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Items: 16


Suppression of prostate cancer pathogenesis using an MDA-9/Syntenin (SDCBP) PDZ1 small molecule inhibitor.

Das SK, Kegelman TP, Pradhan AK, Shen XN, Bhoopathi P, Talukdar S, Maji S, Sarkar D, Emdad L, Fisher PB.

Mol Cancer Ther. 2019 Jul 25. pii: molcanther.1019.2018. doi: 10.1158/1535-7163.MCT-18-1019. [Epub ahead of print]


Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin.

Kegelman TP, Wu B, Das SK, Talukdar S, Beckta JM, Hu B, Emdad L, Valerie K, Sarkar D, Furnari FB, Cavenee WK, Wei J, Purves A, De SK, Pellecchia M, Fisher PB.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):370-375. doi: 10.1073/pnas.1616100114. Epub 2016 Dec 23.


Astrocyte Elevated Gene-1 Regulates β-Catenin Signaling to Maintain Glioma Stem-like Stemness and Self-Renewal.

Hu B, Emdad L, Kegelman TP, Shen XN, Das SK, Sarkar D, Fisher PB.

Mol Cancer Res. 2017 Feb;15(2):225-233. doi: 10.1158/1541-7786.MCR-16-0239. Epub 2016 Nov 30.


The Quest for an Effective Treatment for an Intractable Cancer: Established and Novel Therapies for Pancreatic Adenocarcinoma.

Quinn BA, Lee NA, Kegelman TP, Bhoopathi P, Emdad L, Das SK, Pellecchia M, Sarkar D, Fisher PB.

Adv Cancer Res. 2015;127:283-306. doi: 10.1016/bs.acr.2015.04.009. Epub 2015 May 21. Review.


Astrocyte elevated gene-1 interacts with Akt isoform 2 to control glioma growth, survival, and pathogenesis.

Hu B, Emdad L, Bacolod MD, Kegelman TP, Shen XN, Alzubi MA, Das SK, Sarkar D, Fisher PB.

Cancer Res. 2014 Dec 15;74(24):7321-32. doi: 10.1158/0008-5472.CAN-13-2978. Epub 2014 Oct 10.


Targeting tumor invasion: the roles of MDA-9/Syntenin.

Kegelman TP, Das SK, Emdad L, Hu B, Menezes ME, Bhoopathi P, Wang XY, Pellecchia M, Sarkar D, Fisher PB.

Expert Opin Ther Targets. 2015 Jan;19(1):97-112. doi: 10.1517/14728222.2014.959495. Epub 2014 Sep 15. Review.


In vivo modeling of malignant glioma: the road to effective therapy.

Kegelman TP, Hu B, Emdad L, Das SK, Sarkar D, Fisher PB.

Adv Cancer Res. 2014;121:261-330. doi: 10.1016/B978-0-12-800249-0.00007-X. Review.


MDA-9/syntenin is a key regulator of glioma pathogenesis.

Kegelman TP, Das SK, Hu B, Bacolod MD, Fuller CE, Menezes ME, Emdad L, Dasgupta S, Baldwin AS, Bruce JN, Dent P, Pellecchia M, Sarkar D, Fisher PB.

Neuro Oncol. 2014 Jan;16(1):50-61. doi: 10.1093/neuonc/not157. Epub 2013 Dec 4.


MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.

Das SK, Bhutia SK, Azab B, Kegelman TP, Peachy L, Santhekadur PK, Dasgupta S, Dash R, Dent P, Grant S, Emdad L, Pellecchia M, Sarkar D, Fisher PB.

Cancer Res. 2013 Jan 15;73(2):844-54. doi: 10.1158/0008-5472.CAN-12-1681. Epub 2012 Dec 10.


Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.

Hedvat M, Emdad L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelman TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, Wu B, Stebbins JL, Diaz PW, Reed JC, Pellecchia M, Sarkar D, Fisher PB.

Anticancer Agents Med Chem. 2012 Nov;12(9):1143-55. Review.


MDA-9/syntenin: a positive gatekeeper of melanoma metastasis.

Das SK, Bhutia SK, Kegelman TP, Peachy L, Oyesanya RA, Dasgupta S, Sokhi UK, Azab B, Dash R, Quinn BA, Kim K, Barral PM, Su ZZ, Boukerche H, Sarkar D, Fisher PB.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1-15. Review.


Oncogene AEG-1 promotes glioma-induced neurodegeneration by increasing glutamate excitotoxicity.

Lee SG, Kim K, Kegelman TP, Dash R, Das SK, Choi JK, Emdad L, Howlett EL, Jeon HY, Su ZZ, Yoo BK, Sarkar D, Kim SH, Kang DC, Fisher PB.

Cancer Res. 2011 Oct 15;71(20):6514-23. doi: 10.1158/0008-5472.CAN-11-0782. Epub 2011 Aug 18.


Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics.

Kim K, Lee SG, Kegelman TP, Su ZZ, Das SK, Dash R, Dasgupta S, Barral PM, Hedvat M, Diaz P, Reed JC, Stebbins JL, Pellecchia M, Sarkar D, Fisher PB.

J Cell Physiol. 2011 Oct;226(10):2484-93. doi: 10.1002/jcp.22609. Review.


mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.

Bhutia SK, Das SK, Kegelman TP, Azab B, Dash R, Su ZZ, Wang XY, Rizzi F, Bettuzzi S, Lee SG, Dent P, Grant S, Curiel DT, Sarkar D, Fisher PB.

J Cell Physiol. 2012 May;227(5):1805-13. doi: 10.1002/jcp.22904. Erratum in: J Cell Physiol. 2014 Apr;229(4):531.


Astrocyte elevated gene-1 activates AMPK in response to cellular metabolic stress and promotes protective autophagy.

Bhutia SK, Kegelman TP, Das SK, Azab B, Su ZZ, Lee SG, Sarkar D, Fisher PB.

Autophagy. 2011 May;7(5):547-8. Epub 2011 May 1. No abstract available.


Astrocyte elevated gene-1 induces protective autophagy.

Bhutia SK, Kegelman TP, Das SK, Azab B, Su ZZ, Lee SG, Sarkar D, Fisher PB.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22243-8. doi: 10.1073/pnas.1009479107. Epub 2010 Dec 2.

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