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Items: 1 to 50 of 71

1.

Assembly of B4GALT1/ST6GAL1 heteromers in the Golgi membranes involves lateral interactions via highly charged surface domains.

Khoder-Agha F, Harrus D, Brysbaert G, Lensink MF, Harduin-Lepers A, Glumoff T, Kellokumpu S.

J Biol Chem. 2019 Aug 8. pii: jbc.RA119.009539. doi: 10.1074/jbc.RA119.009539. [Epub ahead of print]

2.

Golgi pH, Ion and Redox Homeostasis: How Much Do They Really Matter?

Kellokumpu S.

Front Cell Dev Biol. 2019 Jun 11;7:93. doi: 10.3389/fcell.2019.00093. eCollection 2019.

3.

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T.

Cancer Res. 2019 Aug 15;79(16):4042-4056. doi: 10.1158/0008-5472.CAN-18-3852. Epub 2019 May 29.

PMID:
31142511
4.

A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I.

Hassinen A, Khoder-Agha F, Khosrowabadi E, Mennerich D, Harrus D, Noel M, Dimova EY, Glumoff T, Harduin-Lepers A, Kietzmann T, Kellokumpu S.

Redox Biol. 2019 Jun;24:101182. doi: 10.1016/j.redox.2019.101182. Epub 2019 Apr 4.

5.

N-acetylglucosaminyltransferases and nucleotide sugar transporters form multi-enzyme-multi-transporter assemblies in golgi membranes in vivo.

Khoder-Agha F, Sosicka P, Escriva Conde M, Hassinen A, Glumoff T, Olczak M, Kellokumpu S.

Cell Mol Life Sci. 2019 May;76(9):1821-1832. doi: 10.1007/s00018-019-03032-5. Epub 2019 Feb 8.

6.

The dimeric structure of wild-type human glycosyltransferase B4GalT1.

Harrus D, Khoder-Agha F, Peltoniemi M, Hassinen A, Ruddock L, Kellokumpu S, Glumoff T.

PLoS One. 2018 Oct 23;13(10):e0205571. doi: 10.1371/journal.pone.0205571. eCollection 2018.

7.

LTCC Packaged Ring Oscillator Based Sensor for Evaluation of Cell Proliferation.

Kilpijärvi J, Halonen N, Sobocinski M, Hassinen A, Senevirathna B, Uvdal K, Abshire P, Smela E, Kellokumpu S, Juuti J, Lloyd Spetz A.

Sensors (Basel). 2018 Oct 7;18(10). pii: E3346. doi: 10.3390/s18103346.

8.

Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.

Tykesson E, Hassinen A, Zielinska K, Thelin MA, Frati G, Ellervik U, Westergren-Thorsson G, Malmström A, Kellokumpu S, Maccarana M.

J Biol Chem. 2018 Aug 31;293(35):13725-13735. doi: 10.1074/jbc.RA118.003875. Epub 2018 Jul 5.

PMID:
29976758
9.

Hypoxia and Reactive Oxygen Species as Modulators of Endoplasmic Reticulum and Golgi Homeostasis.

Mennerich D, Kellokumpu S, Kietzmann T.

Antioxid Redox Signal. 2019 Jan 1;30(1):113-137. doi: 10.1089/ars.2018.7523. Epub 2018 Jun 5.

PMID:
29717631
10.

Publisher Correction: Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.

Benedetti E, Pučić-Baković M, Keser T, Wahl A, Hassinen A, Yang JY, Liu L, Trbojević-Akmačić I, Razdorov G, Štambuk J, Klarić L, Ugrina I, Selman MHJ, Wuhrer M, Rudan I, Polasek O, Hayward C, Grallert H, Strauch K, Peters A, Meitinger T, Gieger C, Vilaj M, Boons GJ, Moremen KW, Ovchinnikova T, Bovin N, Kellokumpu S, Theis FJ, Lauc G, Krumsiek J.

Nat Commun. 2018 Feb 13;9(1):706. doi: 10.1038/s41467-017-02379-2.

11.

Abnormal Golgi pH Homeostasis in Cancer Cells Impairs Apical Targeting of Carcinoembryonic Antigen by Inhibiting Its Glycosyl-Phosphatidylinositol Anchor-Mediated Association with Lipid Rafts.

