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Items: 1 to 50 of 356

1.

Light-Sheet Microscopy and Its Potential for Understanding Developmental Processes.

Wan Y, McDole K, Keller PJ.

Annu Rev Cell Dev Biol. 2019 Jul 12. doi: 10.1146/annurev-cellbio-100818-125311. [Epub ahead of print]

PMID:
31299171
2.

Metabolic Regulation of Developmental Cell Cycles and Zygotic Transcription.

Djabrayan NJ, Smits CM, Krajnc M, Stern T, Yamada S, Lemon WC, Keller PJ, Rushlow CA, Shvartsman SY.

Curr Biol. 2019 Apr 1;29(7):1193-1198.e5. doi: 10.1016/j.cub.2019.02.028. Epub 2019 Mar 14.

PMID:
30880009
3.

Brain-wide circuit interrogation at the cellular level guided by online analysis of neuronal function.

Vladimirov N, Wang C, Höckendorf B, Pujala A, Tanimoto M, Mu Y, Yang CT, Wittenbach JD, Freeman J, Preibisch S, Koyama M, Keller PJ, Ahrens MB.

Nat Methods. 2018 Dec;15(12):1117-1125. doi: 10.1038/s41592-018-0221-x. Epub 2018 Nov 30.

PMID:
30504888
4.

A practical guide to adaptive light-sheet microscopy.

Royer LA, Lemon WC, Chhetri RK, Keller PJ.

Nat Protoc. 2018 Nov;13(11):2462-2500. doi: 10.1038/s41596-018-0043-4.

PMID:
30367170
5.

In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level.

McDole K, Guignard L, Amat F, Berger A, Malandain G, Royer LA, Turaga SC, Branson K, Keller PJ.

Cell. 2018 Oct 18;175(3):859-876.e33. doi: 10.1016/j.cell.2018.09.031. Epub 2018 Oct 11.

PMID:
30318151
6.

Multi-view light-sheet imaging and tracking with the MaMuT software reveals the cell lineage of a direct developing arthropod limb.

Wolff C, Tinevez JY, Pietzsch T, Stamataki E, Harich B, Guignard L, Preibisch S, Shorte S, Keller PJ, Tomancak P, Pavlopoulos A.

Elife. 2018 Mar 29;7. pii: e34410. doi: 10.7554/eLife.34410.

7.

A Preferred Curvature-Based Continuum Mechanics Framework for Modeling Embryogenesis.

Khairy K, Lemon W, Amat F, Keller PJ.

Biophys J. 2018 Jan 23;114(2):267-277. doi: 10.1016/j.bpj.2017.11.015.

8.

A general method to fine-tune fluorophores for live-cell and in vivo imaging.

Grimm JB, Muthusamy AK, Liang Y, Brown TA, Lemon WC, Patel R, Lu R, Macklin JJ, Keller PJ, Ji N, Lavis LD.

Nat Methods. 2017 Oct;14(10):987-994. doi: 10.1038/nmeth.4403. Epub 2017 Sep 4.

9.

Epigenetic Reprogramming of Lineage-Committed Human Mammary Epithelial Cells Requires DNMT3A and Loss of DOT1L.

Breindel JL, Skibinski A, Sedic M, Wronski-Campos A, Zhou W, Keller PJ, Mills J, Bradner J, Onder T, Kuperwasser C.

Stem Cell Reports. 2017 Sep 12;9(3):943-955. doi: 10.1016/j.stemcr.2017.06.019. Epub 2017 Aug 3.

10.

How to Make a Worm Twitch.

Keller PJ.

Biophys J. 2017 May 9;112(9):1737-1738. doi: 10.1016/j.bpj.2017.03.035. No abstract available.

11.

Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms.

Royer LA, Lemon WC, Chhetri RK, Wan Y, Coleman M, Myers EW, Keller PJ.

Nat Biotechnol. 2016 Dec;34(12):1267-1278. doi: 10.1038/nbt.3708. Epub 2016 Oct 31.

PMID:
27798562
12.

