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Items: 1 to 50 of 92

1.

Incidental 18F-FDG uptake in the colon: value of contrast-enhanced CT correlation with colonoscopic findings.

Kirchner J, Schaarschmidt BM, Kour F, Sawicki LM, Martin O, Bode J, Dahl SV, Keitel V, Häussinger D, Antke C, Buchbender C, Antoch G, Heusch P.

Eur J Nucl Med Mol Imaging. 2019 Nov 7. doi: 10.1007/s00259-019-04579-y. [Epub ahead of print]

PMID:
31701188
2.

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Sundaram B, Behnke K, Belancic A, Al-Salihi MA, Thabet Y, Polz R, Pellegrino R, Zhuang Y, Shinde PV, Xu HC, Vasilevska J, Longerich T, Herebian D, Mayatepek E, Bock HH, May P, Kordes C, Aghaeepour N, Mak TW, Keitel V, Häussinger D, Scheller J, Pandyra AA, Lang KS, Lang PA.

Sci Signal. 2019 Oct 29;12(605). pii: eaax1194. doi: 10.1126/scisignal.aax1194.

PMID:
31662486
3.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2019 Aug 13. pii: gutjnl-2019-318215. doi: 10.1136/gutjnl-2019-318215. [Epub ahead of print]

4.

Bile Acid-Activated Receptors: GPBAR1 (TGR5) and Other G Protein-Coupled Receptors.

Keitel V, Stindt J, Häussinger D.

Handb Exp Pharmacol. 2019;256:19-49. doi: 10.1007/164_2019_230. Review.

PMID:
31302759
5.

Targeting FXR in Cholestasis.

Keitel V, Dröge C, Häussinger D.

Handb Exp Pharmacol. 2019;256:299-324. doi: 10.1007/164_2019_231. Review.

PMID:
31201556
6.

A rare cause of a cholestatic jaundice in a North African teenager.

Schreiner P, Stieger B, McLin V, Rougemont AL, Keitel V, Dröge C, Müllhaupt B.

Liver Int. 2019 Nov;39(11):2036-2041. doi: 10.1111/liv.14122. Epub 2019 Jul 24.

PMID:
31021034
7.

Reply.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2019 Sep;70(3):1074-1075. doi: 10.1002/hep.30600. No abstract available.

PMID:
30829412
8.

Alloimmunity and Cholestasis After Liver Transplantation in Children With Progressive Familial Intrahepatic Cholestasis.

Krebs-Schmitt D, Briem-Richter A, Brinkert F, Keitel V, Pukite I, Lenhartz H, Fischer L, Grabhorn E.

J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):169-174. doi: 10.1097/MPG.0000000000002200.

PMID:
30664572
9.

Serum IP-10 levels and increased DPPIV activity are linked to circulating CXCR3+ T cells in cholestatic HCV patients.

Rau M, Schmitt J, Berg T, Kremer AE, Stieger B, Spanaus K, Bengsch B, Romero MR, Marin JJ, Keitel V, Klinker H, Tony HP, Müllhaupt B, Geier A.

PLoS One. 2018 Dec 3;13(12):e0208225. doi: 10.1371/journal.pone.0208225. eCollection 2018.

10.

Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.

Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC.

Gastroenterology. 2019 Mar;156(4):1190-1205.e14. doi: 10.1053/j.gastro.2018.11.018. Epub 2018 Nov 13.

PMID:
30445013
11.

The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis.

Santamaría E, Rodríguez-Ortigosa CM, Uriarte I, Latasa MU, Urtasun R, Alvarez-Sola G, Bárcena-Varela M, Colyn L, Arcelus S, Jiménez M, Deutschmann K, Peleteiro-Vigil A, Gómez-Cambronero J, Milkiewicz M, Milkiewicz P, Sangro B, Keitel V, Monte MJ, Marin JJG, Fernández-Barrena MG, Ávila MA, Berasain C.

Hepatology. 2019 Apr;69(4):1632-1647. doi: 10.1002/hep.30348. Epub 2019 Mar 4.

PMID:
30411380
12.

Role of TGR5 (GPBAR1) in Liver Disease.

Keitel V, Häussinger D.

Semin Liver Dis. 2018 Nov;38(4):333-339. doi: 10.1055/s-0038-1669940. Epub 2018 Oct 24. Review.

PMID:
30357770
13.

Bile Acid G Protein-Coupled Membrane Receptor TGR5 Modulates Aquaporin 2-Mediated Water Homeostasis.

Li S, Qiu M, Kong Y, Zhao X, Choi HJ, Reich M, Bunkelman BH, Liu Q, Hu S, Han M, Xie H, Rosenberg AZ, Keitel V, Kwon TH, Levi M, Li C, Wang W.

