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Items: 1 to 50 of 99

1.

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases.

Shatz W, Aaronson J, Yohe S, Kelley RF, Kalia YN.

Expert Opin Drug Deliv. 2018 Nov 29. doi: 10.1080/17425247.2019.1553953. [Epub ahead of print]

PMID:
30488721
2.

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches.

Loyet KM, Hass PE, Sandoval WN, Morando A, Liu P, Shatz W, Dickmann L, Kenrick M, Good J, Davancaze T, Morimoto AM, Kelley RF, Scheer JM.

Mol Pharm. 2019 Jan 7;16(1):86-95. doi: 10.1021/acs.molpharmaceut.8b00871. Epub 2018 Dec 3.

PMID:
30444371
3.

Protein engineering to increase the potential of a therapeutic antibody Fab for long-acting delivery to the eye.

Tesar D, Luoma J, Wyatt EA, Shi C, Shatz W, Hass PE, Mathieu M, Yi L, Corn JE, Maass KF, Wang K, Dion MZ, Andersen N, Loyet KM, van Lookeren Campagne M, Rajagopal K, Dickmann L, Scheer JM, Kelley RF.

MAbs. 2017 Nov/Dec;9(8):1297-1305. doi: 10.1080/19420862.2017.1372078. Epub 2017 Aug 30.

4.

Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates.

Dostalek M, Prueksaritanont T, Kelley RF.

MAbs. 2017 Jul;9(5):756-766. doi: 10.1080/19420862.2017.1323160. Epub 2017 May 2. Review.

5.

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

Shatz W, Hass PE, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DP, Maia M, Crowell SR, Dickmann L, Scheer JM, Kelley RF.

Mol Pharm. 2016 Sep 6;13(9):2996-3003. doi: 10.1021/acs.molpharmaceut.6b00345. Epub 2016 Jun 14.

PMID:
27244474
6.

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.

Gong Q, Hazen M, Marshall B, Crowell SR, Ou Q, Wong AW, Phung W, Vernes JM, Meng YG, Tejada M, Andersen D, Kelley RF.

MAbs. 2016 Aug-Sep;8(6):1098-106. doi: 10.1080/19420862.2016.1189049. Epub 2016 May 24.

7.

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.

Bumbaca Yadav D, Sharma VK, Boswell CA, Hotzel I, Tesar D, Shang Y, Ying Y, Fischer SK, Grogan JL, Chiang EY, Urban K, Ulufatu S, Khawli LA, Prabhu S, Joseph S, Kelley RF.

J Biol Chem. 2015 Dec 11;290(50):29732-41. doi: 10.1074/jbc.M115.692434. Epub 2015 Oct 21.

8.

Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions.

Pindrus M, Shire SJ, Kelley RF, Demeule B, Wong R, Xu Y, Yadav S.

Mol Pharm. 2015 Nov 2;12(11):3896-907. doi: 10.1021/acs.molpharmaceut.5b00336. Epub 2015 Oct 6.

PMID:
26407030
9.

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display.

Nair PM, Flores H, Gogineni A, Marsters S, Lawrence DA, Kelley RF, Ngu H, Sagolla M, Komuves L, Bourgon R, Settleman J, Ashkenazi A.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5679-84. doi: 10.1073/pnas.1418962112. Epub 2015 Apr 20.

10.

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF.

MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30.

11.

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability.

Sharma VK, Patapoff TW, Kabakoff B, Pai S, Hilario E, Zhang B, Li C, Borisov O, Kelley RF, Chorny I, Zhou JZ, Dill KA, Swartz TE.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18601-6. doi: 10.1073/pnas.1421779112. Epub 2014 Dec 15. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6719.

12.

Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation.

Gao X, Ji JA, Veeravalli K, Wang YJ, Zhang T, Mcgreevy W, Zheng K, Kelley RF, Laird MW, Liu J, Cromwell M.

J Pharm Sci. 2015 Feb;104(2):368-77. doi: 10.1002/jps.24136. Epub 2014 Aug 29.

PMID:
25175600
13.

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Leabman MK, Meng YG, Kelley RF, DeForge LE, Cowan KJ, Iyer S.

