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Items: 1 to 50 of 123

1.

Development of a total serum testosterone, androstenedione, 17-hydroxyprogesterone, 11β-hydroxyandrostenedione and 11-ketotestosterone LC-MS/MS assay and its application to evaluate pre-analytical sample stability.

Hawley JM, Adaway JE, Owen LJ, Keevil BG.

Clin Chem Lab Med. 2020 Jan 13. pii: /j/cclm.ahead-of-print/cclm-2019-0959/cclm-2019-0959.xml. doi: 10.1515/cclm-2019-0959. [Epub ahead of print]

PMID:
31926069
2.

Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy.

Ho JH, Adam S, Azmi S, Ferdousi M, Liu Y, Kalteniece A, Dhage SS, Keevil BG, Syed AA, Ammori BJ, Ahern T, Donn R, Malik RA, Soran H.

PLoS One. 2019 Sep 11;14(9):e0221992. doi: 10.1371/journal.pone.0221992. eCollection 2019.

3.

Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring.

Capiau S, Veenhof H, Koster RA, Bergqvist Y, Boettcher M, Halmingh O, Keevil BG, Koch BCP, Linden R, Pistos C, Stolk LM, Touw DJ, Stove CP, Alffenaar JC.

Ther Drug Monit. 2019 Aug;41(4):409-430. doi: 10.1097/FTD.0000000000000643.

PMID:
31268966
4.

A liquid chromatography-tandem mass spectrometry assay for the profiling of classical and 11-oxygenated androgens in saliva.

Schiffer L, Adaway JE, Arlt W, Keevil BG.

Ann Clin Biochem. 2019 Sep;56(5):564-573. doi: 10.1177/0004563219847498. Epub 2019 May 9. No abstract available.

PMID:
31037957
5.

Assessment of free testosterone concentration.

Keevil BG, Adaway J.

J Steroid Biochem Mol Biol. 2019 Jun;190:207-211. doi: 10.1016/j.jsbmb.2019.04.008. Epub 2019 Apr 7. Review.

PMID:
30970279
6.

Oestradiol measurement during fulvestrant treatment for breast cancer.

Owen LJ, Monaghan PJ, Armstrong A, Keevil BG, Higham C, Salih Z, Howell S.

Br J Cancer. 2019 Feb;120(4):404-406. doi: 10.1038/s41416-019-0378-9. Epub 2019 Jan 25.

PMID:
30679781
7.

Salivary Cortisone to Estimate Cortisol Exposure and Sampling Frequency Required Based on Serum Cortisol Measurements.

Harrison RF, Debono M, Whitaker MJ, Keevil BG, Newell-Price J, Ross RJ.

J Clin Endocrinol Metab. 2019 Mar 1;104(3):765-772. doi: 10.1210/jc.2018-01172.

8.

A novel high-throughput assay for the measurement of salivary progesterone by liquid chromatography tandem mass spectrometry.

Schiffer L, Adaway JE, Baranowski ES, Arlt W, Keevil BG.

Ann Clin Biochem. 2019 Jan;56(1):64-71. doi: 10.1177/0004563218780904. Epub 2018 Jun 11.

PMID:
29792048
9.

Development of a rapid liquid chromatography tandem mass spectrometry method for the quantitation of serum dexamethasone and its clinical verification.

Hawley JM, Owen LJ, Debono M, Newell-Price J, Keevil BG.

Ann Clin Biochem. 2018 Nov;55(6):665-672. doi: 10.1177/0004563218766566. Epub 2018 Mar 29.

PMID:
29534610
10.

A letter in response to 'Liquid chromatography tandem mass spectrometry: challenges in introducing published methods into the clinical laboratory' by Khedr et al.

Marshall DJ, Adaway JE, Keevil BG.

Ann Clin Biochem. 2018 May;55(3):405-406. doi: 10.1177/0004563218754589. Epub 2018 Feb 10. No abstract available.

PMID:
29430933
11.

