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Fueling Cardiac Hypertrophy.

Matsuura TR, Leone TC, Kelly DP.

Circ Res. 2020 Jan 17;126(2):197-199. doi: 10.1161/CIRCRESAHA.119.316358. Epub 2020 Jan 16. No abstract available.


Skeletal muscle energetics and mitochondrial function are impaired following 10 days of bed rest in older adults.

Standley RA, Distefano G, Trevino MB, Chen E, Narain NR, Greenwood B, Kondakci G, Tolstikov VV, Kiebish MA, Yu G, Qi F, Kelly DP, Vega RB, Coen PM, Goodpaster BH.

J Gerontol A Biol Sci Med Sci. 2020 Jan 7. pii: glaa001. doi: 10.1093/gerona/glaa001. [Epub ahead of print]


Strategic Principles to Inform Workforce Development in Developmental and Behavioral Pediatrics.

Dworkin PH, Kelly DP, Schonfeld DJ.

J Dev Behav Pediatr. 2019 Dec 13. doi: 10.1097/DBP.0000000000000767. [Epub ahead of print] No abstract available.


Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L.

Circulation. 2019 Oct 1;140(14):1205-1216.


Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Lombardi AA, Gibb AA, Arif E, Kolmetzky DW, Tomar D, Luongo TS, Jadiya P, Murray EK, Lorkiewicz PK, Hajnóczky G, Murphy E, Arany ZP, Kelly DP, Margulies KB, Hill BG, Elrod JW.

Nat Commun. 2019 Oct 4;10(1):4509. doi: 10.1038/s41467-019-12103-x.


Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy.

Trevino MB, Zhang X, Standley RA, Wang M, Han X, Reis FCG, Periasamy M, Yu G, Kelly DP, Goodpaster BH, Vega RB, Coen PM.

Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E899-E910. doi: 10.1152/ajpendo.00161.2019. Epub 2019 Sep 3.


MondoA drives muscle lipid accumulation and insulin resistance.

Ahn B, Wan S, Jaiswal N, Vega RB, Ayer DE, Titchenell PM, Han X, Won KJ, Kelly DP.

JCI Insight. 2019 Jul 9;5. pii: 129119. doi: 10.1172/jci.insight.129119.


Initiation of Noninvasive Ventilation for Acute Respiratory Failure in a Pediatric Intermediate Care Unit.

Smith A, Kelly DP, Hurlbut J, Melvin P, Russ CM.

Hosp Pediatr. 2019 Jul;9(7):538-544. doi: 10.1542/hpeds.2019-0034.


Serendipitous drug repurposing through social media.

Kelly DP, Blatt J.

Drug Discov Today. 2019 Jul;24(7):1321-1323. doi: 10.1016/j.drudis.2019.05.010. Epub 2019 May 16. No abstract available.


Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

Kumar AA, Kelly DP, Chirinos JA.

Circulation. 2019 Mar 12;139(11):1435-1450. doi: 10.1161/CIRCULATIONAHA.118.036259. Review.


Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD.

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.


Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.

Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM.

Cell Rep. 2019 Feb 5;26(6):1557-1572.e8. doi: 10.1016/j.celrep.2019.01.057.


The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.

Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP.

JCI Insight. 2019 Feb 21;4(4). pii: 124079. doi: 10.1172/jci.insight.124079. eCollection 2019 Feb 21.


KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.

Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q.

Mol Cancer Ther. 2019 Mar;18(3):706-717. doi: 10.1158/1535-7163.MCT-18-0395. Epub 2018 Dec 6.


Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis.

Tamura N, Maejima Y, Matsumura T, Vega RB, Amiya E, Ito Y, Shiheido-Watanabe Y, Ashikaga T, Komuro I, Kelly DP, Hirao K, Isobe M.

Circ Genom Precis Med. 2018 Oct;11(10):e002296. doi: 10.1161/CIRCGEN.118.002296.


Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle.

Maurya SK, Herrera JL, Sahoo SK, Reis FCG, Vega RB, Kelly DP, Periasamy M.

Cell Rep. 2018 Sep 11;24(11):2919-2931. doi: 10.1016/j.celrep.2018.08.036.


Measuring refractive index of glass by using speckle.

Guo C, Li D, Kelly DP, Li H, Ryle JP, Sheridan JT.

Appl Opt. 2018 Aug 1;57(22):E205-E217. doi: 10.1364/AO.57.00E205.


Skeletal muscle mitochondrial remodeling in exercise and diseases.