MAbs. 2013 Nov-Dec;5(6):896-903. doi: 10.4161/mabs.26436.

14.

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation.

Li B, Fouts AE, Stengel K, Luan P, Dillon M, Liang WC, Feierbach B, Kelley RF, Hötzel I.

MAbs. 2014 Mar-Apr;6(2):437-45. doi: 10.4161/mabs.27875. Epub 2014 Jan 16.

15.

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity.

Shatz W, Chung S, Li B, Marshall B, Tejada M, Phung W, Sandoval W, Kelley RF, Scheer JM.

MAbs. 2013 Nov-Dec;5(6):872-81. doi: 10.4161/mabs.26307. Epub 2013 Aug 29.

16.

Development and preclinical characterization of a humanized antibody targeting CXCL12.

Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N.

Clin Cancer Res. 2013 Aug 15;19(16):4433-45. doi: 10.1158/1078-0432.CCR-13-0943. Epub 2013 Jun 28.

17.

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF.

MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189.

18.

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG.

Wang X, Quarmby V, Ng C, Chuntharapai A, Shek T, Eigenbrot C, Kelley RF, Shia S, McCutcheon K, Lowe J, Leddy C, Coachman K, Cain G, Chu F, Hotzel I, Maia M, Wakshull E, Yang J.

MAbs. 2013 Jul-Aug;5(4):540-54. doi: 10.4161/mabs.24822. Epub 2013 Apr 29.

19.

Glycan shifting on hepatitis C virus (HCV) E2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.

Pantua H, Diao J, Ultsch M, Hazen M, Mathieu M, McCutcheon K, Takeda K, Date S, Cheung TK, Phung Q, Hass P, Arnott D, Hongo JA, Matthews DJ, Brown A, Patel AH, Kelley RF, Eigenbrot C, Kapadia SB.

J Mol Biol. 2013 Jun 12;425(11):1899-1914. doi: 10.1016/j.jmb.2013.02.025. Epub 2013 Feb 28.

20.

Structural basis of signaling blockade by anti-IL-13 antibody Lebrikizumab.

Ultsch M, Bevers J, Nakamura G, Vandlen R, Kelley RF, Wu LC, Eigenbrot C.

J Mol Biol. 2013 Apr 26;425(8):1330-9. doi: 10.1016/j.jmb.2013.01.024. Epub 2013 Jan 25.

PMID:
23357170
21.

Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function.

Kelley RF, Meng YG.

Methods Mol Biol. 2012;901:277-93. doi: 10.1007/978-1-61779-931-0_18.

PMID:
22723108
22.

Inhibiting alternative pathway complement activation by targeting the factor D exosite.

Katschke KJ Jr, Wu P, Ganesan R, Kelley RF, Mathieu MA, Hass PE, Murray J, Kirchhofer D, Wiesmann C, van Lookeren Campagne M.

J Biol Chem. 2012 Apr 13;287(16):12886-92. doi: 10.1074/jbc.M112.345082. Epub 2012 Feb 23.

23.

Using linkage-specific monoclonal antibodies to analyze cellular ubiquitylation.

Newton K, Matsumoto ML, Ferrando RE, Wickliffe KE, Rape M, Kelley RF, Dixit VM.

Methods Mol Biol. 2012;832:185-96. doi: 10.1007/978-1-61779-474-2_13.

PMID:
22350886
24.

Engineering and structural characterization of a linear polyubiquitin-specific antibody.

Matsumoto ML, Dong KC, Yu C, Phu L, Gao X, Hannoush RN, Hymowitz SG, Kirkpatrick DS, Dixit VM, Kelley RF.

J Mol Biol. 2012 May 4;418(3-4):134-44. doi: 10.1016/j.jmb.2011.12.053. Epub 2011 Dec 29.

25.

Low-temperature frequency domain study of excitation energy transfer in ethynyl-linked chlorophyll trefoils and aggregates.

Neupane B, Dang NC, Kelley RF, Wasielewski MR, Jankowiak R.

J Phys Chem B. 2011 Sep 8;115(35):10391-9. doi: 10.1021/jp2027252. Epub 2011 Aug 17.

