Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 83

1.

Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline.

Tang Z, Chuang KV, DeCarli C, Jin LW, Beckett L, Keiser MJ, Dugger BN.

Nat Commun. 2019 May 15;10(1):2173. doi: 10.1038/s41467-019-10212-1.

2.

Impact of Nursing Education on Phlebotomy Blood Loss and Hospital-Acquired Anemia: A Quality Improvement Project.

Jones S, Spangler P, Keiser M, Turkelson C.

Dimens Crit Care Nurs. 2019 Jan/Feb;38(1):13-19. doi: 10.1097/DCC.0000000000000333.

PMID:
30499788
3.

Adeno-Associated Virus Production, Purification, and Titering.

Chen YH, Keiser MS, Davidson BL.

Curr Protoc Mouse Biol. 2018 Dec;8(4):e56. doi: 10.1002/cpmo.56. Epub 2018 Nov 29.

PMID:
30489697
4.

Viral Vectors for Gene Transfer.

Chen YH, Keiser MS, Davidson BL.

Curr Protoc Mouse Biol. 2018 Dec;8(4):e58. doi: 10.1002/cpmo.58. Epub 2018 Nov 28. Review.

PMID:
30485696
5.

Comment on "Predicting reaction performance in C-N cross-coupling using machine learning".

Chuang KV, Keiser MJ.

Science. 2018 Nov 16;362(6416). pii: eaat8603. doi: 10.1126/science.aat8603.

PMID:
30442776
6.

Techniques for Intracranial Stereotaxic Injections of Adeno-Associated Viral Vectors in Adult Mice.

Keiser MS, Chen YH, Davidson BL.

Curr Protoc Mouse Biol. 2018 Dec;8(4):e57. doi: 10.1002/cpmo.57. Epub 2018 Nov 5.

PMID:
30395418
7.

Adversarial Controls for Scientific Machine Learning.

Chuang KV, Keiser MJ.

ACS Chem Biol. 2018 Oct 19;13(10):2819-2821. doi: 10.1021/acschembio.8b00881.

PMID:
30336670
8.

The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities.

Cheng C, Spengler RM, Keiser MS, Monteys AM, Rieders JM, Ramachandran S, Davidson BL.

Hum Mol Genet. 2018 Dec 15;27(24):4303-4314. doi: 10.1093/hmg/ddy331.

9.

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box.

Karlgren M, Simoff I, Keiser M, Oswald S, Artursson P.

Drug Metab Dispos. 2018 Nov;46(11):1776-1786. doi: 10.1124/dmd.118.082842. Epub 2018 Aug 20. Review.

PMID:
30126863
10.

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.

PMID:
30053424
11.

Simulated Interprofessional Education Discharge Planning Meeting to Improve Skills Necessary for Effective Interprofessional Practice.

Smith LM, Keiser M, Turkelson C, Yorke AM, Sachs B, Berg K.

Prof Case Manag. 2018 Mar/Apr;23(2):75-83. doi: 10.1097/NCM.0000000000000250.

PMID:
29381672
12.

Predicted Biological Activity of Purchasable Chemical Space.

Irwin JJ, Gaskins G, Sterling T, Mysinger MM, Keiser MJ.

J Chem Inf Model. 2018 Jan 22;58(1):148-164. doi: 10.1021/acs.jcim.7b00316. Epub 2017 Dec 29.

13.

Affinity of Ketamine to Clinically Relevant Transporters.

Keiser M, Hasan M, Oswald S.

Mol Pharm. 2018 Jan 2;15(1):326-331. doi: 10.1021/acs.molpharmaceut.7b00627. Epub 2017 Dec 8.

PMID:
29191019
14.

Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior.

Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, Soung A, DeSalvo M, Kitamoto T, Keiser MJ, Jacobson MP, Daneman R, Bainton RJ.

Cell Rep. 2017 Oct 31;21(5):1304-1316. doi: 10.1016/j.celrep.2017.10.026.

15.

Reflections on 50 Years of Neuroscience Nursing: Publication Trends in Neurotrauma.