The free androgen index is inaccurate in women when the SHBG concentration is low.

Keevil BG, Adaway J, Fiers T, Moghetti P, Kaufman JM.

Clin Endocrinol (Oxf). 2018 May;88(5):706-710. doi: 10.1111/cen.13561. Epub 2018 Feb 26.

PMID:
29405348
12.

Association of sex hormones with physical, laboratory, and imaging markers of anthropometry in men and women from the general population.

Seyfart T, Friedrich N, Kische H, Bülow R, Wallaschofski H, Völzke H, Nauck M, Keevil BG, Haring R.

PLoS One. 2018 Jan 11;13(1):e0189042. doi: 10.1371/journal.pone.0189042. eCollection 2018.

13.

Distribution of Salivary Testosterone in Men and Women in a British General Population-Based Sample: The Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

Keevil BG, Clifton S, Tanton C, Macdowall W, Copas AJ, Lee D, Field N, Mitchell KR, Sonnenberg P, Bancroft J, Mercer CH, Johnson AM, Wellings K, Wu FCW.

J Endocr Soc. 2017 Jan 12;1(1):14-25. doi: 10.1210/js.2016-1029. eCollection 2017 Jan 1.

14.

Elevated luteinizing hormone despite normal testosterone levels in older men-natural history, risk factors and clinical features.

Eendebak RJAH, Ahern T, Swiecicka A, Pye SR, O'Neill TW, Bartfai G, Casanueva FF, Maggi M, Forti G, Giwercman A, Han TS, Słowikowska-Hilczer J, Lean MEJ, Punab M, Pendleton N, Keevil BG, Vanderschueren D, Rutter MK, Tampubolon G, Goodacre R, Huhtaniemi IT, Wu FCW; EMAS Group.

Clin Endocrinol (Oxf). 2018 Mar;88(3):479-490. doi: 10.1111/cen.13524. Epub 2017 Dec 25.

PMID:
29178359
15.

Use of salivary cortisol and cortisone in the high- and low-dose synacthen test.

Elder CJ, Harrison RF, Cross AS, Vilela R, Keevil BG, Wright NP, Ross RJ.

Clin Endocrinol (Oxf). 2018 Jun;88(6):772-778. doi: 10.1111/cen.13509. Epub 2017 Nov 29.

16.

A combined liquid chromatography tandem mass spectrometry assay for the quantification of urinary oxalate and citrate in patients with nephrolithiasis.

Marshall DJ, Adaway JE, Keevil BG.

Ann Clin Biochem. 2018 Jul;55(4):461-468. doi: 10.1177/0004563217739035. Epub 2017 Nov 20.

PMID:
28990817
17.

Sex hormones and quantitative ultrasound parameters at the heel in men and women from the general population.

Pätzug K, Friedrich N, Kische H, Hannemann A, Völzke H, Nauck M, Keevil BG, Haring R.

Bone Rep. 2017 Aug 18;7:51-56. doi: 10.1016/j.bonr.2017.08.003. eCollection 2017 Dec.

18.

Prediction of haematocrit in dried blood spots from the measurement of haemoglobin using commercially available sodium lauryl sulphate.

Richardson G, Marshall D, Keevil BG.

Ann Clin Biochem. 2018 May;55(3):363-367. doi: 10.1177/0004563217726809. Epub 2017 Sep 6.

PMID:
28774182
19.

Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome.

Cho LW, Sathyapalan T, Kilpatrick ES, Keevil BG, Miller AG, Coady AM, Ahmed L, Atkin SL.

BMC Endocr Disord. 2017 May 19;17(1):26. doi: 10.1186/s12902-017-0177-3.

20.

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism.

Arlt W, Lang K, Sitch AJ, Dietz AS, Rhayem Y, Bancos I, Feuchtinger A, Chortis V, Gilligan LC, Ludwig P, Riester A, Asbach E, Hughes BA, O'Neil DM, Bidlingmaier M, Tomlinson JW, Hassan-Smith ZK, Rees DA, Adolf C, Hahner S, Quinkler M, Dekkers T, Deinum J, Biehl M, Keevil BG, Shackleton CH, Deeks JJ, Walch AK, Beuschlein F, Reincke M.

