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Items: 1 to 50 of 82

1.

Correction to "Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3".

Huang C, Liew SS, Lin GR, Poulsen A, Ang MJY, Chia BCS, Chew SY, Kwek ZP, Wee JLK, Ong EH, Retna P, Baburajendran N, Li R, Yu W, Koh-Stenta X, Ngo A, Manesh S, Fulwood J, Ke Z, Chung HH, Sepramaniam S, Chew XH, Dinie N, Lee MA, Chew YS, Low CB, Pendharkar V, Manoharan V, Vuddagiri S, Sangthongpitag K, Joy J, Matter A, Hill J, Keller TH, Foo K.

ACS Med Chem Lett. 2019 Jul 9;10(8):1240. doi: 10.1021/acsmedchemlett.9b00278. eCollection 2019 Aug 8.

2.

Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C.

Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8.

PMID:
31285279
3.

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3.

Huang C, Liew SS, Lin GR, Poulsen A, Ang MJY, Chia BCS, Chew SY, Kwek ZP, Wee JLK, Ong EH, Retna P, Baburajendran N, Li R, Yu W, Koh-Stenta X, Ngo A, Manesh S, Fulwood J, Ke Z, Chung HH, Sepramaniam S, Chew XH, Dinie N, Lee MA, Chew YS, Low CB, Pendharkar V, Manoharan V, Vuddagiri S, Sangthongpitag K, Joy J, Matter A, Hill J, Keller TH, Foo K.

ACS Med Chem Lett. 2019 May 23;10(6):978-984. doi: 10.1021/acsmedchemlett.9b00170. eCollection 2019 Jun 13. Erratum in: ACS Med Chem Lett. 2019 Jul 09;10(8):1240.

PMID:
31223458
4.

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues.

Kwiatkowski J, Baburajendran N, Poulsen A, Liu B, Tee DHY, Wong YX, Poh ZY, Ong EH, Dinie N, Cherian J, Jansson AE, Hill J, Keller TH, Hung AW.

ACS Med Chem Lett. 2019 Feb 15;10(3):318-323. doi: 10.1021/acsmedchemlett.8b00546. eCollection 2019 Mar 14.

PMID:
30891133
5.

Discovery of dual GyrB/ParE inhibitors active against Gram-negative bacteria.

Ho SY, Wang W, Ng FM, Wong YX, Poh ZY, Tan SWE, Ang SH, Liew SS, Joyner Wong YS, Tan Y, Poulsen A, Pendharkar V, Sangthongpitag K, Manchester J, Basarab G, Hill J, Keller TH, Cherian J.

Eur J Med Chem. 2018 Sep 5;157:610-621. doi: 10.1016/j.ejmech.2018.08.025. Epub 2018 Aug 11.

PMID:
30125722
6.

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Li Y, Liu S, Ng EY, Li R, Poulsen A, Hill J, Pobbati AV, Hung AW, Hong W, Keller TH, Kang C.

Biochem J. 2018 Jun 26;475(12):2043-2055. doi: 10.1042/BCJ20180225.

PMID:
29760238
7.

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Kwiatkowski J, Liu B, Tee DHY, Chen G, Ahmad NHB, Wong YX, Poh ZY, Ang SH, Tan ESW, Ong EH, Nurul Dinie, Poulsen A, Pendharkar V, Sangthongpitag K, Lee MA, Sepramaniam S, Ho SY, Cherian J, Hill J, Keller TH, Hung AW.

J Med Chem. 2018 May 24;61(10):4386-4396. doi: 10.1021/acs.jmedchem.8b00060. Epub 2018 May 4.

PMID:
29688013
8.

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Li Y, Zhang Z, Phoo WW, Loh YR, Li R, Yang HY, Jansson AE, Hill J, Keller TH, Nacro K, Luo D, Kang C.

Structure. 2018 Apr 3;26(4):555-564.e3. doi: 10.1016/j.str.2018.02.005. Epub 2018 Mar 8.

9.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor.

Li Y, Ng HQ, Ngo A, Liu S, Tan YW, Kwek PZ, Hung AW, Joy J, Hill J, Keller TH, Kang C.

Biomol NMR Assign. 2017 Oct;11(2):225-229. doi: 10.1007/s12104-017-9753-8. Epub 2017 Aug 14.

PMID:
28808922
10.

Zika Virus Protease: An Antiviral Drug Target.

Kang C, Keller TH, Luo D.

Trends Microbiol. 2017 Oct;25(10):797-808. doi: 10.1016/j.tim.2017.07.001. Epub 2017 Aug 5. Review.

PMID:
28789826
11.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C.

Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6.

12.

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

Li Y, Phoo WW, Loh YR, Zhang Z, Ng EY, Wang W, Keller TH, Luo D, Kang C.

FEBS Lett. 2017 Aug;591(15):2338-2347. doi: 10.1002/1873-3468.12741. Epub 2017 Jul 20.

13.

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Ho SY, Alam J, Jeyaraj DA, Wang W, Lin GR, Ang SH, Tan ESW, Lee MA, Ke Z, Madan B, Virshup DM, Ding LJ, Manoharan V, Chew YS, Low CB, Pendharkar V, Sangthongpitag K, Hill J, Keller TH, Poulsen A.

J Med Chem. 2017 Aug 10;60(15):6678-6692. doi: 10.1021/acs.jmedchem.7b00662. Epub 2017 Jul 20.

PMID:
28671458
14.

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Liu S, Then SW, Lee MY, Ng HQ, Huang Q, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

J Biol Chem. 2016 Aug 19;291(34):17743-53. doi: 10.1074/jbc.M116.737429. Epub 2016 Jun 30.

15.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

Cherian J, Nacro K, Poh ZY, Guo S, Jeyaraj DA, Wong YX, Ho M, Yang HY, Joy JK, Kwek ZP, Liu B, Wee JL, Ong EH, Choong ML, Poulsen A, Lee MA, Pendharkar V, Ding LJ, Manoharan V, Chew YS, Sangthongpitag K, Lim S, Ong ST, Hill J, Keller TH.

J Med Chem. 2016 Apr 14;59(7):3063-78. doi: 10.1021/acs.jmedchem.5b01712. Epub 2016 Apr 5.

PMID:
27011159
16.

Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.

Nilar SH, Lakshminarayana SB, Ma NL, Keller TH, Blasco F, Smith PW.

Curr Comput Aided Drug Des. 2016;12(1):52-61.

PMID:
26777113
17.

Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.

Kang C, Li Y, Cherian J, Liu B, Ng HQ, Lee MY, Binte Ahmad NH, Poh ZY, Wong YX, Huang Q, Wong YL, Hung AW, Hill J, Keller TH.

Biophys J. 2015 Nov 3;109(9):1969-77. doi: 10.1016/j.bpj.2015.10.001.

18.

The use of porcupine inhibitors to target Wnt-driven cancers.

Ho SY, Keller TH.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5472-6. doi: 10.1016/j.bmcl.2015.10.032. Epub 2015 Oct 23. Review.

PMID:
26522946
19.

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Then SW, Lee MY, Ng HQ, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):961-6. doi: 10.1016/j.bbrc.2015.10.036. Epub 2015 Oct 17.

PMID:
26471301
20.

Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Trifilieff A.

J Med Chem. 2015 Sep 10;58(17):6747-52. doi: 10.1021/acs.jmedchem.5b00902. Epub 2015 Aug 28.

PMID:
26288344
21.

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

Li Y, Wong YX, Poh ZY, Wong YL, Lee MY, Ng HQ, Liu B, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2683-9. doi: 10.1016/j.febslet.2015.07.044. Epub 2015 Aug 10.

22.

Wnt addiction of genetically defined cancers reversed by PORCN inhibition.

Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, Keller TH, Lee MA, Matter A, Virshup DM.

Oncogene. 2016 Apr 28;35(17):2197-207. doi: 10.1038/onc.2015.280. Epub 2015 Aug 10.

23.

Discovery and Optimization of a Porcupine Inhibitor.

Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH.

J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16.

PMID:
26110200
24.

Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design.

Poulsen A, Ho SY, Wang W, Alam J, Jeyaraj DA, Ang SH, Tan ES, Lin GR, Cheong VW, Ke Z, Lee MA, Keller TH.

J Chem Inf Model. 2015 Jul 27;55(7):1435-48. doi: 10.1021/acs.jcim.5b00159. Epub 2015 Jun 15.

PMID:
26024410
25.

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.

Ang MJ, Lau QY, Ng FM, Then SW, Poulsen A, Cheong YK, Ngoh ZX, Tan YW, Peng J, Keller TH, Hill J, Chu JJ, Chia CS.

J Enzyme Inhib Med Chem. 2016;31(2):332-9. doi: 10.3109/14756366.2015.1018245. Epub 2015 Sep 4.

PMID:
25792507
26.

One versus two-step Roux-en-Y gastric bypass after gastric banding—data analysis of the German Bariatric Surgery Registry.

Stroh C, Weiner R, Wolff S, Lerche C, Knoll C, Keller T, Bruns C, Manger T; Obesity Surgery Working Group, Competence Network Obesity.

