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Items: 35


Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus.

Párraga Solórzano PK, Yao J, Rock CO, Kehl-Fie TE.

MBio. 2019 Aug 6;10(4). pii: e01321-19. doi: 10.1128/mBio.01321-19.


Metal-independent variants of phosphoglycerate mutase promote resistance to nutritional immunity and retention of glycolysis during infection.

Radin JN, Kelliher JL, Solórzano PKP, Grim KP, Ramezanifard R, Slauch JM, Kehl-Fie TE.

PLoS Pathog. 2019 Jul 25;15(7):e1007971. doi: 10.1371/journal.ppat.1007971. eCollection 2019 Jul.


Synergy between Nutritional Immunity and Independent Host Defenses Contributes to the Importance of the MntABC Manganese Transporter during Staphylococcus aureus Infection.

Radin JN, Zhu J, Brazel EB, McDevitt CA, Kehl-Fie TE.

Infect Immun. 2018 Dec 19;87(1). pii: e00642-18. doi: 10.1128/IAI.00642-18. Print 2019 Jan.


PhoPR Contributes to Staphylococcus aureus Growth during Phosphate Starvation and Pathogenesis in an Environment-Specific Manner.

Kelliher JL, Radin JN, Kehl-Fie TE.

Infect Immun. 2018 Sep 21;86(10). pii: e00371-18. doi: 10.1128/IAI.00371-18. Print 2018 Oct.


Role of Calprotectin in Withholding Zinc and Copper from Candida albicans.

Besold AN, Gilston BA, Radin JN, Ramsoomair C, Culbertson EM, Li CX, Cormack BP, Chazin WJ, Kehl-Fie TE, Culotta VC.

Infect Immun. 2018 Jan 22;86(2). pii: e00779-17. doi: 10.1128/IAI.00779-17. Print 2018 Feb.


The Metallophore Staphylopine Enables Staphylococcus aureus To Compete with the Host for Zinc and Overcome Nutritional Immunity.

Grim KP, San Francisco B, Radin JN, Brazel EB, Kelliher JL, Párraga Solórzano PK, Kim PC, McDevitt CA, Kehl-Fie TE.

MBio. 2017 Oct 31;8(5). pii: e01281-17. doi: 10.1128/mBio.01281-17.


Acquisition of the Phosphate Transporter NptA Enhances Staphylococcus aureus Pathogenesis by Improving Phosphate Uptake in Divergent Environments.

Kelliher JL, Radin JN, Grim KP, Párraga Solórzano PK, Degnan PH, Kehl-Fie TE.

Infect Immun. 2017 Dec 19;86(1). pii: e00631-17. doi: 10.1128/IAI.00631-17. Print 2018 Jan.


Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Juttukonda LJ, Berends ETM, Zackular JP, Moore JL, Stier MT, Zhang Y, Schmitz JE, Beavers WN, Wijers CD, Gilston BA, Kehl-Fie TE, Atkinson J, Washington MK, Peebles RS, Chazin WJ, Torres VJ, Caprioli RM, Skaar EP.

Cell Host Microbe. 2017 Oct 11;22(4):531-542.e8. doi: 10.1016/j.chom.2017.08.009. Epub 2017 Sep 21.


Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.

Peng H, Zhang Y, Palmer LD, Kehl-Fie TE, Skaar EP, Trinidad JC, Giedroc DP.

ACS Infect Dis. 2017 Oct 13;3(10):744-755. doi: 10.1021/acsinfecdis.7b00090. Epub 2017 Sep 6.


Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus.

Peng H, Shen J, Edmonds KA, Luebke JL, Hickey AK, Palmer LD, Chang FJ, Bruce KA, Kehl-Fie TE, Skaar EP, Giedroc DP.

mSphere. 2017 Jun 21;2(3). pii: e00082-17. doi: 10.1128/mSphere.00082-17. eCollection 2017 May-Jun.


A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity.

Garcia YM, Barwinska-Sendra A, Tarrant E, Skaar EP, Waldron KJ, Kehl-Fie TE.

PLoS Pathog. 2017 Jan 19;13(1):e1006125. doi: 10.1371/journal.ppat.1006125. eCollection 2017 Jan.


The Two-Component System ArlRS and Alterations in Metabolism Enable Staphylococcus aureus to Resist Calprotectin-Induced Manganese Starvation.

Radin JN, Kelliher JL, Párraga Solórzano PK, Kehl-Fie TE.

PLoS Pathog. 2016 Nov 30;12(11):e1006040. doi: 10.1371/journal.ppat.1006040. eCollection 2016 Nov.


Competition for Manganese at the Host-Pathogen Interface.

Kelliher JL, Kehl-Fie TE.

Prog Mol Biol Transl Sci. 2016;142:1-25. doi: 10.1016/bs.pmbts.2016.05.002. Epub 2016 Jun 20. Review.


Host-imposed manganese starvation of invading pathogens: two routes to the same destination.

Morey JR, McDevitt CA, Kehl-Fie TE.

Biometals. 2015 Jun;28(3):509-19. doi: 10.1007/s10534-015-9850-z. Epub 2015 Apr 3. Review.


Copper intoxication inhibits aerobic nucleotide synthesis in Streptococcus pneumoniae.

Johnson MD, Kehl-Fie TE, Rosch JW.

Metallomics. 2015 May;7(5):786-94. doi: 10.1039/c5mt00011d. Epub 2015 Mar 2.


Role of copper efflux in pneumococcal pathogenesis and resistance to macrophage-mediated immune clearance.

