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Items: 1 to 50 of 54

1.

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.

Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, Wickeler A, Naguib HE, Keller GM, Vunjak-Novakovic G, Broeckel U, Backx PH, Radisic M.

Cell. 2019 Feb 7;176(4):913-927.e18. doi: 10.1016/j.cell.2018.11.042. Epub 2019 Jan 24.

PMID:
30686581
2.

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.

Lee JH, Protze SI, Laksman Z, Backx PH, Keller GM.

Cell Stem Cell. 2017 Aug 3;21(2):179-194.e4. doi: 10.1016/j.stem.2017.07.003.

3.

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.

Protze SI, Liu J, Nussinovitch U, Ohana L, Backx PH, Gepstein L, Keller GM.

Nat Biotechnol. 2017 Jan;35(1):56-68. doi: 10.1038/nbt.3745. Epub 2016 Dec 12.

PMID:
27941801
4.

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

Rockel JS, Yu C, Whetstone H, Craft AM, Reilly K, Ma H, Tsushima H, Puviindran V, Al-Jazrawe M, Keller GM, Alman BA.

J Clin Invest. 2016 May 2;126(5):1649-63. doi: 10.1172/JCI80205. Epub 2016 Mar 28.

5.

Generation of articular chondrocytes from human pluripotent stem cells.

Craft AM, Rockel JS, Nartiss Y, Kandel RA, Alman BA, Keller GM.

Nat Biotechnol. 2015 Jun;33(6):638-45. doi: 10.10.38/nbt.3210. Epub 2015 May 11.

PMID:
25961409
6.

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Gallagher D, Voronova A, Zander MA, Cancino GI, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD.

Dev Cell. 2015 Jan 12;32(1):31-42. doi: 10.1016/j.devcel.2014.11.031. Epub 2014 Dec 31.

7.

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development.

Voronova A, Gallagher D, Zander M, Cancino G, Bramall A, Krause MP, Abad C, Tekin M, Neilsen PM, Callen DF, Scherer SW, Keller GM, Kaplan DR, Walz K, Miller FD.

Springerplus. 2015 Jun 12;4(Suppl 1):L28. doi: 10.1186/2193-1801-4-S1-L28. eCollection 2015. No abstract available.

8.

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues.

Thavandiran N, Dubois N, Mikryukov A, Massé S, Beca B, Simmons CA, Deshpande VS, McGarry JP, Chen CS, Nanthakumar K, Keller GM, Radisic M, Zandstra PW.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4698-707. doi: 10.1073/pnas.1311120110. Epub 2013 Nov 19. Erratum in: Proc Natl Acad Sci U S A. 2015 Jun 16;112(24):E3151. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16973.

9.

Specification of chondrocytes and cartilage tissues from embryonic stem cells.

Craft AM, Ahmed N, Rockel JS, Baht GS, Alman BA, Kandel RA, Grigoriadis AE, Keller GM.

Development. 2013 Jun;140(12):2597-610. doi: 10.1242/dev.087890.

10.

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.

Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG.

Cell. 2012 Sep 28;151(1):206-20. doi: 10.1016/j.cell.2012.07.035. Epub 2012 Sep 12.

11.

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation.

Wang J, Gallagher D, DeVito LM, Cancino GI, Tsui D, He L, Keller GM, Frankland PW, Kaplan DR, Miller FD.

Cell Stem Cell. 2012 Jul 6;11(1):23-35. doi: 10.1016/j.stem.2012.03.016.

12.

An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.

Han S, Dziedzic N, Gadue P, Keller GM, Gouon-Evans V.

Stem Cells. 2011 Feb;29(2):217-28. doi: 10.1002/stem.576.

13.

Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture.

DeQuach JA, Mezzano V, Miglani A, Lange S, Keller GM, Sheikh F, Christman KL.

PLoS One. 2010 Sep 27;5(9):e13039. doi: 10.1371/journal.pone.0013039.

14.

Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.

Irion S, Clarke RL, Luche H, Kim I, Morrison SJ, Fehling HJ, Keller GM.

