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Items: 1 to 50 of 117

1.

A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds.

Cairney CJ, Godwin LS, Bilsland AE, Burns S, Stevenson KH, McGarry L, Revie J, Moore JD, Wiggins CM, Collinson RS, Mudd C, Tsonou E, Sadaie M, Bennett DC, Narita M, Torrance CJ, Keith WN.

PLoS Genet. 2017 Aug 14;13(8):e1006942. doi: 10.1371/journal.pgen.1006942. eCollection 2017 Aug.

2.

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.

Letsolo BT, Jones RE, Rowson J, Grimstead JW, Keith WN, Jenkins GJ, Baird DM.

PLoS One. 2017 Mar 31;12(3):e0174833. doi: 10.1371/journal.pone.0174833. eCollection 2017.

3.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

4.

Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.

Bilsland AE, Pugliese A, Liu Y, Revie J, Burns S, McCormick C, Cairney CJ, Bower J, Drysdale M, Narita M, Sadaie M, Keith WN.

Neoplasia. 2015 Sep;17(9):704-715. doi: 10.1016/j.neo.2015.08.009.

5.

Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.

Sadaie M, Dillon C, Narita M, Young AR, Cairney CJ, Godwin LS, Torrance CJ, Bennett DC, Keith WN, Narita M.

Mol Biol Cell. 2015 Sep 1;26(17):2971-85. doi: 10.1091/mbc.E15-01-0003. Epub 2015 Jul 1. Erratum in: Mol Biol Cell. 2015 Oct 1;26(19):3556. Narita, Masashi [Corrected to Narita, Masako].

6.

A multi-targeted approach to suppress tumor-promoting inflammation.

Samadi AK, Bilsland A, Georgakilas AG, Amedei A, Amin A, Bishayee A, Azmi AS, Lokeshwar BL, Grue B, Panis C, Boosani CS, Poudyal D, Stafforini DM, Bhakta D, Niccolai E, Guha G, Vasantha Rupasinghe HP, Fujii H, Honoki K, Mehta K, Aquilano K, Lowe L, Hofseth LJ, Ricciardiello L, Ciriolo MR, Singh N, Whelan RL, Chaturvedi R, Ashraf SS, Shantha Kumara HMC, Nowsheen S, Mohammed SI, Keith WN, Helferich WG, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S151-S184. doi: 10.1016/j.semcancer.2015.03.006. Epub 2015 May 5. Review.

7.

Broad targeting of resistance to apoptosis in cancer.

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, Yang H, Samadi AK, Russo GL, Spagnuolo C, Ray SK, Chakrabarti M, Morre JD, Coley HM, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich WG, Yang X, Boosani CS, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Keith WN, Bilsland A, Halicka D, Nowsheen S, Azmi AS.

Semin Cancer Biol. 2015 Dec;35 Suppl:S78-S103. doi: 10.1016/j.semcancer.2015.03.001. Epub 2015 Apr 28. Review.

8.

Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez-Garcia I, Sharma D, Saxena NK, Singh N, Vlachostergios PJ, Guo S, Honoki K, Fujii H, Georgakilas AG, Bilsland A, Amedei A, Niccolai E, Amin A, Ashraf SS, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Keith WN, Nowsheen S.

Semin Cancer Biol. 2015 Dec;35 Suppl:S25-S54. doi: 10.1016/j.semcancer.2015.02.006. Epub 2015 Apr 17. Review.

9.

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

Ferguson LR, Chen H, Collins AR, Connell M, Damia G, Dasgupta S, Malhotra M, Meeker AK, Amedei A, Amin A, Ashraf SS, Aquilano K, Azmi AS, Bhakta D, Bilsland A, Boosani CS, Chen S, Ciriolo MR, Fujii H, Guha G, Halicka D, Helferich WG, Keith WN, Mohammed SI, Niccolai E, Yang X, Honoki K, Parslow VR, Prakash S, Rezazadeh S, Shackelford RE, Sidransky D, Tran PT, Yang ES, Maxwell CA.

Semin Cancer Biol. 2015 Dec;35 Suppl:S5-S24. doi: 10.1016/j.semcancer.2015.03.005. Epub 2015 Apr 11. Review.

10.

Therapeutic targeting of replicative immortality.