J Am Soc Nephrol. 2018 Nov;29(11):2658-2670. doi: 10.1681/ASN.2018030271. Epub 2018 Oct 10.

14.

Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

Lang E, Pozdeev VI, Shinde PV, Xu HC, Sundaram B, Zhuang Y, Poschmann G, Huang J, Stühler K, Pandyra AA, Keitel V, Häussinger D, Lang KS, Lang PA.

Sci Rep. 2018 Aug 15;8(1):12179. doi: 10.1038/s41598-018-30627-y.

15.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood.

Ghallab A, Hofmann U, Sezgin S, Vartak N, Hassan R, Zaza A, Godoy P, Schneider KM, Guenther G, Ahmed YA, Abbas AA, Keitel V, Kuepfer L, Dooley S, Lammert F, Trautwein C, Spiteller M, Drasdo D, Hofmann AF, Jansen PLM, Hengstler JG, Reif R.

Hepatology. 2019 Feb;69(2):666-683. doi: 10.1002/hep.30213. Epub 2018 Nov 19.

16.

Allogeneic haematopoietic stem cell transplantation eliminates alloreactive inhibitory antibodies after liver transplantation for bile salt export pump deficiency.

Brinkert F, Pukite I, Krebs-Schmitt D, Briem-Richter A, Stindt J, Häussinger D, Keitel V, Müller I, Grabhorn E.

J Hepatol. 2018 Oct;69(4):961-965. doi: 10.1016/j.jhep.2018.06.003. Epub 2018 Jun 21.

PMID:
29935200
17.

B Cell-Mediated Maintenance of Cluster of Differentiation 169-Positive Cells Is Critical for Liver Regeneration.

Behnke K, Zhuang Y, Xu HC, Sundaram B, Reich M, Shinde PV, Huang J, Modares NF, Tumanov AV, Polz R, Scheller J, Ware CF, Pfeffer K, Keitel V, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Hepatology. 2018 Dec;68(6):2348-2361. doi: 10.1002/hep.30088. Epub 2018 Nov 5.

18.

Post-transplant Recurrent Bile Salt Export Pump Disease: A Form of Antibody-mediated Graft Dysfunction and Utilization of C4d.

Patel KR, Harpavat S, Finegold M, Eldin K, Hicks J, Firan M, Keitel V, Kubitz R, Wu H.

J Pediatr Gastroenterol Nutr. 2017 Oct;65(4):364-369. doi: 10.1097/MPG.0000000000001653.

PMID:
28945205
19.

Bile acid receptors in the biliary tree: TGR5 in physiology and disease.

Deutschmann K, Reich M, Klindt C, Dröge C, Spomer L, Häussinger D, Keitel V.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt B):1319-1325. doi: 10.1016/j.bbadis.2017.08.021. Epub 2017 Aug 25. Review.

20.

Cholestasis After Pediatric Liver Transplantation-Recurrence of a Progressive Familial Intrahepatic Cholestasis Phenotype as a Rare Differential Diagnosis: A Case Report.

Prusinskas B, Kathemann S, Pilic D, Hegen B, Küster P, Keitel V, Häussinger D, Büscher R, Baba HA, Hoyer PF, Lainka E.

Transplant Proc. 2017 Sep;49(7):1628-1633. doi: 10.1016/j.transproceed.2017.06.011.

PMID:
28838453
21.

Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.

Dröge C, Bonus M, Baumann U, Klindt C, Lainka E, Kathemann S, Brinkert F, Grabhorn E, Pfister ED, Wenning D, Fichtner A, Gotthardt DN, Weiss KH, McKiernan P, Puri RD, Verma IC, Kluge S, Gohlke H, Schmitt L, Kubitz R, Häussinger D, Keitel V.

J Hepatol. 2017 Dec;67(6):1253-1264. doi: 10.1016/j.jhep.2017.07.004. Epub 2017 Jul 19.

PMID:
28733223
22.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M.

Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006.

23.

Defective Platelet Activation and Bleeding Complications upon Cholestasis in Mice.

Gowert NS, Klier M, Reich M, Reusswig F, Donner L, Keitel V, Häussinger D, Elvers M.

Cell Physiol Biochem. 2017;41(6):2133-2149. doi: 10.1159/000475566. Epub 2017 Apr 20.

24.

Role of the G Protein-Coupled Bile Acid Receptor TGR5 in Liver Damage.

Reich M, Klindt C, Deutschmann K, Spomer L, Häussinger D, Keitel V.

Dig Dis. 2017;35(3):235-240. doi: 10.1159/000450917. Epub 2017 Mar 1. Review.

PMID:
28249265
25.

Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection.

Honke N, Shaabani N, Hardt C, Krings C, Häussinger D, Lang PA, Lang KS, Keitel V.

Cell Physiol Biochem. 2017;41(1):323-338. doi: 10.1159/000456168. Epub 2017 Jan 25.

