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Items: 35


Enhanced E. coli LF82 translocation through follicle-associated epithelium in Crohn's disease is dependent on long polar fimbriae and CEACAM6-expression, and increases paracellular permeability.

Keita ÅV, Alkaissi LY, Holm EB, Heil SDS, Chassaing B, Darfeuille-Michaud A, McKay DM, Söderholm JD.

J Crohns Colitis. 2019 Aug 9. pii: jjz144. doi: 10.1093/ecco-jcc/jjz144. [Epub ahead of print]


The Ussing chamber system for measuring intestinal permeability in health and disease.

Thomson A, Smart K, Somerville MS, Lauder SN, Appanna G, Horwood J, Sunder Raj L, Srivastava B, Durai D, Scurr MJ, Keita ÅV, Gallimore AM, Godkin A.

BMC Gastroenterol. 2019 Jun 20;19(1):98. doi: 10.1186/s12876-019-1002-4.


Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease-Focusing on Intestinal Barrier Function.

Schoultz I, Keita ÅV.

Cells. 2019 Feb 22;8(2). pii: E193. doi: 10.3390/cells8020193. Review.


Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome.

Witt ST, Bednarska O, Keita ÅV, Icenhour A, Jones MP, Elsenbruch S, Söderholm JD, Engström M, Mayer EA, Walter S.

Neuroimage Clin. 2019;21:101602. doi: 10.1016/j.nicl.2018.11.012. Epub 2018 Nov 17.


Upregulation of intestinal mucosal mast cells expressing VPAC1 in close proximity to vasoactive intestinal polypeptide in inflammatory bowel disease and murine colitis.

Casado-Bedmar M, Heil SDS, Myrelid P, Söderholm JD, Keita ÅV.

Neurogastroenterol Motil. 2019 Mar;31(3):e13503. doi: 10.1111/nmo.13503. Epub 2018 Nov 8.


Mucosal permeability and mast cells as targets for functional gastrointestinal disorders.

Keita ÅV, Söderholm JD.

Curr Opin Pharmacol. 2018 Dec;43:66-71. doi: 10.1016/j.coph.2018.08.011. Epub 2018 Sep 11. Review.


Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms.

Ganda Mall JP, Löfvendahl L, Lindqvist CM, Brummer RJ, Keita ÅV, Schoultz I.

Sci Rep. 2018 Sep 7;8(1):13404. doi: 10.1038/s41598-018-31492-5.


Infliximab restores colonic barrier to adherent-invasive E. coli in Crohn's disease via effects on epithelial lipid rafts.

Yakymenko O, Schoultz I, Gullberg E, Ström M, Almer S, Wallon C, Wang A, Keita ÅV, Campbell BJ, McKay DM, Söderholm JD.

Scand J Gastroenterol. 2018 Jun;53(6):677-684. doi: 10.1080/00365521.2018.1458146. Epub 2018 Apr 24.


Gut Barrier Dysfunction-A Primary Defect in Twins with Crohn's Disease Predominantly Caused by Genetic Predisposition.

Keita ÅV, Lindqvist CM, Öst Å, Magana CDL, Schoultz I, Halfvarson J.

J Crohns Colitis. 2018 Nov 9;12(10):1200-1209. doi: 10.1093/ecco-jcc/jjy045.


Are self-reported gastrointestinal symptoms among older adults associated with increased intestinal permeability and psychological distress?

Ganda Mall JP, Östlund-Lagerström L, Lindqvist CM, Algilani S, Rasoal D, Repsilber D, Brummer RJ, Keita ÅV, Schoultz I.

BMC Geriatr. 2018 Mar 20;18(1):75. doi: 10.1186/s12877-018-0767-6.


A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models.

Da Silva S, Keita ÅV, Mohlin S, Påhlman S, Theodorou V, Påhlman I, Mattson JP, Söderholm JD.

Inflamm Bowel Dis. 2018 Mar 19;24(4):792-805. doi: 10.1093/ibd/izx079.


ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.

Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, Wang A, Baggio CH, Dicay M, van Dalen R, Ahn Y, Carneiro MBH, Peters NC, Rho JM, MacNaughton WK, Girardin SE, Jijon H, Philpott DJ, Söderholm JD, McKay DM.

J Biol Chem. 2018 Mar 2;293(9):3073-3087. doi: 10.1074/jbc.RA117.000809. Epub 2018 Jan 9.


A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn's Disease and Control Subjects.

Ganda Mall JP, Casado-Bedmar M, Winberg ME, Brummer RJ, Schoultz I, Keita ÅV.

Inflamm Bowel Dis. 2017 Dec 19;24(1):166-178. doi: 10.1093/ibd/izx002. Erratum in: Inflamm Bowel Dis. 2018 Oct 12;24(11):2476.


The stimulation of GLP-1 secretion and delivery of GLP-1 agonists via nanostructured lipid carriers.

Shrestha N, Bouttefeux O, Vanvarenberg K, Lundquist P, Cunarro J, Tovar S, Khodus G, Andersson E, Keita ÅV, Gonzalez Dieguez C, Artursson P, Préat V, Beloqui A.

Nanoscale. 2018 Jan 3;10(2):603-613. doi: 10.1039/c7nr07736j.


Vasoactive Intestinal Polypeptide and Mast Cells Regulate Increased Passage of Colonic Bacteria in Patients With Irritable Bowel Syndrome.

Bednarska O, Walter SA, Casado-Bedmar M, Ström M, Salvo-Romero E, Vicario M, Mayer EA, Keita ÅV.

Gastroenterology. 2017 Oct;153(4):948-960.e3. doi: 10.1053/j.gastro.2017.06.051. Epub 2017 Jul 13.


Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM.

Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14.


Dietary supplementation with soluble plantain non-starch polysaccharides inhibits intestinal invasion of Salmonella Typhimurium in the chicken.

Parsons BN, Wigley P, Simpson HL, Williams JM, Humphrey S, Salisbury AM, Watson AJ, Fry SC, O'Brien D, Roberts CL, O'Kennedy N, Keita AV, Söderholm JD, Rhodes JM, Campbell BJ.

PLoS One. 2014 Feb 3;9(2):e87658. doi: 10.1371/journal.pone.0087658. eCollection 2014.


Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer's patches.

Ermund A, Gustafsson JK, Hansson GC, Keita AV.

PLoS One. 2013 Dec 16;8(12):e83688. doi: 10.1371/journal.pone.0083688. eCollection 2013.


Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis.

Carlsson AH, Yakymenko O, Olivier I, Håkansson F, Postma E, Keita AV, Söderholm JD.

Scand J Gastroenterol. 2013 Oct;48(10):1136-44. doi: 10.3109/00365521.2013.828773. Epub 2013 Aug 26.


Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle-associated epithelium and during stress in rats.

Keita AV, Carlsson AH, Cigéhn M, Ericson AC, McKay DM, Söderholm JD.

Neurogastroenterol Motil. 2013 Jun;25(6):e406-17. doi: 10.1111/nmo.12127. Epub 2013 Apr 18.


Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia.

Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita ÅV, Pardon N, Santos J, Söderholm JD, Tack J, Farré R.

Gut. 2014 Feb;63(2):262-71. doi: 10.1136/gutjnl-2012-303857. Epub 2013 Mar 8.


Soluble plantain fibre blocks adhesion and M-cell translocation of intestinal pathogens.

Roberts CL, Keita AV, Parsons BN, Prorok-Hamon M, Knight P, Winstanley C, O' Kennedy N, Söderholm JD, Rhodes JM, Campbell BJ.

J Nutr Biochem. 2013 Jan;24(1):97-103. doi: 10.1016/j.jnutbio.2012.02.013. Epub 2012 Jul 19.


Barrier dysfunction and bacterial uptake in the follicle-associated epithelium of ileal Crohn's disease.

Keita AV, Söderholm JD.

Ann N Y Acad Sci. 2012 Jul;1258:125-34. doi: 10.1111/j.1749-6632.2012.06502.x. Review.


Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers.

Roberts CL, Keita AV, Duncan SH, O'Kennedy N, Söderholm JD, Rhodes JM, Campbell BJ.

Gut. 2010 Oct;59(10):1331-9. doi: 10.1136/gut.2009.195370. Epub 2010 Sep 2.


The intestinal barrier and its regulation by neuroimmune factors.

Keita AV, Söderholm JD.

Neurogastroenterol Motil. 2010 Jul;22(7):718-33. doi: 10.1111/j.1365-2982.2010.01498.x. Epub 2010 Apr 9. Review.


Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells.

Keita AV, Söderholm JD, Ericson AC.

Neurogastroenterol Motil. 2010 Jul;22(7):770-8, e221-2. doi: 10.1111/j.1365-2982.2010.01471.x. Epub 2010 Feb 10.


Increased expression of protease-activated receptor-2 in mucosal mast cells in Crohn's ileitis.

Christerson U, Keita AV, Söderholm JD, Gustafson-Svärd C.

J Crohns Colitis. 2009 Jun;3(2):100-8. doi: 10.1016/j.crohns.2008.11.003. Epub 2009 Mar 5.


Potential role of protease-activated receptor-2-stimulated activation of cytosolic phospholipase A(2) in intestinal myofibroblast proliferation: Implications for stricture formation in Crohn's disease.

Christerson U, Keita AV, Söderholm JD, Gustafson-Svärd C.

J Crohns Colitis. 2009 Feb;3(1):15-24. doi: 10.1016/j.crohns.2008.10.002. Epub 2008 Dec 6.


CD83+CCR7- dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer's patches of ileal Crohn's disease.

Salim SY, Silva MA, Keita AV, Larsson M, Andersson P, Magnusson KE, Perdue MH, Söderholm JD.

Am J Pathol. 2009 Jan;174(1):82-90. doi: 10.2353/ajpath.2009.080273. Epub 2008 Dec 18.


Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease.

Keita AV, Salim SY, Jiang T, Yang PC, Franzén L, Söderkvist P, Magnusson KE, Söderholm JD.

J Pathol. 2008 Jun;215(2):135-44. doi: 10.1002/path.2337.


Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro.

Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Söderholm JD.

Gut. 2008 Jan;57(1):50-8. Epub 2007 May 24.


Effects of chronic stress on the immune response to oral human serum albumin-conjugated starch microparticles in rats.

Keita AV, Stertman L, Sun YQ, Larhed A, Sjöholm I, Söderholm JD.

J Neuroimmunol. 2007 Feb;183(1-2):33-42. Epub 2006 Dec 14.


Identification of cell adhesion molecules in the human follicle-associated epithelium that improve nanoparticle uptake into the Peyer's patches.

Gullberg E, Keita AV, Salim SY, Andersson M, Caldwell KD, Söderholm JD, Artursson P.

J Pharmacol Exp Ther. 2006 Nov;319(2):632-9. Epub 2006 Aug 16.


Characterization of antigen and bacterial transport in the follicle-associated epithelium of human ileum.

Keita AV, Gullberg E, Ericson AC, Salim SY, Wallon C, Kald A, Artursson P, Söderholm JD.

Lab Invest. 2006 May;86(5):504-16.

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