Yaswen P, MacKenzie KL, Keith WN, Hentosh P, Rodier F, Zhu J, Firestone GL, Matheu A, Carnero A, Bilsland A, Sundin T, Honoki K, Fujii H, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Niccolai E, Aquilano K, Ashraf SS, Nowsheen S, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S104-S128. doi: 10.1016/j.semcancer.2015.03.007. Epub 2015 Apr 11. Review.

11.

Cancer prevention and therapy through the modulation of the tumor microenvironment.

Casey SC, Amedei A, Aquilano K, Azmi AS, Benencia F, Bhakta D, Bilsland AE, Boosani CS, Chen S, Ciriolo MR, Crawford S, Fujii H, Georgakilas AG, Guha G, Halicka D, Helferich WG, Heneberg P, Honoki K, Keith WN, Kerkar SP, Mohammed SI, Niccolai E, Nowsheen S, Vasantha Rupasinghe HP, Samadi A, Singh N, Talib WH, Venkateswaran V, Whelan RL, Yang X, Felsher DW.

Semin Cancer Biol. 2015 Dec;35 Suppl:S199-S223. doi: 10.1016/j.semcancer.2015.02.007. Epub 2015 Apr 10. Review.

12.

Tissue invasion and metastasis: Molecular, biological and clinical perspectives.

Jiang WG, Sanders AJ, Katoh M, Ungefroren H, Gieseler F, Prince M, Thompson SK, Zollo M, Spano D, Dhawan P, Sliva D, Subbarayan PR, Sarkar M, Honoki K, Fujii H, Georgakilas AG, Amedei A, Niccolai E, Amin A, Ashraf SS, Ye L, Helferich WG, Yang X, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Nowsheen S, Pantano F, Santini D.

Semin Cancer Biol. 2015 Dec;35 Suppl:S244-S275. doi: 10.1016/j.semcancer.2015.03.008. Epub 2015 Apr 10. Review.

13.

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Vinay DS, Ryan EP, Pawelec G, Talib WH, Stagg J, Elkord E, Lichtor T, Decker WK, Whelan RL, Kumara HMCS, Signori E, Honoki K, Georgakilas AG, Amin A, Helferich WG, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bilsland A, Bhakta D, Halicka D, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Choi BK, Kwon BS.

Semin Cancer Biol. 2015 Dec;35 Suppl:S185-S198. doi: 10.1016/j.semcancer.2015.03.004. Epub 2015 Mar 25. Review.

14.

Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

Amin ARMR, Karpowicz PA, Carey TE, Arbiser J, Nahta R, Chen ZG, Dong JT, Kucuk O, Khan GN, Huang GS, Mi S, Lee HY, Reichrath J, Honoki K, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Keith WN, Bhakta D, Halicka D, Niccolai E, Fujii H, Aquilano K, Ashraf SS, Nowsheen S, Yang X, Bilsland A, Shin DM.

Semin Cancer Biol. 2015 Dec;35 Suppl:S55-S77. doi: 10.1016/j.semcancer.2015.02.005. Epub 2015 Mar 6. Review.

15.

Broad targeting of angiogenesis for cancer prevention and therapy.

Wang Z, Dabrosin C, Yin X, Fuster MM, Arreola A, Rathmell WK, Generali D, Nagaraju GP, El-Rayes B, Ribatti D, Chen YC, Honoki K, Fujii H, Georgakilas AG, Nowsheen S, Amedei A, Niccolai E, Amin A, Ashraf SS, Helferich B, Yang X, Guha G, Bhakta D, Ciriolo MR, Aquilano K, Chen S, Halicka D, Mohammed SI, Azmi AS, Bilsland A, Keith WN, Jensen LD.

Semin Cancer Biol. 2015 Dec;35 Suppl:S224-S243. doi: 10.1016/j.semcancer.2015.01.001. Epub 2015 Jan 16. Review.

16.

Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias.

Degerman S, Landfors M, Siwicki JK, Revie J, Borssén M, Evelönn E, Forestier E, Chrzanowska KH, Rydén P, Keith WN, Roos G.

Neoplasia. 2014 Jul;16(7):606-15. doi: 10.1016/j.neo.2014.07.001. Epub 2014 Jul 22.

17.

Plasma N-acetyl-glucosaminidase in advanced gastro-intestinal adenocarcinoma correlates with age, stage and outcome.

Hartmann D, von Figura G, Song Z, Harden S, Scott LC, Evans TR, Rudolph KL, Bilsland AE, Keith WN.

Future Oncol. 2015;11(2):193-203.

18.

