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Items: 1 to 50 of 423

1.

Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods.

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Cringoli G, Dana D, Keiser J, Maurelli MP, Matoso LF, Montresor A, Mekonnen Z, Mirams G, Corrêa-Oliveira R, Pinto SA, Rinaldi L, Sayasone S, Thomas E, Vercruysse J, Verweij JJ, Levecke B.

PLoS Negl Trop Dis. 2019 Aug 1;13(8):e0007471. doi: 10.1371/journal.pntd.0007471. eCollection 2019 Aug.

2.

Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries.

Cools P, Vlaminck J, Albonico M, Ame S, Ayana M, José Antonio BP, Cringoli G, Dana D, Keiser J, Maurelli MP, Maya C, Matoso LF, Montresor A, Mekonnen Z, Mirams G, Corrêa-Oliveira R, Pinto SA, Rinaldi L, Sayasone S, Thomas E, Verweij JJ, Vercruysse J, Levecke B.

PLoS Negl Trop Dis. 2019 Aug 1;13(8):e0007446. doi: 10.1371/journal.pntd.0007446. eCollection 2019 Aug.

3.

Clinical evaluation for morbidity associated with soil-transmitted helminth infection in school-age children on Pemba Island, Tanzania.

Bogoch II, Speich B, Lo NC, Moser W, Croll D, Ali SM, Ame SM, Utzinger J, Andrews JR, Keiser J.

PLoS Negl Trop Dis. 2019 Jul 15;13(7):e0007581. doi: 10.1371/journal.pntd.0007581. eCollection 2019 Jul.

4.

AbstractActivity and pharmacokinetics of a praziquantel crystalline polymorph in the Schistosoma mansoni mouse model.

Lombardo FC, Perissutti B, Keiser J.

Eur J Pharm Biopharm. 2019 Jun 29. pii: S0939-6411(19)30220-6. doi: 10.1016/j.ejpb.2019.06.029. [Epub ahead of print]

PMID:
31265895
5.

Reply to Nalin.

Wimmersberger D, Schulz JD, Keiser J.

Clin Infect Dis. 2019 Jul 2;69(2):376-377. doi: 10.1093/cid/ciy1015. No abstract available.

PMID:
31211842
7.

Efficacy and Safety of a Single Dose versus a Multiple Dose Regimen of Mebendazole against Hookworm Infections in Children: A Randomised, Double-blind Trial.

Palmeirim MS, Ame SM, Ali SM, Hattendorf J, Keiser J.

EClinicalMedicine. 2018 Jul 11;1:7-13. doi: 10.1016/j.eclinm.2018.06.004. eCollection 2018 Jul.

8.

Evaluation of emodepside in laboratory models of human intestinal nematode and schistosome infections.

Karpstein T, Pasche V, Häberli C, Scandale I, Neodo A, Keiser J.

Parasit Vectors. 2019 May 14;12(1):226. doi: 10.1186/s13071-019-3476-x.

9.

Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuristrichiura in adolescents: a randomized controlled trial.

Keller L, Palmeirim MS, Ame SM, Ali SM, Puchkov M, Huwyler J, Hattendorf J, Keiser J.

Clin Infect Dis. 2019 May 2. pii: ciz326. doi: 10.1093/cid/ciz326. [Epub ahead of print]

PMID:
31044235
10.

Community-wide soil-transmitted helminth treatment is equity-effective.

Keiser J, Utzinger J.

Lancet. 2019 May 18;393(10185):2011-2012. doi: 10.1016/S0140-6736(18)32981-7. Epub 2019 Apr 18. No abstract available.

11.

Ivermectin Dosing Strategy to Achieve Equivalent Exposure Coverage in Children and Adults.

Brussee JM, Schulz JD, Coulibaly JT, Keiser J, Pfister M.

Clin Pharmacol Ther. 2019 Sep;106(3):661-667. doi: 10.1002/cpt.1456. Epub 2019 May 25.

PMID:
30993667
12.

Efficacy and safety of ivermectin and albendazole co-administration in school-aged children and adults infected with Trichuris trichiura: study protocol for a multi-country randomized controlled double-blind trial.

Patel C, Hürlimann E, Keller L, Hattendorf J, Sayasone S, Ali SM, Ame SM, Coulibaly JT, Keiser J.