PMID:
21819113
26.

High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity.

Bostrom J, Haber L, Koenig P, Kelley RF, Fuh G.

PLoS One. 2011 Apr 22;6(4):e17887. doi: 10.1371/journal.pone.0017887.

27.

Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals.

Phu L, Izrael-Tomasevic A, Matsumoto ML, Bustos D, Dynek JN, Fedorova AV, Bakalarski CE, Arnott D, Deshayes K, Dixit VM, Kelley RF, Vucic D, Kirkpatrick DS.

Mol Cell Proteomics. 2011 May;10(5):M110.003756. doi: 10.1074/mcp.M110.003756. Epub 2010 Nov 3.

28.

K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody.

Matsumoto ML, Wickliffe KE, Dong KC, Yu C, Bosanac I, Bustos D, Phu L, Kirkpatrick DS, Hymowitz SG, Rape M, Kelley RF, Dixit VM.

Mol Cell. 2010 Aug 13;39(3):477-84. doi: 10.1016/j.molcel.2010.07.001. Epub 2010 Jul 22.

29.

Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer.

Junttila TT, Parsons K, Olsson C, Lu Y, Xin Y, Theriault J, Crocker L, Pabonan O, Baginski T, Meng G, Totpal K, Kelley RF, Sliwkowski MX.

Cancer Res. 2010 Jun 1;70(11):4481-9. doi: 10.1158/0008-5472.CAN-09-3704. Epub 2010 May 18.

30.

Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.

Gordon NC, Lien S, Johnson J, Wallweber HJ, Tran T, Currell B, Mathieu M, Quan C, Starovasnik MA, Hymowitz SG, Kelley RF.

J Mol Biol. 2010 Feb 12;396(1):166-77. doi: 10.1016/j.jmb.2009.11.041. Epub 2009 Nov 26.

PMID:
19945466
31.

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation.

Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS.

J Biol Chem. 2009 Dec 18;284(51):35605-11. doi: 10.1074/jbc.M109.035170.

32.

Photophysical properties of an alkyne-bridged bis(zinc porphyrin)-perylene bis(dicarboximide) derivative.

Odom SA, Kelley RF, Ohira S, Ensley TR, Huang C, Padilha LA, Webster S, Coropceanu V, Barlow S, Hagan DJ, Van Stryland EW, Brédas JL, Anderson HL, Wasielewski MR, Marder SR.

J Phys Chem A. 2009 Oct 8;113(40):10826-32. doi: 10.1021/jp905214g.

PMID:
19791813
33.

Synthesis and photophysical properties of donor- and acceptor-substituted 1,7-bis(arylalkynyl)perylene-3,4:9,10-bis(dicarboximide)s.

An Z, Odom SA, Kelley RF, Huang C, Zhang X, Barlow S, Padilha LA, Fu J, Webster S, Hagan DJ, Van Stryland EW, Wasielewski MR, Marder SR.

J Phys Chem A. 2009 May 14;113(19):5585-93. doi: 10.1021/jp900152r.

PMID:
19382799
34.

Excited state, charge transfer, and spin dynamics in DNA hairpin conjugates with perylenediimide hairpin linkers.

Carmieli R, Zeidan TA, Kelley RF, Mi Q, Lewis FD, Wasielewski MR.

J Phys Chem A. 2009 Apr 23;113(16):4691-700. doi: 10.1021/jp900230q.

PMID:
19239215
35.

Charge-transfer and spin dynamics in DNA hairpin conjugates with perylenediimide as a base-pair surrogate.

Zeidan TA, Carmieli R, Kelley RF, Wilson TM, Lewis FD, Wasielewski MR.

J Am Chem Soc. 2008 Oct 22;130(42):13945-55. doi: 10.1021/ja803765r. Epub 2008 Sep 24.

PMID:
18811163
36.

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.

Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM.

Cell. 2008 Aug 22;134(4):668-78. doi: 10.1016/j.cell.2008.07.039.

37.

Fast energy transfer within a self-assembled cyclic porphyrin tetramer.

Jensen RA, Kelley RF, Lee SJ, Wasielewski MR, Hupp JT, Tiede DM.