26.

Dual role of the bile acid receptor Takeda G-protein-coupled receptor 5 for hepatic lipid metabolism in feast and famine.

Häussinger D, Keitel V.

Hepatology. 2017 Mar;65(3):767-770. doi: 10.1002/hep.29017. Epub 2017 Feb 6. No abstract available.

PMID:
28027575
27.

Intrahepatic cholestasis of pregnancy (ICP): case report and review of the literature.

Keitel V, Dröge C, Stepanow S, Fehm T, Mayatepek E, Köhrer K, Häussinger D.

Z Gastroenterol. 2016 Dec;54(12):1327-1333. Epub 2016 Dec 9. Review.

PMID:
27936482
28.

Structural assemblies of the di- and oligomeric G-protein coupled receptor TGR5 in live cells: an MFIS-FRET and integrative modelling study.

Greife A, Felekyan S, Ma Q, Gertzen CG, Spomer L, Dimura M, Peulen TO, Wöhler C, Häussinger D, Gohlke H, Keitel V, Seidel CA.

Sci Rep. 2016 Nov 11;6:36792. doi: 10.1038/srep36792.

29.

Ammonia Attenuates LPS-Induced Upregulation of Pro-Inflammatory Cytokine mRNA in Co-Cultured Astrocytes and Microglia.

Karababa A, Groos-Sahr K, Albrecht U, Keitel V, Shafigullina A, Görg B, Häussinger D.

Neurochem Res. 2017 Mar;42(3):737-749. doi: 10.1007/s11064-016-2060-4. Epub 2016 Sep 21.

PMID:
27655254
30.

Analysis of the Bile Salt Export Pump (ABCB11) Interactome Employing Complementary Approaches.

Przybylla S, Stindt J, Kleinschrodt D, Schulte Am Esch J, Häussinger D, Keitel V, Smits SH, Schmitt L.

PLoS One. 2016 Jul 29;11(7):e0159778. doi: 10.1371/journal.pone.0159778. eCollection 2016.

31.

Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family.

Stindt S, Cebula P, Albrecht U, Keitel V, Schulte am Esch J, Knoefel WT, Bartenschlager R, Häussinger D, Bode JG.

PLoS One. 2016 Feb 17;11(2):e0148711. doi: 10.1371/journal.pone.0148711. eCollection 2016.

32.

Molecular Mechanisms of Glutamine Synthetase Mutations that Lead to Clinically Relevant Pathologies.

Frieg B, Görg B, Homeyer N, Keitel V, Häussinger D, Gohlke H.

PLoS Comput Biol. 2016 Feb 2;12(2):e1004693. doi: 10.1371/journal.pcbi.1004693. eCollection 2016 Feb.

33.

Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration.

Sorg UR, Behnke K, Degrandi D, Reich M, Keitel V, Herebian D, Deenen R, Beyer M, Schultze JL, Köhrer K, Gabbert HE, Mayatepek E, Häussinger D, Pfeffer K.

J Hepatol. 2016 May;64(5):1108-1117. doi: 10.1016/j.jhep.2015.12.006. Epub 2015 Dec 19.

PMID:
26708145
34.

Genetic variants in adult liver diseases.

Dröge C, Häussinger D, Keitel V.

Z Gastroenterol. 2015 Dec;53(12):1436-46. doi: 10.1055/s-0035-1566903. Epub 2015 Dec 14. Review.

PMID:
26666282
35.

Hepatologie 2016: Perspektiven und Herausforderungen.

Häussinger D, Keitel V.

Z Gastroenterol. 2015 Dec;53(12):1413. doi: 10.1055/s-0041-110211. Epub 2015 Dec 14. German. No abstract available.

PMID:
26666277
36.

Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency.

Stindt J, Kluge S, Dröge C, Keitel V, Stross C, Baumann U, Brinkert F, Dhawan A, Engelmann G, Ganschow R, Gerner P, Grabhorn E, Knisely AS, Noli KA, Pukite I, Shepherd RW, Ueno T, Schmitt L, Wiek C, Hanenberg H, Häussinger D, Kubitz R.

Hepatology. 2016 Feb;63(2):524-37. doi: 10.1002/hep.28311. Epub 2015 Dec 15.

PMID:
26516723
37.

Mutational mapping of the transmembrane binding site of the G-protein coupled receptor TGR5 and binding mode prediction of TGR5 agonists.

Gertzen CG, Spomer L, Smits SH, Häussinger D, Keitel V, Gohlke H.

Eur J Med Chem. 2015 Nov 2;104:57-72. doi: 10.1016/j.ejmech.2015.09.024. Epub 2015 Sep 24.

PMID:
26435512
38.

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro.