Gan Z, Fu T, Kelly DP, Vega RB.

Cell Res. 2018 Oct;28(10):969-980. doi: 10.1038/s41422-018-0078-7. Epub 2018 Aug 14. Review.


Empagliflozin and the Prevention of Heart Failure: Will Reverse Translation Lead to New Paradigms for the Treatment of Heart Failure?

Mann DL, Kelly DP.

JACC Basic Transl Sci. 2017 Aug 4;2(4):355-357. doi: 10.1016/j.jacbts.2017.07.004. eCollection 2017 Aug. No abstract available.


Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism.

Sokhadze EM, Lamina EV, Casanova EL, Kelly DP, Opris I, Tasman A, Casanova MF.

Front Syst Neurosci. 2018 May 28;12:20. doi: 10.3389/fnsys.2018.00020. eCollection 2018.


A Cohort Study Comparing Women with Autism Spectrum Disorder with and without Generalized Joint Hypermobility.

Casanova EL, Sharp JL, Edelson SM, Kelly DP, Casanova MF.

Behav Sci (Basel). 2018 Mar 17;8(3). pii: E35. doi: 10.3390/bs8030035.


Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice.

Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1313-1322. doi: 10.1093/gerona/gly051.


Atypical Processing of Novel Distracters in a Visual Oddball Task in Autism Spectrum Disorder.

Sokhadze EM, Lamina EV, Casanova EL, Kelly DP, Opris I, Khachidze I, Casanova MF.

Behav Sci (Basel). 2017 Nov 16;7(4). pii: E79. doi: 10.3390/bs7040079.


A Review of Hologram Storage and Self-Written Waveguides Formation in Photopolymer Media.

Malallah R, Li H, Kelly DP, Healy JJ, Sheridan JT.

Polymers (Basel). 2017 Aug 3;9(8). pii: E337. doi: 10.3390/polym9080337. Review.


Combination Clearance Therapy and Barbiturate Coma for Severe Carbamazepine Overdose.

Agulnik A, Kelly DP, Bruccoleri R, Yuskaitis C, Ebrahimi-Fakhari D, Sahin M, Burns MM, Kohane DS.

Pediatrics. 2017 May;139(5). pii: e20161560. doi: 10.1542/peds.2016-1560.


Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.

Vega RB, Konhilas JP, Kelly DP, Leinwand LA.

Cell Metab. 2017 May 2;25(5):1012-1026. doi: 10.1016/j.cmet.2017.04.025. Review.


Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.

Lee S, Leone TC, Rogosa L, Rumsey J, Ayala J, Coen PM, Fitts RH, Vega RB, Kelly DP.

Am J Physiol Endocrinol Metab. 2017 May 1;312(5):E394-E406. doi: 10.1152/ajpendo.00380.2016. Epub 2017 Mar 7.


Cardiac nuclear receptors: architects of mitochondrial structure and function.

Vega RB, Kelly DP.

J Clin Invest. 2017 Apr 3;127(4):1155-1164. doi: 10.1172/JCI88888. Epub 2017 Feb 13. Review.


Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle.

Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z.

J Biol Chem. 2016 Dec 2;291(49):25306-25318. Epub 2016 Oct 13.


Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness.

Muszynski JA, Spinella PC, Cholette JM, Acker JP, Hall MW, Juffermans NP, Kelly DP, Blumberg N, Nicol K, Liedel J, Doctor A, Remy KE, Tucci M, Lacroix J, Norris PJ; Pediatric Critical Care Blood Research Network (Blood Net).

Transfusion. 2017 Jan;57(1):195-206. doi: 10.1111/trf.13855. Epub 2016 Oct 2. Review.


Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit.

Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z.

EMBO Mol Med. 2016 Oct 4;8(10):1212-1228. doi: 10.15252/emmm.201606372. Print 2016 Oct.


MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.

Ahn B, Soundarapandian MM, Sessions H, Peddibhotla S, Roth GP, Li JL, Sugarman E, Koo A, Malany S, Wang M, Yea K, Brooks J, Leone TC, Han X, Vega RB, Kelly DP.

J Clin Invest. 2016 Sep 1;126(9):3567-79. doi: 10.1172/JCI87382. Epub 2016 Aug 8.


Quality improvement program reduces venous thromboembolism in infants and children with long-gap esophageal atresia (LGEA).

Kelly DP, Bairdain S, Zurakowski D, Dodson B, Harney KM, Jennings RW, Trenor CC.

