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Items: 1 to 50 of 157

1.

Differential role of adenosine signaling cascade in acute and chronic pain.

Adebiyi MG, Manalo J, Kellems RE, Xia Y.

Neurosci Lett. 2019 Sep 5;712:134483. doi: 10.1016/j.neulet.2019.134483. [Epub ahead of print] Review.

PMID:
31494223
2.

Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia.

Iriyama T, Wang G, Yoshikawa M, Mimura N, Matsui H, Sayama S, Kumasawa K, Nagamatsu T, Koga K, Kotani T, Niimi K, Yamamoto E, Kellems RE, Xia Y, Osuga Y, Fujii T.

Sci Rep. 2019 Jul 12;9(1):10107. doi: 10.1038/s41598-019-46660-4.

3.

Erythrocyte Adenosine A2B Receptor-Mediated AMPK Activation: A Missing Component Counteracting CKD by Promoting Oxygen Delivery.

Peng Z, Luo R, Xie T, Zhang W, Liu H, Wang W, Tao L, Kellems RE, Xia Y.

J Am Soc Nephrol. 2019 Aug;30(8):1413-1424. doi: 10.1681/ASN.2018080862. Epub 2019 Jul 5.

PMID:
31278195
4.

Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality.

Adebiyi MG, Zhao Z, Ye Y, Manalo J, Hong Y, Lee CC, Xian W, McKeon F, Culp-Hill R, D' Alessandro A, Kellems RE, Yoo SH, Han L, Xia Y.

FASEB J. 2019 Sep;33(9):10528-10537. doi: 10.1096/fj.201900246RR. Epub 2019 Jun 29.

PMID:
31260634
5.

Tissue Transglutaminase-Mediated AT1 Receptor Sensitization Underlies Pro-inflammatory Cytokine LIGHT-Induced Hypertension.

Liu C, Luo R, Wang W, Peng Z, Johnson GVW, Kellems RE, Xia Y.

Am J Hypertens. 2019 Apr 22;32(5):476-485. doi: 10.1093/ajh/hpz018.

6.

Elevated ecto-5'-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease.

Liu H, Adebiyi M, Liu RR, Song A, Manalo J, Wen YE, Wen AQ, Weng T, Ko J, Idowu M, Kellems RE, Eltzschig HK, Blackburn MR, Juneja HS, Xia Y.

Blood Adv. 2018 Aug 14;2(15):1957-1968. doi: 10.1182/bloodadvances.2018015784.

7.

Sphingosine-1-phosphate receptor 1 mediates elevated IL-6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease.

Zhao S, Adebiyi MG, Zhang Y, Couturier JP, Fan X, Zhang H, Kellems RE, Lewis DE, Xia Y.

FASEB J. 2018 May;32(5):2855-2865. doi: 10.1096/fj.201600788RR. Epub 2018 Jan 17.

8.

Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.

Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y.

Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8.

9.

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.

Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, Mills T, Chen NY, Kim Y, Muge Ozguc F, Diao L, Karmouty-Quintana H, Xia Y, Kellems RE, Chen Z, Blackburn MR, Yoo SH, Shyu AB, Mills GB, Han L.

J Natl Cancer Inst. 2018 Apr 1;110(4):379-389. doi: 10.1093/jnci/djx223.

10.

Erythrocyte purinergic signaling components underlie hypoxia adaptation.

Sun K, Liu H, Song A, Manalo JM, D'Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

J Appl Physiol (1985). 2017 Oct 1;123(4):951-956. doi: 10.1152/japplphysiol.00155.2017. Epub 2017 Jun 1. Review.

11.

Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia.

Huang A, Wu H, Iriyama T, Zhang Y, Sun K, Song A, Liu H, Peng Z, Tang L, Lee M, Huang Y, Ni X, Kellems RE, Xia Y.

Hypertension. 2017 Jul;70(1):209-218. doi: 10.1161/HYPERTENSIONAHA.117.09536. Epub 2017 May 15.

PMID:
28507174
12.

Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase.

Liu C, Kellems RE, Xia Y.

Am J Hypertens. 2017 Aug 1;30(8):756-764. doi: 10.1093/ajh/hpx027. Review.

