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Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments.

Shenoy GN, Loyall J, Berenson CS, Kelleher RJ Jr, Iyer V, Balu-Iyer SV, Odunsi K, Bankert RB.

J Immunol. 2018 Dec 15;201(12):3750-3758. doi: 10.4049/jimmunol.1801041. Epub 2018 Nov 16.


Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.

Carrette LLG, Blum R, Ma W, Kelleher RJ 3rd, Lee JT.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8185-8190. doi: 10.1073/pnas.1800931115. Epub 2018 Jul 23.


Exosomes Associated with Human Ovarian Tumors Harbor a Reversible Checkpoint of T-cell Responses.

Shenoy GN, Loyall J, Maguire O, Iyer V, Kelleher RJ Jr, Minderman H, Wallace PK, Odunsi K, Balu-Iyer SV, Bankert RB.

Cancer Immunol Res. 2018 Feb;6(2):236-247. doi: 10.1158/2326-6066.CIR-17-0113. Epub 2018 Jan 4.


A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.

Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ 3rd, Lee JT.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E668-E675. doi: 10.1073/pnas.1715124115. Epub 2017 Dec 27.


Presenilin-1 mutations and Alzheimer's disease.

Kelleher RJ 3rd, Shen J.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):629-631. doi: 10.1073/pnas.1619574114. Epub 2017 Jan 12. No abstract available.


Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.

Xia D, Kelleher RJ 3rd, Shen J.

Neuron. 2016 Apr 20;90(2):417-22. doi: 10.1016/j.neuron.2016.03.009.


Extracellular Vesicles Present in Human Ovarian Tumor Microenvironments Induce a Phosphatidylserine-Dependent Arrest in the T-cell Signaling Cascade.

Kelleher RJ Jr, Balu-Iyer S, Loyall J, Sacca AJ, Shenoy GN, Peng P, Iyer V, Fathallah AM, Berenson CS, Wallace PK, Tario J, Odunsi K, Bankert RB.

Cancer Immunol Res. 2015 Nov;3(11):1269-78. doi: 10.1158/2326-6066.CIR-15-0086. Epub 2015 Jun 25.


Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.

Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd.

Neuron. 2015 Mar 4;85(5):967-81. doi: 10.1016/j.neuron.2015.02.010.


Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV.

Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ 3rd, Cooper JD, Slaugenhaupt SA.

Acta Neuropathol Commun. 2014 Sep 9;2:133. doi: 10.1186/s40478-014-0133-7.


Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.

Yokota SJ, Facciponte JG, Kelleher RJ Jr, Shultz LD, Loyall JL, Parsons RR, Odunsi K, Frelinger JG, Lord EM, Gerber SA, Balu-Iyer SV, Bankert RB.

Cancer Immun. 2013 May 31;13:11. Print 2013.


Human ovarian tumor ascites fluids rapidly and reversibly inhibit T cell receptor-induced NF-κB and NFAT signaling in tumor-associated T cells.

Simpson-Abelson MR, Loyall JL, Lehman HK, Barnas JL, Minderman H, O'Loughlin KL, Wallace PK, George TC, Peng P, Kelleher RJ Jr, Odunsi K, Bankert RB.

Cancer Immun. 2013 Jul 15;13:14. Print 2013.


Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production.

Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ 3rd.

J Neurosci. 2013 Jul 10;33(28):11606-17. doi: 10.1523/JNEUROSCI.0954-13.2013.


Exposure to factor VIII protein in the presence of phosphatidylserine induces hypo-responsiveness toward factor VIII challenge in hemophilia A mice.

Gaitonde P, Ramakrishnan R, Chin J, Kelleher RJ Jr, Bankert RB, Balu-Iyer SV.

J Biol Chem. 2013 Jun 14;288(24):17051-6. doi: 10.1074/jbc.C112.396325. Epub 2013 May 6.


High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.

Kelleher RJ 3rd, Geigenmüller U, Hovhannisyan H, Trautman E, Pinard R, Rathmell B, Carpenter R, Margulies D.