McNett M, Keiser M, Douglas H, McNair ND.

J Neurosci Nurs. 2018 Apr;50(2):58-61. doi: 10.1097/JNN.0000000000000320.

PMID:
28991097
16.

A Simple Representation of Three-Dimensional Molecular Structure.

Axen SD, Huang XP, Cáceres EL, Gendelev L, Roth BL, Keiser MJ.

J Med Chem. 2017 Sep 14;60(17):7393-7409. doi: 10.1021/acs.jmedchem.7b00696. Epub 2017 Aug 8.

17.

Challenges in the Management of Geriatric Trauma: A Case Report.

Gaebel A, Keiser M.

J Trauma Nurs. 2017 Jul/Aug;24(4):245-250. doi: 10.1097/JTN.0000000000000299. Review.

PMID:
28692621
18.

The Ussing Chamber Assay to Study Drug Metabolism and Transport in the Human Intestine.

Kisser B, Mangelsen E, Wingolf C, Partecke LI, Heidecke CD, Tannergren C, Oswald S, Keiser M.

Curr Protoc Pharmacol. 2017 Jun 22;77:7.17.1-7.17.19. doi: 10.1002/cpph.22.

PMID:
28640954
19.

A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.

Karlgren M, Simoff I, Backlund M, Wegler C, Keiser M, Handin N, Müller J, Lundquist P, Jareborg AC, Oswald S, Artursson P.

J Pharm Sci. 2017 Sep;106(9):2909-2913. doi: 10.1016/j.xphs.2017.04.018. Epub 2017 Apr 24.

PMID:
28450237
20.

The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

Keiser M, Kaltheuner L, Wildberg C, Müller J, Grube M, Partecke LI, Heidecke CD, Oswald S.

J Pharm Sci. 2017 Sep;106(9):2657-2663. doi: 10.1016/j.xphs.2017.04.001. Epub 2017 Apr 10.

PMID:
28408210
21.

RNA Interference of Human α-Synuclein in Mouse.

Kim YC, Miller A, Lins LC, Han SW, Keiser MS, Boudreau RL, Davidson BL, Narayanan NS.

Front Neurol. 2017 Jan 31;8:13. doi: 10.3389/fneur.2017.00013. eCollection 2017.

22.

CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo.

Monteys AM, Ebanks SA, Keiser MS, Davidson BL.

Mol Ther. 2017 Jan 4;25(1):12-23. doi: 10.1016/j.ymthe.2016.11.010. Epub 2017 Jan 4.

23.

Pharmacological indices and pulmonary distribution of rifampicin after repeated oral administration in healthy foals.

Berlin S, Kirschbaum A, Spieckermann L, Oswald S, Keiser M, Grube M, Venner M, Siegmund W.

Equine Vet J. 2017 Sep;49(5):618-623. doi: 10.1111/evj.12662. Epub 2017 Feb 25.

PMID:
28063154
24.

Effects of frequently used pharmaceutical excipients on the organic cation transporters 1-3 and peptide transporters 1/2 stably expressed in MDCKII cells.

Otter M, Oswald S, Siegmund W, Keiser M.

Eur J Pharm Biopharm. 2017 Mar;112:187-195. doi: 10.1016/j.ejpb.2016.11.028. Epub 2016 Nov 27.

PMID:
27903454
25.

RNAi prevents and reverses phenotypes induced by mutant human ataxin-1.

Keiser MS, Monteys AM, Corbau R, Gonzalez-Alegre P, Davidson BL.

Ann Neurol. 2016 Nov;80(5):754-765. doi: 10.1002/ana.24789. Epub 2016 Nov 2.

26.

Expression, regulation and function of intestinal drug transporters: an update.

Müller J, Keiser M, Drozdzik M, Oswald S.

Biol Chem. 2017 Feb 1;398(2):175-192. doi: 10.1515/hsz-2016-0259. Review.

PMID:
27611766
27.

Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy.

Hubeny A, Keiser M, Oswald S, Jedlitschky G, Kroemer HK, Siegmund W, Grube M.