Reich M, Deutschmann K, Sommerfeld A, Klindt C, Kluge S, Kubitz R, Ullmer C, Knoefel WT, Herebian D, Mayatepek E, Häussinger D, Keitel V.

Gut. 2016 Mar;65(3):487-501. doi: 10.1136/gutjnl-2015-309458. Epub 2015 Sep 29.

PMID:
26420419
39.

Multidrug resistance-associated protein 4 expression in ammonia-treated cultured rat astrocytes and cerebral cortex of cirrhotic patients with hepatic encephalopathy.

Jördens MS, Keitel V, Karababa A, Zemtsova I, Bronger H, Häussinger D, Görg B.

Glia. 2015 Nov;63(11):2092-2105. doi: 10.1002/glia.22879. Epub 2015 Jun 23.

PMID:
26102310
40.

Monoterpene (-)-citronellal affects hepatocarcinoma cell signaling via an olfactory receptor.

Maßberg D, Simon A, Häussinger D, Keitel V, Gisselmann G, Conrad H, Hatt H.

Arch Biochem Biophys. 2015 Jan 15;566:100-9. doi: 10.1016/j.abb.2014.12.004. Epub 2014 Dec 13.

PMID:
25513961
41.

Autoimmune BSEP disease: disease recurrence after liver transplantation for progressive familial intrahepatic cholestasis.

Kubitz R, Dröge C, Kluge S, Stross C, Walter N, Keitel V, Häussinger D, Stindt J.

Clin Rev Allergy Immunol. 2015 Jun;48(2-3):273-84. doi: 10.1007/s12016-014-8457-4. Review.

PMID:
25342496
42.

Remote ischemic preconditioning preserves Connexin 43 phosphorylation in the rat heart in vivo.

Brandenburger T, Huhn R, Galas A, Pannen BH, Keitel V, Barthel F, Bauer I, Heinen A.

J Transl Med. 2014 Aug 27;12:228. doi: 10.1186/s12967-014-0228-8.

43.

TGR5: pathogenetic role and/or therapeutic target in fibrosing cholangitis?

Keitel V, Reich M, Häussinger D.

Clin Rev Allergy Immunol. 2015 Jun;48(2-3):218-25. doi: 10.1007/s12016-014-8443-x. Review.

PMID:
25138774
44.

Conjugated bilirubin triggers anemia by inducing erythrocyte death.

Lang E, Gatidis S, Freise NF, Bock H, Kubitz R, Lauermann C, Orth HM, Klindt C, Schuier M, Keitel V, Reich M, Liu G, Schmidt S, Xu HC, Qadri SM, Herebian D, Pandyra AA, Mayatepek E, Gulbins E, Lang F, Häussinger D, Lang KS, Föller M, Lang PA.

Hepatology. 2015 Jan;61(1):275-84. doi: 10.1002/hep.27338. Epub 2014 Nov 24.

45.

Characterization of animal models for primary sclerosing cholangitis (PSC).

Fickert P, Pollheimer MJ, Beuers U, Lackner C, Hirschfield G, Housset C, Keitel V, Schramm C, Marschall HU, Karlsen TH, Melum E, Kaser A, Eksteen B, Strazzabosco M, Manns M, Trauner M; International PSC Study Group (IPSCSG).

J Hepatol. 2014 Jun;60(6):1290-303. doi: 10.1016/j.jhep.2014.02.006. Epub 2014 Feb 19. Review.

46.

A membrane-proximal, C-terminal α-helix is required for plasma membrane localization and function of the G Protein-coupled receptor (GPCR) TGR5.

Spomer L, Gertzen CG, Schmitz B, Häussinger D, Gohlke H, Keitel V.

J Biol Chem. 2014 Feb 7;289(6):3689-702. doi: 10.1074/jbc.M113.502344. Epub 2013 Dec 13.

47.

Role of macrophages in bile acid-induced inflammatory response of fetal lung during maternal cholestasis.

Herraez E, Lozano E, Poli E, Keitel V, De Luca D, Williamson C, Marin JJ, Macias RI.

J Mol Med (Berl). 2014 Apr;92(4):359-72. doi: 10.1007/s00109-013-1106-1. Epub 2013 Dec 7.

PMID:
24317353
48.

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages.

Haselow K, Bode JG, Wammers M, Ehlting C, Keitel V, Kleinebrecht L, Schupp AK, Häussinger D, Graf D.

J Leukoc Biol. 2013 Dec;94(6):1253-64. doi: 10.1189/jlb.0812396. Epub 2013 Aug 29.

PMID:
23990628
49.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

50.

Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term.

Keitel V, Spomer L, Marin JJ, Williamson C, Geenes V, Kubitz R, Häussinger D, Macias RI.

Placenta. 2013 Sep;34(9):810-6. doi: 10.1016/j.placenta.2013.06.302. Epub 2013 Jul 10.

PMID:
23849932

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