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Items: 1 to 50 of 406

1.

Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of hookworm-infected adolescents.

Schulz JD, Neodo A, Coulibaly JT, Keiser J.

Antimicrob Agents Chemother. 2019 Feb 11. pii: AAC.02489-18. doi: 10.1128/AAC.02489-18. [Epub ahead of print]

PMID:
30745388
2.

Pooled population pharmacokinetic analysis of tribendimidine for the treatment of Opisthorchis viverrini infections.

Meister I, Assawasuwannakit P, Vanobberghen F, Penny M, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J.

Antimicrob Agents Chemother. 2019 Feb 4. pii: AAC.01391-18. doi: 10.1128/AAC.01391-18. [Epub ahead of print]

3.

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni.

Lombardo FC, Pasche V, Panic G, Endriss Y, Keiser J.

Nat Protoc. 2019 Feb;14(2):461-481. doi: 10.1038/s41596-018-0101-y.

PMID:
30610241
4.

Structure-activity relationship and in vitro ADMET studies of N-aryl 3-trifluoromethyl pyrido [1,2-a] benzimidazoles that are efficacious in a mouse model of schistosomiasis.

Mayoka G, Keiser J, Haeberli C, Chibale K.

ACS Infect Dis. 2018 Dec 23. doi: 10.1021/acsinfecdis.8b00313. [Epub ahead of print]

PMID:
30580519
5.

Structure-activity relationship studies of tolfenpyrad reveal sub-nanomolar inhibitors of Haemonchus contortus development.

Le T, Kundu A, Ghoshal A, Nguyen N, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang B, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB.

J Med Chem. 2018 Dec 20. doi: 10.1021/acs.jmedchem.8b01789. [Epub ahead of print]

PMID:
30571110
6.

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates.

d'Orchymont F, Hess J, Panic G, Jakubaszek M, Gemperle L, Keiser J, Gasser G.

Medchemcomm. 2018 Oct 10;9(11):1905-1909. doi: 10.1039/c8md00396c. eCollection 2018 Nov 1.

PMID:
30568758
7.

Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial.

Coulibaly JT, Hiroshige N, N'Gbesso YK, Hattendorf J, Keiser J.

Clin Infect Dis. 2018 Nov 29. doi: 10.1093/cid/ciy999. [Epub ahead of print]

PMID:
30496350
8.

Impedance-Based Microfluidic Assay for Automated Antischistosomal Drug Screening.

Chawla K, Modena MM, Ravaynia PS, Lombardo FC, Leonhardt M, Panic G, Bürgel SC, Keiser J, Hierlemann A.

ACS Sens. 2018 Nov 28. doi: 10.1021/acssensors.8b01027. [Epub ahead of print]

PMID:
30426744
9.

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Jabbar A, Wells TNC, Palmer MJ, Gasser RB, Baell JB.

J Med Chem. 2018 Nov 29. doi: 10.1021/acs.jmedchem.8b01544. [Epub ahead of print]

PMID:
30403349
11.

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box.

Pasche V, Laleu B, Keiser J.

ACS Infect Dis. 2018 Nov 16. doi: 10.1021/acsinfecdis.8b00220. [Epub ahead of print]

PMID:
30398059
12.

SAR of a new antischistosomal urea carboxylic acid.

Wu J, Wang C, Häberli C, White KL, Shackleford DM, Chen G, Dong Y, Charman SA, Keiser J, Vennerstrom JL.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3648-3651. doi: 10.1016/j.bmcl.2018.10.039. Epub 2018 Oct 25.

PMID:
30389288
13.

Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol.

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Bethony J, Cringoli G, Dana D, Keiser J, Maurelli MP, Montresor A, Mekonnen Z, Mirams G, Corrêa-Oliveira R, Prichard R, Rashwan N, Rinaldi L, Sayasone S, Thomas E, Verweij JJ, Vercruysse J, Levecke B.

PLoS Negl Trop Dis. 2018 Nov 2;12(11):e0006912. doi: 10.1371/journal.pntd.0006912. eCollection 2018 Nov.

14.

Characteristics and Severity of Disease among 100 Cases of Imported Malaria Seen at a U.S. University Hospital, 2000-2017.