Chem Commun (Camb). 2008 Apr 28;(16):1886-8. doi: 10.1039/b718628b. Epub 2008 Mar 20.

PMID:
18401507
38.

Intramolecular energy transfer within butadiyne-linked chlorophyll and porphyrin dimer-faced, self-assembled prisms.

Kelley RF, Lee SJ, Wilson TM, Nakamura Y, Tiede DM, Osuka A, Hupp JT, Wasielewski MR.

J Am Chem Soc. 2008 Apr 2;130(13):4277-84. doi: 10.1021/ja075494f. Epub 2008 Mar 8.

PMID:
18327918
39.

Controlling energy and charge transfer in linear chlorophyll dimers.

Kelley RF, Tauber MJ, Wilson TM, Wasielewski MR.

Chem Commun (Camb). 2007 Nov 14;(42):4407-9. Epub 2007 Aug 14.

PMID:
17957302
40.

Ultrafast energy transfer within cyclic self-assembled chlorophyll tetramers.

Kelley RF, Goldsmith RH, Wasielewski MR.

J Am Chem Soc. 2007 May 23;129(20):6384-5. Epub 2007 May 2. No abstract available.

PMID:
17472386
41.

Solution-phase structure of an artificial foldamer: X-ray scattering study.

Kelley RF, Rybtchinski B, Stone MT, Moore JS, Wasielewski MR.

J Am Chem Soc. 2007 Apr 11;129(14):4114-5. Epub 2007 Mar 17. No abstract available.

PMID:
17367136
42.

Photoinduced charge separation in self-assembled cofacial pentamers of zinc-5,10,15,20-tetrakis(perylenediimide)porphyrin.

Ahrens MJ, Kelley RF, Dance ZE, Wasielewski MR.

Phys Chem Chem Phys. 2007 Mar 28;9(12):1469-78. Epub 2007 Feb 22.

PMID:
17356754
43.

Photoinitiated charge transport in supramolecular assemblies of a 1,7,N,N'-tetrakis(zinc porphyrin)-perylene-3,4:9,10-bis(dicarboximide).

Kelley RF, Shin WS, Rybtchinski B, Sinks LE, Wasielewski MR.

J Am Chem Soc. 2007 Mar 21;129(11):3173-81. Epub 2007 Feb 24.

PMID:
17319659
44.

Linker-controlled energy and charge transfer within chlorophyll trefoils.

Kelley RF, Tauber MJ, Wasielewski MR.

Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7979-82. No abstract available.

PMID:
17083140
45.

Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.

Lee CV, Hymowitz SG, Wallweber HJ, Gordon NC, Billeci KL, Tsai SP, Compaan DM, Yin J, Gong Q, Kelley RF, DeForge LE, Martin F, Starovasnik MA, Fuh G.

Blood. 2006 Nov 1;108(9):3103-11. Epub 2006 Jul 13.

46.
47.

Electron donor-bridge-acceptor molecules with bridging nitronyl nitroxide radicals: influence of a third spin on charge- and spin-transfer dynamics.

Chernick ET, Mi Q, Kelley RF, Weiss EA, Jones BA, Marks TJ, Ratner MA, Wasielewski MR.

J Am Chem Soc. 2006 Apr 5;128(13):4356-64.

PMID:
16569012
48.

Electron hopping in pi-stacked covalent and self-assembled perylene diimides observed by ENDOR spectroscopy.

Tauber MJ, Kelley RF, Giaimo JM, Rybtchinski B, Wasielewski MR.

J Am Chem Soc. 2006 Feb 15;128(6):1782-3.

PMID:
16464064
49.

Tyrosine plays a dominant functional role in the paratope of a synthetic antibody derived from a four amino acid code.

Fellouse FA, Barthelemy PA, Kelley RF, Sidhu SS.

J Mol Biol. 2006 Mar 17;357(1):100-14. Epub 2005 Dec 19.

PMID:
16413576
50.

Electron-transfer dynamics of photosynthetic reaction centers in thermoresponsive soft materials.

Laible PD, Kelley RF, Wasielewski MR, Firestone MA.

J Phys Chem B. 2005 Dec 15;109(49):23679-86.

PMID:
16375348

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