Development. 2010 Sep 1;137(17):2829-39. doi: 10.1242/dev.042119. Epub 2010 Jul 21.

15.

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.

Grigoriadis AE, Kennedy M, Bozec A, Brunton F, Stenbeck G, Park IH, Wagner EF, Keller GM.

Blood. 2010 Apr 8;115(14):2769-76. doi: 10.1182/blood-2009-07-234690. Epub 2010 Jan 11.

16.

Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue.

Song H, Yoon C, Kattman SJ, Dengler J, Massé S, Thavaratnam T, Gewarges M, Nanthakumar K, Rubart M, Keller GM, Radisic M, Zandstra PW.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3329-34. doi: 10.1073/pnas.0905729106. Epub 2009 Oct 21.

17.

In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardium.

Adler ED, Bystrup A, Briley-Saebo KC, Mani V, Young W, Giovanonne S, Altman P, Kattman SJ, Frank JA, Weinmann HJ, Keller GM, Fayad ZA.

JACC Cardiovasc Imaging. 2009 Sep;2(9):1114-22. doi: 10.1016/j.jcmg.2009.04.015.

18.

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.

Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM.

Stem Cells. 2009 Sep;27(9):2103-13. doi: 10.1002/stem.147.

19.

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

Henckaerts E, Dutheil N, Zeltner N, Kattman S, Kohlbrenner E, Ward P, Clément N, Rebollo P, Kennedy M, Keller GM, Linden RM.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7571-6. doi: 10.1073/pnas.0806821106. Epub 2009 Apr 16.

20.

Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications.

Irion S, Nostro MC, Kattman SJ, Keller GM.

Cold Spring Harb Symp Quant Biol. 2008;73:101-10. doi: 10.1101/sqb.2008.73.065. Epub 2009 Mar 27. Review.

PMID:
19329573
21.

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast.

Cheng X, Huber TL, Chen VC, Gadue P, Keller GM.

Development. 2008 Oct;135(20):3447-58. doi: 10.1242/dev.025916. Epub 2008 Sep 17.

22.

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.

Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM.

Nature. 2008 May 22;453(7194):524-8. doi: 10.1038/nature06894. Epub 2008 Apr 23.

PMID:
18432194
23.

Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Nostro MC, Cheng X, Keller GM, Gadue P.

Cell Stem Cell. 2008 Jan 10;2(1):60-71. doi: 10.1016/j.stem.2007.10.011.

24.

Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development.

Kattman SJ, Adler ED, Keller GM.

Trends Cardiovasc Med. 2007 Oct;17(7):240-6. Review.

PMID:
17936206
25.

Targeting the short form of cFLIP by RNA interference is sufficient to enhance TRAIL sensitivity in PC3 prostate carcinoma cells.

White SJ, Lu P, Keller GM, Voelkel-Johnson C.

Cancer Biol Ther. 2006 Dec;5(12):1618-23. Epub 2006 Dec 5.

PMID:
17106251
27.

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.

Gadue P, Huber TL, Paddison PJ, Keller GM.

Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16806-11. Epub 2006 Oct 31.

28.

Germ layer induction from embryonic stem cells.

Gadue P, Huber TL, Nostro MC, Kattman S, Keller GM.

Exp Hematol. 2005 Sep;33(9):955-64. Review.

PMID:
16140142
29.

The in vitro differentiation of mouse embryonic stem cells into neutrophils.

Lieber JG, Keller GM, Worthen GS.

Methods Enzymol. 2003;365:129-42.

PMID:
14696342
30.

Hematopoietic commitment of ES cells in culture.

Kennedy M, Keller GM.

Methods Enzymol. 2003;365:39-59. No abstract available.

PMID:
14696336
31.

The in vitro production and characterization of neutrophils from embryonic stem cells.

Lieber JG, Webb S, Suratt BT, Young SK, Johnson GL, Keller GM, Worthen GS.

Blood. 2004 Feb 1;103(3):852-9. Epub 2003 Oct 2.

32.

Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro.

Lin RY, Kubo A, Keller GM, Davies TF.

Endocrinology. 2003 Jun;144(6):2644-9.

