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Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane.

James C, Müller M, Goldberg MW, Lenz C, Urlaub H, Kehlenbach RH.

J Biol Chem. 2019 Sep 13. pii: jbc.RA118.007283. doi: 10.1074/jbc.RA118.007283. [Epub ahead of print]


The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.

Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C.

J Biol Chem. 2019 Aug 2;294(31):11741-11750. doi: 10.1074/jbc.RA118.006357. Epub 2019 Jun 11.


Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane.

Blenski M, Kehlenbach RH.

Int J Mol Sci. 2019 Jan 15;20(2). pii: E334. doi: 10.3390/ijms20020334.


Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.

Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B.

PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. eCollection 2018 Dec.


The cargo spectrum of nuclear transport receptors.

Baade I, Kehlenbach RH.

Curr Opin Cell Biol. 2019 Jun;58:1-7. doi: 10.1016/ Epub 2018 Dec 7. Review.


GCN5L1 interacts with αTAT1 and RanBP2 to regulate hepatic α-tubulin acetylation and lysosome trafficking.

Wu K, Wang L, Chen Y, Pirooznia M, Singh K, Wälde S, Kehlenbach RH, Scott I, Gucek M, Sack MN.

J Cell Sci. 2018 Nov 20;131(22). pii: jcs221036. doi: 10.1242/jcs.221036.


In Vivo Labelling of Adenovirus DNA Identifies Chromatin Anchoring and Biphasic Genome Replication.

Komatsu T, Quentin-Froignant C, Carlon-Andres I, Lagadec F, Rayne F, Ragues J, Kehlenbach RH, Zhang W, Ehrhardt A, Bystricky K, Morin R, Lagarde JM, Gallardo F, Wodrich H.

J Virol. 2018 Aug 29;92(18). pii: e00795-18. doi: 10.1128/JVI.00795-18. Print 2018 Sep 15.


Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1.

Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach RH, Bailer SM, Dormann D.

Sci Rep. 2018 May 4;8(1):7084. doi: 10.1038/s41598-018-25007-5.


Extensive Identification and In-depth Validation of Importin 13 Cargoes.

Baade I, Spillner C, Schmitt K, Valerius O, Kehlenbach RH.

Mol Cell Proteomics. 2018 Jul;17(7):1337-1353. doi: 10.1074/mcp.RA118.000623. Epub 2018 Apr 17.


Three-Dimensional Reconstruction of Nuclear Envelope Architecture Using Dual-Color Metal-Induced Energy Transfer Imaging.

Chizhik AM, Ruhlandt D, Pfaff J, Karedla N, Chizhik AI, Gregor I, Kehlenbach RH, Enderlein J.

ACS Nano. 2017 Dec 26;11(12):11839-11846. doi: 10.1021/acsnano.7b04671. Epub 2017 Sep 20.


The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export.

Port SA, Mendes A, Valkova C, Spillner C, Fahrenkrog B, Kaether C, Kehlenbach RH.

J Biol Chem. 2016 Oct 28;291(44):23068-23083. Epub 2016 Sep 9.


Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors.

Landry-Voyer AM, Bilodeau S, Bergeron D, Dionne KL, Port SA, Rouleau C, Boisvert FM, Kehlenbach RH, Bachand F.

Mol Cell Biol. 2016 Nov 28;36(24):3019-3032. Print 2016 Dec 15.


Analysis of CRM1-Dependent Nuclear Export in Permeabilized Cells.

Kehlenbach RH, Port SA.

Methods Mol Biol. 2016;1411:489-501. doi: 10.1007/978-1-4939-3530-7_30.


Distinct functions of the dual leucine zipper kinase depending on its subcellular localization.

Wallbach M, Duque Escobar J, Babaeikelishomi R, Stahnke MJ, Blume R, Schröder S, Kruegel J, Maedler K, Kluth O, Kehlenbach RH, Miosge N, Oetjen E.

Cell Signal. 2016 Apr;28(4):272-83. doi: 10.1016/j.cellsig.2016.01.002. Epub 2016 Jan 9.


Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.

Pfaff J, Rivera Monroy J, Jamieson C, Rajanala K, Vilardi F, Schwappach B, Kehlenbach RH.

J Cell Sci. 2016 Feb 1;129(3):502-16. doi: 10.1242/jcs.179333. Epub 2015 Dec 16.


Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.

Monecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1481-7. doi: 10.1107/S2053230X15021524. Epub 2015 Nov 18.


Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease.

Dickmanns A, Kehlenbach RH, Fahrenkrog B.

Int Rev Cell Mol Biol. 2015;320:171-233. doi: 10.1016/bs.ircmb.2015.07.010. Epub 2015 Aug 19. Review.


Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.

Port SA, Monecke T, Dickmanns A, Spillner C, Hofele R, Urlaub H, Ficner R, Kehlenbach RH.

Cell Rep. 2015 Oct 27;13(4):690-702. doi: 10.1016/j.celrep.2015.09.042. Epub 2015 Oct 17.


MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.

Halder K, Dölker N, Van Q, Gregor I, Dickmanns A, Baade I, Kehlenbach RH, Ficner R, Enderlein J, Grubmüller H, Neumann H.

Biophys J. 2015 Jul 21;109(2):277-86. doi: 10.1016/j.bpj.2015.06.014.


Novel approaches for the identification of nuclear transport receptor substrates.

Kimura M, Thakar K, Karaca S, Imamoto N, Kehlenbach RH.

Methods Cell Biol. 2014;122:353-78. doi: 10.1016/B978-0-12-417160-2.00016-3.


Analysis of nucleocytoplasmic transport in digitonin-permeabilized cells under different cellular conditions.

Furuta M, Kose S, Kehlenbach RH, Imamoto N.

Methods Cell Biol. 2014;122:331-52. doi: 10.1016/B978-0-12-417160-2.00015-1.


Importin 7 and Nup358 promote nuclear import of the protein component of human telomerase.

Frohnert C, Hutten S, Wälde S, Nath A, Kehlenbach RH.

PLoS One. 2014 Feb 20;9(2):e88887. doi: 10.1371/journal.pone.0088887. eCollection 2014.


Resolution doubling in fluorescence microscopy with confocal spinning-disk image scanning microscopy.

Schulz O, Pieper C, Clever M, Pfaff J, Ruhlandt A, Kehlenbach RH, Wouters FS, Großhans J, Bunt G, Enderlein J.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21000-5. doi: 10.1073/pnas.1315858110. Epub 2013 Dec 9.


Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.

Snow CJ, Dar A, Dutta A, Kehlenbach RH, Paschal BM.

J Cell Biol. 2013 May 13;201(4):541-57. doi: 10.1083/jcb.201212117. Epub 2013 May 6.


Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1.

Roloff S, Spillner C, Kehlenbach RH.

J Biol Chem. 2013 Feb 8;288(6):3952-63. doi: 10.1074/jbc.M112.433243. Epub 2012 Dec 21.


Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry.

Thakar K, Karaca S, Port SA, Urlaub H, Kehlenbach RH.

Mol Cell Proteomics. 2013 Mar;12(3):664-78. doi: 10.1074/mcp.M112.024877. Epub 2012 Dec 13.


Post-transcriptional regulation of CD83 expression by AUF1 proteins.

Ehlers C, Schirmer S, Kehlenbach RH, Hauber J, Chemnitz J.

Nucleic Acids Res. 2013 Jan 7;41(1):206-19. doi: 10.1093/nar/gks1069. Epub 2012 Nov 17.


Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.

Malik P, Tabarraei A, Kehlenbach RH, Korfali N, Iwasawa R, Graham SV, Schirmer EC.

J Biol Chem. 2012 Apr 6;287(15):12277-92. doi: 10.1074/jbc.M111.331777. Epub 2012 Feb 14.


The nucleoporin-like protein NLP1 (hCG1) promotes CRM1-dependent nuclear protein export.

Waldmann I, Spillner C, Kehlenbach RH.

J Cell Sci. 2012 Jan 1;125(Pt 1):144-54. doi: 10.1242/jcs.090316. Epub 2012 Jan 16.


The nucleoporin Nup358/RanBP2 promotes nuclear import in a cargo- and transport receptor-specific manner.

Wälde S, Thakar K, Hutten S, Spillner C, Nath A, Rothbauer U, Wiemann S, Kehlenbach RH.

Traffic. 2012 Feb;13(2):218-33. doi: 10.1111/j.1600-0854.2011.01302.x. Epub 2011 Nov 21.


Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.

Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Wälde S, Joseph J, Kehlenbach RH, van Deursen JM.

J Cell Biol. 2011 Aug 22;194(4):597-612. doi: 10.1083/jcb.201102018.