PLoS One. 2012;7(4):e35003. doi: 10.1371/journal.pone.0035003. Epub 2012 Apr 27.


Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice.

Watanabe H, Xia D, Kanekiyo T, Kelleher RJ 3rd, Shen J.

J Neurosci. 2012 Apr 11;32(15):5085-96. doi: 10.1523/JNEUROSCI.0317-12.2012.


Memory T cells in the chronic inflammatory microenvironment of nasal polyposis are hyporesponsive to signaling through the T cell receptor.

Lehman HK, Simpson-Abelson MR, Conway TF Jr, Kelleher RJ Jr, Bernstein JM, Bankert RB.

J Assoc Res Otolaryngol. 2012 Jun;13(3):423-35. doi: 10.1007/s10162-012-0313-8. Epub 2012 Feb 4.


Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.

Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD, Kelleher RJ Jr, Barnas JL, Simpson-Abelson M, Parsons R, Yokota SJ.

PLoS One. 2011;6(9):e24420. doi: 10.1371/journal.pone.0024420. Epub 2011 Sep 15.


Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain.

Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ 3rd, Lee JT.

PLoS Genet. 2011 Sep;7(9):e1002248. doi: 10.1371/journal.pgen.1002248. Epub 2011 Sep 1.


T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets.

Barnas JL, Simpson-Abelson MR, Yokota SJ, Kelleher RJ, Bankert RB.

Cancer Microenviron. 2010 Mar 31;3(1):29-47. doi: 10.1007/s12307-010-0044-5.


Genetics. Gamma-secretase and human disease.

Kelleher RJ 3rd, Shen J.

Science. 2010 Nov 19;330(6007):1055-6. doi: 10.1126/science.1198668. No abstract available.


Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors.

Barnas JL, Simpson-Abelson MR, Brooks SP, Kelleher RJ Jr, Bankert RB.

J Immunol. 2010 Sep 1;185(5):2681-92. doi: 10.4049/jimmunol.1000896. Epub 2010 Aug 4.


A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.

Heilig EA, Xia W, Shen J, Kelleher RJ 3rd.

J Biol Chem. 2010 Jul 16;285(29):22350-9. doi: 10.1074/jbc.M110.116962. Epub 2010 May 11.


Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.

Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J.

Proc Natl Acad Sci U S A. 2010 May 25;107(21):9879-84. doi: 10.1073/pnas.1004676107. Epub 2010 May 10.


Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.

Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ 3rd, Shen J.

PLoS One. 2010 Apr 15;5(4):e10195. doi: 10.1371/journal.pone.0010195.


IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments.

Simpson-Abelson MR, Purohit VS, Pang WM, Iyer V, Odunsi K, Demmy TL, Yokota SJ, Loyall JL, Kelleher RJ Jr, Balu-Iyer S, Bankert RB.

Clin Immunol. 2009 Jul;132(1):71-82. doi: 10.1016/j.clim.2009.03.516. Epub 2009 Apr 22.


Indirect regulation of presenilins in CREB-mediated transcription.

Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ 3rd, Shen J.

J Biol Chem. 2009 May 15;284(20):13705-13. doi: 10.1074/jbc.M809168200. Epub 2009 Mar 16.


Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab.

Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ Jr, Bankert RB, Bernstein SH.

Blood. 2009 Apr 16;113(16):3809-12. doi: 10.1182/blood-2008-10-185280. Epub 2009 Feb 4.


The autistic neuron: troubled translation?

Kelleher RJ 3rd, Bear MF.

Cell. 2008 Oct 31;135(3):401-6. doi: 10.1016/j.cell.2008.10.017.


Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.

Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF Jr, Kelleher RJ Jr, Shultz LD, Barcos M, Bankert RB.

J Immunol. 2008 May 15;180(10):7009-18.


Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.

Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ Jr, Yokota SJ, Bankert RB.

J Immunol. 2007 May 1;178(9):5552-62.


The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.

Shen J, Kelleher RJ 3rd.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):403-9. Epub 2006 Dec 29. Review.


