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Items: 1 to 50 of 60

1.

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET.

Alcobia DC, Ziegler AI, Kondrashov A, Comeo E, Mistry S, Kellam B, Chang A, Woolard J, Hill SJ, Sloan EK.

iScience. 2018 Aug 31;6:280-288. doi: 10.1016/j.isci.2018.08.006. Epub 2018 Aug 11.

PMID:
30240618
2.

Genome-wide copy number variation analysis identifies novel candidate loci associated with pediatric obesity.

Selvanayagam T, Walker S, Gazzellone MJ, Kellam B, Cytrynbaum C, Stavropoulos DJ, Li P, Birken CS, Hamilton J, Weksberg R, Scherer SW.

Eur J Hum Genet. 2018 Jul 5. doi: 10.1038/s41431-018-0189-0. [Epub ahead of print]

PMID:
29976977
3.

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ.

J Med Chem. 2018 May 10;61(9):4272. doi: 10.1021/acs.jmedchem.8b00606. Epub 2018 Apr 24. No abstract available.

4.

A Thieno[2,3- d]pyrimidine Scaffold Is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor.

Fyfe TJ, Zarzycka B, Lim HD, Kellam B, Mistry SN, Katrich V, Scammells PJ, Lane JR, Capuano B.

J Med Chem. 2018 May 15. doi: 10.1021/acs.jmedchem.7b01565. [Epub ahead of print]

PMID:
29683325
5.

Nucleoside-Based Self-Assembling Drugs for Localized Drug Delivery.

Skilling KJ, Stocks MJ, Kellam B, Ashford M, Bradshaw TD, Burroughs L, Marlow M.

ChemMedChem. 2018 Jun 6;13(11):1098-1101. doi: 10.1002/cmdc.201800063. Epub 2018 May 8.

PMID:
29570948
6.

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925.

Conroy S, Kindon ND, Glenn J, Stoddart LA, Lewis RJ, Hill SJ, Kellam B, Stocks MJ.

J Med Chem. 2018 Apr 12;61(7):3089-3113. doi: 10.1021/acs.jmedchem.8b00139. Epub 2018 Mar 28. Erratum in: J Med Chem. 2018 May 10;61(9):4272.

7.

Self-Assembling Benzothiazole-Based Gelators: A Mechanistic Understanding of in Vitro Bioactivation and Gelation.

Citossi F, Smith T, Lee JB, Segal J, Gershkovich P, Stocks MJ, Bradshaw TD, Kellam B, Marlow M.

Mol Pharm. 2018 Apr 2;15(4):1578-1586. doi: 10.1021/acs.molpharmaceut.7b01106. Epub 2018 Mar 15.

PMID:
29502421
8.

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.

Reuter MS, Walker S, Thiruvahindrapuram B, Whitney J, Cohn I, Sondheimer N, Yuen RKC, Trost B, Paton TA, Pereira SL, Herbrick JA, Wintle RF, Merico D, Howe J, MacDonald JR, Lu C, Nalpathamkalam T, Sung WWL, Wang Z, Patel RV, Pellecchia G, Wei J, Strug LJ, Bell S, Kellam B, Mahtani MM, Bassett AS, Bombard Y, Weksberg R, Shuman C, Cohn RD, Stavropoulos DJ, Bowdin S, Hildebrandt MR, Wei W, Romm A, Pasceri P, Ellis J, Ray P, Meyn MS, Monfared N, Hosseini SM, Joseph-George AM, Keeley FW, Cook RA, Fiume M, Lee HC, Marshall CR, Davies J, Hazell A, Buchanan JA, Szego MJ, Scherer SW.

CMAJ. 2018 Feb 5;190(5):E126-E136. doi: 10.1503/cmaj.171151.

9.

Development of novel fluorescent histamine H1-receptor antagonists to study ligand-binding kinetics in living cells.

