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Items: 8

1.

Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers.

Dominguez CL, Floyd DH, Xiao A, Mullins GR, Kefas BA, Xin W, Yacur MN, Abounader R, Lee JK, Wilson GM, Harris TE, Purow BW.

Cancer Discov. 2013 Jul;3(7):782-97. doi: 10.1158/2159-8290.CD-12-0215. Epub 2013 Apr 4.

2.

Notch-1 regulates transcription of the epidermal growth factor receptor through p53.

Purow BW, Sundaresan TK, Burdick MJ, Kefas BA, Comeau LD, Hawkinson MP, Su Q, Kotliarov Y, Lee J, Zhang W, Fine HA.

Carcinogenesis. 2008 May;29(5):918-25. doi: 10.1093/carcin/bgn079. Epub 2008 Mar 20.

3.

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.

Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D, Van de Casteele M.

Biochem Pharmacol. 2004 Aug 1;68(3):409-16.

PMID:
15242807
4.

Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

Van de Casteele M, Kefas BA, Cai Y, Heimberg H, Scott DK, Henquin JC, Pipeleers D, Jonas JC.

Biochem Biophys Res Commun. 2003 Dec 26;312(4):937-44.

PMID:
14651961
5.

AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.

Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de Casteele M.

J Mol Endocrinol. 2003 Apr;30(2):151-61.

PMID:
12683939
6.

AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase.

Kefas BA, Heimberg H, Vaulont S, Meisse D, Hue L, Pipeleers D, Van de Casteele M.

Diabetologia. 2003 Feb;46(2):250-4. Epub 2003 Feb 8.

PMID:
12627324
7.

Sustained activation of AMP-activated protein kinase induces c-Jun N-terminal kinase activation and apoptosis in liver cells.

Meisse D, Van de Casteele M, Beauloye C, Hainault I, Kefas BA, Rider MH, Foufelle F, Hue L.

FEBS Lett. 2002 Aug 28;526(1-3):38-42.

8.

Specific expression of Bax-omega in pancreatic beta-cells is down-regulated by cytokines before the onset of apoptosis.

Van de Casteele M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG.

Endocrinology. 2002 Jan;143(1):320-6.

PMID:
11751624

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