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Items: 39


Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse.

Cross SH, Mckie L, Keighren M, West K, Thaung C, Davey T, Soares DC, Sanchez-Pulido L, Jackson IJ.

Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2875-2887. doi: 10.1167/iovs.18-25954.


Re-evaluation of the causes of variation among mouse aggregation chimaeras.

West JD, Tang PC, Everett CA, MacKay GE, Flockhart JH, Keighren MA.

Biol Open. 2019 May 30;8(5). pii: bio042804. doi: 10.1242/bio.042804.


Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function.

Findlay AS, Carter RN, Starbuck B, McKie L, Nováková K, Budd PS, Keighren MA, Marsh JA, Cross SH, Simon MM, Potter PK, Morton NM, Jackson IJ.

Dis Model Mech. 2018 Dec 18;11(12). pii: dmm036426. doi: 10.1242/dmm.036426.


A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.

Ford MJ, Yeyati PL, Mali GR, Keighren MA, Waddell SH, Mjoseng HK, Douglas AT, Hall EA, Sakaue-Sawano A, Miyawaki A, Meehan RR, Boulter L, Jackson IJ, Mill P, Mort RL.

Dev Cell. 2018 Nov 19;47(4):509-523.e5. doi: 10.1016/j.devcel.2018.10.027.


ZMYND10 functions in a chaperone relay during axonemal dynein assembly.

Mali GR, Yeyati PL, Mizuno S, Dodd DO, Tennant PA, Keighren MA, Zur Lage P, Shoemark A, Garcia-Munoz A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreigsheim A, Jarman AP, Mill P.

Elife. 2018 Jun 19;7. pii: e34389. doi: 10.7554/eLife.34389.


Selection against BALB/c strain cells in mouse chimaeras.

Tang PC, MacKay GE, Flockhart JH, Keighren MA, Kopakaki A, West JD.

Biol Open. 2018 Jan 12;7(1). pii: bio030189. doi: 10.1242/bio.030189.


Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing.

Sharp L, Pratt T, MacKay GE, Keighren MA, Flockhart JH, Chandler EJ, Price DJ, Mason JO, West JD.

BMC Dev Biol. 2017 Jun 29;17(1):8. doi: 10.1186/s12861-017-0149-x.


PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.

Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P.

Am J Hum Genet. 2017 May 4;100(5):706-724. doi: 10.1016/j.ajhg.2017.03.008. Epub 2017 Apr 13.


Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras.

Keighren MA, Flockhart JH, West JD.

Biol Open. 2016 May 15;5(5):596-610. doi: 10.1242/bio.017111.


Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model.

Mort RL, Ross RJH, Hainey KJ, Harrison OJ, Keighren MA, Landini G, Baker RE, Painter KJ, Jackson IJ, Yates CA.

Nat Commun. 2016 Jan 6;7:10288. doi: 10.1038/ncomms10288.


Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers.

Keighren MA, Flockhart J, Hodson BA, Shen GY, Birtley JR, Notarnicola-Harwood A, West JD.

Transgenic Res. 2015 Aug;24(4):665-91. doi: 10.1007/s11248-015-9883-7. Epub 2015 Jun 6.


Fucci2a: a bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice.

Mort RL, Ford MJ, Sakaue-Sawano A, Lindstrom NO, Casadio A, Douglas AT, Keighren MA, Hohenstein P, Miyawaki A, Jackson IJ.

Cell Cycle. 2014;13(17):2681-96. doi: 10.4161/15384101.2015.945381.


Ex vivo culture of mouse embryonic skin and live-imaging of melanoblast migration.

Mort RL, Keighren M, Hay L, Jackson IJ.

J Vis Exp. 2014 May 19;(87). doi: 10.3791/51352.


A dominant-negative mutation of mouse Lmx1b causes glaucoma and is semi-lethal via LDB1-mediated dimerization [corrected].

Cross SH, Macalinao DG, McKie L, Rose L, Kearney AL, Rainger J, Thaung C, Keighren M, Jadeja S, West K, Kneeland SC, Smith RS, Howell GR, Young F, Robertson M, van T' Hof R, John SW, Jackson IJ.

PLoS Genet. 2014 May 8;10(5):e1004359. doi: 10.1371/journal.pgen.1004359. eCollection 2014 May. Erratum in: PLoS Genet. 2014 Dec;10(12):e1004917.


Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes.

Hall EA, Keighren M, Ford MJ, Davey T, Jarman AP, Smith LB, Jackson IJ, Mill P.

PLoS Genet. 2013;9(12):e1003928. doi: 10.1371/journal.pgen.1003928. Epub 2013 Dec 26.


A trans-acting protein effect causes severe eye malformation in the Mp mouse.

Rainger J, Keighren M, Keene DR, Charbonneau NL, Rainger JK, Fisher M, Mella S, Huang JT, Rose L, van't Hof R, Sakai LY, Jackson IJ, Fitzpatrick DR.

