

Fytas G, Zoidis G, Taylor MC, Kelly JM, Tsatsaroni A, Tsotinis A.

Future Med Chem. 2019 Jun;11(11):1259-1266. doi: 10.4155/fmc-2018-0599. Epub 2019 Jun 4.


Synthesis and Evaluation of Nifurtimox-Adamantane Adducts with Trypanocidal Activity.

Foscolos AS, Papanastasiou I, Tsotinis A, Taylor MC, Kelly JM.

ChemMedChem. 2019 Jul 3;14(13):1227-1231. doi: 10.1002/cmdc.201900165. Epub 2019 May 27.


[18F]Fluoroethyltriazolyl Monocyclam Derivatives as Imaging Probes for the Chemokine Receptor CXCR4.

Amor-Coarasa A, Kelly JM, Singh PK, Ponnala S, Nikolopoulou A, Williams C Jr, Vedvyas Y, Jin MM, Warren JD, Babich JW.

Molecules. 2019 Apr 24;24(8). pii: E1612. doi: 10.3390/molecules24081612.


Novel symmetric bis-benzimidazoles: Synthesis, DNA/RNA binding and antitrypanosomal activity.

Popov AB, Stolić I, Krstulović L, Taylor MC, Kelly JM, Tomić S, Tumir L, Bajić M, Raić-Malić S.

Eur J Med Chem. 2019 Jul 1;173:63-75. doi: 10.1016/j.ejmech.2019.04.007. Epub 2019 Apr 7.


Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.

Georgiadis MO, Kourbeli V, Ioannidou V, Karakitsios E, Papanastasiou I, Tsotinis A, Komiotis D, Vocat A, Cole ST, Taylor MC, Kelly JM.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1278-1281. doi: 10.1016/j.bmcl.2019.04.010. Epub 2019 Apr 6.


Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions.

Taylor MC, Francisco AF, Jayawardhana S, Mann GS, Ward AI, Olmo F, Lewis MD, Kelly JM.

Methods Mol Biol. 2019;1955:147-163. doi: 10.1007/978-1-4939-9148-8_11.


"Forward flow": A new measure to quantify free thought and predict creativity.

Gray K, Anderson S, Chen EE, Kelly JM, Christian MS, Patrick J, Huang L, Kenett YN, Lewis K.

Am Psychol. 2019 Jul-Aug;74(5):539-554. doi: 10.1037/amp0000391. Epub 2019 Jan 21.


Albumin-Binding PSMA Ligands: Implications for Expanding the Therapeutic Window.

Kelly JM, Amor-Coarasa A, Ponnala S, Nikolopoulou A, Williams C Jr, DiMagno SG, Babich JW.

J Nucl Med. 2019 May;60(5):656-663. doi: 10.2967/jnumed.118.221150. Epub 2018 Dec 14.


Drug Discovery for Kinetoplastid Diseases: Future Directions.

Rao SPS, Barrett MP, Dranoff G, Faraday CJ, Gimpelewicz CR, Hailu A, Jones CL, Kelly JM, Lazdins-Helds JK, Mäser P, Mengel J, Mottram JC, Mowbray CE, Sacks DL, Scott P, Späth GF, Tarleton RL, Spector JM, Diagana TT.

ACS Infect Dis. 2019 Feb 8;5(2):152-157. doi: 10.1021/acsinfecdis.8b00298. Epub 2018 Dec 13.


Spectro-electrochemical Studies on [Ru(TAP)2(dppz)]2+-Insights into the Mechanism of its Photosensitized Oxidation of Oligonucleotides.

Keane PM, Tory J, Towrie M, Sazanovich IV, Cardin CJ, Quinn SJ, Hartl F, Kelly JM, Long C.

Inorg Chem. 2019 Jan 7;58(1):663-671. doi: 10.1021/acs.inorgchem.8b02859. Epub 2018 Dec 12.


A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model.

Kelly JM, Amor-Coarasa A, Ponnala S, Nikolopoulou A, Williams C Jr, Thiele NA, Schlyer D, Wilson JJ, DiMagno SG, Babich JW.

J Nucl Med. 2019 May;60(5):649-655. doi: 10.2967/jnumed.118.219592. Epub 2018 Nov 9.


Slowed Dark Adaptation in Early AMD: Dual Stimulus Reveals Scotopic and Photopic Abnormalities.

Tahir HJ, Rodrigo-Diaz E, Parry NRA, Kelly JMF, Carden D, Aslam TM, Murray IJ.