Imaging far and wide.

Chhetri RK, Keller PJ.

Elife. 2016 Sep 23;5. pii: e21072. doi: 10.7554/eLife.21072.

13.

Correction: Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.

Conery AR, Centore RC, Neiss A, Keller PJ, Joshi S, Spillane KL, Sandy P, Hatton C, Pardo E, Zawadzke L, Bommi-Reddy A, Gascoigne KE, Bryant BM, Mertz JA, Sims RJ.

Elife. 2016 Jul 14;5. pii: e19432. doi: 10.7554/eLife.19432. No abstract available.

14.

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, Conery AR, Cummings RT, Dakin LA, Flynn EM, Huang OW, Kaufman S, Keller PJ, Kiefer JR, Lai T, Li Y, Liao J, Liu W, Lu H, Pardo E, Tsui V, Wang J, Wang Y, Xu Z, Yan F, Yu D, Zawadzke L, Zhu X, Zhu X, Sims RJ 3rd, Cochran AG, Bellon S, Audia JE, Magnuson S, Albrecht BK.

ACS Med Chem Lett. 2016 Mar 15;7(5):531-6. doi: 10.1021/acsmedchemlett.6b00075. eCollection 2016 May 12.

15.

Repulsive cues combined with physical barriers and cell-cell adhesion determine progenitor cell positioning during organogenesis.

Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E.

Nat Commun. 2016 Apr 18;7:11288. doi: 10.1038/ncomms11288.

16.

Emerging Imaging and Genomic Tools for Developmental Systems Biology.

Liu Z, Keller PJ.

Dev Cell. 2016 Mar 21;36(6):597-610. doi: 10.1016/j.devcel.2016.02.016. Review.

17.

Real-Time Three-Dimensional Cell Segmentation in Large-Scale Microscopy Data of Developing Embryos.

Stegmaier J, Amat F, Lemon WC, McDole K, Wan Y, Teodoro G, Mikut R, Keller PJ.

Dev Cell. 2016 Jan 25;36(2):225-40. doi: 10.1016/j.devcel.2015.12.028.

18.

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.

Conery AR, Centore RC, Neiss A, Keller PJ, Joshi S, Spillane KL, Sandy P, Hatton C, Pardo E, Zawadzke L, Bommi-Reddy A, Gascoigne KE, Bryant BM, Mertz JA, Sims RJ.

Elife. 2016 Jan 5;5. pii: e10483. doi: 10.7554/eLife.10483. Erratum in: Elife. 2016;5. pii: e19432. doi: 10.7554/eLife.19432.

19.

Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux.

Beerman RW, Matty MA, Au GG, Looger LL, Choudhury KR, Keller PJ, Tobin DM.

Cell Rep. 2015 Dec 15;13(10):2107-17. doi: 10.1016/j.celrep.2015.11.010. Epub 2015 Dec 7.

20.

Stochastic electrotransport selectively enhances the transport of highly electromobile molecules.

Kim SY, Cho JH, Murray E, Bakh N, Choi H, Ohn K, Ruelas L, Hubbert A, McCue M, Vassallo SL, Keller PJ, Chung K.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6274-83. doi: 10.1073/pnas.1510133112. Epub 2015 Nov 2.

21.

Whole-animal functional and developmental imaging with isotropic spatial resolution.

Chhetri RK, Amat F, Wan Y, Höckendorf B, Lemon WC, Keller PJ.

Nat Methods. 2015 Dec;12(12):1171-8. doi: 10.1038/nmeth.3632. Epub 2015 Oct 26.

PMID:
26501515
22.

Efficient processing and analysis of large-scale light-sheet microscopy data.

Amat F, Höckendorf B, Wan Y, Lemon WC, McDole K, Keller PJ.

Nat Protoc. 2015 Nov;10(11):1679-96. doi: 10.1038/nprot.2015.111. Epub 2015 Oct 1.

PMID:
26426501
23.

Whole-central nervous system functional imaging in larval Drosophila.

