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Pou4f1 defines a subgroup of Type I spiral ganglion neurons and is necessary for normal inner hair cell presynaptic Ca2+ signaling.

Sherrill HE, Jean P, Driver EC, Sanders TR, Fitzgerald TS, Moser T, Kelley MW.

J Neurosci. 2019 May 13. pii: 2728-18. doi: 10.1523/JNEUROSCI.2728-18.2019. [Epub ahead of print]


Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity.

Montcouquiol M, Kelley MW.

Cold Spring Harb Perspect Med. 2019 Jan 7. pii: a033266. doi: 10.1101/cshperspect.a033266. [Epub ahead of print]


Helios is a key transcriptional regulator of outer hair cell maturation.

Chessum L, Matern MS, Kelly MC, Johnson SL, Ogawa Y, Milon B, McMurray M, Driver EC, Parker A, Song Y, Codner G, Esapa CT, Prescott J, Trent G, Wells S, Dragich AK, Frolenkov GI, Kelley MW, Marcotti W, Brown SDM, Elkon R, Bowl MR, Hertzano R.

Nature. 2018 Nov;563(7733):696-700. doi: 10.1038/s41586-018-0728-4. Epub 2018 Nov 21.


Characterization of spatial and temporal development of Type I and Type II hair cells in the mouse utricle using new cell-type-specific markers.

McInturff S, Burns JC, Kelley MW.

Biol Open. 2018 Nov 19;7(11). pii: bio038083. doi: 10.1242/bio.038083.


Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing.

Matson KJE, Sathyamurthy A, Johnson KR, Kelly MC, Kelley MW, Levine AJ.

J Vis Exp. 2018 Oct 12;(140). doi: 10.3791/58413.


Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression.

Mays JC, Kelly MC, Coon SL, Holtzclaw L, Rath MF, Kelley MW, Klein DC.

PLoS One. 2018 Oct 22;13(10):e0205883. doi: 10.1371/journal.pone.0205883. eCollection 2018.


Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness.

Nakano Y, Kelly MC, Rehman AU, Boger ET, Morell RJ, Kelley MW, Friedman TB, Bánfi B.

Cell. 2018 Jul 26;174(3):536-548.e21. doi: 10.1016/j.cell.2018.06.004. Epub 2018 Jun 28.


Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior.

Sathyamurthy A, Johnson KR, Matson KJE, Dobrott CI, Li L, Ryba AR, Bergman TB, Kelly MC, Kelley MW, Levine AJ.

Cell Rep. 2018 Feb 20;22(8):2216-2225. doi: 10.1016/j.celrep.2018.02.003.


Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea.

Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA.

PLoS Genet. 2017 Oct 23;13(10):e1007048. doi: 10.1371/journal.pgen.1007048. eCollection 2017 Oct.


Molecular architecture underlying fluid absorption by the developing inner ear.

Honda K, Kim SH, Kelly MC, Burns JC, Constance L, Li X, Zhou F, Hoa M, Kelley MW, Wangemann P, Morell RJ, Griffith AJ.

Elife. 2017 Oct 10;6. pii: e26851. doi: 10.7554/eLife.26851.


Cell migration, intercalation and growth regulate mammalian cochlear extension.

Driver EC, Northrop A, Kelley MW.

Development. 2017 Oct 15;144(20):3766-3776. doi: 10.1242/dev.151761. Epub 2017 Sep 4.


Generation of Human Hair Cells In Vitro: Is It All about How the Wnt Blows?

Kelley MW.

Cell Stem Cell. 2017 Jul 6;21(1):11-12. doi: 10.1016/j.stem.2017.06.007.


Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.

May-Simera HL, Gumerson JD, Gao C, Campos M, Cologna SM, Beyer T, Boldt K, Kaya KD, Patel N, Kretschmer F, Kelley MW, Petralia RS, Davey MG, Li T.

Cell Rep. 2016 Oct 25;17(5):1399-1413. doi: 10.1016/j.celrep.2016.09.089.


Dual role for Sox2 in specification of sensory competence and regulation of Atoh1 function.

Puligilla C, Kelley MW.

Dev Neurobiol. 2017 Jan;77(1):3-13. doi: 10.1002/dneu.22401. Epub 2016 Jun 6.


Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.

Burns JC, Kelly MC, Hoa M, Morell RJ, Kelley MW.

