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Items: 1 to 50 of 323

1.

STORI Plots Enable Accurate Tracking of Individual Ion Signals.

Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW.

J Am Soc Mass Spectrom. 2019 Nov 1;30(11):2200-2203.

PMID:
31944753
2.

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes.

Camarillo JM, Swaminathan S, Abshiru NA, Sikora JW, Thomas PM, Kelleher NL.

J Am Soc Mass Spectrom. 2019 Dec 1;30(12):2526-2534.

PMID:
31944731
3.

Elucidating proteoform dynamics underlying the senescence associated secretory phenotype.

Doubleday PF, Fornelli L, Kelleher NL.

J Proteome Res. 2020 Jan 15. doi: 10.1021/acs.jproteome.9b00739. [Epub ahead of print]

PMID:
31940439
4.

Identification of Plasmodium falciparum proteoforms from liver stage models.

Winer B, Edgel KA, Zou X, Sellau J, Hadiwidjojo S, Garver LS, McDonough CE, Kelleher NL, Thomas PM, Villasante E, Ploss A, Gerbasi VR.

Malar J. 2020 Jan 7;19(1):10. doi: 10.1186/s12936-019-3093-3.

5.

Thorough performance evaluation of 213 nm ultraviolet photodissociation for top-down proteomics.

Fornelli L, Srzentić K, Toby TK, Doubleday PF, Huguet R, Mullen C, Melani RD, Dos Santos Seckler H, DeHart CJ, Weisbrod CR, Durbin KR, Greer JB, Early BP, Fellers RT, Zabrouskov V, Thomas P, Compton PD, Kelleher NL.

Mol Cell Proteomics. 2019 Dec 30. pii: mcp.TIR119.001638. doi: 10.1074/mcp.TIR119.001638. [Epub ahead of print]

6.

Discovery of the Biosynthetic Machinery for Stravidins, Biotin Antimetabolites.

Montaser R, Kelleher NL.

ACS Chem Biol. 2020 Jan 9. doi: 10.1021/acschembio.9b00890. [Epub ahead of print]

PMID:
31887014
7.

Novel Interface for High-Throughput Analysis of Biotherapeutics by Electrospray Mass Spectrometry.

Park HM, Winton VJ, Drader JJ, Manalili Wheeler S, Lazar GA, Kelleher NL, Liu Y, Tran JC, Compton PD.

Anal Chem. 2020 Jan 10. doi: 10.1021/acs.analchem.9b04826. [Epub ahead of print]

PMID:
31880920
8.

A MUC16 IgG binding activity selects for a restricted subset of IgG enriched for certain SIV epitope specificities.

Schneider JR, Shen X, Orlandi C, Nyanhete T, Sawant S, Carias AM, Smith AD 4th, Kelleher NL, Veazey RS, Lewis GK, Tomaras GD, Hope TJ.

J Virol. 2019 Nov 27. pii: JVI.01246-19. doi: 10.1128/JVI.01246-19. [Epub ahead of print]

PMID:
31776284
9.

A computational framework to explore large-scale biosynthetic diversity.

Navarro-Muñoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, Thomson RJ, Metcalf WW, Kelleher NL, Barona-Gomez F, Medema MH.

Nat Chem Biol. 2020 Jan;16(1):60-68. doi: 10.1038/s41589-019-0400-9. Epub 2019 Nov 25.

PMID:
31768033
10.

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms.

Huguet R, Mullen C, Srzentić K, Greer JB, Fellers RT, Zabrouskov V, Syka JEP, Kelleher NL, Fornelli L.

Anal Chem. 2019 Dec 17;91(24):15732-15739. doi: 10.1021/acs.analchem.9b03925. Epub 2019 Nov 22.

PMID:
31714757
11.

A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli.

Des Soye BJ, Gerbasi VR, Thomas PM, Kelleher NL, Jewett MC.

Cell Chem Biol. 2019 Dec 19;26(12):1743-1754.e9. doi: 10.1016/j.chembiol.2019.10.008. Epub 2019 Nov 6.

PMID:
31706984
12.

Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry.

Melani RD, Srzentić K, Gerbasi VR, McGee JP, Huguet R, Fornelli L, Kelleher NL.

MAbs. 2019 Nov-Dec;11(8):1351-1357. doi: 10.1080/19420862.2019.1668226. Epub 2019 Oct 13.

13.

Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol.

