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Efficacy of voriconazole against A. fumigatus infection depends on host immune function.

Rosowski EE, He J, Huisken J, Keller NP, Huttenlocher A.

Antimicrob Agents Chemother. 2019 Nov 18. pii: AAC.00917-19. doi: 10.1128/AAC.00917-19. [Epub ahead of print]


Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.

Schoen TJ, Rosowski EE, Knox BP, Bennin D, Keller NP, Huttenlocher A.

J Cell Sci. 2019 Nov 13. pii: jcs.236539. doi: 10.1242/jcs.236539. [Epub ahead of print]


Genome sequencing of evolved aspergilli populations reveals robust genomes, transversions in A. flavus, and sexual aberrancy in non-homologous end-joining mutants.

Álvarez-Escribano I, Sasse C, Bok JW, Na H, Amirebrahimi M, Lipzen A, Schackwitz W, Martin J, Barry K, Gutiérrez G, Cea-Sánchez S, Marcos AT, Grigoriev IV, Keller NP, Braus GH, Cánovas D.

BMC Biol. 2019 Nov 11;17(1):88. doi: 10.1186/s12915-019-0702-0.


Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains.

Baccile JA, Le HH, Pfannenstiel BT, Bok JW, Gomez C, Brandenburger E, Hoffmeister D, Keller NP, Schroeder FC.

Angew Chem Int Ed Engl. 2019 Oct 7;58(41):14589-14593. doi: 10.1002/anie.201909052. Epub 2019 Aug 28.


Depsipeptide Aspergillicins Revealed by Chromatin Reader Protein Deletion.

Greco C, Pfannenstiel BT, Liu JC, Keller NP.

ACS Chem Biol. 2019 Jun 21;14(6):1121-1128. doi: 10.1021/acschembio.9b00161. Epub 2019 May 24.


Unearthing fungal chemodiversity and prospects for drug discovery.

Greco C, Keller NP, Rokas A.

Curr Opin Microbiol. 2019 May 6;51:22-29. doi: 10.1016/j.mib.2019.03.002. [Epub ahead of print] Review.


Harnessing diverse transcriptional regulators for natural product discovery in fungi.

Lyu HN, Liu HW, Keller NP, Yin WB.

Nat Prod Rep. 2019 Apr 29. doi: 10.1039/c8np00027a. [Epub ahead of print]


Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus.

Raffa N, Osherov N, Keller NP.

Int J Mol Sci. 2019 Apr 23;20(8). pii: E1980. doi: 10.3390/ijms20081980. Review.


Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model.

Mueller KD, Zhang H, Serrano CR, Billmyre RB, Huh EY, Wiemann P, Keller NP, Wang Y, Heitman J, Lee SC.

J Microbiol. 2019 Jun;57(6):509-520. doi: 10.1007/s12275-019-8682-x. Epub 2019 May 27.


The HosA Histone Deacetylase Regulates Aflatoxin Biosynthesis Through Direct Regulation of Aflatoxin Cluster Genes.

Lan H, Wu L, Sun R, Keller NP, Yang K, Ye L, He S, Zhang F, Wang S.

Mol Plant Microbe Interact. 2019 Sep;32(9):1210-1228. doi: 10.1094/MPMI-01-19-0033-R. Epub 2019 Jul 31.


Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus.

Ma K, Zhang P, Tao Q, Keller NP, Yang Y, Yin WB, Liu H.

Org Lett. 2019 May 3;21(9):3252-3256. doi: 10.1021/acs.orglett.9b00984. Epub 2019 Apr 12.


A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen.

Raffa N, Keller NP.

PLoS Pathog. 2019 Apr 4;15(4):e1007606. doi: 10.1371/journal.ppat.1007606. eCollection 2019 Apr. No abstract available.


Mycotoxins in Conversation With Bacteria and Fungi.

Venkatesh N, Keller NP.

Front Microbiol. 2019 Mar 19;10:403. doi: 10.3389/fmicb.2019.00403. eCollection 2019. Review.


Co-opting oxylipin signals in microbial disease.

Niu M, Keller NP.

Cell Microbiol. 2019 Jun;21(6):e13025. doi: 10.1111/cmi.13025. Review.


On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.

Pfannenstiel BT, Keller NP.

Biotechnol Adv. 2019 Nov 1;37(6):107345. doi: 10.1016/j.biotechadv.2019.02.001. Epub 2019 Feb 7. Review.


The Zebrafish as a Model Host for Invasive Fungal Infections.

Rosowski EE, Knox BP, Archambault LS, Huttenlocher A, Keller NP, Wheeler RT, Davis JM.

J Fungi (Basel). 2018 Dec 13;4(4). pii: E136. doi: 10.3390/jof4040136. Review.


Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase.

Dindo M, Costanzi E, Pieroni M, Costantini C, Annunziato G, Bruno A, Keller NP, Romani L, Zelante T, Cellini B.

Front Mol Biosci. 2018 Nov 28;5:104. doi: 10.3389/fmolb.2018.00104. eCollection 2018.