Stoddart LA, Vernall AJ, Bouzo-Lorenzo M, Bosma R, Kooistra AJ, de Graaf C, Vischer HF, Leurs R, Briddon SJ, Kellam B, Hill SJ.

Sci Rep. 2018 Jan 25;8(1):1572. doi: 10.1038/s41598-018-19714-2.

10.

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A3 Receptor in Living Cells.

Arruda MA, Stoddart LA, Gherbi K, Briddon SJ, Kellam B, Hill SJ.

Front Pharmacol. 2017 Dec 13;8:908. doi: 10.3389/fphar.2017.00908. eCollection 2017.

11.

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.

Lam R, Gondin AB, Canals M, Kellam B, Briddon SJ, Graham B, Scammells PJ.

J Med Chem. 2018 Feb 8;61(3):1316-1329. doi: 10.1021/acs.jmedchem.7b01811. Epub 2018 Jan 10.

PMID:
29291353
12.

Novel selective β1-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease.

Baker JG, Gardiner SM, Woolard J, Fromont C, Jadhav GP, Mistry SN, Thompson KSJ, Kellam B, Hill SJ, Fischer PM.

FASEB J. 2017 Jul;31(7):3150-3166. doi: 10.1096/fj.201601305R. Epub 2017 Apr 11.

13.

A de novo deletion in a boy with cerebral palsy suggests a refined critical region for the 4q21.22 microdeletion syndrome.

Zarrei M, Merico D, Kellam B, Engchuan W, Scriver T, Jokhan R, Wilson MD, Parr J, Lemire EG, Stavropoulos DJ, Scherer SW.

Am J Med Genet A. 2017 May;173(5):1287-1293. doi: 10.1002/ajmg.a.38176. Epub 2017 Apr 3.

PMID:
28371330
14.

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D'Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW.

Nat Neurosci. 2017 Apr;20(4):602-611. doi: 10.1038/nn.4524. Epub 2017 Mar 6.

15.

Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors.

Schwehm C, Kellam B, Garces AE, Hill SJ, Kindon ND, Bradshaw TD, Li J, Macdonald SJ, Rowedder JE, Stoddart LA, Stocks MJ.

J Med Chem. 2017 Feb 23;60(4):1534-1554. doi: 10.1021/acs.jmedchem.6b01801. Epub 2017 Feb 10.

16.

Developing a self-healing supramolecular nucleoside hydrogel.

Skilling KJ, Kellam B, Ashford M, Bradshaw TD, Marlow M.

Soft Matter. 2016 Nov 4;12(43):8950-8957.

PMID:
27714367
17.

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors.

Emtage AL, Mistry SN, Fischer PM, Kellam B, Laughton CA.

J Biomol Struct Dyn. 2017 Sep;35(12):2604-2619. doi: 10.1080/07391102.2016.1226197. Epub 2016 Sep 1.

PMID:
27532213
18.

Drug-like Antagonists of P2Y Receptors-From Lead Identification to Drug Development.

Conroy S, Kindon N, Kellam B, Stocks MJ.

J Med Chem. 2016 Nov 23;59(22):9981-10005. Epub 2016 Aug 1. Review.

PMID:
27413802
19.

Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications.

Disney AJ, Kellam B, Dekker LV.

ChemMedChem. 2016 May 6;11(9):972-9. doi: 10.1002/cmdc.201500589. Epub 2016 Mar 23.

20.

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

Schembri LS, Stoddart LA, Briddon SJ, Kellam B, Canals M, Graham B, Scammells PJ.

J Med Chem. 2015 Dec 24;58(24):9754-67. doi: 10.1021/acs.jmedchem.5b01664. Epub 2015 Dec 16.

PMID:
26632862
21.

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery.

Stone EL, Citossi F, Singh R, Kaur B, Gaskell M, Farmer PB, Monks A, Hose C, Stevens MF, Leong CO, Stocks M, Kellam B, Marlow M, Bradshaw TD.

