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α4β2 nicotinic acetylcholine receptors intrinsically influence body weight in mice.

Dezfuli G, Olson TT, Martin LM, Keum Y, Siegars BA, Desai A, Uitz M, Sahibzada N, Gillis RA, Kellar KJ.

Neuropharmacology. 2020 Apr;166:107921. doi: 10.1016/j.neuropharm.2019.107921. Epub 2019 Dec 24.


Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats.

Rezvani AH, Wells C, Slade S, Xiao Y, Kellar KJ, Levin ED.

Pharmacol Biochem Behav. 2019 Apr;179:109-112. doi: 10.1016/j.pbb.2019.02.007. Epub 2019 Feb 19.


α4β2 Nicotinic receptor desensitizing compounds can decrease self-administration of cocaine and methamphetamine in rats.

Levin ED, Rezvani AH, Wells C, Slade S, Yenugonda VM, Liu Y, Brown ML, Xiao Y, Kellar KJ.

Eur J Pharmacol. 2019 Feb 15;845:1-7. doi: 10.1016/j.ejphar.2018.12.010. Epub 2018 Dec 7.


Effects of nicotine-containing and "nicotine-free" e-cigarette refill liquids on intracranial self-stimulation in rats.

Harris AC, Muelken P, Smethells JR, Yershova K, Stepanov I, Olson TT, Kellar KJ, LeSage MG.

Drug Alcohol Depend. 2018 Apr 1;185:1-9. doi: 10.1016/j.drugalcdep.2017.11.032. Epub 2018 Feb 1.


The (α4)3(β2)2 Stoichiometry of the Nicotinic Acetylcholine Receptor Predominates in the Rat Motor Cortex.

DeDominicis KE, Sahibzada N, Olson TT, Xiao Y, Wolfe BB, Kellar KJ, Yasuda RP.

Mol Pharmacol. 2017 Sep;92(3):327-337. doi: 10.1124/mol.116.106880. Epub 2017 Jul 11.


Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats.

Rezvani AH, Slade S, Wells C, Yenugonda VM, Liu Y, Brown ML, Xiao Y, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2017 Sep;234(17):2517-2523. doi: 10.1007/s00213-017-4641-6. Epub 2017 May 29.


Evidence for the role of β2* nAChR desensitization in regulating body weight in obese mice.

Dezfuli G, Kellar KJ, Dretchen KL, Tizabi Y, Sahibzada N, Gillis RA.

Neuropharmacology. 2016 Nov;110(Pt A):165-174. doi: 10.1016/j.neuropharm.2016.07.020. Epub 2016 Jul 18.


Anxiolytic- and antidepressant-like effects of the methadone metabolite 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP).

Forcelli PA, Turner JR, Lee BG, Olson TT, Xie T, Xiao Y, Blendy JA, Kellar KJ.

Neuropharmacology. 2016 Feb;101:46-56. doi: 10.1016/j.neuropharm.2015.09.012. Epub 2015 Sep 11.


Correction to N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent.

Misra RN, Xiao HY, Kim KS, Lu S, Han WC, Barbosa SA, Hunt JT, Rawlins DB, Shan W, Ahmed SZ, Qian L, Chen BC, Zhao R, Bednarz MS, Kellar KA, Mulheron JG, Batorsky R, Roongta U, Kamath A, Marathe P, Ranadive SA, Sack JS, Tokarski JS, Pavletich NP, Lee FY, Webster KR, Kimball SD.

J Med Chem. 2015 Sep 24;58(18):7609. doi: 10.1021/acs.jmedchem.5b01294. Epub 2015 Sep 2. No abstract available.


AT-1001 Is a Partial Agonist with High Affinity and Selectivity at Human and Rat α3β4 Nicotinic Cholinergic Receptors.

Tuan EW, Horti AG, Olson TT, Gao Y, Stockmeier CA, Al-Muhtasib N, Bowman Dalley C, Lewin AE, Wolfe BB, Sahibzada N, Xiao Y, Kellar KJ.

Mol Pharmacol. 2015 Oct;88(4):640-9. doi: 10.1124/mol.115.099978. Epub 2015 Jul 10.


Menthol Enhances the Desensitization of Human α3β4 Nicotinic Acetylcholine Receptors.

Ton HT, Smart AE, Aguilar BL, Olson TT, Kellar KJ, Ahern GP.

Mol Pharmacol. 2015 Aug;88(2):256-64. doi: 10.1124/mol.115.098285. Epub 2015 May 11.