Akselrod H, Swierzbinski MJ, Zheng Z, Keiser J, Parenti DM, Simon GL.

Am J Trop Med Hyg. 2018 Oct 22. doi: 10.4269/ajtmh.18-0608. [Epub ahead of print]

PMID:
30350769
15.

In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.

Neodo A, Schulz JD, Huwyler J, Keiser J.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e00762-18. doi: 10.1128/AAC.00762-18. Print 2019 Jan.

PMID:
30323047
16.

Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool.

Ayana M, Vlaminck J, Cools P, Ame S, Albonico M, Dana D, Keiser J, Manly H, Matoso LF, Mekonnen Z, Montresor A, Correa-Oliveira R, Rinaldi L, Sayasone S, Sowersby S, Tesfaye L, Vercruysse J, Mirams G, Levecke B.

PLoS Negl Trop Dis. 2018 Oct 15;12(10):e0006655. doi: 10.1371/journal.pntd.0006655. eCollection 2018 Oct.

17.

A Rapid Appraisal of Factors Influencing Praziquantel Treatment Compliance in Two Communities Endemic for Schistosomiasis in Côte d'Ivoire.

Coulibaly JT, Ouattara M, Barda B, Utzinger J, N'Goran EK, Keiser J.

Trop Med Infect Dis. 2018 Jun 19;3(2). pii: E69. doi: 10.3390/tropicalmed3020069.

18.

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.

Bonate PL, Wang T, Passier P, Bagchus W, Burt H, Lüpfert C, Abla N, Kovac J, Keiser J.

J Pharmacokinet Pharmacodyn. 2018 Sep 14. doi: 10.1007/s10928-018-9601-1. [Epub ahead of print]

19.

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

Liu Z, Xia B, Saric J, Utzinger J, Holmes E, Keiser J, Li JV.

J Proteome Res. 2018 Oct 5;17(10):3565-3573. doi: 10.1021/acs.jproteome.8b00583. Epub 2018 Sep 20.

PMID:
30183313
20.

Toward the 2020 goal of soil-transmitted helminthiasis control and elimination.

Becker SL, Liwanag HJ, Snyder JS, Akogun O, Belizario V Jr, Freeman MC, Gyorkos TW, Imtiaz R, Keiser J, Krolewiecki A, Levecke B, Mwandawiro C, Pullan RL, Addiss DG, Utzinger J.

PLoS Negl Trop Dis. 2018 Aug 14;12(8):e0006606. doi: 10.1371/journal.pntd.0006606. eCollection 2018 Aug. No abstract available.

21.

Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads.

Panic G, Keiser J.

Curr Opin Pharmacol. 2018 Oct;42:27-33. doi: 10.1016/j.coph.2018.06.004. Epub 2018 Aug 1. Review.

PMID:
30077117
22.

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota.

Schneeberger PHH, Coulibaly JT, Gueuning M, Moser W, Coburn B, Frey JE, Keiser J.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):372-378. doi: 10.1016/j.ijpddr.2018.07.001. Epub 2018 Jul 2.

23.

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children.

Hiroshige N, Coulibaly J, Huwyler J, Bonate PL, Keiser J.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00959-18. doi: 10.1128/AAC.00959-18. Print 2018 Sep.

PMID:
29914958
24.

Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children.

Kovač J, Meister I, Neodo A, Panic G, Coulibaly JT, Falcoz C, Keiser J.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02253-17. doi: 10.1128/AAC.02253-17. Print 2018 Aug.

25.

Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.

Moser W, Bärenbold O, Mirams GJ, Cools P, Vlaminck J, Ali SM, Ame SM, Hattendorf J, Vounatsou P, Levecke B, Keiser J.

PLoS Negl Trop Dis. 2018 Jun 4;12(6):e0006562. doi: 10.1371/journal.pntd.0006562. eCollection 2018 Jun.

26.

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

Barda B, Ame SM, Ali SM, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J.

Lancet Infect Dis. 2018 Aug;18(8):864-873. doi: 10.1016/S1473-3099(18)30233-0. Epub 2018 May 29.

PMID:
29858149
27.

Preventive Chemotherapy in the Fight against Soil-Transmitted Helminthiasis: Achievements and Limitations.