Nat Commun. 2015 Oct 15;6:8557. doi: 10.1038/ncomms9557.


Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons.

Coate TM, Spita NA, Zhang KD, Isgrig KT, Kelley MW.

Elife. 2015 Aug 24;4. doi: 10.7554/eLife.07830.


Culture of embryonic mouse cochlear explants and gene transfer by electroporation.

Haque KD, Pandey AK, Kelley MW, Puligilla C.

J Vis Exp. 2015 Jan 12;(95):52260. doi: 10.3791/52260.


Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.

May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW.

Development. 2015 Feb 1;142(3):555-66. doi: 10.1242/dev.113696.


Pou3f4-mediated regulation of ephrin-b2 controls temporal bone development in the mouse.

Raft S, Coate TM, Kelley MW, Crenshaw EB 3rd, Wu DK.

PLoS One. 2014 Oct 9;9(10):e109043. doi: 10.1371/journal.pone.0109043. eCollection 2014.


Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.

Thiede BR, Mann ZF, Chang W, Ku YC, Son YK, Lovett M, Kelley MW, Corwin JT.

Nat Commun. 2014 May 20;5:3840. doi: 10.1038/ncomms4840.


A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.

Mann ZF, Thiede BR, Chang W, Shin JB, May-Simera HL, Lovett M, Corwin JT, Kelley MW.

Nat Commun. 2014 May 20;5:3839. doi: 10.1038/ncomms4839. Erratum in: Nat Commun. 2014;5:4591.


Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW.

PLoS Biol. 2013 Nov;11(11):e1001720. doi: 10.1371/journal.pbio.1001720. Epub 2013 Nov 26.


Expression and function of scleraxis in the developing auditory system.

Mann ZF, Chang W, Lee KY, King KA, Kelley MW.

PLoS One. 2013 Sep 13;8(9):e75521. doi: 10.1371/journal.pone.0075521. eCollection 2013.


Expression of insulin-like growth factor binding proteins during mouse cochlear development.

Okano T, Kelley MW.

Dev Dyn. 2013 Oct;242(10):1210-21. doi: 10.1002/dvdy.24005. Epub 2013 Sep 2.


Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells.

Coate TM, Kelley MW.

Semin Cell Dev Biol. 2013 May;24(5):460-9. doi: 10.1016/j.semcdb.2013.04.003. Epub 2013 May 6. Review.


Making sense with thyroid hormone--the role of T(3) in auditory development.

Ng L, Kelley MW, Forrest D.

Nat Rev Endocrinol. 2013 May;9(5):296-307. doi: 10.1038/nrendo.2013.58. Epub 2013 Mar 26. Review.


Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti.

Szarama KB, Gavara N, Petralia RS, Chadwick RS, Kelley MW.

BMC Dev Biol. 2013 Feb 9;13:6. doi: 10.1186/1471-213X-13-6.


Cilia, Wnt signaling, and the cytoskeleton.

May-Simera HL, Kelley MW.

Cilia. 2012 May 2;1(1):7. doi: 10.1186/2046-2530-1-7.


The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea.

Driver EC, Sillers L, Coate TM, Rose MF, Kelley MW.

Dev Biol. 2013 Apr 1;376(1):86-98. doi: 10.1016/j.ydbio.2013.01.005. Epub 2013 Jan 11.


Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti.

Szarama KB, Stepanyan R, Petralia RS, Gavara N, Frolenkov GI, Kelley MW, Chadwick RS.

Bioarchitecture. 2012 Nov-Dec;2(6):214-9. doi: 10.4161/bioa.22332.


Planar cell polarity in the inner ear.

May-Simera H, Kelley MW.

Curr Top Dev Biol. 2012;101:111-40. doi: 10.1016/B978-0-12-394592-1.00006-5. Review.


A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea.

Jacques BE, Puligilla C, Weichert RM, Ferrer-Vaquer A, Hadjantonakis AK, Kelley MW, Dabdoub A.

Development. 2012 Dec 1;139(23):4395-404. doi: 10.1242/dev.080358.


Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear.

Giese AP, Ezan J, Wang L, Lasvaux L, Lembo F, Mazzocco C, Richard E, Reboul J, Borg JP, Kelley MW, Sans N, Brigande J, Montcouquiol M.

Development. 2012 Oct;139(20):3775-85.


Molecular mechanisms of inner ear development.