A clustered plasticity model of long-term memory engrams.

Govindarajan A, Kelleher RJ, Tonegawa S.

Nat Rev Neurosci. 2006 Jul;7(7):575-83. Review.


B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells.

Lou Q, Conway TF Jr, Egilmez NK, Loyall JL, Bernstein SH, Kelleher RJ Jr, Bankert RB.

Clin Immunol. 2006 Jan;118(1):66-76. Epub 2005 Sep 26.


Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells.

Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ Jr, Bankert RB.

J Immunol. 2005 Jan 15;174(2):898-906.


The management of acute oesophageal obstruction from a food bolus. Can we be more conservative?

Tsikoudas A, Kochillas X, Kelleher RJ, Mills R.

Eur Arch Otorhinolaryngol. 2005 Jul;262(7):528-30. Epub 2004 Dec 9.


Translational regulatory mechanisms in persistent forms of synaptic plasticity.

Kelleher RJ 3rd, Govindarajan A, Tonegawa S.

Neuron. 2004 Sep 30;44(1):59-73. Review.


Retropharyngeal space swelling secondary to minor blunt head and neck trauma.

Kochilas X, Ali A, Montague ML, Kelleher RJ.

J Laryngol Otol. 2004 Jun;118(6):465-7.


Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.

Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ 3rd, Kandel ER, Duff K, Kirkwood A, Shen J.

Neuron. 2004 Apr 8;42(1):23-36.


Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells.

Lou Q, Kelleher RJ Jr, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH.

Blood. 2004 Aug 1;104(3):752-9. Epub 2004 Mar 30.


Translational control by MAPK signaling in long-term synaptic plasticity and memory.

Kelleher RJ 3rd, Govindarajan A, Jung HY, Kang H, Tonegawa S.

Cell. 2004 Feb 6;116(3):467-79.


Human dendritic cells pulsed with autologous Epstein-Barr virus transformed B-cell lymphoblastoid cell (BCL) lysate elicit a BCL specific MHC-class II restricted T-cell response.

Sugano M, Conway TF Jr, Kelleher RJ Jr, Sugiyama Y, Chen FA, Bankert RB, Bernstein SH.

J Exp Clin Cancer Res. 2001 Jun;20(2):175-82.


Dietary fatty acids alter the adhesion properties of lymphocytes to extracellular matrix proteins.

Stephen FD, Kelleher RJ Jr, Langner M, Repasky EA.

Adv Exp Med Biol. 1997;400B:775-88.


Effects of activation-defective TBP mutations on transcription initiation in yeast.

Kim TK, Hashimoto S, Kelleher RJ 3rd, Flanagan PM, Kornberg RD, Horikoshi M, Roeder RG.

Nature. 1994 May 19;369(6477):252-5.


Yeast and human TFIIDs are interchangeable for the response to acidic transcriptional activators in vitro.

Kelleher RJ 3rd, Flanagan PM, Chasman DI, Ponticelli AS, Struhl K, Kornberg RD.

Genes Dev. 1992 Feb;6(2):296-303.


A mediator required for activation of RNA polymerase II transcription in vitro.

Flanagan PM, Kelleher RJ 3rd, Sayre MH, Tschochner H, Kornberg RD.

Nature. 1991 Apr 4;350(6317):436-8.


RNA polymerase II transcription in vitro.

Lue NF, Flanagan PM, Kelleher RJ 3rd, Edwards AM, Kornberg RD.

Methods Enzymol. 1991;194:545-50. No abstract available.


Resolution of factors required for the initiation of transcription by yeast RNA polymerase II.

Flanagan PM, Kelleher RJ, Feaver WJ, Lue NF, LaPointe JW, Kornberg RD.

J Biol Chem. 1990 Jul 5;265(19):11105-7.


A novel mediator between activator proteins and the RNA polymerase II transcription apparatus.

Kelleher RJ 3rd, Flanagan PM, Kornberg RD.

Cell. 1990 Jun 29;61(7):1209-15.


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