Schulz JD, Moser W, Hürlimann E, Keiser J.

Trends Parasitol. 2018 Jul;34(7):590-602. doi: 10.1016/j.pt.2018.04.008. Epub 2018 May 29. Review.

PMID:
29858018
28.

Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial.

Coulibaly JT, Panic G, Yapi RB, Kovač J, Barda B, N'Gbesso YK, Hattendorf J, Keiser J.

BMC Med. 2018 Jun 1;16(1):81. doi: 10.1186/s12916-018-1066-y.

29.

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni.

Pasche V, Laleu B, Keiser J.

Parasit Vectors. 2018 May 15;11(1):298. doi: 10.1186/s13071-018-2855-z.

30.

Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis.

Palmeirim MS, Hürlimann E, Knopp S, Speich B, Belizario V Jr, Joseph SA, Vaillant M, Olliaro P, Keiser J.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006458. doi: 10.1371/journal.pntd.0006458. eCollection 2018 Apr. Review.

31.

Characterizing the Biochemical Response to Schistosoma mansoni Infection and Treatment with Praziquantel in Preschool and School Aged Children.

Panic G, Coulibaly JT, Harvey N, Keiser J, Swann J.

J Proteome Res. 2018 Jun 1;17(6):2028-2033. doi: 10.1021/acs.jproteome.7b00910. Epub 2018 May 21.

PMID:
29701975
33.

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Wimmersberger D, Coulibaly JT, Schulz JD, Puchkow M, Huwyler J, N'Gbesso Y, Hattendorf J, Keiser J.

Clin Infect Dis. 2018 Sep 28;67(8):1247-1255. doi: 10.1093/cid/ciy246.

PMID:
29617737
34.

Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome.

Schneeberger PHH, Coulibaly JT, Panic G, Daubenberger C, Gueuning M, Frey JE, Keiser J.

Parasit Vectors. 2018 Mar 12;11(1):168. doi: 10.1186/s13071-018-2739-2.

35.

The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans.

Levecke B, Easton AV, Cools P, Albonico M, Ame S, Gilleard JS, Keiser J, Montresor A, Prichard R, Vlaminck J, Vercruysse J.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):67-69. doi: 10.1016/j.ijpddr.2017.12.004. Epub 2018 Jan 13.

36.

Evaluation of a novel micro-sampling device, Mitra™, in comparison to dried blood spots, for analysis of praziquantel in Schistosoma haematobium-infected children in rural Côte d'Ivoire.

Kovač J, Panic G, Neodo A, Meister I, Coulibaly JT, Schulz JD, Keiser J.

J Pharm Biomed Anal. 2018 Mar 20;151:339-346. doi: 10.1016/j.jpba.2018.01.030. Epub 2018 Jan 31.

PMID:
29413983
37.

A new soluble and bioactive polymorph of praziquantel.

Zanolla D, Perissutti B, Passerini N, Chierotti MR, Hasa D, Voinovich D, Gigli L, Demitri N, Geremia S, Keiser J, Cerreia Vioglio P, Albertini B.

Eur J Pharm Biopharm. 2018 Jun;127:19-28. doi: 10.1016/j.ejpb.2018.01.018. Epub 2018 Jan 31.

PMID:
29409939
38.

Evaluation of Two DNA Extraction Methods for Detection of Strongyloides stercoralis Infection.

Barda B, Wampfler R, Sayasone S, Phongluxa K, Xayavong S, Keoduangsy K, Schindler C, Keiser J.

J Clin Microbiol. 2018 Mar 26;56(4). pii: e01941-17. doi: 10.1128/JCM.01941-17. Print 2018 Apr.

39.

Progress in antischistosomal N,N'-diaryl urea SAR.

Wu J, Wang C, Leas D, Vargas M, White KL, Shackleford DM, Chen G, Sanford AG, Hemsley RM, Davis PH, Dong Y, Charman SA, Keiser J, Vennerstrom JL.

Bioorg Med Chem Lett. 2017 Dec 29. pii: S0960-894X(17)31238-6. doi: 10.1016/j.bmcl.2017.12.064. [Epub ahead of print]

PMID:
29317164
40.