Obes Surg. 2015 May;25(5):755-62. doi: 10.1007/s11695-014-1527-0.

PMID:
25502287
27.

The importance of molecular complexity in the design of screening libraries.

Nilar SH, Ma NL, Keller TH.

J Comput Aided Mol Des. 2013 Sep;27(9):783-92.

PMID:
24122490
28.

Drug design for flavivirus proteases: what are we missing?

Poulsen A, Kang C, Keller TH.

Curr Pharm Des. 2014;20(21):3422-7. Review.

PMID:
24001226
29.

Fragment-based ligand design of novel potent inhibitors of tankyrases.

Larsson EA, Jansson A, Ng FM, Then SW, Panicker R, Liu B, Sangthongpitag K, Pendharkar V, Tai SJ, Hill J, Dan C, Ho SY, Cheong WW, Poulsen A, Blanchard S, Lin GR, Alam J, Keller TH, Nordlund P.

J Med Chem. 2013 Jun 13;56(11):4497-508. doi: 10.1021/jm400211f. Epub 2013 Jun 4.

PMID:
23672613
30.

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.

Kim YM, Gayen S, Kang C, Joy J, Huang Q, Chen AS, Wee JL, Ang MJ, Lim HA, Hung AW, Li R, Noble CG, Lee le T, Yip A, Wang QY, Chia CS, Hill J, Shi PY, Keller TH.

J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19.

31.

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

Kang C, Gayen S, Wang W, Severin R, Chen AS, Lim HA, Chia CS, Schüller A, Doan DN, Poulsen A, Hill J, Vasudevan SG, Keller TH.

Antiviral Res. 2013 Feb;97(2):137-44. doi: 10.1016/j.antiviral.2012.11.008. Epub 2012 Dec 2.

PMID:
23211132
32.

Mechanistic study of the spiroindolones: a new class of antimalarials.

Zou B, Yap P, Sonntag LS, Leong SY, Yeung BK, Keller TH.

Molecules. 2012 Aug 24;17(9):10131-41. doi: 10.3390/molecules170910131.

33.

Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Tyler JW, Wagner T, Fozard JR, Trifilieff A.

J Med Chem. 2012 Sep 13;55(17):7472-9. doi: 10.1021/jm300459a. Epub 2012 Aug 30.

PMID:
22889281
34.

State of the art technologies in drug discovery 2011.

Matter A, Keller TH.

Curr Opin Chem Biol. 2011 Aug;15(4):461-2. doi: 10.1016/j.cbpa.2011.06.015. Epub 2011 Jul 21. No abstract available.

PMID:
21783401
35.

Structure-activity relationships of antitubercular nitroimidazoles. 3. Exploration of the linker and lipophilic tail of ((s)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-amino PA-824).

Cherian J, Choi I, Nayyar A, Manjunatha UH, Mukherjee T, Lee YS, Boshoff HI, Singh R, Ha YH, Goodwin M, Lakshminarayana SB, Niyomrattanakit P, Jiricek J, Ravindran S, Dick T, Keller TH, Dartois V, Barry CE 3rd.

J Med Chem. 2011 Aug 25;54(16):5639-59. doi: 10.1021/jm1010644. Epub 2011 Jul 26.

36.

Indium mediated allylation in peptide and protein functionalization.

Alam J, Keller TH, Loh TP.

Chem Commun (Camb). 2011 Aug 28;47(32):9066-8. doi: 10.1039/c1cc12926k. Epub 2011 Jul 14.

PMID:
21755083
37.

A translation inhibitor that suppresses dengue virus in vitro and in vivo.

Wang QY, Kondreddi RR, Xie X, Rao R, Nilar S, Xu HY, Qing M, Chang D, Dong H, Yokokawa F, Lakshminarayana SB, Goh A, Schul W, Kramer L, Keller TH, Shi PY.

Antimicrob Agents Chemother. 2011 Sep;55(9):4072-80. doi: 10.1128/AAC.00620-11. Epub 2011 Jul 5.

38.

Anti-infectives: can cellular screening deliver?

Keller TH, Shi PY, Wang QY.

Curr Opin Chem Biol. 2011 Aug;15(4):529-33. doi: 10.1016/j.cbpa.2011.06.007. Epub 2011 Jun 30. Review.

PMID:
21723774
39.

Small molecule inhibitors that selectively block dengue virus methyltransferase.

Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY.

J Biol Chem. 2011 Feb 25;286(8):6233-40. doi: 10.1074/jbc.M110.179184. Epub 2010 Dec 8.

40.

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.

