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Items: 1 to 50 of 167

1.

Correction to: African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.

Fan S, Kelly DE, Beltrame MH, Hansen MEB, Mallick S, Ranciaro A, Hirbo J, Thompson S, Beggs W, Nyambo T, Omar SA, Meskel DW, Belay G, Froment A, Patterson N, Reich D, Tishkoff SA.

Genome Biol. 2019 Oct 9;20(1):204. doi: 10.1186/s13059-019-1821-1.

2.

Isavuconazole and voriconazole inhibition of sterol 14α-demethylases (CYP51) from Aspergillus fumigatus and Homo sapiens.

Warrilow AGS, Parker JE, Price CL, Rolley NJ, Nes WD, Kelly DE, Kelly SL.

Int J Antimicrob Agents. 2019 Oct;54(4):449-455. doi: 10.1016/j.ijantimicag.2019.07.011. Epub 2019 Jul 13.

PMID:
31310805
3.

NanoRefinery of carbonaceous nanomaterials: Complementing dairy manure gasification and their applications in cellular imaging and heavy metal sensing.

Plácido J, Bustamante-López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Nov 1;689:10-20. doi: 10.1016/j.scitotenv.2019.06.390. Epub 2019 Jun 25.

PMID:
31260895
4.

Multivariate analysis of biochar-derived carbonaceous nanomaterials for detection of heavy metal ions in aqueous systems.

Plácido J, Bustamante López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Oct 20;688:751-761. doi: 10.1016/j.scitotenv.2019.06.342. Epub 2019 Jun 24.

PMID:
31255813
5.

African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.

Fan S, Kelly DE, Beltrame MH, Hansen MEB, Mallick S, Ranciaro A, Hirbo J, Thompson S, Beggs W, Nyambo T, Omar SA, Meskel DW, Belay G, Froment A, Patterson N, Reich D, Tishkoff SA.

Genome Biol. 2019 Apr 26;20(1):82. doi: 10.1186/s13059-019-1679-2. Erratum in: Genome Biol. 2019 Oct 9;20(1):204.

6.

The Evolution of Azole Resistance in Candida albicans Sterol 14α-Demethylase (CYP51) through Incremental Amino Acid Substitutions.

Warrilow AG, Nishimoto AT, Parker JE, Price CL, Flowers SA, Kelly DE, Rogers PD, Kelly SL.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02586-18. doi: 10.1128/AAC.02586-18. Print 2019 May.

7.

Microalgae biochar-derived carbon dots and their application in heavy metal sensing in aqueous systems.

Plácido J, Bustamante-López S, Meissner KE, Kelly DE, Kelly SL.

Sci Total Environ. 2019 Mar 15;656:531-539. doi: 10.1016/j.scitotenv.2018.11.393. Epub 2018 Nov 27.

PMID:
30529956
8.

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.

Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22.

9.

Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.

Zhou W, Warrilow AGS, Thomas CD, Ramos E, Parker JE, Price CL, Vanderloop BH, Fisher PM, Loftis MD, Kelly DE, Kelly SL, Nes WD.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct;1863(10):1164-1178. doi: 10.1016/j.bbalip.2018.07.004. Epub 2018 Jul 22.

10.

In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.

Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May.

11.

Azole sensitivity in Leptosphaeria pathogens of oilseed rape: the role of lanosterol 14α-demethylase.

Sewell TR, Hawkins NJ, Stotz HU, Huang Y, Kelly SL, Kelly DE, Fraaije B, Fitt BDL.

Sci Rep. 2017 Nov 20;7(1):15849. doi: 10.1038/s41598-017-15545-9.

12.

Loci associated with skin pigmentation identified in African populations.

Crawford NG, Kelly DE, Hansen MEB, Beltrame MH, Fan S, Bowman SL, Jewett E, Ranciaro A, Thompson S, Lo Y, Pfeifer SP, Jensen JD, Campbell MC, Beggs W, Hormozdiari F, Mpoloka SW, Mokone GG, Nyambo T, Meskel DW, Belay G, Haut J; NISC Comparative Sequencing Program, Rothschild H, Zon L, Zhou Y, Kovacs MA, Xu M, Zhang T, Bishop K, Sinclair J, Rivas C, Elliot E, Choi J, Li SA, Hicks B, Burgess S, Abnet C, Watkins-Chow DE, Oceana E, Song YS, Eskin E, Brown KM, Marks MS, Loftus SK, Pavan WJ, Yeager M, Chanock S, Tishkoff SA.