13.

Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent.

Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D'Alessandro A, Li J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Nemkov T, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC, Xia Y.

Nat Commun. 2017 Feb 7;8:14108. doi: 10.1038/ncomms14108.

14.

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia.

Liu H, Zhang Y, Wu H, D'Alessandro A, Yegutkin GG, Song A, Sun K, Li J, Cheng NY, Huang A, Edward Wen Y, Weng TT, Luo F, Nemkov T, Sun H, Kellems RE, Karmouty-Quintana H, Hansen KC, Zhao B, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MR, Roach RC, Xia Y.

Circulation. 2016 Aug 2;134(5):405-21. doi: 10.1161/CIRCULATIONAHA.116.021311.

15.

Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease.

Wu H, Bogdanov M, Zhang Y, Sun K, Zhao S, Song A, Luo R, Parchim NF, Liu H, Huang A, Adebiyi MG, Jin J, Alexander DC, Milburn MV, Idowu M, Juneja HS, Kellems RE, Dowhan W, Xia Y.

Sci Rep. 2016 Jul 20;6:29637. doi: 10.1038/srep29637.

16.

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia.

Sun K, Zhang Y, D'Alessandro A, Nemkov T, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Vila A, O'Brien J, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Safo M, Hansen KC, Roach RC, Xia Y.

Nat Commun. 2016 Jul 15;7:12086. doi: 10.1038/ncomms12086.

17.

Transglutaminase is a Critical Link Between Inflammation and Hypertension.

Luo R, Liu C, Elliott SE, Wang W, Parchim N, Iriyama T, Daugherty PS, Tao L, Eltzschig HK, Blackwell SC, Sibai BM, Kellems RE, Xia Y.

J Am Heart Assoc. 2016 Jun 30;5(7). pii: e003730. doi: 10.1161/JAHA.116.003730.

18.

Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction.

Hu X, Adebiyi MG, Luo J, Sun K, Le TT, Zhang Y, Wu H, Zhao S, Karmouty-Quintana H, Liu H, Huang A, Wen YE, Zaika OL, Mamenko M, Pochynyuk OM, Kellems RE, Eltzschig HK, Blackburn MR, Walters ET, Huang D, Hu H, Xia Y.

Cell Rep. 2016 Jun 28;16(1):106-119. doi: 10.1016/j.celrep.2016.05.080. Epub 2016 Jun 16.

19.

A pre-eclampsia-associated Epstein-Barr virus antibody cross-reacts with placental GPR50.

Elliott SE, Parchim NF, Kellems RE, Xia Y, Soffici AR, Daugherty PS.

Clin Immunol. 2016 Jul;168:64-71. doi: 10.1016/j.clim.2016.05.002. Epub 2016 May 12.

PMID:
27181993
20.

Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia.

Liu C, Luo R, Elliott SE, Wang W, Parchim NF, Iriyama T, Daugherty PS, Blackwell SC, Sibai BM, Kellems RE, Xia Y.

J Am Heart Assoc. 2015 Dec 16;4(12). pii: e002323. doi: 10.1161/JAHA.115.002323.

21.

Response to Letter Regarding Article, "Elevated Placental Adenosine Signaling Contributes to the Pathogenesis of Preeclampsia".

Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks JM, Blackburn MR, Kellems RE, Xia Y.

Circulation. 2015 Nov 3;132(18):e222-3. doi: 10.1161/CIRCULATIONAHA.115.017262. No abstract available.

22.

Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease.

Luo R, Zhang W, Zhao C, Zhang Y, Wu H, Jin J, Zhang W, Grenz A, Eltzschig HK, Tao L, Kellems RE, Xia Y.

Hypertension. 2015 Jul;66(1):75-84. doi: 10.1161/HYPERTENSIONAHA.115.05578. Epub 2015 May 18.

23.

Hypoxia-independent upregulation of placental hypoxia inducible factor-1α gene expression contributes to the pathogenesis of preeclampsia.

Iriyama T, Wang W, Parchim NF, Song A, Blackwell SC, Sibai BM, Kellems RE, Xia Y.

