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Items: 36

1.

T-cell Dysfunction in Glioblastoma: Applying a New Framework.

Woroniecka KI, Rhodin KE, Chongsathidkiet P, Keith KA, Fecci PE.

Clin Cancer Res. 2018 Aug 15;24(16):3792-3802. doi: 10.1158/1078-0432.CCR-18-0047. Epub 2018 Mar 28. Review.

PMID:
29593027
2.

Synthesis and Antiviral Evaluation of Octadecyloxyethyl Benzyl 9-[(2-Phosphonomethoxy)ethyl]guanine (ODE-Bn-PMEG), a Potent Inhibitor of Transient HPV DNA Amplification.

Beadle JR, Valiaeva N, Yang G, Yu JH, Broker TR, Aldern KA, Harden EA, Keith KA, Prichard MN, Hartman T, Buckheit RW Jr, Chow LT, Hostetler KY.

J Med Chem. 2016 Dec 8;59(23):10470-10478. Epub 2016 Nov 28.

PMID:
27933957
3.

New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion.

Basu A, Antanasijevic A, Wang M, Li B, Mills DM, Ames JA, Nash PJ, Williams JD, Peet NP, Moir DT, Prichard MN, Keith KA, Barnard DL, Caffrey M, Rong L, Bowlin TL.

J Virol. 2014 Feb;88(3):1447-60. doi: 10.1128/JVI.01225-13. Epub 2013 Nov 6.

4.

Synthesis and antiviral activity of certain second generation methylenecyclopropane nucleosides.

Williams JD, Khan AR, Harden EA, Hartline CB, Jefferson GM, Keith KA, Prichard MN, Zemlicka J, Peet NP, Bowlin TL.

Bioorg Med Chem. 2012 Jun 15;20(12):3710-8. doi: 10.1016/j.bmc.2012.04.049. Epub 2012 May 1.

5.

Identification of protein-protein interaction inhibitors targeting vaccinia virus processivity factor for development of antiviral agents.

Schormann N, Sommers CI, Prichard MN, Keith KA, Noah JW, Nuth M, Ricciardi RP, Chattopadhyay D.

Antimicrob Agents Chemother. 2011 Nov;55(11):5054-62. doi: 10.1128/AAC.00278-11. Epub 2011 Aug 15.

6.

Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.

Ruiz J, Beadle JR, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY.

Bioorg Med Chem. 2011 May 1;19(9):2950-8. doi: 10.1016/j.bmc.2011.03.034. Epub 2011 Mar 23.

7.

Antiviral evaluation of octadecyloxyethyl esters of (S)-3-hydroxy-2-(phosphonomethoxy)propyl nucleosides against herpesviruses and orthopoxviruses.

Valiaeva N, Prichard MN, Buller RM, Beadle JR, Hartline CB, Keith KA, Schriewer J, Trahan J, Hostetler KY.

Antiviral Res. 2009 Dec;84(3):254-9. doi: 10.1016/j.antiviral.2009.09.012. Epub 2009 Oct 1.

8.

Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.

Kern ER, Prichard MN, Quenelle DC, Keith KA, Tiwari KN, Maddry JA, Secrist JA 3rd.

Antimicrob Agents Chemother. 2009 Feb;53(2):572-9. doi: 10.1128/AAC.01257-08. Epub 2008 Nov 24.

9.

Isolation and characterization of cidofovir resistant vaccinia viruses.

Becker MN, Obraztsova M, Kern ER, Quenelle DC, Keith KA, Prichard MN, Luo M, Moyer RW.

Virol J. 2008 May 14;5:58. doi: 10.1186/1743-422X-5-58.

10.
11.

Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.

Quenelle DC, Collins DJ, Herrod BP, Keith KA, Trahan J, Beadle JR, Hostetler KY, Kern ER.

Antimicrob Agents Chemother. 2007 Nov;51(11):3940-7. Epub 2007 Sep 10.

12.

Synergistic efficacy of the combination of ST-246 with CMX001 against orthopoxviruses.

Quenelle DC, Prichard MN, Keith KA, Hruby DE, Jordan R, Painter GR, Robertson A, Kern ER.

Antimicrob Agents Chemother. 2007 Nov;51(11):4118-24. Epub 2007 Aug 27.

13.

Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.

Ruiz JC, Beadle JR, Aldern KA, Keith KA, Hartline CB, Kern ER, Hostetler KY.

Antiviral Res. 2007 Jul;75(1):87-90. Epub 2006 Oct 10.

14.

N-(3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6- ethenocycloprop[f]isoindol-2-(1H)-yl)carboxamides: Identification of novel orthopoxvirus egress inhibitors.

Bailey TR, Rippin SR, Opsitnick E, Burns CJ, Pevear DC, Collett MS, Rhodes G, Tohan S, Huggins JW, Baker RO, Kern ER, Keith KA, Dai D, Yang G, Hruby D, Jordan R.

J Med Chem. 2007 Apr 5;50(7):1442-4. Epub 2007 Mar 3.

15.

Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.

Prichard MN, Keith KA, Johnson MP, Harden EA, McBrayer A, Luo M, Qiu S, Chattopadhyay D, Fan X, Torrence PF, Kern ER.

Antimicrob Agents Chemother. 2007 May;51(5):1795-803. Epub 2007 Feb 26.

16.

Antiviral activities of novel 5-phosphono-pent-2-en-1-yl nucleosides and their alkoxyalkyl phosphonoesters.

Choo H, Beadle JR, Kern ER, Prichard MN, Keith KA, Hartline CB, Trahan J, Aldern KA, Korba BE, Hostetler KY.

Antimicrob Agents Chemother. 2007 Feb;51(2):611-5. Epub 2006 Nov 27.

17.

Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.

Quenelle DC, Buller RM, Parker S, Keith KA, Hruby DE, Jordan R, Kern ER.

Antimicrob Agents Chemother. 2007 Feb;51(2):689-95. Epub 2006 Nov 20.

19.

Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.

Fan X, Zhang X, Zhou L, Keith KA, Prichard MN, Kern ER, Torrence PF.

J Med Chem. 2006 Jul 13;49(14):4052-4.

20.

Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.

Fan X, Zhang X, Zhou L, Keith KA, Kern ER, Torrence PF.

Antiviral Res. 2006 Sep;71(2-3):201-5. Epub 2006 May 19.

PMID:
16759713
21.

5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.

Fan X, Zhang X, Zhou L, Keith KA, Kern ER, Torrence PF.

J Med Chem. 2006 Jun 1;49(11):3377-82.

22.

In vitro and in vivo evaluation of isatin-beta-thiosemicarbazone and marboran against vaccinia and cowpox virus infections.

Quenelle DC, Keith KA, Kern ER.

Antiviral Res. 2006 Aug;71(1):24-30. Epub 2006 Mar 29.

PMID:
16621041
23.

A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.

Fan X, Zhang X, Zhou L, Keith KA, Kern ER, Torrence PF.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3224-8. Epub 2006 Apr 5.

PMID:
16603351
24.

Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections.

Prichard MN, Keith KA, Quenelle DC, Kern ER.

Antimicrob Agents Chemother. 2006 Apr;50(4):1336-41.

25.

Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.

Beadle JR, Wan WB, Ciesla SL, Keith KA, Hartline C, Kern ER, Hostetler KY.

J Med Chem. 2006 Mar 23;49(6):2010-5.

PMID:
16539388
26.

Distinct thymidine kinases encoded by cowpox virus and herpes simplex virus contribute significantly to the differential antiviral activity of nucleoside analogs.

Prichard MN, Williams AD, Keith KA, Harden EA, Kern ER.

Antiviral Res. 2006 Aug;71(1):1-6. Epub 2006 Feb 28.

PMID:
16530858
27.
28.

Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents.

Pirrung MC, Pansare SV, Sarma KD, Keith KA, Kern ER.

J Med Chem. 2005 Apr 21;48(8):3045-50.

PMID:
15828843
29.

Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitro.

Keith KA, Wan WB, Ciesla SL, Beadle JR, Hostetler KY, Kern ER.

Antimicrob Agents Chemother. 2004 May;48(5):1869-71.

30.

Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

Keith KA, Hitchcock MJ, Lee WA, HolĂ˝ A, Kern ER.

Antimicrob Agents Chemother. 2003 Jul;47(7):2193-8.

31.

Carrying on the legacy of Lillian Wald. Partnership with the Henry Street Settlement and the Lienhard School of Nursing at Pace University.

Lewenson SB, Keith KA, Kelleher C, Polansky E.

Nurs Leadersh Forum. 2001 Summer;5(4):116-21.

PMID:
12004649
32.

Infant feeding choice among first-time mothers.

Keith KA.

Sch Inq Nurs Pract. 1997 Fall;11(3):199-224; discussion 225-9.

PMID:
9481181
33.

Evaluation of anti-AIDS drugs in conventional mice implanted with a permeable membrane device containing human T cells infected with HIV.

Quenelle DC, Keith KA, Dunleavy KE, Taylor BA, Bowdon BJ, Brazier AD, Mullon CJ, HarrisRE, Allen LB.

Antiviral Res. 1997 Jul;35(2):123-9.

PMID:
9217249
34.

A rational approach in the search for potent inhibitors against HIV proteinase.

Hui KY, Manetta JV, Gygi T, Bowdon BJ, Keith KA, Shannon WM, Lai MH.

FASEB J. 1991 Aug;5(11):2606-10.

PMID:
1868985
35.

Stage-specific cuticular proteins of Ostertagia circumcincta and Ostertagia ostertagi.

Keith KA, Duncan MC, Murray M, Bairden K, Tait A.

Int J Parasitol. 1990 Dec;20(8):1037-45.

PMID:
2074129
36.

A comparison of the submergence response of deepwater and non-deepwater rice.

Keith KA, Raskin I, Kende H.

Plant Physiol. 1986 Feb;80(2):479-82.

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