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Items: 1 to 50 of 74

1.

Metabolic requirements for cancer cell proliferation.

Keibler MA, Wasylenko TM, Kelleher JK, Iliopoulos O, Vander Heiden MG, Stephanopoulos G.

Cancer Metab. 2016 Aug 18;4:16. doi: 10.1186/s40170-016-0156-6. eCollection 2016.

2.

Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts.

Crown SB, Kelleher JK, Rouf R, Muoio DM, Antoniewicz MR.

Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H881-H891. doi: 10.1152/ajpheart.00428.2016. Epub 2016 Aug 5.

3.

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake.

Haskins JW, Zhang S, Means RE, Kelleher JK, Cline GW, Canfrán-Duque A, Suárez Y, Stern DF.

Sci Signal. 2015 Nov 3;8(401):ra111. doi: 10.1126/scisignal.aac5124.

4.

Isotopomer Spectral Analysis: Utilizing Nonlinear Models in Isotopic Flux Studies.

Kelleher JK, Nickol GB.

Methods Enzymol. 2015;561:303-30. doi: 10.1016/bs.mie.2015.06.039. Epub 2015 Aug 19. Review.

PMID:
26358909
5.

Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE.

Jin Z, Bian F, Tomcik K, Kelleher JK, Zhang GF, Brunengraber H.

J Biol Chem. 2015 Jul 24;290(30):18671-7. doi: 10.1074/jbc.M115.651737. Epub 2015 Jun 12.

6.

Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle.

Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G.

J Biol Chem. 2013 May 3;288(18):12967-77. doi: 10.1074/jbc.M112.396796. Epub 2013 Mar 15.

7.

NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data.

Hiller K, Wegner A, Weindl D, Cordes T, Metallo CM, Kelleher JK, Stephanopoulos G.

Bioinformatics. 2013 May 1;29(9):1226-8. doi: 10.1093/bioinformatics/btt119. Epub 2013 Mar 11.

8.

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G.

Nature. 2011 Nov 20;481(7381):380-4. doi: 10.1038/nature10602.

9.

Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry.

Antoniewicz MR, Kelleher JK, Stephanopoulos G.

Anal Chem. 2011 Apr 15;83(8):3211-6. doi: 10.1021/ac200012p. Epub 2011 Mar 17.

10.

Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

Mol Biosyst. 2011 May;7(5):1409-19. doi: 10.1039/c0mb00309c. Epub 2011 Feb 16.

PMID:
21327189
11.

Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice.

Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G.

PLoS One. 2010 Aug 10;5(8):e12057. doi: 10.1371/journal.pone.0012057.

12.

Nontargeted elucidation of metabolic pathways using stable-isotope tracers and mass spectrometry.

Hiller K, Metallo CM, Kelleher JK, Stephanopoulos G.

Anal Chem. 2010 Aug 1;82(15):6621-8. doi: 10.1021/ac1011574.

PMID:
20608743
13.

Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

J Biol Chem. 2009 Nov 27;284(48):33425-36. doi: 10.1074/jbc.M109.049478. Epub 2009 Sep 16.

14.

Dynamics of glutathione and ophthalmate traced with 2H-enriched body water in rats and humans.

Kombu RS, Zhang GF, Abbas R, Mieyal JJ, Anderson VE, Kelleher JK, Sanabria JR, Brunengraber H.

Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E260-9. doi: 10.1152/ajpendo.00080.2009. Epub 2009 Apr 28.

15.

Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle. I. Interrelation between gluconeogenesis and cataplerosis; formation of methoxamates from aminooxyacetate and ketoacids.

Yang L, Kombu RS, Kasumov T, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21978-87. doi: 10.1074/jbc.M803454200. Epub 2008 Jun 10.

16.

Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern.

Yang L, Kasumov T, Kombu RS, Zhu SH, Cendrowski AV, David F, Anderson VE, Kelleher JK, Brunengraber H.