Bioorg Med Chem. 2015 Nov 1;23(21):6891-9. doi: 10.1016/j.bmc.2015.09.052. Epub 2015 Oct 3.

PMID:
26474663
22.

Direct visualisation of internalization of the adenosine A3 receptor and localization with arrestin3 using a fluorescent agonist.

Stoddart LA, Vernall AJ, Briddon SJ, Kellam B, Hill SJ.

Neuropharmacology. 2015 Nov;98:68-77. doi: 10.1016/j.neuropharm.2015.04.013. Epub 2015 Apr 30.

23.

Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.

Schwehm C, Li J, Song H, Hu X, Kellam B, Stocks MJ.

ACS Med Chem Lett. 2015 Jan 13;6(3):324-8. doi: 10.1021/ml500503n. eCollection 2015 Mar 12.

24.

Preparation and structural analysis of (±)-cis-ethyl 2-sulfanylidenedecahydro-1,6-naphthyridine-6-carboxylate and (±)-trans-ethyl 2-oxooctahydro-1H-pyrrolo[3,2-c]pyridine-5-carboxylate.

Schwehm C, Lewis W, Blake AJ, Kellam B, Stocks MJ.

Acta Crystallogr C Struct Chem. 2014 Dec;70(Pt 12):1161-8. doi: 10.1107/S205322961402436X. Epub 2014 Nov 19.

PMID:
25471418
25.

Using extended pedigrees to identify novel autism spectrum disorder (ASD) candidate genes.

Woodbury-Smith M, Paterson AD, Thiruvahindrapduram B, Lionel AC, Marshall CR, Merico D, Fernandez BA, Duku E, Sutcliffe JS, O'Conner I, Chrysler C, Thompson A, Kellam B, Tammimies K, Walker S, Yuen RK, Uddin M, Howe JL, Parlier M, Whitten K, Szatmari P, Vieland VJ, Piven J, Scherer SW.

Hum Genet. 2015 Feb;134(2):191-201. doi: 10.1007/s00439-014-1513-6. Epub 2014 Nov 29.

PMID:
25432440
26.

Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism.

Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ.

FASEB J. 2014 Oct;28(10):4211-22. doi: 10.1096/fj.13-247270. Epub 2014 Jun 26.

27.
28.

Insights into low molecular mass organic gelators: a focus on drug delivery and tissue engineering applications.

Skilling KJ, Citossi F, Bradshaw TD, Ashford M, Kellam B, Marlow M.

Soft Matter. 2014 Jan 14;10(2):237-56. doi: 10.1039/c3sm52244j. Review.

PMID:
24651822
29.

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2.

Dickens MP, Roxburgh P, Hock A, Mezna M, Kellam B, Vousden KH, Fischer PM.

Bioorg Med Chem. 2013 Nov 15;21(22):6868-77. doi: 10.1016/j.bmc.2013.09.038. Epub 2013 Sep 25.

30.

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.

Hill SJ, May LT, Kellam B, Woolard J.

Br J Pharmacol. 2014 Mar;171(5):1102-13. doi: 10.1111/bph.12345. Review.

31.

Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers.

Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B.

Org Biomol Chem. 2013 Sep 14;11(34):5673-82. doi: 10.1039/c3ob41221k.

PMID:
23881285
32.

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes.

Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ.

EMBO Rep. 2013 Aug;14(8):726-32. doi: 10.1038/embor.2013.89. Epub 2013 Jul 2.

33.

The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs.

Vernall AJ, Hill SJ, Kellam B.

Br J Pharmacol. 2014 Mar;171(5):1073-84. doi: 10.1111/bph.12265. Review.

34.

Synthesis and in vitro and in vivo characterization of highly β1-selective β-adrenoceptor partial agonists.

Mistry SN, Baker JG, Fischer PM, Hill SJ, Gardiner SM, Kellam B.