Park HM, Satta R, Davis RG, Goo YA, LeDuc RD, Fellers RT, Greer JB, Romanova EV, Rubakhin SS, Tai R, Thomas PM, Sweedler JV, Kelleher NL, Patrie SM, Lasek AW.

J Proteome Res. 2019 Nov 1;18(11):3999-4012. doi: 10.1021/acs.jproteome.9b00481. Epub 2019 Oct 2.

PMID:
31550894
14.

STORI Plots Enable Accurate Tracking of Individual Ion Signals.

Kafader JO, Beu SC, Early BP, Melani RD, Durbin KR, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Kelleher NL, Compton PD, Senko MW.

J Am Soc Mass Spectrom. 2019 Nov;30(11):2200-2203. doi: 10.1007/s13361-019-02309-0. Epub 2019 Sep 11.

PMID:
31512223
15.

A five-level classification system for proteoform identifications.

Smith LM, Thomas PM, Shortreed MR, Schaffer LV, Fellers RT, LeDuc RD, Tucholski T, Ge Y, Agar JN, Anderson LC, Chamot-Rooke J, Gault J, Loo JA, Paša-Tolić L, Robinson CV, Schlüter H, Tsybin YO, Vilaseca M, Vizcaíno JA, Danis PO, Kelleher NL.

Nat Methods. 2019 Oct;16(10):939-940. doi: 10.1038/s41592-019-0573-x. No abstract available.

PMID:
31451767
16.

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver.

Bennett RL, Bele A, Small EC, Will CM, Nabet B, Oyer JA, Huang X, Ghosh RP, Grzybowski AT, Yu T, Zhang Q, Riva A, Lele TP, Schatz GC, Kelleher NL, Ruthenburg AJ, Liphardt J, Licht JD.

Cancer Discov. 2019 Oct;9(10):1438-1451. doi: 10.1158/2159-8290.CD-19-0393. Epub 2019 Jul 23.

PMID:
31337617
17.

Coupling Fluorescence-Activated Cell Sorting and Targeted Analysis of Histone Modification Profiles in Primary Human Leukocytes.

Camarillo JM, Swaminathan S, Abshiru NA, Sikora JW, Thomas PM, Kelleher NL.

J Am Soc Mass Spectrom. 2019 Dec;30(12):2526-2534. doi: 10.1007/s13361-019-02255-x. Epub 2019 Jul 8.

PMID:
31286445
18.

Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3S)-3-Amino-4-(hexafluoropropan-2-ylidenyl)cyclopentane-1-carboxylic Acid.

Moschitto MJ, Doubleday PF, Catlin DS, Kelleher NL, Liu D, Silverman RB.

J Am Chem Soc. 2019 Jul 10;141(27):10711-10721. doi: 10.1021/jacs.9b03254. Epub 2019 Jun 28.

PMID:
31251613
19.

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.

Donnelly DP, Rawlins CM, DeHart CJ, Fornelli L, Schachner LF, Lin Z, Lippens JL, Aluri KC, Sarin R, Chen B, Lantz C, Jung W, Johnson KR, Koller A, Wolff JJ, Campuzano IDG, Auclair JR, Ivanov AR, Whitelegge JP, Paša-Tolić L, Chamot-Rooke J, Danis PO, Smith LM, Tsybin YO, Loo JA, Ge Y, Kelleher NL, Agar JN.

Nat Methods. 2019 Jul;16(7):587-594. doi: 10.1038/s41592-019-0457-0. Epub 2019 Jun 27. Review.

20.

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

Huang X, LeDuc RD, Fornelli L, Schunter AJ, Bennett RL, Kelleher NL, Licht JD.

J Biol Chem. 2019 Aug 16;294(33):12459-12471. doi: 10.1074/jbc.RA118.006159. Epub 2019 Jun 27.

PMID:
31248990
21.

Native top-down mass spectrometry provides insights into the copper centers of membrane-bound methane monooxygenase.

Ro SY, Schachner LF, Koo CW, Purohit R, Remis JP, Kenney GE, Liauw BW, Thomas PM, Patrie SM, Kelleher NL, Rosenzweig AC.

Nat Commun. 2019 Jun 17;10(1):2675. doi: 10.1038/s41467-019-10590-6.

22.

Identification and Quantification of Proteoforms by Mass Spectrometry.

Schaffer LV, Millikin RJ, Miller RM, Anderson LC, Fellers RT, Ge Y, Kelleher NL, LeDuc RD, Liu X, Payne SH, Sun L, Thomas PM, Tucholski T, Wang Z, Wu S, Wu Z, Yu D, Shortreed MR, Smith LM.