Invest Ophthalmol Vis Sci. 2018 Mar 20;59(4):AMD202-AMD210. doi: 10.1167/iovs.18-24227.


66Ga: A Novelty or a Valuable Preclinical Screening Tool for the Design of Targeted Radiopharmaceuticals?

Amor-Coarasa A, Kelly JM, Ponnala S, Nikolopoulou A, Williams C Jr, Babich JW.

Molecules. 2018 Oct 9;23(10). pii: E2575. doi: 10.3390/molecules23102575.


Physiotherapist-delivered Stress Inoculation Training for acute whiplash-associated disorders: A qualitative study of perceptions and experiences.

Kelly JM, Bunzli S, Ritchie C, Kenardy J, Smeets R, Sterling M.

Musculoskelet Sci Pract. 2018 Dec;38:30-36. doi: 10.1016/j.msksp.2018.09.005. Epub 2018 Sep 6.


Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations.

Adjogatse E, Erskine P, Wells SA, Kelly JM, Wilden JD, Chan AWE, Selwood D, Coker A, Wood S, Cooper JB.

Acta Crystallogr D Struct Biol. 2018 Sep 1;74(Pt 9):861-876. doi: 10.1107/S2059798318009208. Epub 2018 Sep 3.


Evaluation of alpha-II-spectrin breakdown products as potential biomarkers for early recognition and severity of aneurysmal subarachnoid hemorrhage.

Papa L, Rosenthal K, Silvestri F, Axley JC, Kelly JM, Lewis SB.

Sci Rep. 2018 Sep 6;8(1):13308. doi: 10.1038/s41598-018-31631-y.


Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Bistrović A, Krstulović L, Stolić I, Drenjančević D, Talapko J, Taylor MC, Kelly JM, Bajić M, Raić-Malić S.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1323-1334. doi: 10.1080/14756366.2018.1484733.


Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.

Francisco AF, Jayawardhana S, Taylor MC, Lewis MD, Kelly JM.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00832-18. doi: 10.1128/AAC.00832-18. Print 2018 Oct.


Imaging the development of chronic Chagas disease after oral transmission.

Lewis MD, Francisco AF, Jayawardhana S, Langston H, Taylor MC, Kelly JM.

Sci Rep. 2018 Jul 26;8(1):11292. doi: 10.1038/s41598-018-29564-7.


Precision Mass Measurements on Neutron-Rich Rare-Earth Isotopes at JYFLTRAP: Reduced Neutron Pairing and Implications for r-Process Calculations.

Vilen M, Kelly JM, Kankainen A, Brodeur M, Aprahamian A, Canete L, Eronen T, Jokinen A, Kuta T, Moore ID, Mumpower MR, Nesterenko DA, Penttilä H, Pohjalainen I, Porter WS, Rinta-Antila S, Surman R, Voss A, Äystö J.

Phys Rev Lett. 2018 Jun 29;120(26):262701. doi: 10.1103/PhysRevLett.120.262701.


Optimising genetic transformation of Trypanosoma cruzi using hydroxyurea-induced cell-cycle synchronisation.

Olmo F, Costa FC, Mann GS, Taylor MC, Kelly JM.

Mol Biochem Parasitol. 2018 Dec;226:34-36. doi: 10.1016/j.molbiopara.2018.07.002. Epub 2018 Jul 7.


Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.

Costa FC, Francisco AF, Jayawardhana S, Calderano SG, Lewis MD, Olmo F, Beneke T, Gluenz E, Sunter J, Dean S, Kelly JM, Taylor MC.

PLoS Negl Trop Dis. 2018 Apr 2;12(4):e0006388. doi: 10.1371/journal.pntd.0006388. eCollection 2018 Apr.


Chips in the sunshine: color constancy with real versus simulated Munsell chips under illuminants adjacent to the daylight locus.

Kelly JMF, Daugirdiene A, Kulikowski JJ, Murray IJ.

J Opt Soc Am A Opt Image Sci Vis. 2018 Apr 1;35(4):B100-B105. doi: 10.1364/JOSAA.35.00B100.


Phyto-oestrogens affect fertilisation and embryo development in vitro in sheep.

Amir AA, Kelly JM, Kleemann DO, Durmic Z, Blache D, Martin GB.

Reprod Fertil Dev. 2018 Jul;30(8):1109-1115. doi: 10.1071/RD16481.


Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.

Ghashghaei O, Kielland N, Revés M, Taylor MC, Kelly JM, Di Pietro O, Muñoz-Torrero D, Pérez B, Lavilla R.

