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Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway.

Codrich M, Comelli M, Malfatti MC, Mio C, Ayyildiz D, Zhang C, Kelley MR, Terrosu G, Pucillo CEM, Tell G.

DNA Repair (Amst). 2019 Oct;82:102675. doi: 10.1016/j.dnarep.2019.102675. Epub 2019 Aug 7.


Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer.

Fishel ML, Xia H, McGeown J, McIlwain DW, Elbanna M, Craft AA, Kaimakliotis HZ, Sandusky GE, Zhang C, Pili R, Kelley MR, Jerde TJ.

Mol Cancer Ther. 2019 Nov;18(11):1947-1960. doi: 10.1158/1535-7163.MCT-18-1166. Epub 2019 Aug 14.


On the composition of part-set cues.

Kroeger ME, Hueng NL, Curry SD, Copeland MB, Kelley MR.

Q J Exp Psychol (Hove). 2019 Oct;72(10):2365-2370. doi: 10.1177/1747021819838829. Epub 2019 Mar 25.


Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.

Frossi B, Antoniali G, Yu K, Akhtar N, Kaplan MH, Kelley MR, Tell G, Pucillo CEM.

J Biol Chem. 2019 Mar 29;294(13):5198-5207. doi: 10.1074/jbc.RA118.006601. Epub 2019 Jan 31.


Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.

Trilles R, Beglov D, Chen Q, He H, Wireman R, Reed A, Chennamadhavuni S, Panek JS, Brown LE, Vajda S, Porco JA Jr, Kelley MR, Georgiadis MM.

J Med Chem. 2019 Feb 28;62(4):1971-1988. doi: 10.1021/acs.jmedchem.8b01529. Epub 2019 Feb 6.


Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.

Cai Z, Kotzin JJ, Ramdas B, Chen S, Nelanuthala S, Palam LR, Pandey R, Mali RS, Liu Y, Kelley MR, Sandusky G, Mohseni M, Williams A, Henao-Mejia J, Kapur R.

Cell Stem Cell. 2018 Dec 6;23(6):833-849.e5. doi: 10.1016/j.stem.2018.10.013.


Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.

Logsdon DP, Shah F, Carta F, Supuran CT, Kamocka M, Jacobsen MH, Sandusky GE, Kelley MR, Fishel ML.

Sci Rep. 2018 Sep 13;8(1):13759. doi: 10.1038/s41598-018-32034-9.


Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.

Sardar Pasha SPB, Sishtla K, Sulaiman RS, Park B, Shetty T, Shah F, Fishel ML, Wikel JH, Kelley MR, Corson TW.

J Pharmacol Exp Ther. 2018 Oct;367(1):108-118. doi: 10.1124/jpet.118.248088. Epub 2018 Aug 3.


APX3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats.

Yan T, Venkat P, Chopp M, Zacharek A, Yu P, Ning R, Qiao X, Kelley MR, Chen J.

Aging Dis. 2018 Jun 1;9(3):453-466. doi: 10.14336/AD.2017.1130. eCollection 2018 Jun.


Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy.

Kelley MR, Cardarelli RA, Smalley JL, Ollerhead TA, Andrew PM, Brandon NJ, Deeb TZ, Moss SJ.

EBioMedicine. 2018 Jun;32:62-71. doi: 10.1016/j.ebiom.2018.05.029. Epub 2018 Jun 5.


APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells.

McIlwain DW, Fishel ML, Boos A, Kelley MR, Jerde TJ.

Oncotarget. 2017 Dec 13;9(13):10962-10977. doi: 10.18632/oncotarget.23493. eCollection 2018 Feb 16.


Part-set cueing impairment & facilitation in semantic memory.

Kelley MR, Parihar SA.

Memory. 2018 Aug;26(7):1008-1018. doi: 10.1080/09658211.2018.1428993. Epub 2018 Jan 19.


DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1.

Fehrenbacher JC, Guo C, Kelley MR, Vasko MR.

Neuroscience. 2017 Dec 16;366:23-35. doi: 10.1016/j.neuroscience.2017.09.039. Epub 2017 Sep 28.


APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.

Shah F, Goossens E, Atallah NM, Grimard M, Kelley MR, Fishel ML.

Mol Oncol. 2017 Dec;11(12):1711-1732. doi: 10.1002/1878-0261.12138. Epub 2017 Oct 19.


Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.

Shah F, Logsdon D, Messmann RA, Fehrenbacher JC, Fishel ML, Kelley MR.

NPJ Precis Oncol. 2017;1. pii: 19. doi: 10.1038/s41698-017-0023-0. Epub 2017 Jun 8.


Seizing Control of KCC2: A New Therapeutic Target for Epilepsy.

Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ.