Isolation, culture, and transfection of melanocytes.

Godwin LS, Castle JT, Kohli JS, Goff PS, Cairney CJ, Keith WN, Sviderskaya EV, Bennett DC.

Curr Protoc Cell Biol. 2014 Jun 3;63:1.8.1-20. doi: 10.1002/0471143030.cb0108s63. Review.

PMID:
24894835
19.

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.

Bilsland AE, Stevenson K, Liu Y, Hoare S, Cairney CJ, Roffey J, Keith WN.

PLoS Comput Biol. 2014 Feb 13;10(2):e1003448. doi: 10.1371/journal.pcbi.1003448. eCollection 2014 Feb.

20.

Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance.

Venturini L, Daidone MG, Motta R, Cimino-Reale G, Hoare SF, Gronchi A, Folini M, Keith WN, Zaffaroni N.

Neuro Oncol. 2012 Jun;14(6):736-44. doi: 10.1093/neuonc/nos083. Epub 2012 Apr 19.

21.

A small molecule modulator of prion protein increases human mesenchymal stem cell lifespan, ex vivo expansion, and engraftment to bone marrow in NOD/SCID mice.

Mohanty ST, Cairney CJ, Chantry AD, Madan S, Fernandes JA, Howe SJ, Moore HD, Thompson MJ, Chen B, Thrasher A, Keith WN, Bellantuono I.

Stem Cells. 2012 Jun;30(6):1134-43. doi: 10.1002/stem.1065.

22.

Cancer cell senescence: a new frontier in drug development.

Cairney CJ, Bilsland AE, Evans TR, Roffey J, Bennett DC, Narita M, Torrance CJ, Keith WN.

Drug Discov Today. 2012 Mar;17(5-6):269-76. doi: 10.1016/j.drudis.2012.01.019. Epub 2012 Jan 31. Review.

PMID:
22314100
23.

Progeroid syndromes: models for stem cell aging?

Bellantuono I, Sanguinetti G, Keith WN.

Biogerontology. 2012 Feb;13(1):63-75. doi: 10.1007/s10522-011-9347-2. Epub 2011 Jul 8. Review.

PMID:
21739188
24.

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.

Soo JK, Mackenzie Ross AD, Kallenberg DM, Milagre C, Heung Chong W, Chow J, Hill L, Hoare S, Collinson RS, Hossain M, Keith WN, Marais R, Bennett DC.

Pigment Cell Melanoma Res. 2011 Jun;24(3):490-503. doi: 10.1111/j.1755-148X.2011.00850.x. Epub 2011 Apr 20.

25.

Targeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.

Bilsland AE, Cairney CJ, Keith WN.

J Cell Mol Med. 2011 Feb;15(2):179-86. doi: 10.1111/j.1582-4934.2010.01253.x. Review.

26.
27.

Modulation of gene expression using zinc finger-based artificial transcription factors.

Stolzenburg S, Bilsland A, Keith WN, Rots MG.

Methods Mol Biol. 2010;649:117-32. doi: 10.1007/978-1-60761-753-2_7.

PMID:
20680831
28.

TCEAL7 inhibition of c-Myc activity in alternative lengthening of telomeres regulates hTERT expression.

Lafferty-Whyte K, Bilsland A, Hoare SF, Burns S, Zaffaroni N, Cairney CJ, Keith WN.

Neoplasia. 2010 May;12(5):405-14.

29.

Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures.

Degerman S, Siwicki JK, Osterman P, Lafferty-Whyte K, Keith WN, Roos G.

Aging Cell. 2010 Apr;9(2):220-35. doi: 10.1111/j.1474-9726.2010.00550.x.

30.

A gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.

Lafferty-Whyte K, Cairney CJ, Will MB, Serakinci N, Daidone MG, Zaffaroni N, Bilsland A, Keith WN.

Oncogene. 2009 Oct 29;28(43):3765-74. doi: 10.1038/onc.2009.238. Epub 2009 Aug 17.

31.

Dynamic telomerase gene suppression via network effects of GSK3 inhibition.

Bilsland AE, Hoare S, Stevenson K, Plumb J, Gomez-Roman N, Cairney C, Burns S, Lafferty-Whyte K, Roffey J, Hammonds T, Keith WN.

PLoS One. 2009 Jul 31;4(7):e6459. doi: 10.1371/journal.pone.0006459.

32.

A systems biology approach to Down syndrome: identification of Notch/Wnt dysregulation in a model of stem cells aging.