Functional characterization of the HuR:CD83 mRNA interaction.

Pieper D, Schirmer S, Prechtel AT, Kehlenbach RH, Hauber J, Chemnitz J.

PLoS One. 2011;6(8):e23290. doi: 10.1371/journal.pone.0023290. Epub 2011 Aug 4.


The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport.

Wälde S, Kehlenbach RH.

Trends Cell Biol. 2010 Aug;20(8):461-9. doi: 10.1016/j.tcb.2010.05.001. Epub 2010 Jun 4. Review.


The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export.

Hilliard M, Frohnert C, Spillner C, Marcone S, Nath A, Lampe T, Fitzgerald DJ, Kehlenbach RH.

J Biol Chem. 2010 Jul 16;285(29):22202-10. doi: 10.1074/jbc.M110.131821. Epub 2010 May 10.


Notch1 signaling is mediated by importins alpha 3, 4, and 7.

Huenniger K, Krämer A, Soom M, Chang I, Köhler M, Depping R, Kehlenbach RH, Kaether C.

Cell Mol Life Sci. 2010 Sep;67(18):3187-96. doi: 10.1007/s00018-010-0378-7. Epub 2010 May 8.


Identification and functional dissection of localization signals within ataxin-3.

Antony PM, Mäntele S, Mollenkopf P, Boy J, Kehlenbach RH, Riess O, Schmidt T.

Neurobiol Dis. 2009 Nov;36(2):280-92. doi: 10.1016/j.nbd.2009.07.020. Epub 2009 Aug 4.


The nuclear pore component Nup358 promotes transportin-dependent nuclear import.

Hutten S, Wälde S, Spillner C, Hauber J, Kehlenbach RH.

J Cell Sci. 2009 Apr 15;122(Pt 8):1100-10. doi: 10.1242/jcs.040154. Epub 2009 Mar 19.


The Nup358-RanGAP complex is required for efficient importin alpha/beta-dependent nuclear import.

Hutten S, Flotho A, Melchior F, Kehlenbach RH.

Mol Biol Cell. 2008 May;19(5):2300-10. doi: 10.1091/mbc.E07-12-1279. Epub 2008 Feb 27.


Nuclear import of c-Jun is mediated by multiple transport receptors.

Waldmann I, Wälde S, Kehlenbach RH.

J Biol Chem. 2007 Sep 21;282(38):27685-92. Epub 2007 Jul 25.


CRM1-mediated nuclear export: to the pore and beyond.

Hutten S, Kehlenbach RH.

Trends Cell Biol. 2007 Apr;17(4):193-201. Epub 2007 Feb 20.


Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression.

Fries B, Heukeshoven J, Hauber I, Grüttner C, Stocking C, Kehlenbach RH, Hauber J, Chemnitz J.

J Biol Chem. 2007 Feb 16;282(7):4504-15. Epub 2006 Dec 18.


Nup214 is required for CRM1-dependent nuclear protein export in vivo.

Hutten S, Kehlenbach RH.

Mol Cell Biol. 2006 Sep;26(18):6772-85.


Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.

Arnold M, Nath A, Hauber J, Kehlenbach RH.

J Biol Chem. 2006 Jul 28;281(30):20883-90. Epub 2006 May 16.


Stimulated expression of mRNAs in activated T cells depends on a functional CRM1 nuclear export pathway.

Schütz S, Chemnitz J, Spillner C, Frohme M, Hauber J, Kehlenbach RH.

J Mol Biol. 2006 May 12;358(4):997-1009. Epub 2006 Mar 3.


Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element.

Prechtel AT, Chemnitz J, Schirmer S, Ehlers C, Langbein-Detsch I, Stülke J, Dabauvalle MC, Kehlenbach RH, Hauber J.

J Biol Chem. 2006 Apr 21;281(16):10912-25. Epub 2006 Feb 16.


Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo interaction.

Arnold M, Nath A, Wohlwend D, Kehlenbach RH.

J Biol Chem. 2006 Mar 3;281(9):5492-9. Epub 2006 Jan 2.


Analysis of nuclear protein import and export in vitro using fluorescent cargoes.

Kehlenbach RH, Gerace L.

Methods Mol Biol. 2002;189:231-45. No abstract available.


Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.

Kehlenbach RH, Assheuer R, Kehlenbach A, Becker J, Gerace L.

J Biol Chem. 2001 Apr 27;276(17):14524-31. Epub 2001 Jan 30.

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