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The Effects of Cardiovascular Risk Factors on Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Performance in Cognitively Healthy Older Adults.

N De Vito A, Bernstein JPK, Weitzner D, Calamia M, Keller JN.

Arch Clin Neuropsychol. 2019 Oct 24. pii: acz039. doi: 10.1093/arclin/acz039. [Epub ahead of print]


The Complex Interactions Between Obesity, Metabolism and the Brain.

Uranga RM, Keller JN.

Front Neurosci. 2019 May 24;13:513. doi: 10.3389/fnins.2019.00513. eCollection 2019. Review.


Examining Relationships between Multiple Self-Reported Sleep Measures and Gait Domains in Cognitively Healthy Older Adults.

Bernstein JPK, De Vito A, Weitzner DS, MacAulay R, Calamia M, Brouillette R, Foil H, Carmichael OT, Keller JN.

Gerontology. 2019 May 9:1-8. doi: 10.1159/000499737. [Epub ahead of print]


The db mutation improves memory in younger mice in a model of Alzheimer's disease.

Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2157-2167. doi: 10.1016/j.bbadis.2019.04.013. Epub 2019 Apr 26.


Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study).

Szabo-Reed AN, Vidoni E, Binder EF, Burns J, Cullum CM, Gahan WP, Gupta A, Hynan LS, Kerwin DR, Rossetti H, Stowe AM, Vongpatanasin W, Zhu DC, Zhang R, Keller JN.

Contemp Clin Trials. 2019 Apr;79:44-54. doi: 10.1016/j.cct.2019.02.007. Epub 2019 Mar 1.


A Combination of Essential Fatty Acids, Panax Ginseng Extract, and Green Tea Catechins Modifies Brain fMRI Signals in Healthy Older Adults.

Carmichael OT, Pillai S, Shankapal P, McLellan A, Kay DG, Gold BT, Keller JN.

J Nutr Health Aging. 2018;22(7):837-846. doi: 10.1007/s12603-018-1028-2.


Pedometer-assessed steps per day as a predictor of cognitive performance in older adults.

Calamia M, De Vito A, Bernstein JPK, Weitzner DS, Carmichael OT, Keller JN.

Neuropsychology. 2018 Nov;32(8):941-949. doi: 10.1037/neu0000487. Epub 2018 Aug 6.


Multiple self-reported sleep measures are differentially associated with cognitive performance in community-dwelling nondemented elderly.

Bernstein JPK, Calamia M, Keller JN.

Neuropsychology. 2018 Feb;32(2):220-229. doi: 10.1037/neu0000407. Epub 2017 Oct 16.


Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial.

Espeland MA, Carmichael O, Hayden K, Neiberg RH, Newman AB, Keller JN, Wadden TA, Rapp SR, Hill JO, Horton ES, Johnson KC, Wagenknecht L, Wing RR; Action for Health In Diabetes Brain Magnetic Resonance Imaging (Look AHEAD Brain) and Action for Health Movement and Memory Ancillary Study Research Groups.

J Gerontol A Biol Sci Med Sci. 2018 Mar 14;73(4):484-491. doi: 10.1093/gerona/glx165.


Understanding heterogeneity in older adults: Latent growth curve modeling of cognitive functioning.

MacAulay RK, Calamia MR, Cohen AS, Daigle K, Foil H, Brouillette R, Bruce-Keller AJ, Keller JN.

J Clin Exp Neuropsychol. 2018 Apr;40(3):292-302. doi: 10.1080/13803395.2017.1342772. Epub 2017 Jul 1.


Adipose-specific ablation of Nrf2 transiently delayed high-fat diet-induced obesity by altering glucose, lipid and energy metabolism of male mice.

Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

Am J Transl Res. 2016 Dec 15;8(12):5309-5319. eCollection 2016.


Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study.

Rapp SR, Luchsinger JA, Baker LD, Blackburn GL, Hazuda HP, Demos-McDermott KE, Jeffery RW, Keller JN, McCaffery JM, Pajewski NM, Evans M, Wadden TA, Arnold SE, Espeland MA; Look AHEAD Research Group.

J Am Geriatr Soc. 2017 May;65(5):966-972. doi: 10.1111/jgs.14692. Epub 2017 Jan 9.


Reliability and Validity of a Novel Internet-Based Battery to Assess Mood and Cognitive Function in the Elderly.

Myers CA, Keller JN, Allen HR, Brouillette RM, Foil H, Davis AB, Greenway FL, Johnson WD, Martin CK.

J Alzheimers Dis. 2016 Oct 18;54(4):1359-1364.


Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change.

MacAulay RK, Allaire T, Brouillette R, Foil H, Bruce-Keller AJ, Keller JN.

PLoS One. 2016 Aug 3;11(8):e0156732. doi: 10.1371/journal.pone.0156732. eCollection 2016.


I'd Do Anything for Research, But I Won't Do That: Interest in Pharmacological Interventions in Older Adults Enrolled in a Longitudinal Aging Study.

Calamia M, Bernstein JP, Keller JN.

PLoS One. 2016 Jul 20;11(7):e0159664. doi: 10.1371/journal.pone.0159664. eCollection 2016.