Kokkonen N, Khosrowabadi E, Hassinen A, Harrus D, Glumoff T, Kietzmann T, Kellokumpu S.

Antioxid Redox Signal. 2019 Jan 1;30(1):5-21. doi: 10.1089/ars.2017.7389. Epub 2018 Feb 12.

12.

Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.

Benedetti E, Pučić-Baković M, Keser T, Wahl A, Hassinen A, Yang JY, Liu L, Trbojević-Akmačić I, Razdorov G, Štambuk J, Klarić L, Ugrina I, Selman MHJ, Wuhrer M, Rudan I, Polasek O, Hayward C, Grallert H, Strauch K, Peters A, Meitinger T, Gieger C, Vilaj M, Boons GJ, Moremen KW, Ovchinnikova T, Bovin N, Kellokumpu S, Theis FJ, Lauc G, Krumsiek J.

Nat Commun. 2017 Nov 14;8(1):1483. doi: 10.1038/s41467-017-01525-0. Erratum in: Nat Commun. 2018 Feb 13;9(1):706.

13.

Crystal structures of eukaryote glycosyltransferases reveal biologically relevant enzyme homooligomers.

Harrus D, Kellokumpu S, Glumoff T.

Cell Mol Life Sci. 2018 Mar;75(5):833-848. doi: 10.1007/s00018-017-2659-x. Epub 2017 Sep 20. Review.

PMID:
28932871
14.

Low temperature co-fired ceramic packaging of CMOS capacitive sensor chip towards cell viability monitoring.

Halonen N, Kilpijärvi J, Sobocinski M, Datta-Chaudhuri T, Hassinen A, Prakash SB, Möller P, Abshire P, Kellokumpu S, Lloyd Spetz A.

Beilstein J Nanotechnol. 2016 Nov 29;7:1871-1877. doi: 10.3762/bjnano.7.179. eCollection 2016.

15.

UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.

Deen AJ, Arasu UT, Pasonen-Seppänen S, Hassinen A, Takabe P, Wojciechowski S, Kärnä R, Rilla K, Kellokumpu S, Tammi R, Tammi M, Oikari S.

Cell Mol Life Sci. 2016 Aug;73(16):3183-204. doi: 10.1007/s00018-016-2158-5. Epub 2016 Feb 16.

PMID:
26883802
16.

Glycosyltransferase complexes in eukaryotes: long-known, prevalent but still unrecognized.

Kellokumpu S, Hassinen A, Glumoff T.

Cell Mol Life Sci. 2016 Jan;73(2):305-25. doi: 10.1007/s00018-015-2066-0. Epub 2015 Oct 17. Review.

PMID:
26474840
17.

GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain.

Huang HH, Hassinen A, Sundaram S, Spiess AN, Kellokumpu S, Stanley P.

Elife. 2015 Sep 15;4. doi: 10.7554/eLife.08916.

18.

Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3.

Bart G, Vico NO, Hassinen A, Pujol FM, Deen AJ, Ruusala A, Tammi RH, Squire A, Heldin P, Kellokumpu S, Tammi MI.

J Biol Chem. 2015 May 1;290(18):11479-90. doi: 10.1074/jbc.M115.640581. Epub 2015 Mar 20.

19.

Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus.

Hartmann-Fatu C, Trusch F, Moll CN, Michin I, Hassinen A, Kellokumpu S, Bayer P.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1404-1412. doi: 10.1016/j.jmb.2015.01.021. Epub 2015 Feb 7.

PMID:
25660941
20.

Comparison of laparoscopic and open colonic resection within fast-track and traditional perioperative care pathways: Clinical outcomes and in-hospital costs.

Ehrlich A, Kellokumpu S, Wagner B, Kautiainen H, Kellokumpu I.

Scand J Surg. 2015 Dec;104(4):211-8. doi: 10.1177/1457496914557016. Epub 2014 Nov 10.

PMID:
25384909
21.

Organizational interplay of Golgi N-glycosyltransferases involves organelle microenvironment-dependent transitions between enzyme homo- and heteromers.

Hassinen A, Kellokumpu S.