Pediatr Surg Int. 2016 Jul;32(7):691-6. doi: 10.1007/s00383-016-3902-5. Epub 2016 Jun 4.


Mitochondrial protein hyperacetylation in the failing heart.

Horton JL, Martin OJ, Lai L, Riley NM, Richards AL, Vega RB, Leone TC, Pagliarini DJ, Muoio DM, Bedi KC Jr, Margulies KB, Coon JJ, Kelly DP.

JCI Insight. 2016 Feb;2(1). pii: e84897. Epub 2016 Feb 25.


Introducing JACC: Basic to Translational Science: Why Now?

Mann DL, Annex BH, Bishopric NH, Force T, Kelly DP, Libby P, Roberts R, van Rooij E, Tomaselli G, Newby LK.

JACC Basic Transl Sci. 2016 Feb 15;1(1-2):1-2. doi: 10.1016/j.jacbts.2016.01.001. eCollection 2016 Jan-Feb. No abstract available.


The Failing Heart Relies on Ketone Bodies as a Fuel.

Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP.

Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Erratum in: Circulation. 2018 Oct 9;138(15):e422.


Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice.

Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd.

Science. 2015 Dec 4;350(6265):aad2459. doi: 10.1126/science.aad2459. Epub 2015 Dec 3.


Mitochondrial biogenesis and dynamics in the developing and diseased heart.

Dorn GW 2nd, Vega RB, Kelly DP.

Genes Dev. 2015 Oct 1;29(19):1981-91. doi: 10.1101/gad.269894.115. Review.


Fresnel transform as a projection onto a Nijboer-Zernike basis set.

Wu Y, Hillenbrand M, Zhao L, Sinzinger S, Kelly DP.

Opt Lett. 2015 Aug 1;40(15):3472-5. doi: 10.1364/OL.40.003472.


Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK.

J Clin Invest. 2015 Sep;125(9):3461-76. doi: 10.1172/JCI79964. Epub 2015 Aug 4.


Maintaining ancient organelles: mitochondrial biogenesis and maturation.

Vega RB, Horton JL, Kelly DP.

Circ Res. 2015 May 22;116(11):1820-34. doi: 10.1161/CIRCRESAHA.116.305420. Review.


PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.

Ciron C, Zheng L, Bobela W, Knott GW, Leone TC, Kelly DP, Schneider BL.

Acta Neuropathol Commun. 2015 Apr 1;3:16. doi: 10.1186/s40478-015-0200-8.


Inhibitors of Myocyte Triacylglyceride Accumulation.

Hershberger PM, Sugarman E, Maloney P, Peddibhotla S, Koo A, Suyama E, Ruidiaz ME, Heynen-Genel S, Nguyen KH, Vasile S, Mangravita-Novo A, Smith LH, Soundarapandian MM, Salaniwal S, Kung P, Vega RB, Chung TDY, Pinkerton AB, Malany S, Kelly DP.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Dec 15 [updated 2015 Feb 11].


Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure.

Weinheimer CJ, Lai L, Kelly DP, Kovacs A.

Clin Exp Pharmacol Physiol. 2015 Jan;42(1):33-40. doi: 10.1111/1440-1681.12318.


Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach.

Lai L, Leone TC, Keller MP, Martin OJ, Broman AT, Nigro J, Kapoor K, Koves TR, Stevens R, Ilkayeva OR, Vega RB, Attie AD, Muoio DM, Kelly DP.

Circ Heart Fail. 2014 Nov;7(6):1022-31. doi: 10.1161/CIRCHEARTFAILURE.114.001469. Epub 2014 Sep 18.


Numerical solution of nonparaxial scalar diffraction integrals for focused fields.

Hillenbrand M, Kelly DP, Sinzinger S.

J Opt Soc Am A Opt Image Sci Vis. 2014 Aug 1;31(8):1832-41. doi: 10.1364/JOSAA.31.001832.


Mitochondrial function in melanoma.

Theodosakis N, Micevic G, Kelly DP, Bosenberg M.

Arch Biochem Biophys. 2014 Dec 1;563:56-9. doi: 10.1016/ Epub 2014 Jul 2. Review.


Fast nonparaxial scalar focal field calculations.

Hillenbrand M, Hoffmann A, Kelly DP, Sinzinger S.

J Opt Soc Am A Opt Image Sci Vis. 2014 Jun 1;31(6):1206-14. doi: 10.1364/JOSAA.31.001206.


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