Fungal secondary metabolism: regulation, function and drug discovery.

Keller NP.

Nat Rev Microbiol. 2019 Mar;17(3):167-180. doi: 10.1038/s41579-018-0121-1. Review.


A possible role for fumagillin in cellular damage during host infection by Aspergillus fumigatus.

Guruceaga X, Ezpeleta G, Mayayo E, Sueiro-Olivares M, Abad-Diaz-De-Cerio A, Aguirre Urízar JM, Liu HG, Wiemann P, Bok JW, Filler SG, Keller NP, Hernando FL, Ramirez-Garcia A, Rementeria A.

Virulence. 2018;9(1):1548-1561. doi: 10.1080/21505594.2018.1526528.


The epigenetic reader SntB regulates secondary metabolism, development and global histone modifications in Aspergillus flavus.

Pfannenstiel BT, Greco C, Sukowaty AT, Keller NP.

Fungal Genet Biol. 2018 Nov;120:9-18. doi: 10.1016/j.fgb.2018.08.004. Epub 2018 Aug 18.


Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.

Rosowski EE, Raffa N, Knox BP, Golenberg N, Keller NP, Huttenlocher A.

PLoS Pathog. 2018 Aug 2;14(8):e1007229. doi: 10.1371/journal.ppat.1007229. eCollection 2018 Aug.


Fungal attack and host defence pathways unveiled in near-avirulent interactions of Penicillium expansum creA mutants on apples.

Tannous J, Kumar D, Sela N, Sionov E, Prusky D, Keller NP.

Mol Plant Pathol. 2018 Dec;19(12):2635-2650. doi: 10.1111/mpp.12734. Epub 2018 Oct 22.


Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus.

Yang K, Shadkchan Y, Tannous J, Landero Figueroa JA, Wiemann P, Osherov N, Wang S, Keller NP.

Virulence. 2018;9(1):1273-1286. doi: 10.1080/21505594.2018.1496774.


The Antioxidant Gallic Acid Inhibits Aflatoxin Formation in Aspergillus flavus by Modulating Transcription Factors FarB and CreA.

Zhao X, Zhi QQ, Li JY, Keller NP, He ZM.

Toxins (Basel). 2018 Jul 3;10(7). pii: E270. doi: 10.3390/toxins10070270.


A Bcl-2 Associated Athanogene (bagA) Modulates Sexual Development and Secondary Metabolism in the Filamentous Fungus Aspergillus nidulans.

Jain S, Wiemann P, Thill E, Williams B, Keller NP, Kabbage M.

Front Microbiol. 2018 Jun 15;9:1316. doi: 10.3389/fmicb.2018.01316. eCollection 2018.


Deletion of a global regulator LaeB leads to the discovery of novel polyketides in Aspergillus nidulans.

Lin H, Lyu H, Zhou S, Yu J, Keller NP, Chen L, Yin WB.

Org Biomol Chem. 2018 Jul 11;16(27):4973-4976. doi: 10.1039/c8ob01326h.


Fungal Isocyanide Synthases and Xanthocillin Biosynthesis in Aspergillus fumigatus.

Lim FY, Won TH, Raffa N, Baccile JA, Wisecaver J, Rokas A, Schroeder FC, Keller NP.

MBio. 2018 May 29;9(3). pii: e00785-18. doi: 10.1128/mBio.00785-18.


Peptide-Like Nylon-3 Polymers with Activity against Phylogenetically Diverse, Intrinsically Drug-Resistant Pathogenic Fungi.

Rank LA, Walsh NM, Lim FY, Gellman SH, Keller NP, Hull CM.

mSphere. 2018 May 23;3(3). pii: e00223-18. doi: 10.1128/mSphere.00223-18. eCollection 2018 May-Jun.


Conserved Responses in a War of Small Molecules between a Plant-Pathogenic Bacterium and Fungi.

Spraker JE, Wiemann P, Baccile JA, Venkatesh N, Schumacher J, Schroeder FC, Sanchez LM, Keller NP.

MBio. 2018 May 22;9(3). pii: e00820-18. doi: 10.1128/mBio.00820-18.


Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus.

Jain S, Sekonyela R, Knox BP, Palmer JM, Huttenlocher A, Kabbage M, Keller NP.

Fungal Genet Biol. 2018 Aug;117:1-10. doi: 10.1016/j.fgb.2018.05.001. Epub 2018 May 9.


Analysis of the Relationship between Alternative Respiration and Sterigmatocystin Formation in Aspergillus nidulans.

Molnár ÁP, Németh Z, Fekete E, Flipphi M, Keller NP, Karaffa L.

Toxins (Basel). 2018 Apr 20;10(4). pii: E168. doi: 10.3390/toxins10040168.


Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL.

ACS Chem Biol. 2018 May 18;13(5):1142-1147. doi: 10.1021/acschembio.8b00024. Epub 2018 Apr 17.


An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatus.