J Biol Chem. 2014 Sep 26;289(39):26937-48. doi: 10.1074/jbc.M114.595058. Epub 2014 Aug 18.

22.

Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence.

Samoylenko A, Hossain JA, Mennerich D, Kellokumpu S, Hiltunen JK, Kietzmann T.

Antioxid Redox Signal. 2013 Dec 10;19(17):2157-96. doi: 10.1089/ars.2012.4662. Epub 2013 Apr 15. Review.

23.

Functional organization of Golgi N- and O-glycosylation pathways involves pH-dependent complex formation that is impaired in cancer cells.

Hassinen A, Pujol FM, Kokkonen N, Pieters C, Kihlström M, Korhonen K, Kellokumpu S.

J Biol Chem. 2011 Nov 4;286(44):38329-40. doi: 10.1074/jbc.M111.277681. Epub 2011 Sep 12.

24.

Golgi pH, its regulation and roles in human disease.

Rivinoja A, Pujol FM, Hassinen A, Kellokumpu S.

Ann Med. 2012 Sep;44(6):542-54. doi: 10.3109/07853890.2011.579150. Epub 2011 May 17. Review.

PMID:
21585247
25.

Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.

Hassinen A, Rivinoja A, Kauppila A, Kellokumpu S.

J Biol Chem. 2010 Jun 4;285(23):17771-7. doi: 10.1074/jbc.M110.103184. Epub 2010 Apr 8.

26.

Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria.

Jansen ID, Mardones P, Lecanda F, de Vries TJ, Recalde S, Hoeben KA, Schoenmaker T, Ravesloot JH, van Borren MM, van Eijden TM, Bronckers AL, Kellokumpu S, Medina JF, Everts V, Oude Elferink RP.

FASEB J. 2009 Oct;23(10):3470-81. doi: 10.1096/fj.08-122598. Epub 2009 Jun 29.

PMID:
19564250
27.

Elevated Golgi pH impairs terminal N-glycosylation by inducing mislocalization of Golgi glycosyltransferases.

Rivinoja A, Hassinen A, Kokkonen N, Kauppila A, Kellokumpu S.

J Cell Physiol. 2009 Jul;220(1):144-54. doi: 10.1002/jcp.21744.

PMID:
19277980
28.

Localization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodents.

Bronckers AL, Lyaruu DM, Jansen ID, Medina JF, Kellokumpu S, Hoeben KA, Gawenis LR, Oude-Elferink RP, Everts V.

J Exp Zool B Mol Dev Evol. 2009 Jun 15;312B(4):375-87. doi: 10.1002/jez.b.21267.

29.

The anion exchanger Ae2 is required for enamel maturation in mouse teeth.

Lyaruu DM, Bronckers AL, Mulder L, Mardones P, Medina JF, Kellokumpu S, Oude Elferink RP, Everts V.

Matrix Biol. 2008 Mar;27(2):119-27. Epub 2007 Oct 11.

30.

Hypoxia upregulates carcinoembryonic antigen expression in cancer cells.

Kokkonen N, Ulibarri IF, Kauppila A, Luosujärvi H, Rivinoja A, Pospiech H, Kellokumpu I, Kellokumpu S.

Int J Cancer. 2007 Dec 1;121(11):2443-50.

31.

ERp27, a new non-catalytic endoplasmic reticulum-located human protein disulfide isomerase family member, interacts with ERp57.

Alanen HI, Williamson RA, Howard MJ, Hatahet FS, Salo KE, Kauppila A, Kellokumpu S, Ruddock LW.

J Biol Chem. 2006 Nov 3;281(44):33727-38. Epub 2006 Aug 28.

32.

Elevated Golgi pH in breast and colorectal cancer cells correlates with the expression of oncofetal carbohydrate T-antigen.

Rivinoja A, Kokkonen N, Kellokumpu I, Kellokumpu S.

J Cell Physiol. 2006 Jul;208(1):167-74.

PMID:
16547942
33.

Defective acidification of intracellular organelles results in aberrant secretion of cathepsin D in cancer cells.

Kokkonen N, Rivinoja A, Kauppila A, Suokas M, Kellokumpu I, Kellokumpu S.

J Biol Chem. 2004 Sep 17;279(38):39982-8. Epub 2004 Jul 16.

34.