Molecules. 2018 Jan 16;23(1). pii: E177. doi: 10.3390/molecules23010177.


A eukaryotic nicotinate-inducible gene cluster: convergent evolution in fungi and bacteria.

Ámon J, Fernández-Martín R, Bokor E, Cultrone A, Kelly JM, Flipphi M, Scazzocchio C, Hamari Z.

Open Biol. 2017 Dec;7(12). pii: 170199. doi: 10.1098/rsob.170199.


The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications.

Poynton FE, Bright SA, Blasco S, Williams DC, Kelly JM, Gunnlaugsson T.

Chem Soc Rev. 2017 Dec 11;46(24):7706-7756. doi: 10.1039/c7cs00680b. Review.


Polyethylene glycol-b-poly(lactic acid) polymersomes as vehicles for enzyme replacement therapy.

Kelly JM, Gross AL, Martin DR, Byrne ME.

Nanomedicine (Lond). 2017 Dec;12(23):2591-2606. doi: 10.2217/nnm-2017-0221. Epub 2017 Nov 7.


Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.

Campos MC, Phelan J, Francisco AF, Taylor MC, Lewis MD, Pain A, Clark TG, Kelly JM.

Sci Rep. 2017 Oct 31;7(1):14407. doi: 10.1038/s41598-017-14986-6.


Assessment of PSMA targeting ligands bearing novel chelates with application to theranostics: Stability and complexation kinetics of 68Ga3+, 111In3+, 177Lu3+ and 225Ac3.

Kelly JM, Amor-Coarasa A, Nikolopoulou A, Kim D, Williams C Jr, Vallabhajosula S, Babich JW.

Nucl Med Biol. 2017 Dec;55:38-46. doi: 10.1016/j.nucmedbio.2017.10.001. Epub 2017 Oct 3.


An Eighteen-Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy.

Thiele NA, Brown V, Kelly JM, Amor-Coarasa A, Jermilova U, MacMillan SN, Nikolopoulou A, Ponnala S, Ramogida CF, Robertson AKH, Rodríguez-Rodríguez C, Schaffer P, Williams C Jr, Babich JW, Radchenko V, Wilson JJ.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717. doi: 10.1002/anie.201709532. Epub 2017 Oct 16.


Photochemically active DNA-intercalating ruthenium and related complexes - insights by combining crystallography and transient spectroscopy.

Cardin CJ, Kelly JM, Quinn SJ.

Chem Sci. 2017 Jul 1;8(7):4705-4723. doi: 10.1039/c7sc01070b. Epub 2017 Apr 12.


Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients.

Schonhoft JD, Monteiro C, Plate L, Eisele YS, Kelly JM, Boland D, Parker CG, Cravatt BF, Teruya S, Helmke S, Maurer M, Berk J, Sekijima Y, Novais M, Coelho T, Powers ET, Kelly JW.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaam7621. doi: 10.1126/scitranslmed.aam7621.


Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders.

Pushkarskaya H, Tolin D, Ruderman L, Henick D, Kelly JM, Pittenger C, Levy I.

Psychiatry Res. 2017 Dec;258:305-315. doi: 10.1016/j.psychres.2017.08.058. Epub 2017 Aug 24.


Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.

Brand S, Ko EJ, Viayna E, Thompson S, Spinks D, Thomas M, Sandberg L, Francisco AF, Jayawardhana S, Smith VC, Jansen C, De Rycker M, Thomas J, MacLean L, Osuna-Cabello M, Riley J, Scullion P, Stojanovski L, Simeons FRC, Epemolu O, Shishikura Y, Crouch SD, Bakshi TS, Nixon CJ, Reid IH, Hill AP, Underwood TZ, Hindley SJ, Robinson SA, Kelly JM, Fiandor JM, Wyatt PG, Marco M, Miles TJ, Read KD, Gilbert IH.

J Med Chem. 2017 Sep 14;60(17):7284-7299. doi: 10.1021/acs.jmedchem.7b00463. Epub 2017 Aug 27.


Lipophilic conformationally constrained spiro carbocyclic 2,6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: An extended SAR study.

Zoidis G, Tsotinis A, Tsatsaroni A, Taylor MC, Kelly JM, Efstathiou A, Smirlis D, Fytas G.

Chem Biol Drug Des. 2018 Feb;91(2):408-421. doi: 10.1111/cbdd.13088. Epub 2017 Sep 18.

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