JCI Insight. 2017 Apr 20;2(8). pii: 93136. doi: 10.1172/jci.insight.93136. eCollection 2017 Apr 20.

21.

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression.

Hassan-Smith ZK, Jenkinson C, Smith DJ, Hernandez I, Morgan SA, Crabtree NJ, Gittoes NJ, Keevil BG, Stewart PM, Hewison M.

PLoS One. 2017 Feb 15;12(2):e0170665. doi: 10.1371/journal.pone.0170665. eCollection 2017.

22.

Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men.

Eendebak RJ, Swiecicka A, Gromski PS, Pye SR, O'Neill TW, Marshall A, Keevil BG, Tampubolon G, Goodacre R, Wu FC, Rutter MK.

Clin Endocrinol (Oxf). 2017 May;86(5):660-668. doi: 10.1111/cen.13305. Epub 2017 Feb 28.

PMID:
28160328
23.

Affective alterations in patients with Cushing's syndrome in remission are associated with decreased BDNF and cortisone levels.

Valassi E, Crespo I, Keevil BG, Aulinas A, Urgell E, Santos A, Trainer PJ, Webb SM.

Eur J Endocrinol. 2017 Feb;176(2):221-231.

PMID:
27932530
24.

Endogenous testosterone is associated with lower amygdala reactivity to angry faces and reduced aggressive behavior in healthy young women.

Buades-Rotger M, Engelke C, Beyer F, Keevil BG, Brabant G, Krämer UM.

Sci Rep. 2016 Dec 7;6:38538. doi: 10.1038/srep38538.

25.

Salivary Testosterone Levels and Health Status in Men and Women in the British General Population: Findings from the Third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).

Clifton S, Macdowall W, Copas AJ, Tanton C, Keevil BG, Lee DM, Mitchell KR, Field N, Sonnenberg P, Bancroft J, Mercer CH, Wallace AM, Johnson AM, Wellings K, Wu FC.

J Clin Endocrinol Metab. 2016 Nov;101(11):3939-3951. Epub 2016 Aug 23.

26.

The androgen receptor gene CAG repeat 
in relation to 4-year changes in 
androgen-sensitive endpoints in 
community-dwelling older European men.

Eendebak RJ, Huhtaniemi IT, Pye SR, Ahern T, O'Neill TW, Bartfai G, Casanueva FF, Maggi M, Forti G, Alston RD, Giwercman A, Han TS, Kula K, Lean ME, Punab M, Pendleton N, Keevil BG, Vanderschueren D, Rutter MK, Tampubolon G, Goodacre R, Wu FC; EMAS Group.

Eur J Endocrinol. 2016 Dec;175(6):583-593. Epub 2016 Sep 15.

PMID:
27634944
27.

Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance.

Hawley JM, Owen LJ, Lockhart SJ, Monaghan PJ, Armston A, Chadwick CA, Wilshaw H, Freire M, Perry L, Keevil BG.

Clin Chem. 2016 Sep;62(9):1220-9. doi: 10.1373/clinchem.2016.255034. Epub 2016 Jul 20.

28.

Endogenous glucocorticoid analysis by liquid chromatography-tandem mass spectrometry in routine clinical laboratories.

Hawley JM, Keevil BG.

J Steroid Biochem Mol Biol. 2016 Sep;162:27-40. doi: 10.1016/j.jsbmb.2016.05.014. Epub 2016 May 18. Review.

PMID:
27208627
29.

Associations of androgens with health care utilization and costs in women-Perspectives of a population-based cohort study.

Haring R, Wallaschofski H, Völzke H, Flessa S, Keevil BG, Nauck M, Baumeister SE.

Maturitas. 2016 Jul;89:5-8. doi: 10.1016/j.maturitas.2016.04.003. Epub 2016 Apr 9.