Lemon WC, Pulver SR, Höckendorf B, McDole K, Branson K, Freeman J, Keller PJ.

Nat Commun. 2015 Aug 11;6:7924. doi: 10.1038/ncomms8924.

24.

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C.

Nat Commun. 2015 Jun 24;6:7505. doi: 10.1038/ncomms8505.

25.

Visualizing whole-brain activity and development at the single-cell level using light-sheet microscopy.

Keller PJ, Ahrens MB.

Neuron. 2015 Feb 4;85(3):462-83. doi: 10.1016/j.neuron.2014.12.039. Review.

26.

Proper migration and axon outgrowth of zebrafish cranial motoneuron subpopulations require the cell adhesion molecule MDGA2A.

Ingold E, Vom Berg-Maurer CM, Burckhardt CJ, Lehnherr A, Rieder P, Keller PJ, Stelzer EH, Greber UF, Neuhauss SC, Gesemann M.

Biol Open. 2015 Jan 8;4(2):146-54. doi: 10.1242/bio.20148482.

27.

Light-sheet imaging for systems neuroscience.

Keller PJ, Ahrens MB, Freeman J.

Nat Methods. 2015 Jan;12(1):27-9. doi: 10.1038/nmeth.3214. No abstract available.

PMID:
25549267
28.

Making biology transparent.

Höckendorf B, Lavis LD, Keller PJ.

Nat Biotechnol. 2014 Nov;32(11):1104-5. doi: 10.1038/nbt.3061. No abstract available.

PMID:
25380446
29.

Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules.

Arendt LM, Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, Kuperwasser C.

Breast Cancer Res. 2014 Oct 15;16(5):453. doi: 10.1186/s13058-014-0453-3.

30.

Light sheet-based imaging and analysis of early embryogenesis in the fruit fly.

Khairy K, Lemon WC, Amat F, Keller PJ.

Methods Mol Biol. 2015;1189:79-97. doi: 10.1007/978-1-4939-1164-6_6.

PMID:
25245688
31.

Development of the annelid axochord: insights into notochord evolution.

Lauri A, Brunet T, Handberg-Thorsager M, Fischer AH, Simakov O, Steinmetz PR, Tomer R, Keller PJ, Arendt D.

Science. 2014 Sep 12;345(6202):1365-8. doi: 10.1126/science.1253396.

32.

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.

Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R.

J Cell Sci. 2014 Oct 15;127(Pt 20):4381-95. doi: 10.1242/jcs.146217. Epub 2014 Sep 1.

33.

Light-sheet functional imaging in fictively behaving zebrafish.

Vladimirov N, Mu Y, Kawashima T, Bennett DV, Yang CT, Looger LL, Keller PJ, Freeman J, Ahrens MB.

Nat Methods. 2014 Sep;11(9):883-4. doi: 10.1038/nmeth.3040. Epub 2014 Jul 27. No abstract available.

PMID:
25068735
34.

Fast, accurate reconstruction of cell lineages from large-scale fluorescence microscopy data.

Amat F, Lemon W, Mossing DP, McDole K, Wan Y, Branson K, Myers EW, Keller PJ.

Nat Methods. 2014 Sep;11(9):951-8. doi: 10.1038/nmeth.3036. Epub 2014 Jul 20.

PMID:
25042785
35.

Live imaging and quantitative analysis of gastrulation in mouse embryos using light-sheet microscopy and 3D tracking tools.

Ichikawa T, Nakazato K, Keller PJ, Kajiura-Kobayashi H, Stelzer EH, Mochizuki A, Nonaka S.

Nat Protoc. 2014 Mar;9(3):575-85. doi: 10.1038/nprot.2014.035. Epub 2014 Feb 13. Erratum in: Nat Protoc. 2014 Oct;9(10):2513.

PMID:
24525751
36.

Live imaging of nervous system development and function using light-sheet microscopy.

Lemon WC, Keller PJ.

Mol Reprod Dev. 2015 Jul-Aug;82(7-8):605-18. doi: 10.1002/mrd.22258. Epub 2013 Sep 16. Review.