BMC Infect Dis. 2019 Mar 18;19(1):262. doi: 10.1186/s12879-019-3882-x.

13.

Drug Combinations Against Soil-Transmitted Helminth Infections.

Moser W, Schindler C, Keiser J.

Adv Parasitol. 2019;103:91-115. doi: 10.1016/bs.apar.2018.08.002. Epub 2018 Sep 7.

PMID:
30878060
14.

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB.

J Med Chem. 2019 Apr 11;62(7):3367-3380. doi: 10.1021/acs.jmedchem.8b01790. Epub 2019 Mar 28.

PMID:
30875218
15.

Combining Mechanochemistry and Spray Congealing for New Praziquantel Pediatric Formulations in Schistosomiasis Treatment.

Albertini B, Perissutti B, Bertoni S, Zanolla D, Franceschinis E, Voinovich D, Lombardo F, Keiser J, Passerini N.

Int J Mol Sci. 2019 Mar 12;20(5). pii: E1233. doi: 10.3390/ijms20051233.

16.

Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2-12 years.

Schulz JD, Coulibaly JT, Schindler C, Wimmersberger D, Keiser J.

J Antimicrob Chemother. 2019 Jun 1;74(6):1642-1647. doi: 10.1093/jac/dkz083.

17.

Correction: Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool.

Ayana M, Vlaminck J, Cools P, Ame S, Albonico M, Dana D, Keiser J, Manly H, Matoso LF, Mekonnen Z, Montresor A, Correa-Oliveira R, Rinaldi L, Sayasone S, Sowerby SJ, Tesfaye L, Vercruysse J, Mirams G, Levecke B.

PLoS Negl Trop Dis. 2019 Mar 4;13(3):e0007224. doi: 10.1371/journal.pntd.0007224. eCollection 2019 Mar.

18.

Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents.

Schulz JD, Neodo A, Coulibaly JT, Keiser J.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02489-18. doi: 10.1128/AAC.02489-18. Print 2019 Apr.

PMID:
30745388
19.

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Opisthorchis viverrini Infections.

Meister I, Assawasuwannakit P, Vanobberghen F, Penny MA, Odermatt P, Sayasone S, Huwyler J, Tarning J, Keiser J.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01391-18. doi: 10.1128/AAC.01391-18. Print 2019 Apr.

20.

Life cycle maintenance and drug-sensitivity assays for early drug discovery in Schistosoma mansoni.

Lombardo FC, Pasche V, Panic G, Endriss Y, Keiser J.

Nat Protoc. 2019 Feb;14(2):461-481. doi: 10.1038/s41596-018-0101-y.

PMID:
30610241
21.
22.

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Wells TNC, Palmer MJ, Jabbar A, Gasser RB, Baell JB.

J Med Chem. 2019 Jan 24;62(2):1036-1053. doi: 10.1021/acs.jmedchem.8b01789. Epub 2019 Jan 7.

PMID:
30571110
23.

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates.

d'Orchymont F, Hess J, Panic G, Jakubaszek M, Gemperle L, Keiser J, Gasser G.

Medchemcomm. 2018 Oct 10;9(11):1905-1909. doi: 10.1039/c8md00396c. eCollection 2018 Nov 1.

PMID:
30568758
24.

Efficacy and Safety of Ascending Dosages of Tribendimidine Against Hookworm Infections in Children: A Randomized Controlled Trial.

Coulibaly JT, Hiroshige N, N'Gbesso YK, Hattendorf J, Keiser J.

Clin Infect Dis. 2019 Aug 16;69(5):845-852. doi: 10.1093/cid/ciy999.

PMID:
30496350
25.

Impedance-Based Microfluidic Assay for Automated Antischistosomal Drug Screening.

Chawla K, Modena MM, Ravaynia PS, Lombardo FC, Leonhardt M, Panic G, Bürgel SC, Keiser J, Hierlemann A.

ACS Sens. 2018 Dec 28;3(12):2613-2620. doi: 10.1021/acssensors.8b01027. Epub 2018 Nov 28.

26.

Optimization of Novel 1-Methyl-1 H-Pyrazole-5-carboxamides Leads to High Potency Larval Development Inhibitors of the Barber's Pole Worm.