High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity.

Qosa H, Mohamed LA, Al Rihani SB, Batarseh YS, Duong QV, Keller JN, Kaddoumi A.

J Alzheimers Dis. 2016 Jul 6;53(4):1499-516. doi: 10.3233/JAD-151179.


The fine-tuning of proteolytic pathways in Alzheimer's disease.

Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Angeletti M, Keller JN, Eleuteri AM.

Cell Mol Life Sci. 2016 Sep;73(18):3433-51. doi: 10.1007/s00018-016-2238-6. Epub 2016 Apr 27. Review.


Dietary Plant Lectins Appear to Be Transported from the Gut to Gain Access to and Alter Dopaminergic Neurons of Caenorhabditis elegans, a Potential Etiology of Parkinson's Disease.

Zheng J, Wang M, Wei W, Keller JN, Adhikari B, King JF, King ML, Peng N, Laine RA.

Front Nutr. 2016 Mar 7;3:7. doi: 10.3389/fnut.2016.00007. eCollection 2016.


Elevated adiponectin prevents HIV protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice.

Dasuri K, Pepping JK, Fernandez-Kim SO, Gupta S, Keller JN, Scherer PE, Bruce-Keller AJ.

Biochim Biophys Acta. 2016 Jun;1862(6):1228-35. doi: 10.1016/j.bbadis.2016.02.009. Epub 2016 Feb 18.


Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model.

Mohamed LA, Keller JN, Kaddoumi A.

Biochim Biophys Acta. 2016 Apr;1862(4):778-787. doi: 10.1016/j.bbadis.2016.01.013. Epub 2016 Jan 15.


Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial.

Rebello CJ, Keller JN, Liu AG, Johnson WD, Greenway FL.

BBA Clin. 2015 Jan 16;3:123-5. doi: 10.1016/j.bbacli.2015.01.001. eCollection 2015 Jun.


Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain.

Dasuri K, Zhang L, Kim SO, Bruce-Keller AJ, Keller JN.

Biochim Biophys Acta. 2016 Feb;1862(2):274-83. doi: 10.1016/j.bbadis.2015.11.002. Epub 2015 Nov 10.


Oleocanthal enhances amyloid-β clearance from the brains of TgSwDI mice and in vitro across a human blood-brain barrier model.

Qosa H, Batarseh YS, Mohyeldin MM, El Sayed KA, Keller JN, Kaddoumi A.

ACS Chem Neurosci. 2015 Nov 18;6(11):1849-59. doi: 10.1021/acschemneuro.5b00190. Epub 2015 Sep 16.


Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice.

Qosa H, Mohamed LA, Batarseh YS, Alqahtani S, Ibrahim B, LeVine H 3rd, Keller JN, Kaddoumi A.

J Nutr Biochem. 2015 Dec;26(12):1479-90. doi: 10.1016/j.jnutbio.2015.07.022. Epub 2015 Aug 13.


Effects of Ghrelin on the Proteolytic Pathways of Alzheimer's Disease Neuronal Cells.

Cecarini V, Bonfili L, Cuccioloni M, Keller JN, Bruce-Keller AJ, Eleuteri AM.

Mol Neurobiol. 2016 Jul;53(5):3168-3178. doi: 10.1007/s12035-015-9227-x. Epub 2015 Jun 2.


Longitudinal assessment of neuropsychological and temporal/spatial gait characteristics of elderly fallers: taking it all in stride.

MacAulay RK, Allaire TD, Brouillette RM, Foil HC, Bruce-Keller AJ, Han H, Johnson WD, Keller JN.

Front Aging Neurosci. 2015 Mar 18;7:34. doi: 10.3389/fnagi.2015.00034. eCollection 2015.


Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model.

Qosa H, LeVine H 3rd, Keller JN, Kaddoumi A.

Biochim Biophys Acta. 2014 Sep;1842(9):1806-15. doi: 10.1016/j.bbadis.2014.06.029. Epub 2014 Jul 2.


A longitudinal study on dual-tasking effects on gait: cognitive change predicts gait variance in the elderly.

MacAulay RK, Brouillette RM, Foil HC, Bruce-Keller AJ, Keller JN.

PLoS One. 2014 Jun 6;9(6):e99436. doi: 10.1371/journal.pone.0099436. eCollection 2014.


Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors.

Pepping JK, Otvos L Jr, Surmacz E, Gupta S, Keller JN, Bruce-Keller AJ.

J Neuroimmune Pharmacol. 2014 Jun;9(3):388-98. doi: 10.1007/s11481-014-9529-1. Epub 2014 Feb 23.


Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling.

Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, Kaddoumi A.

Neuropharmacology. 2014 Apr;79:668-78. doi: 10.1016/j.neuropharm.2014.01.023. Epub 2014 Jan 24.


Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.

Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Rossi G, Keller JN, Angeletti M, Eleuteri AM.

Biochim Biophys Acta. 2014 Feb;1842(2):127-34. doi: 10.1016/j.bbadis.2013.11.002. Epub 2013 Nov 8.


Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents.