Science. 2017 Nov 17;358(6365). pii: eaan8433. doi: 10.1126/science.aan8433. Epub 2017 Oct 12.

13.

Co-production of 11α-hydroxyprogesterone and ethanol using recombinant yeast expressing fungal steroid hydroxylases.

Hull CM, Warrilow AGS, Rolley NJ, Price CL, Donnison IS, Kelly DE, Kelly SL.

Biotechnol Biofuels. 2017 Sep 29;10:226. doi: 10.1186/s13068-017-0904-z. eCollection 2017.

14.

Global variation in gene expression and the value of diverse sampling.

Kelly DE, Hansen MEB, Tishkoff SA.

Curr Opin Syst Biol. 2017 Feb;1:102-108. doi: 10.1016/j.coisb.2016.12.018. Epub 2017 Mar 3.

15.

The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.

Warrilow AGS, Parker JE, Price CL, Garvey EP, Hoekstra WJ, Schotzinger RJ, Wiederhold NP, Nes WD, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00333-17. doi: 10.1128/AAC.00333-17. Print 2017 Jul.

16.

In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.

Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G.

Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May.

17.

Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa.

Warrilow AG, Price CL, Parker JE, Rolley NJ, Smyrniotis CJ, Hughes DD, Thoss V, Nes WD, Kelly DE, Holman TR, Kelly SL.

Sci Rep. 2016 Jun 13;6:27690. doi: 10.1038/srep27690.

18.

The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.

Warrilow AG, Parker JE, Price CL, Nes WD, Garvey EP, Hoekstra WJ, Schotzinger RJ, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4530-8. doi: 10.1128/AAC.00349-16. Print 2016 Aug.

19.

In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus.

Warrilow AG, Parker JE, Price CL, Nes WD, Kelly SL, Kelly DE.

Antimicrob Agents Chemother. 2015 Dec;59(12):7771-8. doi: 10.1128/AAC.01806-15. Epub 2015 Oct 12.

20.

Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51).

Lamb DC, Warrilow AG, Rolley NJ, Parker JE, Nes WD, Smith SN, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2015 Aug;59(8):4707-13. doi: 10.1128/AAC.00476-15. Epub 2015 May 26.

21.

Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens.

Price CL, Parker JE, Warrilow AG, Kelly DE, Kelly SL.

Pest Manag Sci. 2015 Aug;71(8):1054-8. doi: 10.1002/ps.4029. Epub 2015 May 20. Review.

PMID:
25914201
22.

Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.

Price CL, Warrilow AG, Parker JE, Mullins JG, Nes WD, Kelly DE, Kelly SL.

Appl Environ Microbiol. 2015 May 15;81(10):3379-86. doi: 10.1128/AEM.03965-14. Epub 2015 Mar 6.

23.

Use of 70% alcohol for the routine removal of microbial hard surface bioburden in life science cleanrooms.

Salvage R, Hull CM, Kelly DE, Kelly SL.

Future Microbiol. 2014;9(10):1123-30. doi: 10.2217/fmb.14.73.

PMID:
25405882
24.

Co-production of bioethanol and probiotic yeast biomass from agricultural feedstock: application of the rural biorefinery concept.

Hull CM, Loveridge EJ, Donnison IS, Kelly DE, Kelly SL.

AMB Express. 2014 Sep 1;4:64. doi: 10.1186/s13568-014-0064-5. eCollection 2014.

25.

Resistance to antifungals that target CYP51.

Parker JE, Warrilow AG, Price CL, Mullins JG, Kelly DE, Kelly SL.

J Chem Biol. 2014 Aug 27;7(4):143-61. doi: 10.1007/s12154-014-0121-1. eCollection 2014 Oct. Review.

26.

Co-production of ethanol and squalene using a Saccharomyces cerevisiae ERG1 (squalene epoxidase) mutant and agro-industrial feedstock.

Hull CM, Loveridge EJ, Rolley NJ, Donnison IS, Kelly SL, Kelly DE.

Biotechnol Biofuels. 2014 Sep 24;7(1):133. doi: 10.1186/s13068-014-0133-7. eCollection 2014.