Comparison of a peanut agglutinin test and an immunochemical faecal occult blood test in detecting colorectal neoplasia in symptomatic patients.

Vironen J, Kellokumpu S, Andersson LC, Kellokumpu I.

Scand J Clin Lab Invest. 2004 Apr;64(2):140-5.

PMID:
15115252
35.

The AE2 anion exchanger is necessary for the structural integrity of the Golgi apparatus in mammalian cells.

Holappa K, Muñoz MT, Egea G, Kellokumpu S.

FEBS Lett. 2004 Apr 23;564(1-2):97-103.

37.

Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member.

Alanen HI, Williamson RA, Howard MJ, Lappi AK, Jäntti HP, Rautio SM, Kellokumpu S, Ruddock LW.

J Biol Chem. 2003 Aug 1;278(31):28912-20. Epub 2003 May 21.

38.

Retrieval-independent localization of lysyl hydroxylase in the endoplasmic reticulum via a peptide fold in its iron-binding domain.

Suokas M, Lampela O, Juffer AH, Myllylä R, Kellokumpu S.

Biochem J. 2003 Mar 15;370(Pt 3):913-20.

39.

Abnormal glycosylation and altered Golgi structure in colorectal cancer: dependence on intra-Golgi pH.

Kellokumpu S, Sormunen R, Kellokumpu I.

FEBS Lett. 2002 Apr 10;516(1-3):217-24.

40.

Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues.

Vaarala MH, Porvari KS, Kellokumpu S, Kyllönen AP, Vihko PT.

J Pathol. 2001 Jan;193(1):134-40.

PMID:
11169526
41.

Identification of the full-length AE2 (AE2a) isoform as the Golgi-associated anion exchanger in fibroblasts.

Holappa K, Suokas M, Soininen P, Kellokumpu S.

J Histochem Cytochem. 2001 Feb;49(2):259-69.

PMID:
11156694
42.
43.

Primary structure of a sperm cell anion exchanger and its messenger ribonucleic acid expression during spermatogenesis.

Holappa K, Mustonen M, Parvinen M, Vihko P, Rajaniemi H, Kellokumpu S.

Biol Reprod. 1999 Oct;61(4):981-6.

PMID:
10491633
44.

EAST, an epidermal growth factor receptor- and Eps15-associated protein with Src homology 3 and tyrosine-based activation motif domains.

Lohi O, Poussu A, Meriläinen J, Kellokumpu S, Wasenius VM, Lehto VP.

J Biol Chem. 1998 Aug 14;273(33):21408-15.

45.

Mouse 17 beta-hydroxysteroid dehydrogenase type 2 mRNA is predominantly expressed in hepatocytes and in surface epithelial cells of the gastrointestinal and urinary tracts.

Mustonen MV, Poutanen MH, Kellokumpu S, de Launoit Y, Isomaa VV, Vihko RK, Vihko PT.

J Mol Endocrinol. 1998 Feb;20(1):67-74.

PMID:
9513083
46.

A splice-site mutation that induces exon skipping and reduction in lysyl hydroxylase mRNA levels but does not create a nonsense codon in Ehlers-Danlos syndrome type VI.

Pajunen L, Suokas M, Hautala T, Kellokumpu S, Tebbe B, Kivirikko KI, Myllylä R.

DNA Cell Biol. 1998 Feb;17(2):117-23.

PMID:
9502428
47.

Detection of colorectal neoplasia with peanut-agglutinin (PNA)-reactive carbohydrate structures in rectal mucus.

Kellokumpu IH, Andersson LC, Kellokumpu SJ.

Int J Cancer. 1997 Dec 19;74(6):648-53.

48.
49.

Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium.

Parkkila S, Parkkila AK, Juvonen T, Waheed A, Sly WS, Saarnio J, Kaunisto K, Kellokumpu S, Rajaniemi H.

Hepatology. 1996 Nov;24(5):1104-8.

PMID:
8903383
50.

Defective maturation of a viral glycoprotein and partial loss of the Golgi stack structure during in vitro myogenesis.

Kellokumpu S, Sormunen R, Väänänen HK, Metsikkö K.

Exp Cell Res. 1995 Sep;220(1):101-11.

PMID:
7664827

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