J Med Chem. 2013 May 23;56(10):3852-65. doi: 10.1021/jm400348g. Epub 2013 May 10.

35.

Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay.

Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ.

Chem Biol. 2012 Sep 21;19(9):1105-15. doi: 10.1016/j.chembiol.2012.07.014.

36.

Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.

Vernall AJ, Stoddart LA, Briddon SJ, Hill SJ, Kellam B.

J Med Chem. 2012 Feb 23;55(4):1771-82. doi: 10.1021/jm201722y. Epub 2012 Feb 13.

PMID:
22277057
37.

Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors.

Baker JG, Adams LA, Salchow K, Mistry SN, Middleton RJ, Hill SJ, Kellam B.

J Med Chem. 2011 Oct 13;54(19):6874-87. doi: 10.1021/jm2008562. Epub 2011 Sep 16.

38.

Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells.

Briddon SJ, Kellam B, Hill SJ.

Methods Mol Biol. 2011;746:211-36. doi: 10.1007/978-1-61779-126-0_11.

PMID:
21607859
39.

Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone.

Jadhav GP, Chhabra SR, Telford G, Hooi DS, Righetti K, Williams P, Kellam B, Pritchard DI, Fischer PM.

J Med Chem. 2011 May 12;54(9):3348-59. doi: 10.1021/jm2001019. Epub 2011 Apr 13.

PMID:
21488685
40.

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands.

Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ.

Br J Pharmacol. 2010 Feb;159(4):772-86. doi: 10.1111/j.1476-5381.2009.00488.x. Epub 2010 Jan 26.

41.

Effectiveness of an acoustical product in reducing high-frequency sound within unoccupied incubators.

Kellam B, Bhatia J.

J Pediatr Nurs. 2009 Aug;24(4):338-43. doi: 10.1016/j.pedn.2008.05.002. Epub 2008 Nov 4.

PMID:
19632512
42.

Sound spectral analysis in the intensive care nursery: measuring high-frequency sound.

Kellam B, Bhatia J.

J Pediatr Nurs. 2008 Aug;23(4):317-23. doi: 10.1016/j.pedn.2007.09.009.

PMID:
18638675
43.

Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells.

Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ.

FASEB J. 2008 Mar;22(3):850-60. Epub 2007 Oct 24.

PMID:
17959910
44.

Accelerated formation of multicellular 3-D structures by cell-to-cell cross-linking.

De Bank PA, Hou Q, Warner RM, Wood IV, Ali BE, Macneil S, Kendall DA, Kellam B, Shakesheff KM, Buttery LD.

Biotechnol Bioeng. 2007 Aug 15;97(6):1617-25.

PMID:
17304565
45.

New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.

Middleton RJ, Briddon SJ, Cordeaux Y, Yates AS, Dale CL, George MW, Baker JG, Hill SJ, Kellam B.

J Med Chem. 2007 Feb 22;50(4):782-93. Epub 2007 Jan 24.

PMID:
17249651
46.

Binding of the anticancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.

AbuKhader M, Heap J, De Matteis C, Kellam B, Doughty SW, Minton N, Paoli M.

J Med Chem. 2005 Dec 1;48(24):7714-9.

PMID:
16302811
47.

Fluorophore-tagged GPCR ligands.

Middleton RJ, Kellam B.

Curr Opin Chem Biol. 2005 Oct;9(5):517-25. Review.

PMID:
16125436
48.

Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor.

Yates AS, Doughty SW, Kendall DA, Kellam B.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3758-62.

PMID:
15993070
49.

Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

Sleeman MC, Smith P, Kellam B, Chhabra SR, Bycroft BW, Schofield CJ.

Chembiochem. 2004 Jun 7;5(6):879-82. No abstract available.

PMID:
15174175
50.

Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells.

Briddon SJ, Middleton RJ, Cordeaux Y, Flavin FM, Weinstein JA, George MW, Kellam B, Hill SJ.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4673-8. Epub 2004 Mar 16.

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