Lind AL, Lim FY, Soukup AA, Keller NP, Rokas A.

mSphere. 2018 Mar 14;3(2). pii: e00050-18. doi: 10.1128/mSphere.00050-18. eCollection 2018 Mar-Apr.


CoIN: co-inducible nitrate expression system for secondary metabolites in Aspergillus nidulans.

Wiemann P, Soukup AA, Folz JS, Wang PM, Noack A, Keller NP.

Fungal Biol Biotechnol. 2018 Mar 13;5:6. doi: 10.1186/s40694-018-0049-2. eCollection 2018.


Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey MT, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu CC, Keller NP, Kelleher NL.

Biochemistry. 2018 Jun 12;57(23):3237-3243. doi: 10.1021/acs.biochem.8b00076. Epub 2018 Mar 20.


A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus-Host Interactions.

Choera T, Zelante T, Romani L, Keller NP.

Front Immunol. 2018 Jan 22;8:1996. doi: 10.3389/fimmu.2017.01996. eCollection 2017. Review.


NRPS-Derived Isoquinolines and Lipopetides Mediate Antagonism between Plant Pathogenic Fungi and Bacteria.

Khalid S, Baccile JA, Spraker JE, Tannous J, Imran M, Schroeder FC, Keller NP.

ACS Chem Biol. 2018 Jan 19;13(1):171-179. doi: 10.1021/acschembio.7b00731. Epub 2017 Dec 18.


Microbial volatile communication in human organotypic lung models.

Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ.

Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4.


Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species.

Lind AL, Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F, Goldman GH, Rokas A.

PLoS Biol. 2017 Nov 17;15(11):e2003583. doi: 10.1371/journal.pbio.2003583. eCollection 2017 Nov.


A Cellular Fusion Cascade Regulated by LaeA Is Required for Sclerotial Development in Aspergillus flavus.

Zhao X, Spraker JE, Bok JW, Velk T, He ZM, Keller NP.

Front Microbiol. 2017 Oct 5;8:1925. doi: 10.3389/fmicb.2017.01925. eCollection 2017.


Does the Host Contribute to Modulation of Mycotoxin Production by Fruit Pathogens?

Kumar D, Barad S, Sionov E, Keller NP, Prusky DB.

Toxins (Basel). 2017 Sep 12;9(9). pii: E280. doi: 10.3390/toxins9090280. Review.


Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus Aspergillus.

Pfannenstiel BT, Zhao X, Wortman J, Wiemann P, Throckmorton K, Spraker JE, Soukup AA, Luo X, Lindner DL, Lim FY, Knox BP, Haas B, Fischer GJ, Choera T, Butchko RAE, Bok JW, Affeldt KJ, Keller NP, Palmer JM.

MBio. 2017 Sep 5;8(5). pii: e01246-17. doi: 10.1128/mBio.01246-17.


Multikingdom microscale models.

Barkal LJ, Berthier E, Theberge AB, Keller NP, Beebe DJ.

PLoS Pathog. 2017 Aug 24;13(8):e1006424. doi: 10.1371/journal.ppat.1006424. eCollection 2017 Aug. Review. No abstract available.


A Cationic Polymer That Shows High Antifungal Activity against Diverse Human Pathogens.

Rank LA, Walsh NM, Liu R, Lim FY, Bok JW, Huang M, Keller NP, Gellman SH, Hull CM.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00204-17. doi: 10.1128/AAC.00204-17. Print 2017 Oct.


A scalable platform to identify fungal secondary metabolites and their gene clusters.

Clevenger KD, Bok JW, Ye R, Miley GP, Verdan MH, Velk T, Chen C, Yang K, Robey MT, Gao P, Lamprecht M, Thomas PM, Islam MN, Palmer JM, Wu CC, Keller NP, Kelleher NL.

Nat Chem Biol. 2017 Aug;13(8):895-901. doi: 10.1038/nchembio.2408. Epub 2017 Jun 12.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 Jun 6;19(10):2174-2176. doi: 10.1016/j.celrep.2017.05.075. No abstract available.


Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae.

Knox BP, Huttenlocher A, Keller NP.

Fungal Genet Biol. 2017 Aug;105:52-54. doi: 10.1016/j.fgb.2017.05.005. Epub 2017 May 27.


Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus.

Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP.

Front Microbiol. 2017 May 9;8:831. doi: 10.3389/fmicb.2017.00831. eCollection 2017.


A cryptic pigment biosynthetic pathway uncovered by heterologous expression is essential for conidial development in Pestalotiopsis fici.

Zhang P, Wang X, Fan A, Zheng Y, Liu X, Wang S, Zou H, Oakley BR, Keller NP, Yin WB.

Mol Microbiol. 2017 Aug;105(3):469-483. doi: 10.1111/mmi.13711. Epub 2017 Jun 6.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 May 2;19(5):1008-1021. doi: 10.1016/j.celrep.2017.04.019. Erratum in: Cell Rep. 2017 Jun 6;19(10 ):2174-2176.

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