27.

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.

Warrilow AG, Hull CM, Parker JE, Garvey EP, Hoekstra WJ, Moore WR, Schotzinger RJ, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. doi: 10.1128/AAC.03707-14. Epub 2014 Sep 15.

28.

Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51).

Warrilow AG, Hull CM, Rolley NJ, Parker JE, Nes WD, Smith SN, Kelly DE, Kelly SL.

Appl Environ Microbiol. 2014 Oct;80(19):6154-66. doi: 10.1128/AEM.01195-14. Epub 2014 Aug 1.

29.

Paralog re-emergence: a novel, historically contingent mechanism in the evolution of antimicrobial resistance.

Hawkins NJ, Cools HJ, Sierotzki H, Shaw MW, Knogge W, Kelly SL, Kelly DE, Fraaije BA.

Mol Biol Evol. 2014 Jul;31(7):1793-802. doi: 10.1093/molbev/msu134. Epub 2014 Apr 14.

30.

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

Hoobler EK, Rai G, Warrilow AG, Perry SC, Smyrniotis CJ, Jadhav A, Simeonov A, Parker JE, Kelly DE, Maloney DJ, Kelly SL, Holman TR.

PLoS One. 2013 Jun 24;8(6):e65928. doi: 10.1371/journal.pone.0065928. Print 2013.

31.

The cytochrome P450 complement (CYPome) of Mycosphaerella graminicola.

Newsome AW, Nelson D, Corran A, Kelly SL, Kelly DE.

Biotechnol Appl Biochem. 2013 Jan-Feb;60(1):52-64. doi: 10.1002/bab.1062. Epub 2013 Jan 25.

PMID:
23586992
32.

Microbial cytochromes P450: biodiversity and biotechnology. Where do cytochromes P450 come from, what do they do and what can they do for us?

Kelly SL, Kelly DE.

Philos Trans R Soc Lond B Biol Sci. 2013 Jan 6;368(1612):20120476. doi: 10.1098/rstb.2012.0476. Print 2013 Feb 19. Review.

33.

Prothioconazole and prothioconazole-desthio activities against Candida albicans sterol 14-α-demethylase.

Parker JE, Warrilow AG, Cools HJ, Fraaije BA, Lucas JA, Rigdova K, Griffiths WJ, Kelly DE, Kelly SL.

Appl Environ Microbiol. 2013 Mar;79(5):1639-45. doi: 10.1128/AEM.03246-12. Epub 2012 Dec 28.

34.

Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.

Warrilow AG, Parker JE, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2013 Mar;57(3):1352-60. doi: 10.1128/AAC.02067-12. Epub 2012 Dec 28.

35.

Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2.

Hull CM, Bader O, Parker JE, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2012 Dec;56(12):6417-21. doi: 10.1128/AAC.01145-12. Epub 2012 Oct 1.

36.

Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.

Hull CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2012 Aug;56(8):4223-32. doi: 10.1128/AAC.06253-11. Epub 2012 May 21.

37.

S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

Warrilow AG, Mullins JG, Hull CM, Parker JE, Lamb DC, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2012 Apr;56(4):2099-107. doi: 10.1128/AAC.05389-11. Epub 2012 Jan 17.

38.

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.

Mullins JG, Parker JE, Cools HJ, Togawa RC, Lucas JA, Fraaije BA, Kelly DE, Kelly SL.

PLoS One. 2011;6(6):e20973. doi: 10.1371/journal.pone.0020973. Epub 2011 Jun 27.

39.

Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity.

Cools HJ, Mullins JG, Fraaije BA, Parker JE, Kelly DE, Lucas JA, Kelly SL.

Appl Environ Microbiol. 2011 Jun;77(11):3830-7. doi: 10.1128/AEM.00027-11. Epub 2011 Apr 8.

40.

Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals.

Parker JE, Warrilow AG, Cools HJ, Martel CM, Nes WD, Fraaije BA, Lucas JA, Kelly DE, Kelly SL.

Appl Environ Microbiol. 2011 Feb;77(4):1460-5. doi: 10.1128/AEM.01332-10. Epub 2010 Dec 17.

41.

Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol.