Drug Metab Dispos. 2016 Oct;44(10):1562-8. doi: 10.1124/dmd.116.069807. Epub 2016 Aug 8.

PMID:
27504015
28.

Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds.

Bruni G, Rennekamp AJ, Velenich A, McCarroll M, Gendelev L, Fertsch E, Taylor J, Lakhani P, Lensen D, Evron T, Lorello PJ, Huang XP, Kolczewski S, Carey G, Caldarone BJ, Prinssen E, Roth BL, Keiser MJ, Peterson RT, Kokel D.

Nat Chem Biol. 2016 Jul;12(7):559-66. doi: 10.1038/nchembio.2097. Epub 2016 May 30.

29.

Genomic Alterations Are Enhanced in Placentas from Pregnancies with Fetal Growth Restriction and Preeclampsia: Preliminary Results.

Biron-Shental T, Sharony R, Shtorch-Asor A, Keiser M, Sadeh-Mestechkin D, Laish I, Amiel A.

Mol Syndromol. 2016 Feb;6(6):276-80. doi: 10.1159/000444064. Epub 2016 Jan 27.

30.

Polygenic overlap between schizophrenia risk and antipsychotic response: a genomic medicine approach.

Ruderfer DM, Charney AW, Readhead B, Kidd BA, Kähler AK, Kenny PJ, Keiser MJ, Moran JL, Hultman CM, Scott SA, Sullivan PF, Purcell SM, Dudley JT, Sklar P.

Lancet Psychiatry. 2016 Apr;3(4):350-7. doi: 10.1016/S2215-0366(15)00553-2. Epub 2016 Feb 23.

31.

Leveraging Large-scale Behavioral Profiling in Zebrafish to Explore Neuroactive Polypharmacology.

McCarroll MN, Gendelev L, Keiser MJ, Kokel D.

ACS Chem Biol. 2016 Apr 15;11(4):842-9. doi: 10.1021/acschembio.5b00800. Epub 2016 Feb 17.

32.

Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Consecutive Administration in Foals.

Berlin S, Spieckermann L, Oswald S, Keiser M, Lumpe S, Ullrich A, Grube M, Hasan M, Venner M, Siegmund W.

Mol Pharm. 2016 Mar 7;13(3):1089-99. doi: 10.1021/acs.molpharmaceut.5b00907. Epub 2016 Feb 11.

PMID:
26808255
33.

The Nonmetabolized β-Blocker Nadolol Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein, but Not of OATP1B1 and OATP1B3.

Misaka S, Knop J, Singer K, Hoier E, Keiser M, Müller F, Glaeser H, König J, Fromm MF.

Mol Pharm. 2016 Feb 1;13(2):512-9. doi: 10.1021/acs.molpharmaceut.5b00733. Epub 2016 Jan 19.

PMID:
26702643
34.

Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.

Keiser MS, Kordasiewicz HB, McBride JL.

Hum Mol Genet. 2016 Apr 15;25(R1):R53-64. doi: 10.1093/hmg/ddv442. Epub 2015 Oct 26. Review.

35.

Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy.

Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL.

Brain. 2015 Dec;138(Pt 12):3555-66. doi: 10.1093/brain/awv292. Epub 2015 Oct 21.

36.

Prediction and validation of enzyme and transporter off-targets for metformin.

Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM.

J Pharmacokinet Pharmacodyn. 2015 Oct;42(5):463-75. doi: 10.1007/s10928-015-9436-y. Epub 2015 Sep 3.

37.

Systems pharmacology augments drug safety surveillance.

Lorberbaum T, Nasir M, Keiser MJ, Vilar S, Hripcsak G, Tatonetti NP.

Clin Pharmacol Ther. 2015 Feb;97(2):151-8. doi: 10.1002/cpt.2. Epub 2014 Dec 20.

38.

Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics.

Bexten M, Oswald S, Grube M, Jia J, Graf T, Zimmermann U, Rodewald K, Zolk O, Schwantes U, Siegmund W, Keiser M.