Wu DK, Kelley MW.

Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a008409. doi: 10.1101/cshperspect.a008409. Review.


Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla.

Jacques BE, Dabdoub A, Kelley MW.

Hear Res. 2012 Jul;289(1-2):27-39. doi: 10.1016/j.heares.2012.04.018. Epub 2012 May 2.


Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea.

Szarama KB, Gavara N, Petralia RS, Kelley MW, Chadwick RS.

Development. 2012 Jun;139(12):2187-97. doi: 10.1242/dev.073734. Epub 2012 May 9.


Stem cell therapy for the inner ear: recent advances and future directions.

Okano T, Kelley MW.

Trends Amplif. 2012 Mar;16(1):4-18. doi: 10.1177/1084713812440336. Epub 2012 Apr 17. Review.


Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis.

Rachel RA, May-Simera HL, Veleri S, Gotoh N, Choi BY, Murga-Zamalloa C, McIntyre JC, Marek J, Lopez I, Hackett AN, Zhang J, Brooks M, den Hollander AI, Beales PL, Li T, Jacobson SG, Sood R, Martens JR, Liu P, Friedman TB, Khanna H, Koenekoop RK, Kelley MW, Swaroop A.

J Clin Invest. 2012 Apr;122(4):1233-45. doi: 10.1172/JCI60981. Epub 2012 Mar 26. Erratum in: J Clin Invest. 2012 Aug 1;122(8):3025. Zhang, Jun [added].


Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.

Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW.

Neuron. 2012 Jan 12;73(1):49-63. doi: 10.1016/j.neuron.2011.10.029.


Examining planar cell polarity in the mammalian cochlea.

May-Simera H, Kelley MW.

Methods Mol Biol. 2012;839:157-71. doi: 10.1007/978-1-61779-510-7_13.


Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea.

Okano T, Xuan S, Kelley MW.

J Neurosci. 2011 Dec 7;31(49):18104-18. doi: 10.1523/JNEUROSCI.3619-11.2011.


Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting.

Tadenev AL, Kulaga HM, May-Simera HL, Kelley MW, Katsanis N, Reed RR.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10320-5. doi: 10.1073/pnas.1016531108. Epub 2011 Jun 6.


Response to a letter to the editor.

Kelley MW, Mann ZF.

Hear Res. 2011 Oct;280(1-2):1-2. doi: 10.1016/j.heares.2011.04.009. Epub 2011 May 1. No abstract available.


Rbpj regulates development of prosensory cells in the mammalian inner ear.

Yamamoto N, Chang W, Kelley MW.

Dev Biol. 2011 May 15;353(2):367-79. doi: 10.1016/j.ydbio.2011.03.016. Epub 2011 Mar 21.


Development of tonotopy in the auditory periphery.

Mann ZF, Kelley MW.

Hear Res. 2011 Jun;276(1-2):2-15. doi: 10.1016/j.heares.2011.01.011. Epub 2011 Jan 27. Review.


CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear.

Hertzano R, Puligilla C, Chan SL, Timothy C, Depireux DA, Ahmed Z, Wolf J, Eisenman DJ, Friedman TB, Riazuddin S, Kelley MW, Strome SE.

J Assoc Res Otolaryngol. 2010 Sep;11(3):407-18. doi: 10.1007/s10162-010-0211-x. Epub 2010 Apr 13.


Transfection of mouse cochlear explants by electroporation.

Driver EC, Kelley MW.

Curr Protoc Neurosci. 2010 Apr;Chapter 4:Unit 4.34.1-10. doi: 10.1002/0471142301.ns0434s51.


Sox2 induces neuronal formation in the developing mammalian cochlea.

Puligilla C, Dabdoub A, Brenowitz SD, Kelley MW.

J Neurosci. 2010 Jan 13;30(2):714-22. doi: 10.1523/JNEUROSCI.3852-09.2010.


Specification of cell fate in the mammalian cochlea.

Driver EC, Kelley MW.

Birth Defects Res C Embryo Today. 2009 Sep;87(3):212-21. doi: 10.1002/bdrc.20154. Review.


Regulation of cell fate and patterning in the developing mammalian cochlea.

Kelley MW, Driver EC, Puligilla C.

Curr Opin Otolaryngol Head Neck Surg. 2009 Oct;17(5):381-7. doi: 10.1097/MOO.0b013e3283303347.

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