Martel CM, Parker JE, Jackson CJ, Warrilow AG, Rolley N, Greig C, Morris SM, Donnison IS, Kelly DE, Kelly SL.

Bioresour Technol. 2011 Jan;102(2):1503-8. doi: 10.1016/j.biortech.2010.07.099. Epub 2010 Jul 29.

PMID:
20801645
42.

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.

Martel CM, Parker JE, Warrilow AG, Rolley NJ, Kelly SL, Kelly DE.

Antimicrob Agents Chemother. 2010 Nov;54(11):4920-3. doi: 10.1128/AAC.00349-10. Epub 2010 Aug 23.

43.

Identification and characterization of four azole-resistant erg3 mutants of Candida albicans.

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Rolley N, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2010 Nov;54(11):4527-33. doi: 10.1128/AAC.00348-10. Epub 2010 Aug 23.

44.

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

Warrilow AG, Melo N, Martel CM, Parker JE, Nes WD, Kelly SL, Kelly DE.

Antimicrob Agents Chemother. 2010 Oct;54(10):4225-34. doi: 10.1128/AAC.00316-10. Epub 2010 Jul 26.

45.

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

Warrilow AG, Martel CM, Parker JE, Melo N, Lamb DC, Nes WD, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2010 Oct;54(10):4235-45. doi: 10.1128/AAC.00587-10. Epub 2010 Jul 12.

46.

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2010 Sep;54(9):3578-83. doi: 10.1128/AAC.00303-10. Epub 2010 Jun 14.

47.

Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function.

Cools HJ, Parker JE, Kelly DE, Lucas JA, Fraaije BA, Kelly SL.

Appl Environ Microbiol. 2010 May;76(9):2866-72. doi: 10.1128/AEM.02158-09. Epub 2010 Mar 19.

48.

Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans.

Martel CM, Warrilow AG, Jackson CJ, Mullins JG, Togawa RC, Parker JE, Morris MS, Donnison IS, Kelly DE, Kelly SL.

Bioresour Technol. 2010 Jun;101(12):4395-402. doi: 10.1016/j.biortech.2010.01.084. Epub 2010 Feb 12.

PMID:
20153640
49.

The 2008 update of the Aspergillus nidulans genome annotation: a community effort.

Wortman JR, Gilsenan JM, Joardar V, Deegan J, Clutterbuck J, Andersen MR, Archer D, Bencina M, Braus G, Coutinho P, von Döhren H, Doonan J, Driessen AJ, Durek P, Espeso E, Fekete E, Flipphi M, Estrada CG, Geysens S, Goldman G, de Groot PW, Hansen K, Harris SD, Heinekamp T, Helmstaedt K, Henrissat B, Hofmann G, Homan T, Horio T, Horiuchi H, James S, Jones M, Karaffa L, Karányi Z, Kato M, Keller N, Kelly DE, Kiel JA, Kim JM, van der Klei IJ, Klis FM, Kovalchuk A, Krasevec N, Kubicek CP, Liu B, Maccabe A, Meyer V, Mirabito P, Miskei M, Mos M, Mullins J, Nelson DR, Nielsen J, Oakley BR, Osmani SA, Pakula T, Paszewski A, Paulsen I, Pilsyk S, Pócsi I, Punt PJ, Ram AF, Ren Q, Robellet X, Robson G, Seiboth B, van Solingen P, Specht T, Sun J, Taheri-Talesh N, Takeshita N, Ussery D, vanKuyk PA, Visser H, van de Vondervoort PJ, de Vries RP, Walton J, Xiang X, Xiong Y, Zeng AP, Brandt BW, Cornell MJ, van den Hondel CA, Visser J, Oliver SG, Turner G.

Fungal Genet Biol. 2009 Mar;46 Suppl 1:S2-13. doi: 10.1016/j.fgb.2008.12.003. Epub 2008 Dec 25.

50.

Identification, characterization, and azole-binding properties of Mycobacterium smegmatis CYP164A2, a homolog of ML2088, the sole cytochrome P450 gene of Mycobacterium leprae.

Warrilow AG, Jackson CJ, Parker JE, Marczylo TH, Kelly DE, Lamb DC, Kelly SL.

Antimicrob Agents Chemother. 2009 Mar;53(3):1157-64. doi: 10.1128/AAC.01237-08. Epub 2008 Dec 15.

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