[(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

Gao Y, Mease RC, Olson TT, Kellar KJ, Dannals RF, Pomper MG, Horti AG.

Nucl Med Biol. 2015 May;42(5):488-493. doi: 10.1016/j.nucmedbio.2014.12.008. Epub 2014 Dec 20.


Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.

Liu Y, Paige M, Olson TT, Al-Muhtasib N, Xie T, Hou S, White MP, Cordova A, Guo JL, Kellar KJ, Xiao Y, Brown ML.

Bioorg Med Chem Lett. 2014 Jul 1;24(13):2954-6. doi: 10.1016/j.bmcl.2014.04.036. Epub 2014 Apr 23.


18F-ASEM, a radiolabeled antagonist for imaging the α7-nicotinic acetylcholine receptor with PET.

Horti AG, Gao Y, Kuwabara H, Wang Y, Abazyan S, Yasuda RP, Tran T, Xiao Y, Sahibzada N, Holt DP, Kellar KJ, Pletnikov MV, Pomper MG, Wong DF, Dannals RF.

J Nucl Med. 2014 Apr;55(4):672-7. doi: 10.2967/jnumed.113.132068. Epub 2014 Feb 20.


Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain.

Hussmann GP, DeDominicis KE, Turner JR, Yasuda RP, Klehm J, Forcelli PA, Xiao Y, Richardson JR, Sahibzada N, Wolfe BB, Lindstrom J, Blendy JA, Kellar KJ.

J Neurochem. 2014 May;129(4):721-31. doi: 10.1111/jnc.12653. Epub 2014 Feb 7.


Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors.

Gao Y, Kellar KJ, Yasuda RP, Tran T, Xiao Y, Dannals RF, Horti AG.

J Med Chem. 2013 Oct 10;56(19):7574-89. doi: 10.1021/jm401184f. Epub 2013 Sep 19.


Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.

Yenugonda VM, Xiao Y, Levin ED, Rezvani AH, Tran T, Al-Muhtasib N, Sahibzada N, Xie T, Wells C, Slade S, Johnson JE, Dakshanamurthy S, Kong HS, Tomita Y, Liu Y, Paige M, Kellar KJ, Brown ML.

J Med Chem. 2013 Nov 14;56(21):8404-21. doi: 10.1021/jm4008455. Epub 2013 Oct 18.


Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice.

Levin ED, Sexton HG, Gordon K, Gordon CJ, Xiao Y, Kellar KJ, Yenugonda VM, Liu Y, White MP, Paige M, Brown ML, Rezvani AH.

Eur J Pharmacol. 2013 Oct 15;718(1-3):167-72. doi: 10.1016/j.ejphar.2013.08.037. Epub 2013 Sep 12.


Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.

Liu Y, Richardson J, Tran T, Al-Muhtasib N, Xie T, Yenugonda VM, Sexton HG, Rezvani AH, Levin ED, Sahibzada N, Kellar KJ, Brown ML, Xiao Y, Paige M.

J Med Chem. 2013 Apr 11;56(7):3000-11. doi: 10.1021/jm4000374. Epub 2013 Apr 1.


Effects of chronic sazetidine-A, a selective α4β2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats.

Rezvani AH, Cauley M, Xiao Y, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2013 Mar;226(1):35-43. doi: 10.1007/s00213-012-2895-6. Epub 2012 Oct 26.


Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain.

Hussmann GP, Turner JR, Lomazzo E, Venkatesh R, Cousins V, Xiao Y, Yasuda RP, Wolfe BB, Perry DC, Rezvani AH, Levin ED, Blendy JA, Kellar KJ.

J Pharmacol Exp Ther. 2012 Nov;343(2):441-50. doi: 10.1124/jpet.112.198085. Epub 2012 Aug 16.


A new radioligand binding assay to measure the concentration of drugs in rodent brain ex vivo.

Hussmann GP, Kellar KJ.

J Pharmacol Exp Ther. 2012 Nov;343(2):434-40. doi: 10.1124/jpet.112.198069. Epub 2012 Aug 16.


Rapid, simultaneous detection of Clostridium sordellii and Clostridium perfringens in archived tissues by a novel PCR-based microsphere assay: diagnostic implications for pregnancy-associated toxic shock syndrome cases.

Bhatnagar J, Deleon-Carnes M, Kellar KL, Bandyopadhyay K, Antoniadou ZA, Shieh WJ, Paddock CD, Zaki SR.

Infect Dis Obstet Gynecol. 2012;2012:972845. doi: 10.1155/2012/972845. Epub 2012 Mar 22.


Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.

Rezvani AH, Timofeeva O, Sexton HG, DeCuir D, Xiao Y, Gordon CJ, Kellar KJ, Levin ED.

Eur J Pharmacol. 2012 May 5;682(1-3):110-7. doi: 10.1016/j.ejphar.2012.02.031. Epub 2012 Feb 24.


Assessing the effects of chronic sazetidine-A delivery on nicotine self-administration in both male and female rats.

Johnson JE, Slade S, Wells C, Petro A, Sexton H, Rezvani AH, Brown ML, Paige MA, McDowell BE, Xiao Y, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2012 Jul;222(2):269-76. doi: 10.1007/s00213-012-2642-z.


Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial.

Newhouse P, Kellar K, Aisen P, White H, Wesnes K, Coderre E, Pfaff A, Wilkins H, Howard D, Levin ED.

Neurology. 2012 Jan 10;78(2):91-101. doi: 10.1212/WNL.0b013e31823efcbb.


Multiple cytokines are released when blood from patients with tuberculosis is stimulated with Mycobacterium tuberculosis antigens.

Kellar KL, Gehrke J, Weis SE, Mahmutovic-Mayhew A, Davila B, Zajdowicz MJ, Scarborough R, LoBue PA, Lardizabal AA, Daley CL, Reves RR, Bernardo J, Campbell BH, Whitworth WC, Mazurek GH.

PLoS One. 2011;6(11):e26545. doi: 10.1371/journal.pone.0026545. Epub 2011 Nov 21.


Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed α4β2 nicotinic receptors.

Hussmann GP, Yasuda RP, Xiao Y, Wolfe BB, Kellar KJ.

J Biol Chem. 2011 Nov 18;286(46):39726-37. doi: 10.1074/jbc.M111.289546. Epub 2011 Sep 22.


Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons.

Lomazzo E, Hussmann GP, Wolfe BB, Yasuda RP, Perry DC, Kellar KJ.

J Neurochem. 2011 Oct;119(1):153-64. doi: 10.1111/j.1471-4159.2011.07408.x. Epub 2011 Sep 1.


Cellular immune responses to nine Mycobacterium tuberculosis vaccine candidates following intranasal vaccination.

Sable SB, Cheruvu M, Nandakumar S, Sharma S, Bandyopadhyay K, Kellar KL, Posey JE, Plikaytis BB, Amara RR, Shinnick TM.

PLoS One. 2011;6(7):e22718. doi: 10.1371/journal.pone.0022718. Epub 2011 Jul 25.


Cerebellar nicotinic cholinergic receptors are intrinsic to the cerebellum: implications for diverse functional roles.

Turner JR, Ortinski PI, Sherrard RM, Kellar KJ.

Cerebellum. 2011 Dec;10(4):748-57. doi: 10.1007/s12311-011-0285-y.


Mycobacterium tuberculosis components stimulate production of the antimicrobial peptide hepcidin.

Sow FB, Nandakumar S, Velu V, Kellar KL, Schlesinger LS, Amara RR, Lafuse WP, Shinnick TM, Sable SB.

Tuberculosis (Edinb). 2011 Jul;91(4):314-21. doi: 10.1016/ Epub 2011 Apr 8.


Sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor ligand: effects on dizocilpine and scopolamine-induced attentional impairments in female Sprague-Dawley rats.

Rezvani AH, Cauley M, Sexton H, Xiao Y, Brown ML, Paige MA, McDowell BE, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2011 Jun;215(4):621-30. doi: 10.1007/s00213-010-2161-8. Epub 2011 Jan 28.


Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus.

Lomazzo E, MacArthur L, Yasuda RP, Wolfe BB, Kellar KJ.

J Neurochem. 2010 Nov;115(3):625-34. doi: 10.1111/j.1471-4159.2010.06967.x. Epub 2010 Sep 27.


Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats.

Rezvani AH, Slade S, Wells C, Petro A, Lumeng L, Li TK, Xiao Y, Brown ML, Paige MA, McDowell BE, Rose JE, Kellar KJ, Levin ED.

Psychopharmacology (Berl). 2010 Aug;211(2):161-74. doi: 10.1007/s00213-010-1878-8. Epub 2010 Jun 10.


Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.

Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM.

Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. doi: 10.1016/j.bmcl.2010.01.042. Epub 2010 Jan 20.


[18F]ZW-104, a new radioligand for imaging alpha2-alpha3-alpha4/beta2 central nicotinic acetylcholine receptors: Evaluation in mutant mice.