Retrospective assessment of resource use and costs in two investigator-initiated randomized trials exemplified a comprehensive cost item list.

Speich B, von Niederhäusern B, Blum CA, Keiser J, Schur N, Fürst T, Kasenda B, Christ-Crain M, Hemkens LG, Pauli-Magnus C, Schwenkglenks M, Briel M; MAking Randomized Trials Affordable (MARTA) Group.

J Clin Epidemiol. 2018 Apr;96:73-83. doi: 10.1016/j.jclinepi.2017.12.022. Epub 2017 Dec 30.

PMID:
29292203
41.

Schistosoma haematobium Egg Excretion does not Increase after Exercise: Implications for Diagnostic Testing.

Coulibaly JT, Andrews JR, Lo NC, N'Goran EK, Utzinger J, Keiser J, Bogoch II.

Am J Trop Med Hyg. 2018 Mar;98(3):772-775. doi: 10.4269/ajtmh.17-0728. Epub 2017 Dec 14.

PMID:
29260647
42.

An isolable magnesium diphosphaethynolate complex.

Gilliard RJ, Heift D, Benkő Z, Keiser JM, Rheingold AL, Grützmacher H, Protasiewicz JD.

Dalton Trans. 2018 Jan 15;47(3):666-669. doi: 10.1039/c7dt04539e.

PMID:
29242885
43.

Efficacy and safety of tribendimidine versus praziquantel against Opisthorchis viverrini in Laos: an open-label, randomised, non-inferiority, phase 2 trial.

Sayasone S, Keiser J, Meister I, Vonghachack Y, Xayavong S, Senggnam K, Phongluxa K, Hattendorf J, Odermatt P.

Lancet Infect Dis. 2018 Feb;18(2):155-161. doi: 10.1016/S1473-3099(17)30624-2. Epub 2017 Nov 16.

PMID:
29153938
44.

Immunohistochemical Investigations of Treatment with Ro 13-3978, Praziquantel, Oxamniquine, and Mefloquine in Schistosoma mansoni-Infected Mice.

Panic G, Ruf MT, Keiser J.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01142-17. doi: 10.1128/AAC.01142-17. Print 2017 Dec.

45.

Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis.

Moser W, Schindler C, Keiser J.

BMJ. 2017 Sep 25;358:j4307. doi: 10.1136/bmj.j4307. Review.

46.

Evaluation of the pharmacokinetic-pharmacodynamic relationship of praziquantel in the Schistosoma mansoni mouse model.

Abla N, Keiser J, Vargas M, Reimers N, Haas H, Spangenberg T.

PLoS Negl Trop Dis. 2017 Sep 21;11(9):e0005942. doi: 10.1371/journal.pntd.0005942. eCollection 2017 Sep.

47.

Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial.

Moser W, Coulibaly JT, Ali SM, Ame SM, Amour AK, Yapi RB, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J.

Lancet Infect Dis. 2017 Nov;17(11):1162-1171. doi: 10.1016/S1473-3099(17)30487-5. Epub 2017 Aug 29.

PMID:
28864027
48.
49.

Screening of the 'Open Scaffolds' collection from Compounds Australia identifies a new chemical entity with anthelmintic activities against different developmental stages of the barber's pole worm and other parasitic nematodes.

Preston S, Jiao Y, Baell JB, Keiser J, Crawford S, Koehler AV, Wang T, Simpson MM, Kaplan RM, Cowley KJ, Simpson KJ, Hofmann A, Jabbar A, Gasser RB.

Int J Parasitol Drugs Drug Resist. 2017 Dec;7(3):286-294. doi: 10.1016/j.ijpddr.2017.05.004. Epub 2017 May 28.

50.

Side Benefits of Mass Drug Administration for Lymphatic Filariasis on Strongyloides stercoralis Prevalence on Pemba Island, Tanzania.

Barda B, Albonico M, Buonfrate D, Ame SM, Ali S, Speich B, Keiser J.

Am J Trop Med Hyg. 2017 Sep;97(3):681-683. doi: 10.4269/ajtmh.17-0050. Epub 2017 Jul 19. Erratum in: Am J Trop Med Hyg. 2018 Feb;98(2):635.

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