Johnson MD, Kehl-Fie TE, Klein R, Kelly J, Burnham C, Mann B, Rosch JW.

Infect Immun. 2015 Apr;83(4):1684-94. doi: 10.1128/IAI.03015-14. Epub 2015 Feb 9.


The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration.

Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM.

PLoS Pathog. 2014 Oct 16;10(10):e1004450. doi: 10.1371/journal.ppat.1004450. eCollection 2014 Oct.


The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus.

Luebke JL, Shen J, Bruce KE, Kehl-Fie TE, Peng H, Skaar EP, Giedroc DP.

Mol Microbiol. 2014 Dec;94(6):1343-60. doi: 10.1111/mmi.12835. Epub 2014 Nov 17.


MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese.

Kehl-Fie TE, Zhang Y, Moore JL, Farrand AJ, Hood MI, Rathi S, Chazin WJ, Caprioli RM, Skaar EP.

Infect Immun. 2013 Sep;81(9):3395-405. doi: 10.1128/IAI.00420-13. Epub 2013 Jul 1.


Cdc42 promotes host defenses against fatal infection.

Lee K, Boyd KL, Parekh DV, Kehl-Fie TE, Baldwin HS, Brakebusch C, Skaar EP, Boothby M, Zent R.

Infect Immun. 2013 Aug;81(8):2714-23. doi: 10.1128/IAI.01114-12. Epub 2013 May 20.


Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.

Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8206-11. doi: 10.1073/pnas.1303674110. Epub 2013 Apr 29.


Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens.

Damo SM, Kehl-Fie TE, Sugitani N, Holt ME, Rathi S, Murphy WJ, Zhang Y, Betz C, Hench L, Fritz G, Skaar EP, Chazin WJ.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3841-6. doi: 10.1073/pnas.1220341110. Epub 2013 Feb 19.


Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration.

Hood MI, Mortensen BL, Moore JL, Zhang Y, Kehl-Fie TE, Sugitani N, Chazin WJ, Caprioli RM, Skaar EP.

PLoS Pathog. 2012;8(12):e1003068. doi: 10.1371/journal.ppat.1003068. Epub 2012 Dec 6. Erratum in: PLoS Pathog. 2013;9(1). 10.1371/annotation/2968451e-04b8-4705-bee9-9e40bceffe67.


Modulation of Kingella kingae adherence to human epithelial cells by type IV Pili, capsule, and a novel trimeric autotransporter.

Porsch EA, Kehl-Fie TE, St Geme JW 3rd.

MBio. 2012 Oct 23;3(5). pii: e00372-12. doi: 10.1128/mBio.00372-12.


Inhibition of bacterial superoxide defense: a new front in the struggle between host and pathogen.

Damo S, Chazin WJ, Skaar EP, Kehl-Fie TE.

Virulence. 2012 May 1;3(3):325-8. doi: 10.4161/viru.19635. Epub 2012 May 1. Review. No abstract available.


Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut.

Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M.

Cell Host Microbe. 2012 Mar 15;11(3):227-39. doi: 10.1016/j.chom.2012.01.017.


Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus.

Kehl-Fie TE, Chitayat S, Hood MI, Damo S, Restrepo N, Garcia C, Munro KA, Chazin WJ, Skaar EP.

Cell Host Microbe. 2011 Aug 18;10(2):158-64. doi: 10.1016/j.chom.2011.07.004.


Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus.

Grossoehme N, Kehl-Fie TE, Ma Z, Adams KW, Cowart DM, Scott RA, Skaar EP, Giedroc DP.

J Biol Chem. 2011 Apr 15;286(15):13522-31. doi: 10.1074/jbc.M111.220012. Epub 2011 Feb 21.


Examination of type IV pilus expression and pilus-associated phenotypes in Kingella kingae clinical isolates.

Kehl-Fie TE, Porsch EA, Yagupsky P, Grass EA, Obert C, Benjamin DK Jr, St Geme JW 3rd.

Infect Immun. 2010 Apr;78(4):1692-9. doi: 10.1128/IAI.00908-09. Epub 2010 Feb 9.


Nutritional immunity beyond iron: a role for manganese and zinc.

Kehl-Fie TE, Skaar EP.

Curr Opin Chem Biol. 2010 Apr;14(2):218-24. doi: 10.1016/j.cbpa.2009.11.008. Epub 2009 Dec 16. Review.


Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR.

Kehl-Fie TE, Porsch EA, Miller SE, St Geme JW 3rd.

J Bacteriol. 2009 Aug;191(15):4976-86. doi: 10.1128/JB.00123-09. Epub 2009 May 22.


Kingella kingae expresses type IV pili that mediate adherence to respiratory epithelial and synovial cells.

Kehl-Fie TE, Miller SE, St Geme JW 3rd.

J Bacteriol. 2008 Nov;190(21):7157-63. doi: 10.1128/JB.00884-08. Epub 2008 Aug 29.


Identification and characterization of an RTX toxin in the emerging pathogen Kingella kingae.

Kehl-Fie TE, St Geme JW 3rd.

J Bacteriol. 2007 Jan;189(2):430-6. Epub 2006 Nov 10.


SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity.

Interthal H, Chen HJ, Kehl-Fie TE, Zotzmann J, Leppard JB, Champoux JJ.

EMBO J. 2005 Jun 15;24(12):2224-33. Epub 2005 May 26.


Legionella pneumophila DotU and IcmF are required for stability of the Dot/Icm complex.

Sexton JA, Miller JL, Yoneda A, Kehl-Fie TE, Vogel JP.

Infect Immun. 2004 Oct;72(10):5983-92.

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