Proteomics. 2019 May;19(10):e1800361. doi: 10.1002/pmic.201800361. Review.

PMID:
31050378
23.

Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas.

Lue JK, Prabhu SA, Liu Y, Gonzalez Y, Verma A, Mundi PS, Abshiru N, Camarillo JM, Mehta S, Chen EI, Qiao C, Nandakumar R, Cremers S, Kelleher NL, Elemento O, Amengual JE.

Clin Cancer Res. 2019 Sep 1;25(17):5271-5283. doi: 10.1158/1078-0432.CCR-18-3989. Epub 2019 Apr 12.

PMID:
30979734
24.

Standard Proteoforms and Their Complexes for Native Mass Spectrometry.

Schachner LF, Ives AN, McGee JP, Melani RD, Kafader JO, Compton PD, Patrie SM, Kelleher NL.

J Am Soc Mass Spectrom. 2019 Jul;30(7):1190-1198. doi: 10.1007/s13361-019-02191-w. Epub 2019 Apr 8.

PMID:
30963455
25.

Accurate Estimation of Context-Dependent False Discovery Rates in Top-Down Proteomics.

LeDuc RD, Fellers RT, Early BP, Greer JB, Shams DP, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2019 Apr;18(4):796-805. doi: 10.1074/mcp.RA118.000993. Epub 2019 Jan 15.

PMID:
30647073
26.

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins.

Kafader JO, Melani RD, Senko MW, Makarov AA, Kelleher NL, Compton PD.

Anal Chem. 2019 Feb 19;91(4):2776-2783. doi: 10.1021/acs.analchem.8b04519. Epub 2019 Jan 29.

PMID:
30609364
27.

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies.

Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Bu RL, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, de Mello FG, Compton PD, Kelleher NL, Klein WL.

J Neurochem. 2019 Mar;148(6):822-836. doi: 10.1111/jnc.14647. Epub 2019 Jan 29.

PMID:
30565253
28.

A comprehensive pipeline for translational top-down proteomics from a single blood draw.

Toby TK, Fornelli L, Srzentić K, DeHart CJ, Levitsky J, Friedewald J, Kelleher NL.

Nat Protoc. 2019 Jan;14(1):119-152. doi: 10.1038/s41596-018-0085-7.

29.

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria.

Fisher OS, Kenney GE, Ross MO, Ro SY, Lemma BE, Batelu S, Thomas PM, Sosnowski VC, DeHart CJ, Kelleher NL, Stemmler TL, Hoffman BM, Rosenzweig AC.

Nat Commun. 2018 Oct 15;9(1):4276. doi: 10.1038/s41467-018-06681-5.

30.

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.

Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutierrez-Diaz BT, Wang KK, Johnson MR, Volk AG, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goosens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Strikoudis A, Kelly S, Ueberheide B, Mantis C, Kandela I, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Kumar S, Crispino JD, Shilatifard A, Ntziachristos P.

Clin Cancer Res. 2019 Jan 1;25(1):222-239. doi: 10.1158/1078-0432.CCR-18-1740. Epub 2018 Sep 17.

31.

Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells.

Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA.

PLoS One. 2018 Sep 7;13(9):e0203351. doi: 10.1371/journal.pone.0203351. eCollection 2018.

32.

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia.

Swaroop A, Oyer JA, Will CM, Huang X, Yu W, Troche C, Bulic M, Durham BH, Wen QJ, Crispino JD, MacKerell AD Jr, Bennett RL, Kelleher NL, Licht JD.

Oncogene. 2019 Jan;38(5):671-686. doi: 10.1038/s41388-018-0474-y. Epub 2018 Aug 31.

33.

Estimating the Distribution of Protein Post-Translational Modification States by Mass Spectrometry.

Compton PD, Kelleher NL, Gunawardena J.

J Proteome Res. 2018 Aug 3;17(8):2727-2734. doi: 10.1021/acs.jproteome.8b00150. Epub 2018 Jul 10.

34.

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ.

Anal Chem. 2018 Jul 17;90(14):8553-8560. doi: 10.1021/acs.analchem.8b01638. Epub 2018 Jul 5.

35.

Natural products from thioester reductase containing biosynthetic pathways.

Mullowney MW, McClure RA, Robey MT, Kelleher NL, Thomson RJ.