Zhou J, Keenan MJ, Fernandez-Kim SO, Pistell PJ, Ingram DK, Li B, Raggio AM, Shen L, Zhang H, McCutcheon KL, Tulley RT, Blackman MR, Keller JN, Martin RJ.

Mol Nutr Food Res. 2013 Nov;57(11):2071-4. doi: 10.1002/mnfr.201300135. Epub 2013 Jul 1.


Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly.

Brouillette RM, Foil H, Fontenot S, Correro A, Allen R, Martin CK, Bruce-Keller AJ, Keller JN.

PLoS One. 2013 Jun 11;8(6):e65925. doi: 10.1371/journal.pone.0065925. Print 2013.


A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease.

Beckett TL, Studzinski CM, Keller JN, Paul Murphy M, Niedowicz DM.

Brain Res. 2013 Apr 10;1505:61-7. doi: 10.1016/j.brainres.2013.01.046. Epub 2013 Feb 12.


Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice.

Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN.

Biochim Biophys Acta. 2013 Sep;1832(9):1456-62. doi: 10.1016/j.bbadis.2013.01.002. Epub 2013 Jan 9.


Leptin regulates amyloid β production via the γ-secretase complex.

Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP.

Biochim Biophys Acta. 2013 Mar;1832(3):439-44. doi: 10.1016/j.bbadis.2012.12.009. Epub 2012 Dec 26.


Steps per day, peak cadence, body mass index, and age in community-dwelling older adults.

Schuna JM Jr, Brouillette RM, Foil HC, Fontenot SL, Keller JN, Tudor-Locke C.

Med Sci Sports Exerc. 2013 May;45(5):914-9. doi: 10.1249/MSS.0b013e31827e47ac.


NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet.

Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ.

Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E392-404. doi: 10.1152/ajpendo.00398.2012. Epub 2012 Dec 11.


Preliminary comparison of clinical and free-living measures of stepping cadence in older adults.

Tudor-Locke C, Barreira TV, Brouillette RM, Foil HC, Keller JN.

J Phys Act Health. 2013 Nov;10(8):1175-80. Epub 2012 Dec 3.


Comparison of older adults' steps per day using NL-1000 pedometer and two GT3X+ accelerometer filters.

Barreira TV, Brouillette RM, Foil HC, Keller JN, Tudor-Locke C.

J Aging Phys Act. 2013 Oct;21(4):402-16. Epub 2012 Nov 19.


Obesity increases cerebrocortical reactive oxygen species and impairs brain function.

Freeman LR, Zhang L, Nair A, Dasuri K, Francis J, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

Free Radic Biol Med. 2013 Mar;56:226-33. doi: 10.1016/j.freeradbiomed.2012.08.577. Epub 2012 Oct 29.


Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.

Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H 3rd, Keller JN, Murphy MP.

Ann Neurol. 2012 Oct;72(4):564-70. doi: 10.1002/ana.23633.


Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome.

Dasuri K, Ebenezer P, Fernandez-Kim SO, Zhang L, Gao Z, Bruce-Keller AJ, Freeman LR, Keller JN.

Free Radic Res. 2013 Jan;47(1):8-19. doi: 10.3109/10715762.2012.733003. Epub 2012 Oct 16.


Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis.

Dasuri K, Zhang L, Keller JN.

Free Radic Biol Med. 2013 Sep;62:170-185. doi: 10.1016/j.freeradbiomed.2012.09.016. Epub 2012 Sep 19. Review.


Body mass index and the risk of dementia among Louisiana low income diabetic patients.

Hu G, Horswell R, Wang Y, Li W, Besse J, Xiao K, Chen H, Keller JN, Heymsfield SB, Ryan DH, Katzmarzyk PT.

PLoS One. 2012;7(9):e44537. doi: 10.1371/journal.pone.0044537. Epub 2012 Sep 5.


Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions.

Freeman LR, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN.

PLoS One. 2012;7(8):e43193. doi: 10.1371/journal.pone.0043193. Epub 2012 Aug 17.


Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H 3rd, Keller JN, Murphy MP.

J Alzheimers Dis. 2012;32(1):127-38.


Brain injury caused by HIV protease inhibitors: role of lipodystrophy and insulin resistance.

Gupta S, Knight AG, Losso BY, Ingram DK, Keller JN, Bruce-Keller AJ.

Antiviral Res. 2012 Jul;95(1):19-29. doi: 10.1016/j.antiviral.2012.04.010. Epub 2012 May 9.


Development of diet-induced insulin resistance in adult Drosophila melanogaster.

Morris SN, Coogan C, Chamseddin K, Fernandez-Kim SO, Kolli S, Keller JN, Bauer JH.

Biochim Biophys Acta. 2012 Aug;1822(8):1230-7. doi: 10.1016/j.bbadis.2012.04.012. Epub 2012 Apr 20.


Relationship between cognitive domains, physical performance, and gait in elderly and demented subjects.

Bruce-Keller AJ, Brouillette RM, Tudor-Locke C, Foil HC, Gahan WP, Nye DM, Guillory L, Keller JN.

J Alzheimers Dis. 2012;30(4):899-908. doi: 10.3233/JAD-2012-120025.


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