Hypertension. 2015 Jun;65(6):1307-15. doi: 10.1161/HYPERTENSIONAHA.115.05314. Epub 2015 Apr 6.

24.

Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity.

Sun K, Zhang Y, Bogdanov MV, Wu H, Song A, Li J, Dowhan W, Idowu M, Juneja HS, Molina JG, Blackburn MR, Kellems RE, Xia Y.

Blood. 2015 Mar 5;125(10):1643-52. doi: 10.1182/blood-2014-08-595751. Epub 2015 Jan 13.

25.

Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.

Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks MJ, Blackburn MR, Kellems RE, Xia Y.

Circulation. 2015 Feb 24;131(8):730-41. doi: 10.1161/CIRCULATIONAHA.114.013740. Epub 2014 Dec 23.

26.

Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia.

Parchim NF, Wang W, Iriyama T, Ashimi OA, Siddiqui AH, Blackwell S, Sibai B, Kellems RE, Xia Y.

Hypertension. 2015 Feb;65(2):430-9. doi: 10.1161/HYPERTENSIONAHA.114.04439. Epub 2014 Dec 1.

27.

Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.

Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y.

J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16.

28.

Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression.

Ning C, Wen J, Zhang Y, Dai Y, Wang W, Zhang W, Qi L, Grenz A, Eltzschig HK, Blackburn MR, Kellems RE, Xia Y.

FASEB J. 2014 Jun;28(6):2725-35. doi: 10.1096/fj.13-247833. Epub 2014 Mar 10.

29.

Characterization of antibody specificities associated with preeclampsia.

Elliott SE, Parchim NF, Liu C, Xia Y, Kellems RE, Soffici AR, Daugherty PS.

Hypertension. 2014 May;63(5):1086-93. doi: 10.1161/HYPERTENSIONAHA.113.02362. Epub 2014 Jan 20.

30.

Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia.

Wang W, Parchim NF, Iriyama T, Luo R, Zhao C, Liu C, Irani RA, Zhang W, Ning C, Zhang Y, Blackwell SC, Chen L, Tao L, Hicks MJ, Kellems RE, Xia Y.

Hypertension. 2014 Mar;63(3):595-606. doi: 10.1161/HYPERTENSIONAHA.113.02458. Epub 2013 Dec 9.

31.

Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification.

Liu C, Wang W, Parchim N, Irani RA, Blackwell SC, Sibai B, Jin J, Kellems RE, Xia Y.

Hypertension. 2014 Feb;63(2):353-61. doi: 10.1161/HYPERTENSIONAHA.113.02361. Epub 2013 Nov 4.

32.

Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond.

Xia Y, Kellems RE.

Circ Res. 2013 Jun 21;113(1):78-87. doi: 10.1161/CIRCRESAHA.113.300752. Review.

33.

Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.

Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y.

Circ Res. 2013 May 24;112(11):1466-78. doi: 10.1161/CIRCRESAHA.111.300166. Epub 2013 Apr 12.

34.

Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia.

Siddiqui AH, Irani RA, Zhang W, Wang W, Blackwell SC, Kellems RE, Xia Y.

Hypertension. 2013 Feb;61(2):472-9. doi: 10.1161/HYPERTENSIONAHA.111.00157. Epub 2013 Jan 2. Erratum in: Hypertension. 2013 Jun;61(6):e61.

35.

Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia.

Wang W, Irani RA, Zhang Y, Ramin SM, Blackwell SC, Tao L, Kellems RE, Xia Y.

Hypertension. 2012 Sep;60(3):712-21. doi: 10.1161/HYPERTENSIONAHA.112.191817. Epub 2012 Aug 6.

36.

OS069. Light, a TNF superfamily member, contributes to pathophysiology in a mouse model of preeclampsia.

Wang W, Irani RA, Zhang Y, Kellems RE, Xia Y.

Pregnancy Hypertens. 2012 Jul;2(3):214. doi: 10.1016/j.preghy.2012.04.070. Epub 2012 Jun 13.

PMID:
26105284
37.

OS057. Pathophysiological role of elevated tissue transglutaminase in autoantibody-induced features of preeclampsia in pregnant mice.