Pethe K, Sequeira PC, Agarwalla S, Rhee K, Kuhen K, Phong WY, Patel V, Beer D, Walker JR, Duraiswamy J, Jiricek J, Keller TH, Chatterjee A, Tan MP, Ujjini M, Rao SP, Camacho L, Bifani P, Mak PA, Ma I, Barnes SW, Chen Z, Plouffe D, Thayalan P, Ng SH, Au M, Lee BH, Tan BH, Ravindran S, Nanjundappa M, Lin X, Goh A, Lakshminarayana SB, Shoen C, Cynamon M, Kreiswirth B, Dartois V, Peters EC, Glynne R, Brenner S, Dick T.

Nat Commun. 2010 Aug 24;1:57. doi: 10.1038/ncomms1060.

41.

Spiroindolones, a potent compound class for the treatment of malaria.

Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT.

Science. 2010 Sep 3;329(5996):1175-80. doi: 10.1126/science.1193225.

42.

Functionalization of peptides and proteins by Mukaiyama aldol reaction.

Alam J, Keller TH, Loh TP.

J Am Chem Soc. 2010 Jul 21;132(28):9546-8. doi: 10.1021/ja102733a.

PMID:
20583846
43.

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, Plouffe D, Henson K, Wagner T, Winzeler EA, Petersen F, Brun R, Dartois V, Diagana TT, Keller TH.

J Med Chem. 2010 Jul 22;53(14):5155-64. doi: 10.1021/jm100410f.

PMID:
20568778
44.

Inhibition of dengue virus by an ester prodrug of an adenosine analog.

Chen YL, Yin Z, Lakshminarayana SB, Qing M, Schul W, Duraiswamy J, Kondreddi RR, Goh A, Xu HY, Yip A, Liu B, Weaver M, Dartois V, Keller TH, Shi PY.

Antimicrob Agents Chemother. 2010 Aug;54(8):3255-61. doi: 10.1128/AAC.00397-10. Epub 2010 Jun 1.

45.

Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.

Chen YL, Yin Z, Duraiswamy J, Schul W, Lim CC, Liu B, Xu HY, Qing M, Yip A, Wang G, Chan WL, Tan HP, Lo M, Liung S, Kondreddi RR, Rao R, Gu H, He H, Keller TH, Shi PY.

Antimicrob Agents Chemother. 2010 Jul;54(7):2932-9. doi: 10.1128/AAC.00140-10. Epub 2010 May 10.

46.

Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT.

Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. doi: 10.1128/AAC.01526-09. Epub 2010 Mar 29.

47.

Inhibition of dengue virus polymerase by blocking of the RNA tunnel.

Niyomrattanakit P, Chen YL, Dong H, Yin Z, Qing M, Glickman JF, Lin K, Mueller D, Voshol H, Lim JY, Nilar S, Keller TH, Shi PY.

J Virol. 2010 Jun;84(11):5678-86. doi: 10.1128/JVI.02451-09. Epub 2010 Mar 17.

48.

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.

Yin Z, Chen YL, Kondreddi RR, Chan WL, Wang G, Ng RH, Lim JY, Lee WY, Jeyaraj DA, Niyomrattanakit P, Wen D, Chao A, Glickman JF, Voshol H, Mueller D, Spanka C, Dressler S, Nilar S, Vasudevan SG, Shi PY, Keller TH.

J Med Chem. 2009 Dec 24;52(24):7934-7. doi: 10.1021/jm901044z.

PMID:
20014868
49.

An adenosine nucleoside inhibitor of dengue virus.

Yin Z, Chen YL, Schul W, Wang QY, Gu F, Duraiswamy J, Kondreddi RR, Niyomrattanakit P, Lakshminarayana SB, Goh A, Xu HY, Liu W, Liu B, Lim JY, Ng CY, Qing M, Lim CC, Yip A, Wang G, Chan WL, Tan HP, Lin K, Zhang B, Zou G, Bernard KA, Garrett C, Beltz K, Dong M, Weaver M, He H, Pichota A, Dartois V, Keller TH, Shi PY.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20435-9. doi: 10.1073/pnas.0907010106. Epub 2009 Nov 16.

50.

A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.

Bodenreider C, Beer D, Keller TH, Sonntag S, Wen D, Yap L, Yau YH, Shochat SG, Huang D, Zhou T, Caflisch A, Su XC, Ozawa K, Otting G, Vasudevan SG, Lescar J, Lim SP.

Anal Biochem. 2009 Dec 15;395(2):195-204. doi: 10.1016/j.ab.2009.08.013. Epub 2009 Aug 13.

PMID:
19682971

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