PLoS Genet. 2013;9(12):e1003998. doi: 10.1371/journal.pgen.1003998. Epub 2013 Dec 12.


A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy.

Jadeja S, Mort RL, Keighren M, Hart AW, Joynson R, Wells S, Potter PK, Jackson IJ.

Invest Ophthalmol Vis Sci. 2013 May 1;54(5):3569-78. doi: 10.1167/iovs.12-11125.


Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, Taylor MS, Lawson KA, Dorin JR, Jackson AP.

Cell. 2012 May 25;149(5):1008-22. doi: 10.1016/j.cell.2012.04.011. Epub 2012 May 10.


Evaluation of methods for one-dimensional spatial analysis of two-dimensional patterns in mouse chimaeras.

Hodson BA, Unbekandt M, Keighren MA, Springbett A, West JD.

J Anat. 2011 Sep;219(3):418-37. doi: 10.1111/j.1469-7580.2011.01395.x. Epub 2011 May 27.


Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

Mill P, Lockhart PJ, Fitzpatrick E, Mountford HS, Hall EA, Reijns MA, Keighren M, Bahlo M, Bromhead CJ, Budd P, Aftimos S, Delatycki MB, Savarirayan R, Jackson IJ, Amor DJ.

Am J Hum Genet. 2011 Apr 8;88(4):508-15. doi: 10.1016/j.ajhg.2011.03.015.


Involvement of the melanocortin-1 receptor in acute pain and pain of inflammatory but not neuropathic origin.

Delaney A, Keighren M, Fleetwood-Walker SM, Jackson IJ.

PLoS One. 2010 Sep 13;5(9):e12498. doi: 10.1371/journal.pone.0012498.


Palmitoylation regulates epidermal homeostasis and hair follicle differentiation.

Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ.

PLoS Genet. 2009 Nov;5(11):e1000748. doi: 10.1371/journal.pgen.1000748. Epub 2009 Nov 26.


Humanized MC1R transgenic mice reveal human specific receptor function.

Jackson IJ, Budd PS, Keighren M, McKie L.

Hum Mol Genet. 2007 Oct 1;16(19):2341-8. Epub 2007 Jul 25.


Genomic localization of a Dct-LacZ transgene locus: a simple assay for transgene status.

Takemoto Y, Keighren M, Jackson IJ, Yamamoto H.

Pigment Cell Res. 2006 Dec;19(6):644-5. No abstract available.


Evaluation of the mouse TgTP6.3 tauGFP transgene as a lineage marker in chimeras.

MacKay GE, Keighren MA, Wilson L, Pratt T, Flockhart JH, Mason JO, Price DJ, West JD.

J Anat. 2005 Jan;206(1):79-92.


Polyploid cells in the mouse ovary.

Keighren MA, Macfadyen LP, Hill AS, Patek CE, Telfer EE, West JD.

J Anat. 2003 Jun;202(6):563-71.


Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium.

Collinson JM, Morris L, Reid AI, Ramaesh T, Keighren MA, Flockhart JH, Hill RE, Tan SS, Ramaesh K, Dhillon B, West JD.

Dev Dyn. 2002 Aug;224(4):432-40.


Murine submucosal glands are clonally derived and show a cystic fibrosis gene-dependent distribution pattern.

Borthwick DW, West JD, Keighren MA, Flockhart JH, Innes BA, Dorin JR.

Am J Respir Cell Mol Biol. 1999 Jun;20(6):1181-9.


A quantitative test for developmental neutrality of a transgenic lineage marker in mouse chimaeras.

West JD, Keighren MA, Flockhart JH.

Genet Res. 1996 Apr;67(2):135-46.


Biochemical evidence for cell fusion in placentas of mouse aggregation chimeras.

West JD, Flockhart JH, Keighren M.

Dev Biol. 1995 Mar;168(1):76-85.


Restricted distribution of tetraploid cells in mouse tetraploid<==>diploid chimaeras.

James RM, Klerkx AH, Keighren M, Flockhart JH, West JD.

Dev Biol. 1995 Jan;167(1):213-26.


Quantitative analysis of mid-gestation mouse aggregation chimaeras: non-random composition of the placenta.

James R, Flockhart JH, Keighren M, West JD.

Roux Arch Dev Biol. 1993 May;202(5):296-305. doi: 10.1007/BF00363218.


Cloning of the am (glutamate dehydrogenase) gene of Neurospora crassa through the use of a synthetic DNA probe.

Kinnaird JH, Keighren MA, Kinsey JA, Eaton M, Fincham JR.

Gene. 1982 Dec;20(3):387-96.


New mutational variants of Neurospora NADP-specific glutamate dehydrogenase.

Kinsey JA, Fincham JR, Siddig MA, Keighren M.

Genetics. 1980 Jun;95(2):305-16.


Frameshift mutations affecting the N-terminal sequence of Neurospora NADP-specific glutamate dehydrogenase.

Siddig MA, Kinsey JA, Fincham JR, Keighren M.

J Mol Biol. 1980 Feb 25;137(2):125-35. No abstract available.


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