J Biol Chem. 2008 Aug 8;283(32):21988-96. doi: 10.1074/jbc.M803455200. Epub 2008 Jun 10.

17.

Estimating glutathione synthesis with deuterated water: a model for peptide biosynthesis.

Cabral CB, Bullock KH, Bischoff DJ, Tompkins RG, Yu YM, Kelleher JK.

Anal Biochem. 2008 Aug 1;379(1):40-4. doi: 10.1016/j.ab.2008.04.042. Epub 2008 Apr 29.

18.

Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line.

Yoo H, Antoniewicz MR, Stephanopoulos G, Kelleher JK.

J Biol Chem. 2008 Jul 25;283(30):20621-7. doi: 10.1074/jbc.M706494200. Epub 2008 Mar 25.

19.

Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis.

Antoniewicz MR, Kelleher JK, Stephanopoulos G.

Anal Chem. 2007 Oct 1;79(19):7554-9. Epub 2007 Sep 7.

PMID:
17822305
20.

Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol.

Antoniewicz MR, Kraynie DF, Laffend LA, González-Lergier J, Kelleher JK, Stephanopoulos G.

Metab Eng. 2007 May;9(3):277-92. Epub 2007 Feb 23.

21.

Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes.

Kovacs WJ, Tape KN, Shackelford JE, Duan X, Kasumov T, Kelleher JK, Brunengraber H, Krisans SK.

Histochem Cell Biol. 2007 Mar;127(3):273-90. Epub 2006 Dec 19.

PMID:
17180682
22.

Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions.

Antoniewicz MR, Kelleher JK, Stephanopoulos G.

Metab Eng. 2007 Jan;9(1):68-86. Epub 2006 Sep 17.

23.

Evaluation of regression models in metabolic physiology: predicting fluxes from isotopic data without knowledge of the pathway.

Antoniewicz MR, Stephanopoulos G, Kelleher JK.

Metabolomics. 2006 Mar;2(1):41-52. Epub 2006 May 20.

24.

Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements.

Antoniewicz MR, Kelleher JK, Stephanopoulos G.

Metab Eng. 2006 Jul;8(4):324-37. Epub 2006 Apr 24.

PMID:
16631402
25.

Isotopomer spectral analysis of intermediates of cholesterol synthesis in patients with cerebrotendinous xanthomatosis.

Clarenbach JJ, Lindenthal B, Dotti MT, Federico A, Kelleher JK, von Bergmann K.

Metabolism. 2005 Mar;54(3):335-44.

PMID:
15736111
26.

In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver.

Bederman IR, Kasumov T, Reszko AE, David F, Brunengraber H, Kelleher JK.

J Biol Chem. 2004 Oct 8;279(41):43217-26. Epub 2004 Jul 28.

27.

Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis.

Bederman IR, Reszko AE, Kasumov T, David F, Wasserman DH, Kelleher JK, Brunengraber H.

J Biol Chem. 2004 Oct 8;279(41):43207-16. Epub 2004 Jul 28.

28.

Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes.

Yoo H, Stephanopoulos G, Kelleher JK.

J Lipid Res. 2004 Jul;45(7):1324-32. Epub 2004 Apr 21.

29.
30.

Metabolic and transcriptional patterns accompanying glutamine depletion and repletion in mouse hepatoma cells: a model for physiological regulatory networks.

Wong MS, Raab RM, Rigoutsos I, Stephanopoulos GN, Kelleher JK.

Physiol Genomics. 2004 Jan 15;16(2):247-55.

PMID:
14612591
31.

Probing the link between citrate and malonyl-CoA in perfused rat hearts.

Poirier M, Vincent G, Reszko AE, Bouchard B, Kelleher JK, Brunengraber H, Des Rosiers C.

Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1379-86. Epub 2002 Jun 13.

32.

Isotopomer spectral analysis of intermediates of cholesterol synthesis in human subjects and hepatic cells.

Lindenthal B, Aldaghlas TA, Holleran AL, Sudhop T, Berthold HK, Von Bergmann K, Kelleher JK.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1222-30.