Liu C, Wang W, Parchim NF, Irani RA, Ning C, Sun K, Kellems RE, Xia Y.

Pregnancy Hypertens. 2012 Jul;2(3):208. doi: 10.1016/j.preghy.2012.04.058. Epub 2012 Jun 13.

PMID:
26105271
38.

Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice.

Zhou CC, Chang J, Mi T, Abbasi S, Gu D, Huang L, Zhang W, Kellems RE, Schwartz RJ, Xia Y.

PLoS One. 2012;7(2):e29236. doi: 10.1371/journal.pone.0029236. Epub 2012 Feb 17.

39.

Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage.

Zhang W, Wang W, Yu H, Zhang Y, Dai Y, Ning C, Tao L, Sun H, Kellems RE, Blackburn MR, Xia Y.

Hypertension. 2012 Jan;59(1):136-44. doi: 10.1161/HYPERTENSIONAHA.111.173328. Epub 2011 Nov 7.

40.

Receptor-activating autoantibodies and disease: preeclampsia and beyond.

Xia Y, Kellems RE.

Expert Rev Clin Immunol. 2011 Sep;7(5):659-74. doi: 10.1586/eci.11.56. Review.

41.

Impaired erectile function in CD73-deficient mice with reduced endogenous penile adenosine production.

Wen J, Dai Y, Zhang Y, Zhang W, Kellems RE, Xia Y.

J Sex Med. 2011 Aug;8(8):2172-80. doi: 10.1111/j.1743-6109.2011.02316.x. Epub 2011 May 19.

42.

A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation.

Wen J, Grenz A, Zhang Y, Dai Y, Kellems RE, Blackburn MR, Eltzschig HK, Xia Y.

FASEB J. 2011 Aug;25(8):2823-30. doi: 10.1096/fj.11-181057. Epub 2011 May 12.

43.

A2B adenosine receptor-mediated induction of IL-6 promotes CKD.

Dai Y, Zhang W, Wen J, Zhang Y, Kellems RE, Xia Y.

J Am Soc Nephrol. 2011 May;22(5):890-901. doi: 10.1681/ASN.2010080890. Epub 2011 Apr 21.

44.

Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia.

Zhou CC, Irani RA, Dai Y, Blackwell SC, Hicks MJ, Ramin SM, Kellems RE, Xia Y.

J Immunol. 2011 May 15;186(10):6024-34. doi: 10.4049/jimmunol.1004026. Epub 2011 Apr 11.

45.

Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice.

Siddiqui AH, Irani RA, Zhang Y, Dai Y, Blackwell SC, Ramin SM, Kellems RE, Xia Y.

Am J Hypertens. 2011 May;24(5):606-12. doi: 10.1038/ajh.2010.247. Epub 2010 Dec 23.

46.

Detrimental effects of adenosine signaling in sickle cell disease.

Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y.

Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19.

47.

Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling.

Irani RA, Zhang Y, Zhou CC, Blackwell SC, Hicks MJ, Ramin SM, Kellems RE, Xia Y.

Hypertension. 2010 May;55(5):1246-53. doi: 10.1161/HYPERTENSIONAHA.110.150540. Epub 2010 Mar 29.

48.

Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia.

Zhou CC, Irani RA, Zhang Y, Blackwell SC, Mi T, Wen J, Shelat H, Geng YJ, Ramin SM, Kellems RE, Xia Y.

Circulation. 2010 Jan 26;121(3):436-44. doi: 10.1161/CIRCULATIONAHA.109.902890. Epub 2010 Jan 11.

49.

Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity.

Siddiqui AH, Irani RA, Blackwell SC, Ramin SM, Kellems RE, Xia Y.

Hypertension. 2010 Feb;55(2):386-93. doi: 10.1161/HYPERTENSIONAHA.109.140061. Epub 2009 Dec 7.

50.

The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia.

Irani RA, Zhang Y, Blackwell SC, Zhou CC, Ramin SM, Kellems RE, Xia Y.

J Exp Med. 2009 Nov 23;206(12):2809-22. doi: 10.1084/jem.20090872. Epub 2009 Nov 2.

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