Cairney CJ, Sanguinetti G, Ranghini E, Chantry AD, Nostro MC, Bhattacharyya A, Svendsen CN, Keith WN, Bellantuono I.

Biochim Biophys Acta. 2009 Apr;1792(4):353-63. doi: 10.1016/j.bbadis.2009.01.015. Epub 2009 Feb 6.

33.

Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms.

Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, Keith WN.

Biochim Biophys Acta. 2009 Apr;1792(4):341-52. doi: 10.1016/j.bbadis.2009.02.003. Epub 2009 Feb 12. Review.

34.

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma.

Sitaram RT, Cairney CJ, Grabowski P, Keith WN, Hallberg B, Ljungberg B, Roos G.

Int J Cancer. 2009 Aug 15;125(4):783-90. doi: 10.1002/ijc.24335.

35.

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A.

Zhang X, Neganova I, Przyborski S, Yang C, Cooke M, Atkinson SP, Anyfantis G, Fenyk S, Keith WN, Hoare SF, Hughes O, Strachan T, Stojkovic M, Hinds PW, Armstrong L, Lako M.

J Cell Biol. 2009 Jan 12;184(1):67-82. doi: 10.1083/jcb.200801009.

36.

Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells.

Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L, Lako M.

Regen Med. 2008 Jul;3(4):505-22. doi: 10.2217/17460751.3.4.505.

37.

High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma.

Cairney CJ, Hoare SF, Daidone MG, Zaffaroni N, Keith WN.

Br J Cancer. 2008 Apr 22;98(8):1467-74. doi: 10.1038/sj.bjc.6604328. Epub 2008 Apr 15.

38.

Targeting telomerase for cancer therapeutics.

Shay JW, Keith WN.

Br J Cancer. 2008 Feb 26;98(4):677-83. doi: 10.1038/sj.bjc.6604209. Epub 2008 Jan 29. Review.

39.

Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.

Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M.

Stem Cells. 2008 Feb;26(2):455-64. Epub 2007 Nov 29.

40.

Stem cell ageing: does it happen and can we intervene?

Bellantuono I, Keith WN.

Expert Rev Mol Med. 2007 Nov 19;9(31):1-20. Review.

PMID:
18021462
41.

Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity.

Cairney CJ, Keith WN.

Biochimie. 2008 Jan;90(1):13-23. Epub 2007 Aug 6. Review.

PMID:
17854971
42.

Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells.

Keith WN, Thomson CM, Howcroft J, Maitland NJ, Shay JW.

Drug Discov Today. 2007 Aug;12(15-16):611-21. Epub 2007 Jul 27. Review.

PMID:
17706542
43.

Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell.

Serakinci N, Hoare SF, Kassem M, Atkinson SP, Keith WN.

Regen Med. 2006 Jan;1(1):125-31.

44.

Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.

Atkinson SP, Keith WN.

Expert Rev Mol Med. 2007 Mar 13;9(7):1-26.

PMID:
17352843
45.

Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses.

Bilsland AE, Merron A, Vassaux G, Keith WN.

Cancer Res. 2007 Feb 1;67(3):1299-307.

46.

Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart.

Serakinci N, Christensen R, Graakjaer J, Cairney CJ, Keith WN, Alsner J, Saretzki G, Kolvraa S.

Exp Cell Res. 2007 Mar 10;313(5):1056-67. Epub 2007 Jan 8.

PMID:
17274981
47.

Therapeutic potential of adult stem cells.

Serakinci N, Keith WN.

Eur J Cancer. 2006 Jun;42(9):1243-6. Epub 2006 May 5. Review.

PMID:
16678403
48.

Cancer stem cells: opportunities for novel diagnostics and drug discovery.

Keith WN.

Eur J Cancer. 2006 Jun;42(9):1195-6. Epub 2006 Apr 19. No abstract available.

PMID:
16624547
49.

Transcriptional repression of telomerase RNA gene expression by c-Jun-NH2-kinase and Sp1/Sp3.

Bilsland AE, Stevenson K, Atkinson S, Kolch W, Keith WN.

Cancer Res. 2006 Feb 1;66(3):1363-70.

50.

Properties of a telomerase-specific Cre/Lox switch for transcriptionally targeted cancer gene therapy.

Bilsland AE, Fletcher-Monaghan A, Keith WN.

Neoplasia. 2005 Nov;7(11):1020-9.

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