PMID:
27180153
30.

LC-MS/MS analysis of steroids in the clinical laboratory.

Keevil BG.

Clin Biochem. 2016 Sep;49(13-14):989-97. doi: 10.1016/j.clinbiochem.2016.04.009. Epub 2016 Apr 27.

PMID:
27131495
31.

Sex hormone-binding globulin has no effect on salivary testosterone.

Keevil BG, Fiers T, Kaufman JM, Macdowall W, Clifton S, Lee D, Wu F.

Ann Clin Biochem. 2016 Nov;53(6):717-720. doi: 10.1177/0004563216646800. Epub 2016 Jul 20. No abstract available.

PMID:
27117450
32.

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.

Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MK, Newell-Price J, Walmsley SR.

Blood. 2016 May 26;127(21):2641-4. doi: 10.1182/blood-2016-02-696922. Epub 2016 Mar 22. No abstract available.

33.

Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Normal Total Testosterone.

Antonio L, Wu FC, O'Neill TW, Pye SR, Ahern TB, Laurent MR, Huhtaniemi IT, Lean ME, Keevil BG, Rastrelli G, Forti G, Bartfai G, Casanueva FF, Kula K, Punab M, Giwercman A, Claessens F, Decallonne B, Vanderschueren D; European Male Ageing Study Study Group.

J Clin Endocrinol Metab. 2016 Jul;101(7):2647-57. doi: 10.1210/jc.2015-4106. Epub 2016 Feb 24.

PMID:
26909800
34.

High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum.

Jenkinson C, Taylor AE, Hassan-Smith ZK, Adams JS, Stewart PM, Hewison M, Keevil BG.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 1;1014:56-63. doi: 10.1016/j.jchromb.2016.01.049. Epub 2016 Feb 2.

35.

Salivary Cortisone Reflects Cortisol Exposure Under Physiological Conditions and After Hydrocortisone.

Debono M, Harrison RF, Whitaker MJ, Eckland D, Arlt W, Keevil BG, Ross RJ.

J Clin Endocrinol Metab. 2016 Apr;101(4):1469-77. doi: 10.1210/jc.2015-3694. Epub 2016 Jan 26.

36.

A direct assay for the routine measurement of testosterone, androstenedione, dihydrotestosterone and dehydroepiandrosterone by liquid chromatography tandem mass spectrometry.

Owen LJ, Wu FC, Büttler RM, Keevil BG.

Ann Clin Biochem. 2016 Sep;53(Pt 5):580-7. doi: 10.1177/0004563215621096. Epub 2015 Nov 20.

PMID:
26589631
37.

Candidate Reference Measurement Procedure for the Quantification of Total Serum Cortisol with LC-MS/MS.

Hawley JM, Owen LJ, MacKenzie F, Mussell C, Cowen S, Keevil BG.

Clin Chem. 2016 Jan;62(1):262-9. doi: 10.1373/clinchem.2015.243576. Epub 2015 Nov 3.

38.

Endogenous Androgens and Sex Hormone-Binding Globulin in Women and Risk of Metabolic Syndrome and Type 2 Diabetes.

Fenske B, Kische H, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Keevil BG, Brabant G, Haring R.

J Clin Endocrinol Metab. 2015 Dec;100(12):4595-603. doi: 10.1210/jc.2015-2546. Epub 2015 Oct 7.

PMID:
26445113
39.

Serum and plasma 5-hydroxyindoleacetic acid as an alternative to 24-h urine 5-hydroxyindoleacetic acid measurement.

Adaway JE, Dobson R, Walsh J, Cuthbertson DJ, Monaghan PJ, Trainer PJ, Valle JW, Keevil BG.

Ann Clin Biochem. 2016 Sep;53(Pt 5):554-60. doi: 10.1177/0004563215613109. Epub 2015 Oct 5.

PMID:
26438520
40.

Association of sex hormones with incident 10-year cardiovascular disease and mortality in women.