Trends Neurosci. 2017 Sep;40(9):555-571. doi: 10.1016/j.tins.2017.06.008. Epub 2017 Aug 10. Review.


Draft Genome Sequence of Lawsonia intracellularis Strain E40504, Isolated from a Horse Diagnosed with Equine Proliferative Enteropathy.

Mirajkar NS, Kelley MR, Gebhart CJ.

Genome Announc. 2017 May 11;5(19). pii: e00330-17. doi: 10.1128/genomeA.00330-17.


Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.

Ding J, Fishel ML, Reed AM, McAdams E, Czader MB, Cardoso AA, Kelley MR.

Mol Cancer Ther. 2017 Jul;16(7):1401-1411. doi: 10.1158/1535-7163.MCT-17-0099. Epub 2017 Apr 26.


Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage.

Kelley MR, Fehrenbacher JC.

Neural Regen Res. 2017 Jan;12(1):72-74. doi: 10.4103/1673-5374.198986. No abstract available.


Three Semantic Serial Position Functions at the Same Time.

Neath I, Kelley MR, Surprenant AM.

Exp Psychol. 2016 Nov;63(6):351-360. doi: 10.1027/1618-3169/a000344.


Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.

Logsdon DP, Grimard M, Luo M, Shahda S, Jiang Y, Tong Y, Yu Z, Zyromski N, Schipani E, Carta F, Supuran CT, Korc M, Ivan M, Kelley MR, Fishel ML.

Mol Cancer Ther. 2016 Nov;15(11):2722-2732. Epub 2016 Aug 17.


Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.

Kelley MR, Wikel JH, Guo C, Pollok KE, Bailey BJ, Wireman R, Fishel ML, Vasko MR.

J Pharmacol Exp Ther. 2016 Nov;359(2):300-309. Epub 2016 Sep 8.


Expandable and Rapidly Differentiating Human Induced Neural Stem Cell Lines for Multiple Tissue Engineering Applications.

Cairns DM, Chwalek K, Moore YE, Kelley MR, Abbott RD, Moss S, Kaplan DL.

Stem Cell Reports. 2016 Sep 13;7(3):557-570. doi: 10.1016/j.stemcr.2016.07.017. Epub 2016 Aug 25.


Compromising KCC2 transporter activity enhances the development of continuous seizure activity.

Kelley MR, Deeb TZ, Brandon NJ, Dunlop J, Davies PA, Moss SJ.

Neuropharmacology. 2016 Sep;108:103-10. doi: 10.1016/j.neuropharm.2016.04.029. Epub 2016 Apr 21.


Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons.

Georgiadis MM, Chen Q, Meng J, Guo C, Wireman R, Reed A, Vasko MR, Kelley MR.

DNA Repair (Amst). 2016 May;41:32-41. doi: 10.1016/j.dnarep.2016.03.009. Epub 2016 Mar 29.


Spatial part-set cuing facilitation.

Kelley MR, Parasiuk Y, Salgado-Benz J, Crocco M.

Memory. 2016 Jul;24(6):737-45. doi: 10.1080/09658211.2015.1046382. Epub 2015 Aug 7.


APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER.

Kim HS, Guo C, Thompson EL, Jiang Y, Kelley MR, Vasko MR, Lee SH.

Mutat Res. 2015 Sep;779:96-104. doi: 10.1016/j.mrfmmm.2015.06.010. Epub 2015 Jun 26.


Serial position functions in general knowledge.

Kelley MR, Neath I, Surprenant AM.

J Exp Psychol Learn Mem Cogn. 2015 Nov;41(6):1715-1727. doi: 10.1037/xlm0000141. Epub 2015 Jun 15.


Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo.

Sivakumaran S, Cardarelli RA, Maguire J, Kelley MR, Silayeva L, Morrow DH, Mukherjee J, Moore YE, Mather RJ, Duggan ME, Brandon NJ, Dunlop J, Zicha S, Moss SJ, Deeb TZ.

J Neurosci. 2015 May 27;35(21):8291-6. doi: 10.1523/JNEUROSCI.5205-14.2015.


KCC2 activity is critical in limiting the onset and severity of status epilepticus.

Silayeva L, Deeb TZ, Hines RM, Kelley MR, Munoz MB, Lee HH, Brandon NJ, Dunlop J, Maguire J, Davies PA, Moss SJ.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3523-8. doi: 10.1073/pnas.1415126112. Epub 2015 Mar 2.


Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.

Fishel ML, Wu X, Devlin CM, Logsdon DP, Jiang Y, Luo M, He Y, Yu Z, Tong Y, Lipking KP, Maitra A, Rajeshkumar NV, Scandura G, Kelley MR, Ivan M.

J Biol Chem. 2015 Jan 30;290(5):3057-68. doi: 10.1074/jbc.M114.621995. Epub 2014 Dec 9.


Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice.

Shannon HE, Fishel ML, Xie J, Gu D, McCarthy BP, Riley AA, Sinn AL, Silver JM, Peterman K, Kelley MR, Hanenberg H, Korc M, Pollok KE, Territo PR.

Pancreas. 2015 Jan;44(1):64-75. doi: 10.1097/MPA.0000000000000238.


Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.

Kelley MR, Jiang Y, Guo C, Reed A, Meng H, Vasko MR.

PLoS One. 2014 Sep 4;9(9):e106485. doi: 10.1371/journal.pone.0106485. eCollection 2014.


Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.

Li Y, Liu X, Zhou T, Kelley MR, Edwards PA, Gao H, Qiao X.

Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4461-9. doi: 10.1167/iovs.14-14451.


Targeting DNA repair pathways for cancer treatment: what's new?

Kelley MR, Logsdon D, Fishel ML.

Future Oncol. 2014 May;10(7):1215-37. doi: 10.2217/fon.14.60. Review.


A remember-know analysis of the semantic serial position function.

Kelley MR, Neath I, Surprenant AM.

Am J Psychol. 2014 Summer;127(2):137-45.


Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.

Li Y, Liu X, Zhou T, Kelley MR, Edwards P, Gao H, Qiao X.

Redox Biol. 2014 Feb 21;2:485-94. doi: 10.1016/j.redox.2014.01.023. eCollection 2014.


The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

Domenis R, Bergamin N, Gianfranceschi G, Vascotto C, Romanello M, Rigo S, Vagnarelli G, Faggiani M, Parodi P, Kelley MR, Beltrami CA, Cesselli D, Tell G, Beltrami AP.

PLoS One. 2014 Feb 19;9(2):e89232. doi: 10.1371/journal.pone.0089232. eCollection 2014.


The joint influence of collaboration and part-set cueing.

Kelley MR, Pentz C, Reysen MB.

Q J Exp Psychol (Hove). 2014 Oct;67(10):1977-85. doi: 10.1080/17470218.2014.881405. Epub 2014 Mar 5.


Formation and reactivity of an (alkene)peroxoiridium(III) intermediate supported by an amidinato ligand.

Kelley MR, Rohde JU.

Dalton Trans. 2014 Jan 14;43(2):527-37. doi: 10.1039/c3dt52283k. Epub 2013 Oct 14.


Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines.

Cesaratto L, Codarin E, Vascotto C, Leonardi A, Kelley MR, Tiribelli C, Tell G.

PLoS One. 2013 Aug 15;8(8):e70909. doi: 10.1371/journal.pone.0070909. eCollection 2013.


Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.

Zhang J, Luo M, Marasco D, Logsdon D, LaFavers KA, Chen Q, Reed A, Kelley MR, Gross ML, Georgiadis MM.

Biochemistry. 2013 Apr 30;52(17):2955-66. doi: 10.1021/bi400179m. Epub 2013 Apr 18.


Part-set cuing facilitation for spatial information.

Cole SM, Reysen MB, Kelley MR.

J Exp Psychol Learn Mem Cogn. 2013 Sep;39(5):1615-20. doi: 10.1037/a0032424. Epub 2013 Apr 8.


Guanidinato complexes of iridium: ligand-donor strength, O2 reactivity, and (alkene)peroxoiridium(III) intermediates.

Kelley MR, Rohde JU.

Inorg Chem. 2013 Mar 4;52(5):2564-80. doi: 10.1021/ic302570s. Epub 2013 Feb 19.


Three more semantic serial position functions and a SIMPLE explanation.

Kelley MR, Neath I, Surprenant AM.

Mem Cognit. 2013 May;41(4):600-10. doi: 10.3758/s13421-012-0286-1.


APE1/Ref-1 regulates STAT3 transcriptional activity and APE1/Ref-1-STAT3 dual-targeting effectively inhibits pancreatic cancer cell survival.

Cardoso AA, Jiang Y, Luo M, Reed AM, Shahda S, He Y, Maitra A, Kelley MR, Fishel ML.

PLoS One. 2012;7(10):e47462. doi: 10.1371/journal.pone.0047462. Epub 2012 Oct 19.


Evidence for a reactive (alkene)peroxoiridium(III) intermediate in the oxidation of an alkene complex with O2.

Kelley MR, Rohde JU.

Chem Commun (Camb). 2012 Mar 18;48(23):2876-8. doi: 10.1039/c2cc17332h. Epub 2012 Feb 7.


Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.

Luo M, Zhang J, He H, Su D, Chen Q, Gross ML, Kelley MR, Georgiadis MM.

Biochemistry. 2012 Jan 17;51(2):695-705. doi: 10.1021/bi201034z. Epub 2012 Jan 4.


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