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Items: 44

1.

A Small-Molecule Inhibitor of trans-Translation Synergistically Interacts with Cathelicidin Antimicrobial Peptides To Impair Survival of Staphylococcus aureus.

Huang Y, Alumasa JN, Callaghan LT, Baugh RS, Rae CD, Keiler KC, McGillivray SM.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02362-18. doi: 10.1128/AAC.02362-18. Print 2019 Apr.

2.

A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes.

Goralski TDP, Kirimanjeswara GS, Keiler KC.

MBio. 2018 Dec 18;9(6). pii: e02436-18. doi: 10.1128/mBio.02436-18.

3.

Bioresponsive peptide-polysaccharide nanogels - A versatile delivery system to augment the utility of bioactive cargo.

Simonson AW, Lawanprasert A, Goralski TDP, Keiler KC, Medina SH.

Nanomedicine. 2019 Apr;17:391-400. doi: 10.1016/j.nano.2018.10.008. Epub 2018 Nov 3.

PMID:
30399437
4.

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells.

Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler KC.

ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi: 10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7.

5.

Tetrazole-Based trans-Translation Inhibitors Kill Bacillus anthracis Spores To Protect Host Cells.

Alumasa JN, Goralski TDP, Keiler KC.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01199-17. doi: 10.1128/AAC.01199-17. Print 2017 Oct.

6.

Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA.

Dillon NA, Peterson ND, Feaga HA, Keiler KC, Baughn AD.

Sci Rep. 2017 Jul 21;7(1):6135. doi: 10.1038/s41598-017-06415-5.

7.

Teaching broader impacts of science with undergraduate research.

Keiler KC, Jackson KL, Jaworski L, Lopatto D, Ades SE.

PLoS Biol. 2017 Mar 21;15(3):e2001318. doi: 10.1371/journal.pbio.2001318. eCollection 2017 Mar.

8.

Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria.

Feaga HA, Quickel MD, Hankey-Giblin PA, Keiler KC.

PLoS Genet. 2016 Mar 30;12(3):e1005964. doi: 10.1371/journal.pgen.1005964. eCollection 2016 Mar.

9.

Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication.

Goralski TD, Dewan KK, Alumasa JN, Avanzato V, Place DE, Markley RL, Katkere B, Rabadi SM, Bakshi CS, Keiler KC, Kirimanjeswara GS.

Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82. doi: 10.1128/AAC.03089-15. Print 2016 Jun.

10.

Clicking on trans-translation drug targets.

Alumasa JN, Keiler KC.

Front Microbiol. 2015 May 19;6:498. doi: 10.3389/fmicb.2015.00498. eCollection 2015. No abstract available.

11.

Mechanisms of ribosome rescue in bacteria.

Keiler KC.

Nat Rev Microbiol. 2015 May;13(5):285-97. doi: 10.1038/nrmicro3438. Epub 2015 Apr 13. Review.

PMID:
25874843
12.

Release of nonstop ribosomes is essential.

Feaga HA, Viollier PH, Keiler KC.

MBio. 2014 Nov 11;5(6):e01916. doi: 10.1128/mBio.01916-14.

13.

Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.

El-Mowafi SA, Sineva E, Alumasa JN, Nicoloff H, Tomsho JW, Ades SE, Keiler KC.

Antimicrob Agents Chemother. 2015 Jan;59(1):193-205. doi: 10.1128/AAC.03979-14. Epub 2014 Oct 20.

14.

Cell-based assay to identify inhibitors of the Hfq-sRNA regulatory pathway.

El-Mowafi SA, Alumasa JN, Ades SE, Keiler KC.

Antimicrob Agents Chemother. 2014 Sep;58(9):5500-9. doi: 10.1128/AAC.03311-14. Epub 2014 Jul 7.

15.

Resolving nonstop translation complexes is a matter of life or death.

Keiler KC, Feaga HA.

J Bacteriol. 2014 Jun;196(12):2123-30. doi: 10.1128/JB.01490-14. Epub 2014 Apr 4. Review.

16.

The potential of trans-translation inhibitors as antibiotics.

Keiler KC, Alumasa JN.

Future Microbiol. 2013 Oct;8(10):1235-7. doi: 10.2217/fmb.13.110. No abstract available.

PMID:
24059913
17.

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity.

Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H, Chatterjee AK, Brinker A, Engels IH, Keiler KC.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.

18.

tmRNA is essential in Shigella flexneri.

Ramadoss NS, Zhou X, Keiler KC.

PLoS One. 2013;8(2):e57537. doi: 10.1371/journal.pone.0057537. Epub 2013 Feb 25.