PMID:
23996352
37.

Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis.

Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V, Kuperwasser C.

Cancer Res. 2013 Oct 1;73(19):6080-93. doi: 10.1158/0008-5472.CAN-13-0926. Epub 2013 Aug 19.

38.

Live imaging of whole mouse embryos during gastrulation: migration analyses of epiblast and mesodermal cells.

Ichikawa T, Nakazato K, Keller PJ, Kajiura-Kobayashi H, Stelzer EH, Mochizuki A, Nonaka S.

PLoS One. 2013 Jul 8;8(7):e64506. doi: 10.1371/journal.pone.0064506. Print 2013.

39.

The role of oxidative stress in nervous system aging.

Sims-Robinson C, Hur J, Hayes JM, Dauch JR, Keller PJ, Brooks SV, Feldman EL.

PLoS One. 2013 Jul 2;8(7):e68011. doi: 10.1371/journal.pone.0068011. Print 2013.

40.

Imaging morphogenesis: technological advances and biological insights.

Keller PJ.

Science. 2013 Jun 7;340(6137):1234168. doi: 10.1126/science.1234168. Review.

PMID:
23744952
41.

Towards comprehensive cell lineage reconstructions in complex organisms using light-sheet microscopy.

Amat F, Keller PJ.

Dev Growth Differ. 2013 May;55(4):563-78. doi: 10.1111/dgd.12063. Epub 2013 Apr 29. Review.

PMID:
23621671
42.

Whole-brain functional imaging at cellular resolution using light-sheet microscopy.

Ahrens MB, Orger MB, Robson DN, Li JM, Keller PJ.

Nat Methods. 2013 May;10(5):413-20. doi: 10.1038/nmeth.2434. Epub 2013 Mar 18.

PMID:
23524393
43.

In vivo imaging of zebrafish embryogenesis.

Keller PJ.

Methods. 2013 Aug 15;62(3):268-78. doi: 10.1016/j.ymeth.2013.03.015. Epub 2013 Mar 21.

44.

New technologies in imaging.

Galbraith CG, Keller PJ, Nogales E.

Mol Biol Cell. 2013 Mar;24(6):669. doi: 10.1091/mbc.E12-12-0867. No abstract available.

45.

Fast and robust optical flow for time-lapse microscopy using super-voxels.

Amat F, Myers EW, Keller PJ.

Bioinformatics. 2013 Feb 1;29(3):373-80. doi: 10.1093/bioinformatics/bts706. Epub 2012 Dec 14.

46.

Light sheet microscopy in cell biology.

Tomer R, Khairy K, Keller PJ.

Methods Mol Biol. 2013;931:123-37. doi: 10.1007/978-1-62703-056-4_7. Review.

PMID:
23027001
47.

Tandem fluorescent protein timers for in vivo analysis of protein dynamics.

Khmelinskii A, Keller PJ, Bartosik A, Meurer M, Barry JD, Mardin BR, Kaufmann A, Trautmann S, Wachsmuth M, Pereira G, Huber W, Schiebel E, Knop M.

Nat Biotechnol. 2012 Jun 24;30(7):708-14. doi: 10.1038/nbt.2281.

PMID:
22729030
48.

Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy.

Tomer R, Khairy K, Amat F, Keller PJ.

Nat Methods. 2012 Jun 3;9(7):755-63. doi: 10.1038/nmeth.2062.

PMID:
22660741
49.

Stem cell maintenance of the mammary gland: it takes two.

Keller PJ, Arendt LM, Kuperwasser C.

Cell Stem Cell. 2011 Dec 2;9(6):496-7. doi: 10.1016/j.stem.2011.11.008.

50.

A computational statistics approach for estimating the spatial range of morphogen gradients.

Kanodia JS, Kim Y, Tomer R, Khan Z, Chung K, Storey JD, Lu H, Keller PJ, Shvartsman SY.

Development. 2011 Nov;138(22):4867-74. doi: 10.1242/dev.071571. Epub 2011 Oct 17.

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