PMID:
12746328
33.

Hematopoietic Development of ES Cells in Culture.

Keller GM, Webb S, Kennedy M.

Methods Mol Med. 2002;63:209-30. doi: 10.1385/1-59259-140-X:209.

PMID:
21437810
34.

Genomic instability-based transgenic models of prostate cancer.

Voelkel-Johnson C, Voeks DJ, Greenberg NM, Barrios R, Maggouta F, Kurtz DT, Schwartz DA, Keller GM, Papenbrock T, Clawson GA, Norris JS.

Carcinogenesis. 2000 Aug;21(8):1623-7.

PMID:
10910968
36.

Stem cell factor augments Fc epsilon RI-mediated TNF-alpha production and stimulates MAP kinases via a different pathway in MC/9 mast cells.

Ishizuka T, Kawasome H, Terada N, Takeda K, Gerwins P, Keller GM, Johnson GL, Gelfand EW.

J Immunol. 1998 Oct 1;161(7):3624-30.

37.

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.

Kawasome H, Papst P, Webb S, Keller GM, Johnson GL, Gelfand EW, Terada N.

Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5033-8.

38.

Macrocerebellum: neuroimaging and clinical features of a newly recognized condition.

Bodensteiner JB, Schaefer GB, Keller GM, Thompson JN, Bowen MK.

J Child Neurol. 1997 Sep;12(6):365-8.

PMID:
9309519
39.

Size of the corpus callosum in cerebral palsy.

Sheth RD, Schaefer GB, Keller GM, Hobbs GR, Ortiz O, Bodensteiner JB.

J Neuroimaging. 1996 Jul;6(3):180-3.

PMID:
8704295
40.

Incidental pineal cysts in a prospectively ascertained normal cohort.

Bodensteiner JB, Schaefer GB, Keller GM, McConnell JR.

Clin Pediatr (Phila). 1996 May;35(5):277-9. No abstract available.

PMID:
8804549
41.

In vitro differentiation of embryonic stem cells.

Keller GM.

Curr Opin Cell Biol. 1995 Dec;7(6):862-9. Review.

PMID:
8608017
42.

Product inhibition of benzo[a]pyrene metabolism in uninduced rat liver microsomes: effect of diol epoxide formation.

Keller GM, Christou M, Pottenger LH, Wilson NM, Jefcoate CR.

Chem Biol Interact. 1987 Feb;61(2):159-75.

PMID:
3103934
43.

Generation of purified stromal cell cultures that support lymphoid and myeloid precursors.

Dorshkind K, Johnson A, Collins L, Keller GM, Phillips RA.

J Immunol Methods. 1986 May 1;89(1):37-47.

PMID:
3486229
44.

Maintenance of hemopoiesis in long-term bone marrow cultures from S1/S1d and W/Wv mice.

Keller GM, Phillips RA.

Exp Hematol. 1984 Dec;12(11):822-4.

PMID:
6510482
45.
46.

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

Dorshkind K, Keller GM, Phillips RA, Miller RG, Bosma GC, O'Toole M, Bosma MJ.

J Immunol. 1984 Apr;132(4):1804-8.

PMID:
6607948
47.

Hemopoiesis in spleen and bone marrow cultures.

Keller GM, Johnson GR, Phillips RA.

J Cell Physiol. 1983 Jul;116(1):7-15.

PMID:
6602139
48.

Modulation of microsomal benzo[a]pyrene metabolism by DNA.

Keller GM, Jefcoate CR.

Mol Pharmacol. 1983 May;23(3):735-42.

PMID:
6306433
49.

Kinetic determinants of benzo[a]pyrene metabolism to dihydrodiol epoxides by 3-methylcholanthrene-induced rat liver microsomes.

Keller GM, Turner CR, Jefcoate CR.

Mol Pharmacol. 1982 Sep;22(2):451-8. No abstract available.

PMID:
6292697
50.

Detection in vitro of a unique, multipotent hemopoietic progenitor.

Keller GM, Phillips RA.

J Cell Physiol Suppl. 1982;1:31-6. No abstract available.

PMID:
6978343

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