19.

RNA visualization in bacteria by fluorescence in situ hybridization.

Russell JH, Keiler KC.

Methods Mol Biol. 2012;905:87-95. doi: 10.1007/978-1-61779-949-5_7.

PMID:
22736000
20.

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.

McGillivray SM, Tran DN, Ramadoss NS, Alumasa JN, Okumura CY, Sakoulas G, Vaughn MM, Zhang DX, Keiler KC, Nizet V.

Antimicrob Agents Chemother. 2012 Apr;56(4):1854-61. doi: 10.1128/AAC.05131-11. Epub 2012 Jan 17.

21.

Localization of the bacterial RNA infrastructure.

Keiler KC.

Adv Exp Med Biol. 2011;722:231-8. doi: 10.1007/978-1-4614-0332-6_15.

22.

Bifunctional transfer-messenger RNA.

Keiler KC, Ramadoss NS.

Biochimie. 2011 Nov;93(11):1993-7. doi: 10.1016/j.biochi.2011.05.029. Epub 2011 Jun 1. Review.

23.

RNA localization in bacteria.

Keiler KC.

Curr Opin Microbiol. 2011 Apr;14(2):155-9. doi: 10.1016/j.mib.2011.01.009. Epub 2011 Feb 24. Review. Erratum in: Curr Opin Microbiol. 2011 Jun;14(3):371.

24.

Protein localization and dynamics within a bacterial organelle.

Hughes HV, Huitema E, Pritchard S, Keiler KC, Brun YV, Viollier PH.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5599-604. doi: 10.1073/pnas.0909119107. Epub 2010 Mar 8.

25.

Beyond ribosome rescue: tmRNA and co-translational processes.

Hayes CS, Keiler KC.

FEBS Lett. 2010 Jan 21;584(2):413-9. doi: 10.1016/j.febslet.2009.11.023. Review.

26.

Subcellular localization of a bacterial regulatory RNA.

Russell JH, Keiler KC.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16405-9. doi: 10.1073/pnas.0904904106. Epub 2009 Sep 11.

27.

Correct timing of dnaA transcription and initiation of DNA replication requires trans translation.

Cheng L, Keiler KC.

J Bacteriol. 2009 Jul;191(13):4268-75. doi: 10.1128/JB.00362-09. Epub 2009 May 8.

28.

Biology of trans-translation.

Keiler KC.

Annu Rev Microbiol. 2008;62:133-51. doi: 10.1146/annurev.micro.62.081307.162948. Review.

PMID:
18557701
29.

Screen for localized proteins in Caulobacter crescentus.

Russell JH, Keiler KC.

PLoS One. 2008 Mar 12;3(3):e1756. doi: 10.1371/journal.pone.0001756.

30.

Proteomic identification of tmRNA substrates.

Hong SJ, Lessner FH, Mahen EM, Keiler KC.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17128-33. Epub 2007 Oct 15.

31.

Peptide signals encode protein localization.

Russell JH, Keiler KC.

J Bacteriol. 2007 Nov;189(21):7581-5. Epub 2007 Aug 31.

32.

Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease.

Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC.

Protein Sci. 2007 Aug;16(8):1535-42. Epub 2007 Jun 28.

33.

Physiology of tmRNA: what gets tagged and why?

Keiler KC.

Curr Opin Microbiol. 2007 Apr;10(2):169-75. Epub 2007 Mar 26. Review.

PMID:
17383929
34.

Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria.

Lessner FH, Venters BJ, Keiler KC.

J Bacteriol. 2007 Jan;189(1):272-5. Epub 2006 Nov 3.

35.

Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB.

Hong SJ, Tran QA, Keiler KC.

Mol Microbiol. 2005 Jul;57(2):565-75.

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40.

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA.

Keiler KC, Waller PR, Sauer RT.

Science. 1996 Feb 16;271(5251):990-3.

PMID:
8584937
41.

Sequence determinants of C-terminal substrate recognition by the Tsp protease.

Keiler KC, Sauer RT.

J Biol Chem. 1996 Feb 2;271(5):2589-93.

42.

Identification of active site residues of the Tsp protease.

Keiler KC, Sauer RT.

J Biol Chem. 1995 Dec 1;270(48):28864-8.

43.

C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease.

Keiler KC, Silber KR, Downard KM, Papayannopoulos IA, Biemann K, Sauer RT.

Protein Sci. 1995 Aug;4(8):1507-15.

44.

Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini.

Silber KR, Keiler KC, Sauer RT.

Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):295-9.

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