Le TG, Kundu A, Ghoshal A, Nguyen NH, Preston S, Jiao Y, Ruan B, Xue L, Huang F, Keiser J, Hofmann A, Chang BCH, Garcia-Bustos J, Jabbar A, Wells TNC, Palmer MJ, Gasser RB, Baell JB.

J Med Chem. 2018 Dec 13;61(23):10875-10894. doi: 10.1021/acs.jmedchem.8b01544. Epub 2018 Nov 29.

PMID:
30403349
28.

Early Antischistosomal Leads Identified from in Vitro and in Vivo Screening of the Medicines for Malaria Venture Pathogen Box.

Pasche V, Laleu B, Keiser J.

ACS Infect Dis. 2019 Jan 11;5(1):102-110. doi: 10.1021/acsinfecdis.8b00220. Epub 2018 Nov 16.

PMID:
30398059
29.

SAR of a new antischistosomal urea carboxylic acid.

Wu J, Wang C, Häberli C, White KL, Shackleford DM, Chen G, Dong Y, Charman SA, Keiser J, Vennerstrom JL.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3648-3651. doi: 10.1016/j.bmcl.2018.10.039. Epub 2018 Oct 25.

PMID:
30389288
30.

Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol.

Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Bethony J, Cringoli G, Dana D, Keiser J, Maurelli MP, Montresor A, Mekonnen Z, Mirams G, Corrêa-Oliveira R, Prichard R, Rashwan N, Rinaldi L, Sayasone S, Thomas E, Verweij JJ, Vercruysse J, Levecke B.

PLoS Negl Trop Dis. 2018 Nov 2;12(11):e0006912. doi: 10.1371/journal.pntd.0006912. eCollection 2018 Nov.

31.

Characteristics and Severity of Disease among 100 Cases of Imported Malaria Seen at a U.S. University Hospital, 2000-2017.

Akselrod H, Swierzbinski MJ, Zheng Z, Keiser J, Parenti DM, Simon GL.

Am J Trop Med Hyg. 2018 Dec;99(6):1511-1517. doi: 10.4269/ajtmh.18-0608.

PMID:
30350769
32.

In Vitro and In Vivo Drug-Drug Interaction Study of the Effects of Ivermectin and Oxantel Pamoate on Tribendimidine.

Neodo A, Schulz JD, Huwyler J, Keiser J.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e00762-18. doi: 10.1128/AAC.00762-18. Print 2019 Jan.

33.

Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool.

Ayana M, Vlaminck J, Cools P, Ame S, Albonico M, Dana D, Keiser J, Manly H, Matoso LF, Mekonnen Z, Montresor A, Correa-Oliveira R, Rinaldi L, Sayasone S, Sowersby SJ, Tesfaye L, Vercruysse J, Mirams G, Levecke B.

PLoS Negl Trop Dis. 2018 Oct 15;12(10):e0006655. doi: 10.1371/journal.pntd.0006655. eCollection 2018 Oct. Erratum in: PLoS Negl Trop Dis. 2019 Mar 4;13(3):e0007224.

34.

A Rapid Appraisal of Factors Influencing Praziquantel Treatment Compliance in Two Communities Endemic for Schistosomiasis in Côte d'Ivoire.

Coulibaly JT, Ouattara M, Barda B, Utzinger J, N'Goran EK, Keiser J.

Trop Med Infect Dis. 2018 Jun 19;3(2). pii: E69. doi: 10.3390/tropicalmed3020069.

35.

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale.

Bonate PL, Wang T, Passier P, Bagchus W, Burt H, Lüpfert C, Abla N, Kovac J, Keiser J.

J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):747-762. doi: 10.1007/s10928-018-9601-1. Epub 2018 Sep 14.

36.

Effects of Vancomycin and Ciprofloxacin on the NMRI Mouse Metabolism.

Liu Z, Xia B, Saric J, Utzinger J, Holmes E, Keiser J, Li JV.

J Proteome Res. 2018 Oct 5;17(10):3565-3573. doi: 10.1021/acs.jproteome.8b00583. Epub 2018 Sep 20.

PMID:
30183313
37.

Toward the 2020 goal of soil-transmitted helminthiasis control and elimination.