Saba W, Valette H, Granon S, Xiao Y, Kellar KJ, Dollé F, Bottlaender M.

Synapse. 2010 Jul;64(7):570-2. doi: 10.1002/syn.20776. No abstract available.


Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats.

Levin ED, Rezvani AH, Xiao Y, Slade S, Cauley M, Wells C, Hampton D, Petro A, Rose JE, Brown ML, Paige MA, McDowell BE, Kellar KJ.

J Pharmacol Exp Ther. 2010 Mar;332(3):933-9. doi: 10.1124/jpet.109.162073. Epub 2009 Dec 10.


18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons.

Valette H, Xiao Y, Peyronneau MA, Damont A, Kozikowski AP, Wei ZL, Kassiou M, Kellar KJ, Dollé F, Bottlaender M.

J Nucl Med. 2009 Aug;50(8):1349-55. doi: 10.2967/jnumed.108.061374.


Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function.

Xiao Y, Abdrakhmanova GR, Baydyuk M, Hernandez S, Kellar KJ.

Acta Pharmacol Sin. 2009 Jun;30(6):842-50. doi: 10.1038/aps.2009.69. Epub 2009 May 18.


Multiplexed microsphere-based flow cytometric immunoassays.

Kellar KL, Mahmutovic AJ, Bandyopadhyay K.

Curr Protoc Cytom. 2006 Feb;Chapter 13:Unit13.1. doi: 10.1002/0471142956.cy1301s35.


Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia.

He Q, Eko FO, Lyn D, Ananaba GA, Bandea C, Martinez J, Joseph K, Kellar K, Black CM, Igietseme JU.

J Immunol. 2008 Sep 15;181(6):4037-42.


Analgesic effects of Sazetidine-A, a new nicotinic cholinergic drug.

Cucchiaro G, Xiao Y, Gonzalez-Sulser A, Kellar KJ.

Anesthesiology. 2008 Sep;109(3):512-9. doi: 10.1097/ALN.0b013e3181834490.


Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.

Gao Y, Kuwabara H, Spivak CE, Xiao Y, Kellar K, Ravert HT, Kumar A, Alexander M, Hilton J, Wong DF, Dannals RF, Horti AG.

J Med Chem. 2008 Aug 14;51(15):4751-64. doi: 10.1021/jm800323d. Epub 2008 Jul 8.


Toxicological analysis of low-nicotine and nicotine-free cigarettes.

Chen J, Higby R, Tian D, Tan D, Johnson MD, Xiao Y, Kellar KJ, Feng S, Shields PG.

Toxicology. 2008 Jul 30;249(2-3):194-203. doi: 10.1016/j.tox.2008.05.009. Epub 2008 May 24.


Identification of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of Met kinase.

Schroeder GM, Chen XT, Williams DK, Nirschl DS, Cai ZW, Wei D, Tokarski JS, An Y, Sack J, Chen Z, Huynh T, Vaccaro W, Poss M, Wautlet B, Gullo-Brown J, Kellar K, Manne V, Hunt JT, Wong TW, Lombardo LJ, Fargnoli J, Borzilleri RM.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1945-51. doi: 10.1016/j.bmcl.2008.01.121. Epub 2008 Feb 7.


Transport of multiple nicotinic acetylcholine receptors in the rat optic nerve: high densities of receptors containing alpha6 and beta3 subunits.

Cox BC, Marritt AM, Perry DC, Kellar KJ.

J Neurochem. 2008 Jun;105(5):1924-38. doi: 10.1111/j.1471-4159.2008.05282.x. Epub 2008 Feb 5.


Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type.

Moaddel R, Oliveira RV, Kimura T, Hyppolite P, Juhaszova M, Xiao Y, Kellar KJ, Bernier M, Wainer IW.

Anal Chem. 2008 Jan 1;80(1):48-54. Epub 2007 Dec 7.


The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo.

Mao D, Perry DC, Yasuda RP, Wolfe BB, Kellar KJ.

J Neurochem. 2008 Jan;104(2):446-56. Epub 2007 Oct 24.


Rapid microsphere assay for identification of cryptosporidium hominis and cryptosporidium parvum in stool and environmental samples.

Bandyopadhyay K, Kellar KL, Moura I, Casaqui Carollo MC, Graczyk TK, Slemenda S, Johnston SP, da Silva AJ.

J Clin Microbiol. 2007 Sep;45(9):2835-40. Epub 2007 Jul 25.

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