Mol Pharm. 2015 Jan 5;12(1):171-8. doi: 10.1021/mp500532x. Epub 2014 Dec 10.

PMID:
25466967
39.

Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.

Siegmund W, Modess C, Scheuch E, Methling K, Keiser M, Nassif A, Rosskopf D, Bednarski PJ, Borlak J, Terhaag B.

Br J Clin Pharmacol. 2015 Mar;79(3):501-13. doi: 10.1111/bcp.12522.

40.

Broad therapeutic benefit after RNAi expression vector delivery to deep cerebellar nuclei: implications for spinocerebellar ataxia type 1 therapy.

Keiser MS, Boudreau RL, Davidson BL.

Mol Ther. 2014 Mar;22(3):588-595. doi: 10.1038/mt.2013.279. Epub 2013 Dec 12.

41.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K.

PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712. Epub 2013 Nov 19.

42.

OATP1B3 is expressed in pancreatic β-islet cells and enhances the insulinotropic effect of the sulfonylurea derivative glibenclamide.

Meyer Zu Schwabedissen HE, Boettcher K, Steiner T, Schwarz UI, Keiser M, Kroemer HK, Siegmund W.

Diabetes. 2014 Feb;63(2):775-84. doi: 10.2337/db13-1005. Epub 2013 Oct 22.

43.

Characterization of the intestinal and hepatic uptake/efflux transport of the magnetic resonance imaging contrast agent gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid.

Jia J, Puls D, Oswald S, Jedlitschky G, Kühn JP, Weitschies W, Hosten N, Siegmund W, Keiser M.

Invest Radiol. 2014 Feb;49(2):78-86. doi: 10.1097/RLI.0b013e3182a70043.

PMID:
24056116
44.

Response.

Nassif A, Siegmund W, Keiser M, Weitschies W, Kühn JP.

Radiology. 2013 Apr;267(1):315. No abstract available.

PMID:
23641488
45.

Recent advances in RNA interference therapeutics for CNS diseases.

Ramachandran PS, Keiser MS, Davidson BL.

Neurotherapeutics. 2013 Jul;10(3):473-85. doi: 10.1007/s13311-013-0183-8. Review.

46.

RNAi or overexpression: alternative therapies for Spinocerebellar Ataxia Type 1.

Keiser MS, Geoghegan JC, Boudreau RL, Lennox KA, Davidson BL.

Neurobiol Dis. 2013 Aug;56:6-13. doi: 10.1016/j.nbd.2013.04.003. Epub 2013 Apr 10.

47.

Altered Purkinje cell miRNA expression and SCA1 pathogenesis.

Rodriguez-Lebron E, Liu G, Keiser M, Behlke MA, Davidson BL.

Neurobiol Dis. 2013 Jun;54:456-63. doi: 10.1016/j.nbd.2013.01.019. Epub 2013 Jan 30.

48.

Steroid hormones specifically modify the activity of organic anion transporting polypeptides.

Koenen A, Köck K, Keiser M, Siegmund W, Kroemer HK, Grube M.

Eur J Pharm Sci. 2012 Nov 20;47(4):774-80. doi: 10.1016/j.ejps.2012.08.017. Epub 2012 Sep 8.

PMID:
22982504
49.

Pharmaceutical excipients influence the function of human uptake transporting proteins.

Engel A, Oswald S, Siegmund W, Keiser M.

Mol Pharm. 2012 Sep 4;9(9):2577-81. doi: 10.1021/mp3001815. Epub 2012 Aug 1.

PMID:
22808947
50.

Visualization of hepatic uptake transporter function in healthy subjects by using gadoxetic acid-enhanced MR imaging.

Nassif A, Jia J, Keiser M, Oswald S, Modess C, Nagel S, Weitschies W, Hosten N, Siegmund W, Kühn JP.

Radiology. 2012 Sep;264(3):741-50. doi: 10.1148/radiol.12112061. Epub 2012 Jul 6.

PMID:
22771883

Supplemental Content

Loading ...
Support Center