Becker SL, Liwanag HJ, Snyder JS, Akogun O, Belizario V Jr, Freeman MC, Gyorkos TW, Imtiaz R, Keiser J, Krolewiecki A, Levecke B, Mwandawiro C, Pullan RL, Addiss DG, Utzinger J.

PLoS Negl Trop Dis. 2018 Aug 14;12(8):e0006606. doi: 10.1371/journal.pntd.0006606. eCollection 2018 Aug. No abstract available.

38.

Acting beyond 2020: better characterization of praziquantel and promising antischistosomal leads.

Panic G, Keiser J.

Curr Opin Pharmacol. 2018 Oct;42:27-33. doi: 10.1016/j.coph.2018.06.004. Epub 2018 Aug 1. Review.

PMID:
30077117
39.

Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota.

Schneeberger PHH, Coulibaly JT, Gueuning M, Moser W, Coburn B, Frey JE, Keiser J.

Int J Parasitol Drugs Drug Resist. 2018 Dec;8(3):372-378. doi: 10.1016/j.ijpddr.2018.07.001. Epub 2018 Jul 2.

40.

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children.

Hiroshige N, Coulibaly J, Huwyler J, Bonate PL, Keiser J.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00959-18. doi: 10.1128/AAC.00959-18. Print 2018 Sep.

41.

Pharmacokinetics of Praziquantel in Schistosoma mansoni- and Schistosoma haematobium-Infected School- and Preschool-Aged Children.

Kovač J, Meister I, Neodo A, Panic G, Coulibaly JT, Falcoz C, Keiser J.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e02253-17. doi: 10.1128/AAC.02253-17. Print 2018 Aug.

42.

Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.

Moser W, Bärenbold O, Mirams GJ, Cools P, Vlaminck J, Ali SM, Ame SM, Hattendorf J, Vounatsou P, Levecke B, Keiser J.

PLoS Negl Trop Dis. 2018 Jun 4;12(6):e0006562. doi: 10.1371/journal.pntd.0006562. eCollection 2018 Jun.

43.

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial.

Barda B, Ame SM, Ali SM, Albonico M, Puchkov M, Huwyler J, Hattendorf J, Keiser J.

Lancet Infect Dis. 2018 Aug;18(8):864-873. doi: 10.1016/S1473-3099(18)30233-0. Epub 2018 May 29.

PMID:
29858149
44.

Preventive Chemotherapy in the Fight against Soil-Transmitted Helminthiasis: Achievements and Limitations.

Schulz JD, Moser W, Hürlimann E, Keiser J.

Trends Parasitol. 2018 Jul;34(7):590-602. doi: 10.1016/j.pt.2018.04.008. Epub 2018 May 29. Review.

PMID:
29858018
45.

Efficacy and safety of ascending doses of praziquantel against Schistosoma haematobium infection in preschool-aged and school-aged children: a single-blind randomised controlled trial.

Coulibaly JT, Panic G, Yapi RB, Kovač J, Barda B, N'Gbesso YK, Hattendorf J, Keiser J.

BMC Med. 2018 Jun 1;16(1):81. doi: 10.1186/s12916-018-1066-y.

46.

Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni.

Pasche V, Laleu B, Keiser J.

Parasit Vectors. 2018 May 15;11(1):298. doi: 10.1186/s13071-018-2855-z.

47.

Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis.

Palmeirim MS, Hürlimann E, Knopp S, Speich B, Belizario V Jr, Joseph SA, Vaillant M, Olliaro P, Keiser J.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006458. doi: 10.1371/journal.pntd.0006458. eCollection 2018 Apr. Review.

48.

Characterizing the Biochemical Response to Schistosoma mansoni Infection and Treatment with Praziquantel in Preschool and School Aged Children.

Panic G, Coulibaly JT, Harvey N, Keiser J, Swann J.

J Proteome Res. 2018 Jun 1;17(6):2028-2033. doi: 10.1021/acs.jproteome.7b00910. Epub 2018 May 21.

PMID:
29701975
50.

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool-aged and School-aged Children: A Randomized Controlled Dose-finding Trial.

Wimmersberger D, Coulibaly JT, Schulz JD, Puchkow M, Huwyler J, N'Gbesso Y, Hattendorf J, Keiser J.

Clin Infect Dis. 2018 Sep 28;67(8):1247-1255. doi: 10.1093/cid/ciy246.

PMID:
29617737

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