Schaffrath G, Kische H, Gross S, Wallaschofski H, Völzke H, Dörr M, Nauck M, Keevil BG, Brabant G, Haring R.

Maturitas. 2015 Dec;82(4):424-30. doi: 10.1016/j.maturitas.2015.08.009. Epub 2015 Aug 28.

PMID:
26385535
41.

Associations between Serum Sex Hormone Concentrations and Whole Blood Gene Expression Profiles in the General Population.

Haring R, Schurmann C, Homuth G, Steil L, Völker U, Völzke H, Keevil BG, Nauck M, Wallaschofski H.

PLoS One. 2015 May 22;10(5):e0127466. doi: 10.1371/journal.pone.0127466. eCollection 2015.

42.

Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men.

Antonio L, Wu FC, O'Neill TW, Pye SR, Carter EL, Finn JD, Rutter MK, Laurent MR, Huhtaniemi IT, Han TS, Lean ME, Keevil BG, Pendleton N, Rastrelli G, Forti G, Bartfai G, Casanueva FF, Kula K, Punab M, Giwercman A, Claessens F, Decallonne B, Vanderschueren D; EMAS Study Group.

J Clin Endocrinol Metab. 2015 Apr;100(4):1396-404. doi: 10.1210/jc.2014-4184. Epub 2015 Jan 30.

PMID:
25636052
43.

Case for the wider adoption of mass spectrometry-based adrenal steroid testing, and beyond.

Monaghan PJ, Keevil BG, Stewart PM, Trainer PJ.

J Clin Endocrinol Metab. 2014 Dec;99(12):4434-7. doi: 10.1210/jc.2014-2258. No abstract available.

PMID:
25322267
44.

Liquid chromatography tandem mass spectrometry in the clinical laboratory.

Adaway JE, Keevil BG, Owen LJ.

Ann Clin Biochem. 2015 Jan;52(Pt 1):18-38. doi: 10.1177/0004563214557678. Epub 2014 Oct 13. Review.

PMID:
25313226
45.

A novel method for the measurement of plasma metanephrines using online solid phase extraction-liquid chromatography tandem mass spectrometry.

Adaway JE, Peitzsch M, Keevil BG.

Ann Clin Biochem. 2015 May;52(Pt 3):361-9. doi: 10.1177/0004563214546560. Epub 2014 Jul 21.

PMID:
25047871
46.

How do we measure hyperandrogenemia in patients with PCOS?

Keevil BG.

J Clin Endocrinol Metab. 2014 Mar;99(3):777-9. doi: 10.1210/jc.2014-1307. No abstract available.

PMID:
24823705
47.

A widely applicable plasma renin activity assay by LC-MS/MS with offline solid phase extraction.

Owen LJ, Adaway J, Morris K, Lockhart S, Keevil BG.

Ann Clin Biochem. 2014 May;51(Pt 3):409-11. doi: 10.1177/0004563214524558. Epub 2014 Feb 25.

PMID:
24569391
48.

Salivary testosterone measurement by liquid chromatography tandem mass spectrometry in adult males and females.

Keevil BG, MacDonald P, Macdowall W, Lee DM, Wu FC; NATSAL Team.

Ann Clin Biochem. 2014 May;51(Pt 3):368-78. doi: 10.1177/0004563213506412. Epub 2013 Nov 5.

49.

Novel liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for measuring steroids.

Keevil BG.

Best Pract Res Clin Endocrinol Metab. 2013 Oct;27(5):663-74. doi: 10.1016/j.beem.2013.05.015. Epub 2013 Jul 10. Review.

PMID:
24094637
50.

A rapid direct assay for the routine measurement of oestradiol and oestrone by liquid chromatography tandem mass spectrometry.

Owen LJ, Wu FC, Keevil BG.

Ann Clin Biochem. 2014 May;51(Pt 3):360-7. doi: 10.1177/0004563213501478. Epub 2013 Oct 1.

PMID:
24084694

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