Nat Prod Rep. 2018 Sep 19;35(9):847-878. doi: 10.1039/c8np00013a. Review.

36.

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques.

Fornelli L, Srzentić K, Huguet R, Mullen C, Sharma S, Zabrouskov V, Fellers RT, Durbin KR, Compton PD, Kelleher NL.

Anal Chem. 2018 Jul 17;90(14):8421-8429. doi: 10.1021/acs.analchem.8b00984. Epub 2018 Jun 28.

37.

The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth.

Alvares K, DeHart CJ, Thomas PM, Kelleher NL, Veis A.

Connect Tissue Res. 2018 Dec;59(sup1):20-29. doi: 10.1080/03008207.2017.1408605.

38.

Repurposed HisC Aminotransferases Complete the Biosynthesis of Some Methanobactins.

Park YJ, Kenney GE, Schachner LF, Kelleher NL, Rosenzweig AC.

Biochemistry. 2018 Jun 26;57(25):3515-3523. doi: 10.1021/acs.biochem.8b00296. Epub 2018 May 10.

39.

β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site.

Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D.

J Am Chem Soc. 2018 May 9;140(18):5914-5924. doi: 10.1021/jacs.7b13003. Epub 2018 Apr 30.

40.

A Targeted, Differential Top-Down Proteomic Methodology for Comparison of ApoA-I Proteoforms in Individuals with High and Low HDL Efflux Capacity.

Seckler HDS, Fornelli L, Mutharasan RK, Thaxton CS, Fellers R, Daviglus M, Sniderman A, Rader D, Kelleher NL, Lloyd-Jones DM, Compton PD, Wilkins JT.

J Proteome Res. 2018 Jun 1;17(6):2156-2164. doi: 10.1021/acs.jproteome.8b00100. Epub 2018 Apr 27.

41.

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL.

ACS Chem Biol. 2018 May 18;13(5):1142-1147. doi: 10.1021/acschembio.8b00024. Epub 2018 Apr 17.

42.

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk.

Ntai I, Fornelli L, DeHart CJ, Hutton JE, Doubleday PF, LeDuc RD, van Nispen AJ, Fellers RT, Whiteley G, Boja ES, Rodriguez H, Kelleher NL.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4140-4145. doi: 10.1073/pnas.1716122115. Epub 2018 Apr 2.

43.

Proteoforms as the next proteomics currency.

Smith LM, Kelleher NL.

Science. 2018 Mar 9;359(6380):1106-1107. doi: 10.1126/science.aat1884. Epub 2018 Mar 8. No abstract available.

44.

Total Synthesis of Tambromycin Enabled by Indole C-H Functionalization.

Miley GP, Rote JC, Silverman RB, Kelleher NL, Thomson RJ.

Org Lett. 2018 Apr 20;20(8):2369-2373. doi: 10.1021/acs.orglett.8b00700. Epub 2018 Mar 27.

45.

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids.

Martin RW, Des Soye BJ, Kwon YC, Kay J, Davis RG, Thomas PM, Majewska NI, Chen CX, Marcum RD, Weiss MG, Stoddart AE, Amiram M, Ranji Charna AK, Patel JR, Isaacs FJ, Kelleher NL, Hong SH, Jewett MC.

Nat Commun. 2018 Mar 23;9(1):1203. doi: 10.1038/s41467-018-03469-5.

46.

The biosynthesis of methanobactin.

Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM Jr, Krebs C, Kelleher NL, Rosenzweig AC.

Science. 2018 Mar 23;359(6382):1411-1416. doi: 10.1126/science.aap9437.

47.

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey MT, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu CC, Keller NP, Kelleher NL.

Biochemistry. 2018 Jun 12;57(23):3237-3243. doi: 10.1021/acs.biochem.8b00076. Epub 2018 Mar 20.

48.

Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics.

Parkinson EI, Tryon JH, Goering AW, Ju KS, McClure RA, Kemball JD, Zhukovsky S, Labeda DP, Thomson RJ, Kelleher NL, Metcalf WW.

ACS Chem Biol. 2018 Apr 20;13(4):1029-1037. doi: 10.1021/acschembio.7b01089. Epub 2018 Mar 13.

49.

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, Sweedler JV, Rhodes JS, Kelleher NL.

Anal Chem. 2018 Mar 20;90(6):3802-3810. doi: 10.1021/acs.analchem.7b04108. Epub 2018 Feb 26.

50.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

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