33.

Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.

Lindenthal B, Aldaghlas TA, Kelleher JK, Henkel SM, Tolba R, Haidl G, von Bergmann K.

J Lipid Res. 2001 Jul;42(7):1089-95.

34.
35.

Progestins block cholesterol synthesis to produce meiosis-activating sterols.

Lindenthal B, Holleran AL, Aldaghlas TA, Ruan B, Schroepfer GJ Jr, Wilson WK, Kelleher JK.

FASEB J. 2001 Mar;15(3):775-84.

PMID:
11259396
37.

Estimating gluconeogenesis with [U-13C]glucose: molecular condensation requires a molecular approach.

Kelleher JK.

Am J Physiol. 1999 Sep;277(3):E395-400. doi: 10.1152/ajpendo.1999.277.3.E395. Review.

PMID:
10484348
38.

Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes.

Holleran AL, Lindenthal B, Aldaghlas TA, Kelleher JK.

Metabolism. 1998 Dec;47(12):1504-13.

PMID:
9867082
39.

Role of acetyl-L-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis.

Ricciolini R, Scalibastri M, Kelleher JK, Carminati P, Calvani M, Arduini A.

J Neurochem. 1998 Dec;71(6):2510-7.

40.

Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis.

Lligona-Trulla L, Arduini A, Aldaghlas TA, Calvani M, Kelleher JK.

J Lipid Res. 1997 Jul;38(7):1454-62.

41.

Quantitative analysis of acetoacetate metabolism in AS-30D hepatoma cells with 13C and 14C isotopic techniques.

Holleran AL, Fiskum G, Kelleher JK.

Am J Physiol. 1997 Jun;272(6 Pt 1):E945-51.

PMID:
9227436
42.

Applications of mass isotopomer analysis to nutrition research.

Brunengraber H, Kelleher JK, Des Rosiers C.

Annu Rev Nutr. 1997;17:559-96. Review.

PMID:
9240940
43.

Monte Carlo spreadsheet modeling of stable isotope biosynthesis.

Masterson TM, Kelleher JK.

Comput Biol Med. 1996 Sep;26(5):429-37.

PMID:
8889340
44.

Glutamine metabolism in AS-30D hepatoma cells. Evidence for its conversion into lipids via reductive carboxylation.

Holleran AL, Briscoe DA, Fiskum G, Kelleher JK.

Mol Cell Biochem. 1995 Nov 22;152(2):95-101.

PMID:
8751155
45.

Acetoacetate metabolism in AS-30D hepatoma cells.

Briscoe DA, Fiskum G, Holleran AL, Kelleher JK.

Mol Cell Biochem. 1994 Jul 27;136(2):131-7.

PMID:
7845366
46.

Isotopomer spectral analysis of cholesterol synthesis: applications in human hepatoma cells.

Kelleher JK, Kharroubi AT, Aldaghlas TA, Shambat IB, Kennedy KA, Holleran AL, Masterson TM.

Am J Physiol. 1994 Mar;266(3 Pt 1):E384-95.

PMID:
8166258
47.

Isotopomer spectral analysis of triglyceride fatty acid synthesis in 3T3-L1 cells.

Kharroubi AT, Masterson TM, Aldaghlas TA, Kennedy KA, Kelleher JK.

Am J Physiol. 1992 Oct;263(4 Pt 1):E667-75.

PMID:
1415685
48.

Model equations for condensation biosynthesis using stable isotopes and radioisotopes.

Kelleher JK, Masterson TM.

Am J Physiol. 1992 Jan;262(1 Pt 1):E118-25.

PMID:
1733242
49.
50.

Calcium sensitive isocitrate and 2-oxoglutarate dehydrogenase activities in rat liver and AS-30D hepatoma mitochondria.

Murphy AN, Kelleher JK, Fiskum G.

Biochem Biophys Res Commun. 1988 Dec 30;157(3):1218-25.

PMID:
3207422

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